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The map label for this gene is moaE2 [H]

Identifier: 169627743

GI number: 169627743

Start: 642080

End: 643273

Strand: Reverse

Name: moaE2 [H]

Synonym: MAB_0640c

Alternate gene names: 169627743

Gene position: 643273-642080 (Counterclockwise)

Preceding gene: 169627747

Following gene: 169627742

Centisome position: 12.69

GC content: 67.76

Gene sequence:

>1194_bases
ATGCGTTCCGTCGCAGAGCACCAGCAAGTCGTTGCCGAACTGATCCAGGCACCTGTGCCCGTACGGATACCGGTCGGCGC
GGCTGAGCGGTTGGTGCTGGCCGCCGACGTCGTCGCACCGCTGAATCTGCCGGTGTTCGACAACTCCGCGATGGACGGTT
ATGCGGTTCGGCACGAGGATTTGGTTGGGGCAAGCCCCGCTGGCCCGATAACCCTTCCGGTCACCGAGGACATCCCCGCC
GGGCGCACCGATGAACTGACCCTCAACCCGGGCACCGCGCATCGGATCATGACCGGTGCGCCAGTTCCCGCCGGTGCCAG
CGCCGTAGTACCCGTCGAAGTCACCGACGGCGGCACCGAGACGGTGACCATCACCCAGGAGCCCGCTGCCGGACAACATG
TCCGCTGCGCGGGAGAGGATGTGCGGGCCGGCGACACCGTGTTGACCGCAGGCACCCGCCTCAACGCGCCGGCACTGGGC
CTTGCCGCCGCGCTCGGCCTGGACGAGCTGACCGTGCATCCCCGCCTGCGGGTGGTGATCGCGTCAACCGGCAGCGAGCT
GGTGCCGCCCGGCACACCCCTTCGGCCAGGGCAGATCTACGAATCGAACGCGGTCATGCTCGCCGCCGCCGTCCAGGAGG
CCGGTGCGGACGCGGTGGTGGCACCGACCGTCGCCGACGATGTCGAGCAATTCCTGGCCGTACTCGAAGAATTCGGCGCG
CAGGCCGATCTGGTGATCACCACCGGGGGGGTGAGCGCGGGCGCCTATGAGGTGGTCAAGGACGCACTGACCGATGCGGG
TGTTCGGTTCGTTTCGGTGGCCATGCAACCCGGCAAGCCGCAGGGGGCCGGTCACGTCAACGGTGTTCCAGTGCTCACGC
TGCCGGGCAATCCGGTCAGCGCACTGGTGTCATTCGAGGTGTTCATTCGCGAACCGCTGCGCGCCGCGATGGGATTGACC
CCGGCGCGGACACGCCACGAAGCCGTCCTCACCGATGCCATATCCGCCCCCGCCGGCAAACGCCAGTTCCGGCGCGGATA
CTGGGCCGCCGACAAGGGCACCGTGACCGCCGTCGGACCTCCCGCATCGCATCATCTGCGCTGGCTTGCGGTATCGAACT
GCCTGCTGGACATCCCCGAAGACGTCACCCAACTGCCTGCGGGAACGACAGTCAGTGTGTGGAATCTGAGCTGA

Upstream 100 bases:

>100_bases
ATGGTGTCGCCACCGCACGTCGAGGGCATGCCGGGCGCACACAACTCGGCGAAAACCCCTGCGTGCGGTATGCGCTCGGC
ATTCGGGCAATAATGAGCCG

Downstream 100 bases:

>100_bases
TCAAGGCGGCCGTGAGCGGCGTTGCGATCAGTGTGTTCCCCAGCTCGCGGACCGCATCACTAGGATGGTCCGGTGGCAAG
ACGCCCCCGCCCCGCAGGTT

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase 2 [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MRSVAEHQQVVAELIQAPVPVRIPVGAAERLVLAADVVAPLNLPVFDNSAMDGYAVRHEDLVGASPAGPITLPVTEDIPA
GRTDELTLNPGTAHRIMTGAPVPAGASAVVPVEVTDGGTETVTITQEPAAGQHVRCAGEDVRAGDTVLTAGTRLNAPALG
LAAALGLDELTVHPRLRVVIASTGSELVPPGTPLRPGQIYESNAVMLAAAVQEAGADAVVAPTVADDVEQFLAVLEEFGA
QADLVITTGGVSAGAYEVVKDALTDAGVRFVSVAMQPGKPQGAGHVNGVPVLTLPGNPVSALVSFEVFIREPLRAAMGLT
PARTRHEAVLTDAISAPAGKRQFRRGYWAADKGTVTAVGPPASHHLRWLAVSNCLLDIPEDVTQLPAGTTVSVWNLS

Sequences:

>Translated_397_residues
MRSVAEHQQVVAELIQAPVPVRIPVGAAERLVLAADVVAPLNLPVFDNSAMDGYAVRHEDLVGASPAGPITLPVTEDIPA
GRTDELTLNPGTAHRIMTGAPVPAGASAVVPVEVTDGGTETVTITQEPAAGQHVRCAGEDVRAGDTVLTAGTRLNAPALG
LAAALGLDELTVHPRLRVVIASTGSELVPPGTPLRPGQIYESNAVMLAAAVQEAGADAVVAPTVADDVEQFLAVLEEFGA
QADLVITTGGVSAGAYEVVKDALTDAGVRFVSVAMQPGKPQGAGHVNGVPVLTLPGNPVSALVSFEVFIREPLRAAMGLT
PARTRHEAVLTDAISAPAGKRQFRRGYWAADKGTVTAVGPPASHHLRWLAVSNCLLDIPEDVTQLPAGTTVSVWNLS
>Mature_397_residues
MRSVAEHQQVVAELIQAPVPVRIPVGAAERLVLAADVVAPLNLPVFDNSAMDGYAVRHEDLVGASPAGPITLPVTEDIPA
GRTDELTLNPGTAHRIMTGAPVPAGASAVVPVEVTDGGTETVTITQEPAAGQHVRCAGEDVRAGDTVLTAGTRLNAPALG
LAAALGLDELTVHPRLRVVIASTGSELVPPGTPLRPGQIYESNAVMLAAAVQEAGADAVVAPTVADDVEQFLAVLEEFGA
QADLVITTGGVSAGAYEVVKDALTDAGVRFVSVAMQPGKPQGAGHVNGVPVLTLPGNPVSALVSFEVFIREPLRAAMGLT
PARTRHEAVLTDAISAPAGKRQFRRGYWAADKGTVTAVGPPASHHLRWLAVSNCLLDIPEDVTQLPAGTTVSVWNLS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=307, Percent_Identity=38.4364820846906, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI10880983, Length=307, Percent_Identity=38.4364820846906, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1787049, Length=358, Percent_Identity=38.268156424581, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI25147659, Length=293, Percent_Identity=32.7645051194539, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562606, Length=341, Percent_Identity=24.0469208211144, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136978, Length=297, Percent_Identity=33.6700336700337, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24638841, Length=297, Percent_Identity=33.6700336700337, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 40822; Mature: 40822

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVAEHQQVVAELIQAPVPVRIPVGAAERLVLAADVVAPLNLPVFDNSAMDGYAVRHED
CCCHHHHHHHHHHHHHCCCCEEEECCCHHHEEEEEHHHCCCCCCEECCCCCCCEEEECCC
LVGASPAGPITLPVTEDIPAGRTDELTLNPGTAHRIMTGAPVPAGASAVVPVEVTDGGTE
CCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCEEEECCCCCCCCCEEEEEEECCCCCE
TVTITQEPAAGQHVRCAGEDVRAGDTVLTAGTRLNAPALGLAAALGLDELTVHPRLRVVI
EEEEEECCCCCCEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEECCEEEEEE
ASTGSELVPPGTPLRPGQIYESNAVMLAAAVQEAGADAVVAPTVADDVEQFLAVLEEFGA
EECCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCCCCEEEECHHHHHHHHHHHHHHHHCC
QADLVITTGGVSAGAYEVVKDALTDAGVRFVSVAMQPGKPQGAGHVNGVPVLTLPGNPVS
CEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHH
ALVSFEVFIREPLRAAMGLTPARTRHEAVLTDAISAPAGKRQFRRGYWAADKGTVTAVGP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECC
PASHHLRWLAVSNCLLDIPEDVTQLPAGTTVSVWNLS
CHHHCEEEEEECCHHHCCCHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MRSVAEHQQVVAELIQAPVPVRIPVGAAERLVLAADVVAPLNLPVFDNSAMDGYAVRHED
CCCHHHHHHHHHHHHHCCCCEEEECCCHHHEEEEEHHHCCCCCCEECCCCCCCEEEECCC
LVGASPAGPITLPVTEDIPAGRTDELTLNPGTAHRIMTGAPVPAGASAVVPVEVTDGGTE
CCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCEEEECCCCCCCCCEEEEEEECCCCCE
TVTITQEPAAGQHVRCAGEDVRAGDTVLTAGTRLNAPALGLAAALGLDELTVHPRLRVVI
EEEEEECCCCCCEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEECCEEEEEE
ASTGSELVPPGTPLRPGQIYESNAVMLAAAVQEAGADAVVAPTVADDVEQFLAVLEEFGA
EECCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCCCCEEEECHHHHHHHHHHHHHHHHCC
QADLVITTGGVSAGAYEVVKDALTDAGVRFVSVAMQPGKPQGAGHVNGVPVLTLPGNPVS
CEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHH
ALVSFEVFIREPLRAAMGLTPARTRHEAVLTDAISAPAGKRQFRRGYWAADKGTVTAVGP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEEECC
PASHHLRWLAVSNCLLDIPEDVTQLPAGTTVSVWNLS
CHHHCEEEEEECCHHHCCCHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]