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The map label for this gene is menE [H]

Identifier: 169627764

GI number: 169627764

Start: 663692

End: 665098

Strand: Direct

Name: menE [H]

Synonym: MAB_0661

Alternate gene names: 169627764

Gene position: 663692-665098 (Clockwise)

Preceding gene: 169627763

Following gene: 169627765

Centisome position: 13.1

GC content: 62.76

Gene sequence:

>1407_bases
ATGAGCTACGGTGAGCTCATCGGTGCCGTCGAAGACCTGGCCGCGACACTTGAAGCCGGCTCGGTCACGCACGGTTCGCG
TGTCGTCGTCCTCTCGGACAATGGACCCCAGACATATCTTTCGGTACTGGCATGTGCCCGGCTCGGCGCCATCGCGGTCA
TGGTTGACGATTCCTTGCCCGCGGCGACTGTCGCGCGGTTCAGTGAGATAACCCGGCCTGCTGCCATCATTCCGAACGAG
GGCGGTGGTGTCGGTGCCGAAAATGGCGAAAGAGCTTATCCGAAGGCGCAACCCGACAGTGGTGCGGACGAAGCGCTCGC
GATGATCTTCACCAGCGGCACCACCGGTGAGCCGAAGGCCGTGCTGCTGCCCAATCGGACGTTCTTCGCTATTCCGGACA
TTCTGCGCGCCGAGGGACTGCGCTGGATCGATTGGGTAGCGGGGGAGACAACCTACTCACCGCTGCCGGCGACGCATATC
GGCGGGCTGTGGTGGATCCTCAATGGGCTGATGCACGGTGCTTCGTGCATCACCGGTGGCGAGCAGGGAGCGTCGCTGCG
GGAACTACTTGTCGACAATGAGGTGGCCACCGCGTGTCTGGTGCCTACTCTCCTCACCAGATTGGTCTCGGAACTCAAGC
TCACCGGTACGGATGTTCCCGCATTGCGCTTCATTGCCTACGGCGGTTCACGGGCGATAGCCGCCGATGTGAGGTTCATC
GAAGCAGCCGGAGTGCGGACGGCTCAGGTTTATGGGCTGAGTGAAACAGGCTGTACCGCATTATGTCTGCCGACAGATAG
CGAATCCATTTCCAGGATTGAACAGGGGGCTGTGGGCCGCCCCTACCCGGGCGTGCAAACCTACCTTTCCCCTGAGGGCG
GGGGCGACCCGACCACGGGTGCCGAGTCCGCCTCCTACGGCACATTGTGGATCAAGTCGCCGGCCAACATGCTGGGGTAC
TGGGGAAGCCCCGAGCGCACCGGCGAGGTGCTGGCCGAAGGCTGGGTGAACACCGGTGATCTGGTGGAGCGTCGTGCCGA
CGGGTTCTTCTATATCAGGGGACGCTCGTCGGAAATGATCATCTCTGGCGGTGTCAACGTGGTTCCCGATGAGGTCGACC
GGATCGCTGAGGACATAGCGGGTGTGCGTGAAGCGGCGTGTTACGAGATACCCGACGAGGAATTCGGAGCACTGGTCGGA
TTGGCCGTAGTTGCCACCACCGAACTCGATGGTGCGGGCACCGCGGCGTTGAAGCAGCGGATCGCGGCCAGGTATCGGCG
TGAGTCGGAGTCGATGGCCAGGCCGTCGACCATCGTCCTGGTTGAGGACATCCCCCGGACCAAATCCGGCAAGGTGATGC
GTTCAGCGTTGTCCGCCTCGCTCAACGGGGCACGTGCGCGTGTCTGA

Upstream 100 bases:

>100_bases
GTCTCATTCGCCACCGCCCACCGTGCTGGAACGAATCGTCGCACAGGCCCGGACACGGCCGGATTCAATCGCGTTGCGTC
GCTGCGATGGTCGTGACGCC

Downstream 100 bases:

>100_bases
AACTACGAGGGACCGGATTCTGGCGGCAGTGTGCGAGGTGCTGTACATCTCGGAAGCTGATCTCTTTGAAGGCGATTCGA
CCGATCTGCGGGAGCTGGGC

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAIAVMVDDSLPAATVARFSEITRPAAIIPNE
GGGVGAENGERAYPKAQPDSGADEALAMIFTSGTTGEPKAVLLPNRTFFAIPDILRAEGLRWIDWVAGETTYSPLPATHI
GGLWWILNGLMHGASCITGGEQGASLRELLVDNEVATACLVPTLLTRLVSELKLTGTDVPALRFIAYGGSRAIAADVRFI
EAAGVRTAQVYGLSETGCTALCLPTDSESISRIEQGAVGRPYPGVQTYLSPEGGGDPTTGAESASYGTLWIKSPANMLGY
WGSPERTGEVLAEGWVNTGDLVERRADGFFYIRGRSSEMIISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGALVG
LAVVATTELDGAGTAALKQRIAARYRRESESMARPSTIVLVEDIPRTKSGKVMRSALSASLNGARARV

Sequences:

>Translated_468_residues
MSYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAIAVMVDDSLPAATVARFSEITRPAAIIPNE
GGGVGAENGERAYPKAQPDSGADEALAMIFTSGTTGEPKAVLLPNRTFFAIPDILRAEGLRWIDWVAGETTYSPLPATHI
GGLWWILNGLMHGASCITGGEQGASLRELLVDNEVATACLVPTLLTRLVSELKLTGTDVPALRFIAYGGSRAIAADVRFI
EAAGVRTAQVYGLSETGCTALCLPTDSESISRIEQGAVGRPYPGVQTYLSPEGGGDPTTGAESASYGTLWIKSPANMLGY
WGSPERTGEVLAEGWVNTGDLVERRADGFFYIRGRSSEMIISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGALVG
LAVVATTELDGAGTAALKQRIAARYRRESESMARPSTIVLVEDIPRTKSGKVMRSALSASLNGARARV
>Mature_467_residues
SYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAIAVMVDDSLPAATVARFSEITRPAAIIPNEG
GGVGAENGERAYPKAQPDSGADEALAMIFTSGTTGEPKAVLLPNRTFFAIPDILRAEGLRWIDWVAGETTYSPLPATHIG
GLWWILNGLMHGASCITGGEQGASLRELLVDNEVATACLVPTLLTRLVSELKLTGTDVPALRFIAYGGSRAIAADVRFIE
AAGVRTAQVYGLSETGCTALCLPTDSESISRIEQGAVGRPYPGVQTYLSPEGGGDPTTGAESASYGTLWIKSPANMLGYW
GSPERTGEVLAEGWVNTGDLVERRADGFFYIRGRSSEMIISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGALVGL
AVVATTELDGAGTAALKQRIAARYRRESESMARPSTIVLVEDIPRTKSGKVMRSALSASLNGARARV

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=409, Percent_Identity=28.8508557457213, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI187761343, Length=409, Percent_Identity=28.8508557457213, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI38505220, Length=371, Percent_Identity=26.1455525606469, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI156151445, Length=371, Percent_Identity=27.7628032345013, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI42544132, Length=499, Percent_Identity=21.8436873747495, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI122937307, Length=375, Percent_Identity=22.4, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI115511026, Length=265, Percent_Identity=23.7735849056604, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788107, Length=396, Percent_Identity=25.2525252525253, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI145693145, Length=378, Percent_Identity=27.5132275132275, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788595, Length=480, Percent_Identity=26.0416666666667, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790505, Length=528, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786810, Length=502, Percent_Identity=22.7091633466135, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=476, Percent_Identity=24.7899159663866, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=496, Percent_Identity=25.8064516129032, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71996755, Length=481, Percent_Identity=24.1164241164241, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531443, Length=381, Percent_Identity=26.7716535433071, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560308, Length=361, Percent_Identity=26.0387811634349, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17559526, Length=450, Percent_Identity=23.7777777777778, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=385, Percent_Identity=25.1948051948052, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=385, Percent_Identity=25.1948051948052, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=385, Percent_Identity=25.1948051948052, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25141359, Length=375, Percent_Identity=24, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=358, Percent_Identity=24.8603351955307, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=552, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319699, Length=369, Percent_Identity=23.8482384823848, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319264, Length=410, Percent_Identity=24.8780487804878, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859661, Length=382, Percent_Identity=25.130890052356, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24581924, Length=373, Percent_Identity=27.3458445040214, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356441, Length=389, Percent_Identity=24.6786632390745, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648260, Length=372, Percent_Identity=23.3870967741935, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648255, Length=395, Percent_Identity=24.8101265822785, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24653035, Length=382, Percent_Identity=23.8219895287958, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24648253, Length=395, Percent_Identity=24.8101265822785, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161076582, Length=400, Percent_Identity=23, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355181, Length=389, Percent_Identity=25.9640102827763, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356947, Length=376, Percent_Identity=24.7340425531915, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI20130357, Length=389, Percent_Identity=23.1362467866324, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358303, Length=342, Percent_Identity=23.6842105263158, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 49151; Mature: 49020

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAIAVMVDDSLP
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCC
AATVARFSEITRPAAIIPNEGGGVGAENGERAYPKAQPDSGADEALAMIFTSGTTGEPKA
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCE
VLLPNRTFFAIPDILRAEGLRWIDWVAGETTYSPLPATHIGGLWWILNGLMHGASCITGG
EEECCCCEEECCHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
EQGASLRELLVDNEVATACLVPTLLTRLVSELKLTGTDVPALRFIAYGGSRAIAADVRFI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEHHHEEH
EAAGVRTAQVYGLSETGCTALCLPTDSESISRIEQGAVGRPYPGVQTYLSPEGGGDPTTG
HHCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCC
AESASYGTLWIKSPANMLGYWGSPERTGEVLAEGWVNTGDLVERRADGFFYIRGRSSEMI
CCCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCEE
ISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGALVGLAVVATTELDGAGTAALKQR
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHH
IAARYRRESESMARPSTIVLVEDIPRTKSGKVMRSALSASLNGARARV
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAIAVMVDDSLP
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCC
AATVARFSEITRPAAIIPNEGGGVGAENGERAYPKAQPDSGADEALAMIFTSGTTGEPKA
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCE
VLLPNRTFFAIPDILRAEGLRWIDWVAGETTYSPLPATHIGGLWWILNGLMHGASCITGG
EEECCCCEEECCHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
EQGASLRELLVDNEVATACLVPTLLTRLVSELKLTGTDVPALRFIAYGGSRAIAADVRFI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEHHHEEH
EAAGVRTAQVYGLSETGCTALCLPTDSESISRIEQGAVGRPYPGVQTYLSPEGGGDPTTG
HHCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCC
AESASYGTLWIKSPANMLGYWGSPERTGEVLAEGWVNTGDLVERRADGFFYIRGRSSEMI
CCCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCEE
ISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGALVGLAVVATTELDGAGTAALKQR
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCCHHHHHHH
IAARYRRESESMARPSTIVLVEDIPRTKSGKVMRSALSASLNGARARV
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA