Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 169627715

GI number: 169627715

Start: 610480

End: 611640

Strand: Reverse

Name: fadA [H]

Synonym: MAB_0612c

Alternate gene names: 169627715

Gene position: 611640-610480 (Counterclockwise)

Preceding gene: 169627723

Following gene: 169627712

Centisome position: 12.07

GC content: 66.84

Gene sequence:

>1161_bases
ATGGGTAATCCGGTCATCGTCGAAGCGACGCGCAGCGCCATCGGCAAACGCGGTGGATGGCTCGCGGGGCTGCATCCCGC
CGAGCTGCTGGGCAGCATCCAAAGGTCGGTGATCGCACGCGCCGGCCTGGATCCGAATGAGGTCGAGCAGGTCATCGGCG
GCTGCGTGACCCAATTCGGCGAGCAGGGCGGGCACATCACACGACAGGCATGGCTGCATGCCGGGCTGCCCGAAGCCACC
GGCGCCACCACCATCGACTGCCAGTGCGGTAGCGCGCAGCAGGCCAACCATCTCATCGCCGGCCTGATCTACTCCGGCGC
GATCGATACCGGCATCGCCTGCGGTATCGAGTCCATGAGCCGAGTGCCCCTTGGCGCCAACGTCGGCGGTACCGGCATTC
CGCGGCCCGACTCCTGGGATATCGACATGCCCAATCAGTTCGAGGCCGCCGAGCGCATCGCCAAGCGCCGCGGCATCACC
CGCGCCGACGTCGACGGGCTGGGGGTGCGTTCGCAGGCGCTCGCCGCCCAGGCCTGGGCCGAGGGGCGATTCGACCGAGA
GATCACACCGCTCGATGCCCCGCAGGTGGACAAGGAAGGCAACCCCACCGGCGAGACCAAGACCGTCAACCGCGACCAGG
GTCTGCGCGAGACCACTCTGGAATCACTGGGCAACCTGAAACCCGTTATCGCCGAAGGTATTCACACCGCAGGTACGTCC
TCGCAGATTTCCGACGGCGCCGCGGCGGTGCTGCTGATGGACAGCGACAAGGCCAAGGCCCTCGGATTGCGGCCGCGGGC
CCGCATCGTGTCTCAGGCCCTGGTGGGCGCTGAGCCCTACTACCACCTGGATGGCCCGGTGCAGTCGACACAGCGTGTAC
TGGACCGCGCCGGCATGAAGATCGGTGATATCGACGTCGTCGAGATCAACGAGGCCTTCGCTTCTGTGGTGCTGTCATGG
GCTGCCGTGCACAAGCCCGACTTCGATCGCGTGAACGTCAACGGCGGTGCCATCGCCCTGGGCCACCCGGTGGGCAGCAC
CGGCAGCCGCCTGATCACCACGGCGCTGCACGAACTCGAGCGCACCGACAAGTCAACGGCTTTGATCACCATGTGCGCTG
GTGGCGCGCTGTCCACCGGAACCATCATCGAGCGCGTCTAG

Upstream 100 bases:

>100_bases
ACAAAACGTGGTGCACGGGGGGAGAACGCGTTCTCGTTGCTTCCGGACTGGAACGTGTTCTACCGTGAAGCCAACGTTCA
GAGTGCAAAGGAGCAGCTCC

Downstream 100 bases:

>100_bases
CACCTCTGACGAAAGGGCCCCGGCGTCATGGCGCCGGGGCCCTTTCGTCAGCTTGCCCGTCCGTAGCCTGCCGGGCAGAA
GTCCACTTCCCAATGTTTGA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MGNPVIVEATRSAIGKRGGWLAGLHPAELLGSIQRSVIARAGLDPNEVEQVIGGCVTQFGEQGGHITRQAWLHAGLPEAT
GATTIDCQCGSAQQANHLIAGLIYSGAIDTGIACGIESMSRVPLGANVGGTGIPRPDSWDIDMPNQFEAAERIAKRRGIT
RADVDGLGVRSQALAAQAWAEGRFDREITPLDAPQVDKEGNPTGETKTVNRDQGLRETTLESLGNLKPVIAEGIHTAGTS
SQISDGAAAVLLMDSDKAKALGLRPRARIVSQALVGAEPYYHLDGPVQSTQRVLDRAGMKIGDIDVVEINEAFASVVLSW
AAVHKPDFDRVNVNGGAIALGHPVGSTGSRLITTALHELERTDKSTALITMCAGGALSTGTIIERV

Sequences:

>Translated_386_residues
MGNPVIVEATRSAIGKRGGWLAGLHPAELLGSIQRSVIARAGLDPNEVEQVIGGCVTQFGEQGGHITRQAWLHAGLPEAT
GATTIDCQCGSAQQANHLIAGLIYSGAIDTGIACGIESMSRVPLGANVGGTGIPRPDSWDIDMPNQFEAAERIAKRRGIT
RADVDGLGVRSQALAAQAWAEGRFDREITPLDAPQVDKEGNPTGETKTVNRDQGLRETTLESLGNLKPVIAEGIHTAGTS
SQISDGAAAVLLMDSDKAKALGLRPRARIVSQALVGAEPYYHLDGPVQSTQRVLDRAGMKIGDIDVVEINEAFASVVLSW
AAVHKPDFDRVNVNGGAIALGHPVGSTGSRLITTALHELERTDKSTALITMCAGGALSTGTIIERV
>Mature_385_residues
GNPVIVEATRSAIGKRGGWLAGLHPAELLGSIQRSVIARAGLDPNEVEQVIGGCVTQFGEQGGHITRQAWLHAGLPEATG
ATTIDCQCGSAQQANHLIAGLIYSGAIDTGIACGIESMSRVPLGANVGGTGIPRPDSWDIDMPNQFEAAERIAKRRGITR
ADVDGLGVRSQALAAQAWAEGRFDREITPLDAPQVDKEGNPTGETKTVNRDQGLRETTLESLGNLKPVIAEGIHTAGTSS
QISDGAAAVLLMDSDKAKALGLRPRARIVSQALVGAEPYYHLDGPVQSTQRVLDRAGMKIGDIDVVEINEAFASVVLSWA
AVHKPDFDRVNVNGGAIALGHPVGSTGSRLITTALHELERTDKSTALITMCAGGALSTGTIIERV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=386, Percent_Identity=37.0466321243523, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=36.2025316455696, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=35.1758793969849, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=32.5757575757576, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=29.7674418604651, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=382, Percent_Identity=28.0104712041885, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787663, Length=407, Percent_Identity=40.2948402948403, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=38.1313131313131, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=37.4064837905237, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI87082165, Length=399, Percent_Identity=38.0952380952381, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788683, Length=433, Percent_Identity=29.0993071593533, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=33.8383838383838, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=30.9644670050761, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25147385, Length=396, Percent_Identity=31.3131313131313, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=28.9351851851852, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=25.9351620947631, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=34.2639593908629, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=31.1881188118812, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24655093, Length=402, Percent_Identity=35.8208955223881, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=33.6683417085427, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=33.5858585858586, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=29.2343387470998, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40388; Mature: 40257

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNPVIVEATRSAIGKRGGWLAGLHPAELLGSIQRSVIARAGLDPNEVEQVIGGCVTQFG
CCCCEEEECCHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EQGGHITRQAWLHAGLPEATGATTIDCQCGSAQQANHLIAGLIYSGAIDTGIACGIESMS
HCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHCHHHHH
RVPLGANVGGTGIPRPDSWDIDMPNQFEAAERIAKRRGITRADVDGLGVRSQALAAQAWA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
EGRFDREITPLDAPQVDKEGNPTGETKTVNRDQGLRETTLESLGNLKPVIAEGIHTAGTS
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCC
SQISDGAAAVLLMDSDKAKALGLRPRARIVSQALVGAEPYYHLDGPVQSTQRVLDRAGMK
CCCCCCCEEEEEEECCCCHHCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCE
IGDIDVVEINEAFASVVLSWAAVHKPDFDRVNVNGGAIALGHPVGSTGSRLITTALHELE
ECCEEEEEHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHH
RTDKSTALITMCAGGALSTGTIIERV
HCCCCEEEEEEECCCCCCCCHHHHCC
>Mature Secondary Structure 
GNPVIVEATRSAIGKRGGWLAGLHPAELLGSIQRSVIARAGLDPNEVEQVIGGCVTQFG
CCCEEEECCHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
EQGGHITRQAWLHAGLPEATGATTIDCQCGSAQQANHLIAGLIYSGAIDTGIACGIESMS
HCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHCHHHHH
RVPLGANVGGTGIPRPDSWDIDMPNQFEAAERIAKRRGITRADVDGLGVRSQALAAQAWA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
EGRFDREITPLDAPQVDKEGNPTGETKTVNRDQGLRETTLESLGNLKPVIAEGIHTAGTS
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCC
SQISDGAAAVLLMDSDKAKALGLRPRARIVSQALVGAEPYYHLDGPVQSTQRVLDRAGMK
CCCCCCCEEEEEEECCCCHHCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCE
IGDIDVVEINEAFASVVLSWAAVHKPDFDRVNVNGGAIALGHPVGSTGSRLITTALHELE
ECCEEEEEHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHH
RTDKSTALITMCAGGALSTGTIIERV
HCCCCEEEEEEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]