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The map label for this gene is hsaB [H]

Identifier: 169627689

GI number: 169627689

Start: 586993

End: 587574

Strand: Direct

Name: hsaB [H]

Synonym: MAB_0586

Alternate gene names: 169627689

Gene position: 586993-587574 (Clockwise)

Preceding gene: 169627688

Following gene: 169627690

Centisome position: 11.58

GC content: 60.14

Gene sequence:

>582_bases
ATGTCTACACCGGAGATTGATCCTCGTACCTTCCGGAATGTACTGGGGCAATTCTGCACCGGTATCACCATCATCACCAC
GACGCATGAGGACGTGCCGGTGGGGTTTGCCTGCCAGTCTTTCGCGGCGCTGTCACTGGAGCCGCCGCTGGTGCTGTTCT
GCCCGACCAAGCAATCTCGATCCTGGGCGGCCATTGCGGCGTCCGGTAAGTTCTGTGTGAATGTTCTCGCCGAGGACCAG
CGTGAGGTCTCGGCCCGATTCGGATCACGAGAGCCCGATAAGTTCGCCGGAATTAACTGGCGTCCATCAGGTCTCGGTTC
ACCGATCATCAATGGTTCGCTGGCGCATATCGATTGCGAAGTCGCAAACGTCCACGACGGCGGGGACCACTGGGTGGTCT
TCGGATCCGTCAAGGAGCTCTCAGAACGCGCGGTGATTCCGTCGGCCGAATCTGCCGCGCGTCCGCTGTTGTTCTACCGC
GGGCAGTACACCGGTATCGAGCCGGACAAGAACACGCCCGCGGATTGGCGCAACGATCTGGAAGCATTCCTCACCGCGAC
CACCGAGGACACCTGGTTGTAA

Upstream 100 bases:

>100_bases
TGGAAGTCGATGACGAGAGCTGGGTCGCGCGGGAGAGCGTCGGCGTCAGCTTGTGGGGTCACGACTTCAGCGTCGGTTTC
AAGTAGAGGTTCGCGCCGAT

Downstream 100 bases:

>100_bases
CCGCGCCGTCGCTTATTACCCTGTGGGCCTGGCCAATCCGGTGTAGCGTCACATATCCAGGTGCTACCTCGGTGAGGGCG
GGTCATGGCGTTGTATCAGT

Product: oxidoreductase

Products: NAD(+); reduced flavin [C]

Alternate protein names: Flavin:NADH reductase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSTPEIDPRTFRNVLGQFCTGITIITTTHEDVPVGFACQSFAALSLEPPLVLFCPTKQSRSWAAIAASGKFCVNVLAEDQ
REVSARFGSREPDKFAGINWRPSGLGSPIINGSLAHIDCEVANVHDGGDHWVVFGSVKELSERAVIPSAESAARPLLFYR
GQYTGIEPDKNTPADWRNDLEAFLTATTEDTWL

Sequences:

>Translated_193_residues
MSTPEIDPRTFRNVLGQFCTGITIITTTHEDVPVGFACQSFAALSLEPPLVLFCPTKQSRSWAAIAASGKFCVNVLAEDQ
REVSARFGSREPDKFAGINWRPSGLGSPIINGSLAHIDCEVANVHDGGDHWVVFGSVKELSERAVIPSAESAARPLLFYR
GQYTGIEPDKNTPADWRNDLEAFLTATTEDTWL
>Mature_192_residues
STPEIDPRTFRNVLGQFCTGITIITTTHEDVPVGFACQSFAALSLEPPLVLFCPTKQSRSWAAIAASGKFCVNVLAEDQR
EVSARFGSREPDKFAGINWRPSGLGSPIINGSLAHIDCEVANVHDGGDHWVVFGSVKELSERAVIPSAESAARPLLFYRG
QYTGIEPDKNTPADWRNDLEAFLTATTEDTWL

Specific function: Catalyzes the reduction of free flavins (FMN or FAD) by NADH. Subsequently, the reduced flavins diffuse to the HsaA oxygenase subunit [H]

COG id: COG1853

COG function: function code R; Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the non-flavoprotein flavin reductase family [H]

Homologues:

Organism=Escherichia coli, GI87081819, Length=137, Percent_Identity=27.007299270073, Blast_Score=71, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002563
- InterPro:   IPR012349
- InterPro:   IPR009002 [H]

Pfam domain/function: PF01613 Flavin_Reduct [H]

EC number: 1.6.8.- [C]

Molecular weight: Translated: 21084; Mature: 20953

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPEIDPRTFRNVLGQFCTGITIITTTHEDVPVGFACQSFAALSLEPPLVLFCPTKQSR
CCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHEEEECCCCEEEEECCCCCC
SWAAIAASGKFCVNVLAEDQREVSARFGSREPDKFAGINWRPSGLGSPIINGSLAHIDCE
CEEEEEECCCEEEEEHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEEE
VANVHDGGDHWVVFGSVKELSERAVIPSAESAARPLLFYRGQYTGIEPDKNTPADWRNDL
EEEECCCCCEEEEECCHHHHHHHCCCCCCHHHCCCEEEECCCCCCCCCCCCCCCHHHHHH
EAFLTATTEDTWL
HHHEEECCCCCCC
>Mature Secondary Structure 
STPEIDPRTFRNVLGQFCTGITIITTTHEDVPVGFACQSFAALSLEPPLVLFCPTKQSR
CCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHEEEECCCCEEEEECCCCCC
SWAAIAASGKFCVNVLAEDQREVSARFGSREPDKFAGINWRPSGLGSPIINGSLAHIDCE
CEEEEEECCCEEEEEHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEEE
VANVHDGGDHWVVFGSVKELSERAVIPSAESAARPLLFYRGQYTGIEPDKNTPADWRNDL
EEEECCCCCEEEEECCHHHHHHHCCCCCCHHHCCCEEEECCCCCCCCCCCCCCCHHHHHH
EAFLTATTEDTWL
HHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; flavin [C]

Specific reaction: NADH + flavin = NAD(+) + reduced flavin [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]