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The map label for this gene is ddn [H]

Identifier: 169627712

GI number: 169627712

Start: 608171

End: 608659

Strand: Reverse

Name: ddn [H]

Synonym: MAB_0609c

Alternate gene names: 169627712

Gene position: 608659-608171 (Counterclockwise)

Preceding gene: 169627715

Following gene: 169627709

Centisome position: 12.01

GC content: 62.78

Gene sequence:

>489_bases
ATGACCGCACCGGGATCATCCGCGAACGCACCCGCCCAACTGAATTCCGAGTTCGCCGGCAAGGTCATCAAGTGGATGAC
CACGGTCAATGTTTGGCTGTATCAGCGTACCGACGGCCGTCTCGGTGGAAAGTGGCGTGTCGGCGCGGCTTTCCCGTGGG
GCATACCGGTATTGCTGCTCACCACGACCGGCCGCAAGACCGGGCAGCAGCGTCTCAGCGCGCTGCTCTACCTACCCGAC
GGCGACAAGGTGGTTTTGGTCGCGTCGCAGGGCGGGCGCGCCTCCAACCCGGCGTGGTATCTCAACCTGAAGGCGAATTC
TGAAGTCACCGTTCAGATCAAGGGCGATATCCGCACCATGACGGCGCGCACCGCGACCGACGCAGAACGTGCCTACTACT
GGCCCAAGCTGGTCGAGCTGTACGCGGACTTCGACAAATACCAGTCGTACACGACCCGCCAGATCCCGGTCGTCATCCTG
GAGCCCTAG

Upstream 100 bases:

>100_bases
TCCGCCTGGTGTGTGACGAGGGCTTCGATGTAGGCATTCGCAGCGGCGATACGTGCTTCGTCTGAGGCTCCGGGTGTTGA
CACACTCGTAGCATAGGGCC

Downstream 100 bases:

>100_bases
CCCCATCGACACGCCGCGTCTTGCGCGGATCACTCGCGAAATGCGTCGTAACACGGCGTGTCGGCGGAAAGGGTTAGCCT
TGCGAGCCGTAGACCGGAAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTAPGSSANAPAQLNSEFAGKVIKWMTTVNVWLYQRTDGRLGGKWRVGAAFPWGIPVLLLTTTGRKTGQQRLSALLYLPD
GDKVVLVASQGGRASNPAWYLNLKANSEVTVQIKGDIRTMTARTATDAERAYYWPKLVELYADFDKYQSYTTRQIPVVIL
EP

Sequences:

>Translated_162_residues
MTAPGSSANAPAQLNSEFAGKVIKWMTTVNVWLYQRTDGRLGGKWRVGAAFPWGIPVLLLTTTGRKTGQQRLSALLYLPD
GDKVVLVASQGGRASNPAWYLNLKANSEVTVQIKGDIRTMTARTATDAERAYYWPKLVELYADFDKYQSYTTRQIPVVIL
EP
>Mature_161_residues
TAPGSSANAPAQLNSEFAGKVIKWMTTVNVWLYQRTDGRLGGKWRVGAAFPWGIPVLLLTTTGRKTGQQRLSALLYLPDG
DKVVLVASQGGRASNPAWYLNLKANSEVTVQIKGDIRTMTARTATDAERAYYWPKLVELYADFDKYQSYTTRQIPVVILE
P

Specific function: Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites;

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deazaflavin-dependent nitroreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012349
- InterPro:   IPR009002
- InterPro:   IPR004378 [H]

Pfam domain/function: PF04075 DUF385 [H]

EC number: NA

Molecular weight: Translated: 17968; Mature: 17837

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPGSSANAPAQLNSEFAGKVIKWMTTVNVWLYQRTDGRLGGKWRVGAAFPWGIPVLLL
CCCCCCCCCCCCCCCHHHHHHHHEEEEEEEEEEEEECCCCCCCEEEECCCCCCCCEEEEE
TTTGRKTGQQRLSALLYLPDGDKVVLVASQGGRASNPAWYLNLKANSEVTVQIKGDIRTM
EECCCCCHHHHEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCEEEE
TARTATDAERAYYWPKLVELYADFDKYQSYTTRQIPVVILEP
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
>Mature Secondary Structure 
TAPGSSANAPAQLNSEFAGKVIKWMTTVNVWLYQRTDGRLGGKWRVGAAFPWGIPVLLL
CCCCCCCCCCCCCCHHHHHHHHEEEEEEEEEEEEECCCCCCCEEEECCCCCCCCEEEEE
TTTGRKTGQQRLSALLYLPDGDKVVLVASQGGRASNPAWYLNLKANSEVTVQIKGDIRTM
EECCCCCHHHHEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCEEEE
TARTATDAERAYYWPKLVELYADFDKYQSYTTRQIPVVILEP
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]