BacMap

Definition	Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession	NC_010397
Length	5,067,172

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The map label for this gene is fabG [C]

Identifier: 169627711

GI number: 169627711

Start: 607186

End: 608097

Strand: Direct

Name: fabG [C]

Synonym: MAB_0608

Alternate gene names: 169627711

Gene position: 607186-608097 (Clockwise)

Preceding gene: 169627710

Following gene: 169627713

Centisome position: 11.98

GC content: 66.89

Gene sequence:

>912_bases
ATGCCAGGTTTACTCGACGGTCGGGTCGTCATCATCACGGGCGCGGGCCGTGGCATCGGCCGGGCGCACGCACTGGCGTT
CGCCGCAGAAGGGGCGCGGGTCGTCGTCAACGACATCGGTGTCGGCCTGGATGGGTCGGCGGGCATCAGTCCCGCCCAGG
AGGTCGTCGAGGAGATCACGGCCGCCGGTGGCGAGGCCGTCACCAATGGGGACGATGTCGCCGACTGGAGCGGGGCCAAG
AACCTCATCGACACCGCCGTCAATTCCTTTGGCCGCCTGGATGTCCTGGTCAACAATGCCGGATTCCTGCGCGACCGGAT
GCTTGCCAATATGAGTGAGGAGGAGTGGGACGCAGTGATCCGTGTGCATCTCAAGGGTCACTTCGCTCCGTTGCGGCACG
CCGCCGCATACTGGCGCGACGAGTTCAAGGCCGGTAACGCGGTGGACGCCCGCATTATCAACACCAGCTCCGCCGCCGGT
CTGCAGGGCAGTGTCGGACAAGGGAATTACGCCGCCGCCAAGGCTGGTATCGCCACCCTGACGCTGCAGGCCGCCGCCGA
GATGGGTCGCTACGGCATCACCGTGAACGCCATCGCGCCGGCCGCGCGCACGCGAATGACCGAGGCTGTTTTCGCCGAGA
CCATGGCTAAGCCGGAGGATGGCGCGTTCGACGCGATGGCTCCCGAGAACGTCTCGCCGCTGGTGGTATGGCTGGGTAGC
CCGGAGTCGCGTGAGGTCACCGGCAAGGTGTTCGAGGTCGAGGCCGGCATCATTCGCGTTGCCGAGGGCTGGGCGCATGG
CCCCCAGGTGGACAAGGGAGCACGCTGGGACCCAAGCGAATTGGGCCCCGTGGTCACCGACCTGCTGGACAAGGCCCGCA
CGCCGGTTCCGGTCTACGGCTCGCAAGGCTAA

Upstream 100 bases:

>100_bases
GACCGGTTCGGTCCTCACGGTTCACGGCGGAGGGGAGCGTCCGGCGTTCCTCGACGCGGCCAATGTCAACAGCAATGAGA
ACGGCGAAAAGGAATAGAAC

Downstream 100 bases:

>100_bases
CCCTTTCCGCCGACACGCCGTGTTACGACGCATTTCGCGAGTGATCCGCGCAAGACGCGGCGTGTCGATGGGGCTAGGGC
TCCAGGATGACGACCGGGAT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MPGLLDGRVVIITGAGRGIGRAHALAFAAEGARVVVNDIGVGLDGSAGISPAQEVVEEITAAGGEAVTNGDDVADWSGAK
NLIDTAVNSFGRLDVLVNNAGFLRDRMLANMSEEEWDAVIRVHLKGHFAPLRHAAAYWRDEFKAGNAVDARIINTSSAAG
LQGSVGQGNYAAAKAGIATLTLQAAAEMGRYGITVNAIAPAARTRMTEAVFAETMAKPEDGAFDAMAPENVSPLVVWLGS
PESREVTGKVFEVEAGIIRVAEGWAHGPQVDKGARWDPSELGPVVTDLLDKARTPVPVYGSQG

Sequences:

>Translated_303_residues
MPGLLDGRVVIITGAGRGIGRAHALAFAAEGARVVVNDIGVGLDGSAGISPAQEVVEEITAAGGEAVTNGDDVADWSGAK
NLIDTAVNSFGRLDVLVNNAGFLRDRMLANMSEEEWDAVIRVHLKGHFAPLRHAAAYWRDEFKAGNAVDARIINTSSAAG
LQGSVGQGNYAAAKAGIATLTLQAAAEMGRYGITVNAIAPAARTRMTEAVFAETMAKPEDGAFDAMAPENVSPLVVWLGS
PESREVTGKVFEVEAGIIRVAEGWAHGPQVDKGARWDPSELGPVVTDLLDKARTPVPVYGSQG
>Mature_302_residues
PGLLDGRVVIITGAGRGIGRAHALAFAAEGARVVVNDIGVGLDGSAGISPAQEVVEEITAAGGEAVTNGDDVADWSGAKN
LIDTAVNSFGRLDVLVNNAGFLRDRMLANMSEEEWDAVIRVHLKGHFAPLRHAAAYWRDEFKAGNAVDARIINTSSAAGL
QGSVGQGNYAAAKAGIATLTLQAAAEMGRYGITVNAIAPAARTRMTEAVFAETMAKPEDGAFDAMAPENVSPLVVWLGSP
ESREVTGKVFEVEAGIIRVAEGWAHGPQVDKGARWDPSELGPVVTDLLDKARTPVPVYGSQG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=258, Percent_Identity=48.4496124031008, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI15277342, Length=268, Percent_Identity=37.3134328358209, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=30.859375, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI19923817, Length=274, Percent_Identity=27.007299270073, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI31542939, Length=237, Percent_Identity=27.8481012658228, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=29.4820717131474, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4758504, Length=202, Percent_Identity=31.6831683168317, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI7705925, Length=265, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI224922801, Length=185, Percent_Identity=31.3513513513514, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI83715985, Length=195, Percent_Identity=30.2564102564103, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40254986, Length=207, Percent_Identity=28.9855072463768, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=264, Percent_Identity=32.1969696969697, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=30.5019305019305, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI2367175, Length=262, Percent_Identity=32.824427480916, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=31.0861423220974, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790717, Length=273, Percent_Identity=31.1355311355311, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787526, Length=265, Percent_Identity=26.7924528301887, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=28.1368821292776, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787905, Length=265, Percent_Identity=30.5660377358491, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789378, Length=262, Percent_Identity=29.7709923664122, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788459, Length=266, Percent_Identity=27.8195488721804, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789057, Length=267, Percent_Identity=26.2172284644195, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=196, Percent_Identity=30.1020408163265, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=257, Percent_Identity=42.4124513618677, Blast_Score=188, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=35, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17555706, Length=267, Percent_Identity=33.7078651685393, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17562908, Length=234, Percent_Identity=29.9145299145299, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=274, Percent_Identity=28.1021897810219, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=224, Percent_Identity=29.9107142857143, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=203, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=205, Percent_Identity=30.2439024390244, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=204, Percent_Identity=31.8627450980392, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=29.1457286432161, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=215, Percent_Identity=28.8372093023256, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=251, Percent_Identity=25.0996015936255, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17555612, Length=225, Percent_Identity=28.4444444444444, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=247, Percent_Identity=28.3400809716599, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=287, Percent_Identity=26.4808362369338, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=200, Percent_Identity=31.5, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=206, Percent_Identity=28.1553398058252, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=267, Percent_Identity=25.0936329588015, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=25.4752851711027, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=251, Percent_Identity=25.8964143426295, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=207, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=215, Percent_Identity=31.1627906976744, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=222, Percent_Identity=29.2792792792793, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=238, Percent_Identity=25.6302521008403, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=25.968992248062, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=24.4186046511628, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=236, Percent_Identity=25.8474576271186, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=288, Percent_Identity=24.3055555555556, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=266, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17558628, Length=207, Percent_Identity=29.4685990338164, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=261, Percent_Identity=47.1264367816092, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324126, Length=281, Percent_Identity=25.9786476868327, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859837, Length=287, Percent_Identity=41.8118466898955, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24639444, Length=262, Percent_Identity=33.206106870229, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357673, Length=281, Percent_Identity=29.5373665480427, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=201, Percent_Identity=31.3432835820896, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737361, Length=203, Percent_Identity=30.5418719211823, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI23397609, Length=197, Percent_Identity=32.994923857868, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24644339, Length=198, Percent_Identity=29.2929292929293, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24580925, Length=217, Percent_Identity=30.4147465437788, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571526, Length=196, Percent_Identity=28.0612244897959, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31537; Mature: 31406

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLLDGRVVIITGAGRGIGRAHALAFAAEGARVVVNDIGVGLDGSAGISPAQEVVEEIT
CCCCCCCEEEEEEECCCCCCHHHHHHEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
AAGGEAVTNGDDVADWSGAKNLIDTAVNSFGRLDVLVNNAGFLRDRMLANMSEEEWDAVI
HCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHCEEE
RVHLKGHFAPLRHAAAYWRDEFKAGNAVDARIINTSSAAGLQGSVGQGNYAAAKAGIATL
EEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCHHHH
TLQAAAEMGRYGITVNAIAPAARTRMTEAVFAETMAKPEDGAFDAMAPENVSPLVVWLGS
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECC
PESREVTGKVFEVEAGIIRVAEGWAHGPQVDKGARWDPSELGPVVTDLLDKARTPVPVYG
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SQG
CCC
>Mature Secondary Structure 
PGLLDGRVVIITGAGRGIGRAHALAFAAEGARVVVNDIGVGLDGSAGISPAQEVVEEIT
CCCCCCEEEEEEECCCCCCHHHHHHEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
AAGGEAVTNGDDVADWSGAKNLIDTAVNSFGRLDVLVNNAGFLRDRMLANMSEEEWDAVI
HCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHCEEE
RVHLKGHFAPLRHAAAYWRDEFKAGNAVDARIINTSSAAGLQGSVGQGNYAAAKAGIATL
EEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHCHHHH
TLQAAAEMGRYGITVNAIAPAARTRMTEAVFAETMAKPEDGAFDAMAPENVSPLVVWLGS
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECC
PESREVTGKVFEVEAGIIRVAEGWAHGPQVDKGARWDPSELGPVVTDLLDKARTPVPVYG
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SQG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]