BacMap

Definition	Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence.
Accession	NC_010397
Length	5,067,172

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The map label for this gene is fabG2 [H]

Identifier: 169627472

GI number: 169627472

Start: 363950

End: 364729

Strand: Direct

Name: fabG2 [H]

Synonym: MAB_0368

Alternate gene names: 169627472

Gene position: 363950-364729 (Clockwise)

Preceding gene: 169627470

Following gene: 169627473

Centisome position: 7.18

GC content: 65.26

Gene sequence:

>780_bases
ATGGATATCAATGGTGTGTCTGCAATCGTCACGGGTGGCGCCTCAGGTCTTGGTGCCGCAACTGCTCGCCTGCTCGCCGC
ACAGGGCGCCAAGGTCGTCATCGCCGACGTCCAGGACGAAAAGGGTGAGGCTCTGGCCAAGGAACTCGGTGGCGCCTTCG
TGCACACCGACGTCACCAGCGAGGCCGACGGTATTGCTGCCGTCGACGCCGCCAAGGAGCTCGGCCCGGTGCGCGTCCTC
ATCAACTGCGCGGGCGTCGGCTGGCCCGGCCGCACCATCGGCAAGGACGGCCAGTACGCCTCGGCGCACTCGCTGGACAT
CTTCTCCAAGGTCATCGGCATCAACTTGATCGGGTCGTTCAACCTGATCCGGCTGGCGGCCACCGCGATCAGCCAGGAAG
AGCCGGTCGATGAGTTCGGCGAGCGTGGCGCCATCGTCAACACCGCATCCGTGGCGGCCTTCGACGGCCAGATCGGGCAG
GCCGCCTACTCGGCGTCCAAGGGCGGCATCGTCGGCATGACCCTGCCGATTGCCCGCGATCTGTCGGTTGTCGGCATTCG
TGTGAACACCATCGCACCCGGTCTCATCGATACCCCGATCTACGGTGAGGGCGAGTCCGCGCAACAGTTCAAGGACCGGC
TGGCACCGAACGTGCTGTACCCGCAGCGCCTGGGTAACCCCGAAGAATTCGCCTCGCTGGCTCTGGAGCTGGTCACCAAC
AGCTACATGAACGCCGAGACAATTCGCATCGACGGTGGGGCCCGGCTCCAGCCGAAGTAG

Upstream 100 bases:

>100_bases
CGGGCGACGAGATCTTGGATGGCGAGTCGGTCATCGGTCACGGATACAAAGCCTATGGGCCCTCCAGCTCCCAACCAACC
GATCGGTTATGGTGCGGCTC

Downstream 100 bases:

>100_bases
AGCAACTTGTCGGTGGCCTATGGAACATTGGAGAGATGGCCACCACGGCGACGGAGGCTGACACAGGCCGAACCCTGTCG
GGGCACGACGAGGCTGCCGA

Product: Short-chain dehydrogenase/reductas

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDINGVSAIVTGGASGLGAATARLLAAQGAKVVIADVQDEKGEALAKELGGAFVHTDVTSEADGIAAVDAAKELGPVRVL
INCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAISQEEPVDEFGERGAIVNTASVAAFDGQIGQ
AAYSASKGGIVGMTLPIARDLSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEEFASLALELVTN
SYMNAETIRIDGGARLQPK

Sequences:

>Translated_259_residues
MDINGVSAIVTGGASGLGAATARLLAAQGAKVVIADVQDEKGEALAKELGGAFVHTDVTSEADGIAAVDAAKELGPVRVL
INCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAISQEEPVDEFGERGAIVNTASVAAFDGQIGQ
AAYSASKGGIVGMTLPIARDLSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEEFASLALELVTN
SYMNAETIRIDGGARLQPK
>Mature_259_residues
MDINGVSAIVTGGASGLGAATARLLAAQGAKVVIADVQDEKGEALAKELGGAFVHTDVTSEADGIAAVDAAKELGPVRVL
INCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAISQEEPVDEFGERGAIVNTASVAAFDGQIGQ
AAYSASKGGIVGMTLPIARDLSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEEFASLALELVTN
SYMNAETIRIDGGARLQPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=51.5384615384615, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI83715985, Length=260, Percent_Identity=48.4615384615385, Blast_Score=217, Evalue=7e-57,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=30.4, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=29.277566539924, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=30.1158301158301, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI59889578, Length=183, Percent_Identity=32.7868852459016, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI10190704, Length=264, Percent_Identity=31.4393939393939, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI32483357, Length=265, Percent_Identity=28.3018867924528, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI33667109, Length=249, Percent_Identity=29.3172690763052, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542939, Length=268, Percent_Identity=28.3582089552239, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI66933014, Length=240, Percent_Identity=27.9166666666667, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI225579078, Length=271, Percent_Identity=27.3062730627306, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4503817, Length=221, Percent_Identity=26.6968325791855, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI126723750, Length=266, Percent_Identity=27.8195488721804, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI4504505, Length=210, Percent_Identity=30.952380952381, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=29.5019157088123, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=32.1705426356589, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082100, Length=272, Percent_Identity=31.6176470588235, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=28.2945736434109, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082160, Length=266, Percent_Identity=28.9473684210526, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787905, Length=261, Percent_Identity=29.8850574712644, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786812, Length=272, Percent_Identity=26.8382352941176, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=29.1187739463602, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789057, Length=203, Percent_Identity=30.0492610837438, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367365, Length=254, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789378, Length=266, Percent_Identity=27.8195488721804, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=46.2745098039216, Blast_Score=211, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=32.4324324324324, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=33.8461538461538, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI72000259, Length=276, Percent_Identity=27.8985507246377, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=28.6764705882353, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=28.3582089552239, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=27.5092936802974, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=29.2592592592593, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=28.7822878228782, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=272, Percent_Identity=31.25, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=262, Percent_Identity=28.6259541984733, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=28.3088235294118, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=276, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=271, Percent_Identity=28.7822878228782, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=274, Percent_Identity=26.6423357664234, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=210, Percent_Identity=30, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=26.5454545454545, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=248, Percent_Identity=31.4516129032258, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737361, Length=261, Percent_Identity=52.1072796934866, Blast_Score=237, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=33.5907335907336, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=29.8449612403101, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI23397609, Length=270, Percent_Identity=30.3703703703704, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161076371, Length=240, Percent_Identity=29.5833333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357041, Length=234, Percent_Identity=30.3418803418803, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=265, Percent_Identity=27.5471698113208, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=267, Percent_Identity=29.2134831460674, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26628; Mature: 26628

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINGVSAIVTGGASGLGAATARLLAAQGAKVVIADVQDEKGEALAKELGGAFVHTDVTS
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCEEEEECCCC
EADGIAAVDAAKELGPVRVLINCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSF
CCCCEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCC
NLIRLAATAISQEEPVDEFGERGAIVNTASVAAFDGQIGQAAYSASKGGIVGMTLPIARD
HHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEECCCCCHHHHHCCCCCEEEEECCCCCC
LSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEEFASLALELVTN
CEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHC
SYMNAETIRIDGGARLQPK
CCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MDINGVSAIVTGGASGLGAATARLLAAQGAKVVIADVQDEKGEALAKELGGAFVHTDVTS
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCEEEEECCCC
EADGIAAVDAAKELGPVRVLINCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSF
CCCCEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCC
NLIRLAATAISQEEPVDEFGERGAIVNTASVAAFDGQIGQAAYSASKGGIVGMTLPIARD
HHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEECCCCCHHHHHCCCCCEEEEECCCCCC
LSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEEFASLALELVTN
CEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHC
SYMNAETIRIDGGARLQPK
CCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]