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The map label for this gene is tcyB [H]

Identifier: 169627382

GI number: 169627382

Start: 275879

End: 277324

Strand: Reverse

Name: tcyB [H]

Synonym: MAB_0277c

Alternate gene names: 169627382

Gene position: 277324-275879 (Counterclockwise)

Preceding gene: 169627383

Following gene: 169627379

Centisome position: 5.47

GC content: 65.28

Gene sequence:

>1446_bases
GTGTTTCGTGCCATCGTGCTTGCGCTTCTGGCGCTTGTGGCGGTAGCCGGATGTGCGGCCCCAACACAGGAGCCGCTGCG
GGTCGGCACCGAGGGCGTGTACGCGCCGTTCAGCTTCCACGACGGGCACACCGGCGAGCTGACGGGTTACGACGTGGACG
TGGCCCGCGCCGTCGGCGAGAAGCTGGGTCGCCCCGTGGAATTCGTCGAGATTCCCTGGGATGCGATCTTCGCCGGATTG
GACGCAGAACGGTTCGACGTCGTCGCCAACCAAGTCACGATCACCCCGGCGCGCAAGGCAAAGTACGACATTTCCACACC
GTACGCAGTGGGCGAGGGTGTGATCGTGACGCGGGCCGACGACAACAGCATTCACAGCCTGTCCGATGTACGGGGCAAGG
TGGCCGCCGAGAACGCGACCAGTAATTGGTCGCAGATCGCCCGCGACGCCGGCGCCCGCGTTGAGGCGGTGGAGGGCTTC
ACCCAATCCATCACACTGCTCAGCCAGGGTCGGGTAGACGTCGTCATCAACGACAGCATCGCCGTCTATGCCTACCTGGC
CAGCACCGGTGACCCTGCGGTGAAGATCGCCGGGGCCACCGGCCAGCGCAGCGAGCAGGGGTTCGCCGCACGCAAGAACA
GCGGCCTGCTGCCGGACCTGGACAAGGCGCTGGATCAGTTGGCGGCCGATGGGACGCTCACCCGCATCTCTCAGAAGTAC
CTCAAGACGGACGCCAGCGGGACTACCAAACCACAAGCCGGGAAGGGAGATTCCGGCAGTACGCGGTCCGACACCCAGCT
GGTGCTGGACAACCTGTGGCCCATGGCCCGAGCCATGATCACCGTCACGCTGCCGCTGACCGCCATCAGCTTCGTGATCG
GACTGGTGATCGCCCTCGGGGTCGCACTGGCCCGCATGTCCGGTCATCGCGTGGTGACCGGCCTCGCCCGCATCTACATC
TCTGTCATCCGTGGCACGCCGCTGCTGCTGCAGCTGTTTCTCATCTTCTTCGCGCTGCCCGAATTCGGGGTCAAGATCAG
TCCCTTTCCTGCCGCCGTCATCGCGTTCAGTCTCAACGTGGGCGGCTACGCCGCCGAAATCATTCGTTCGTCCATCCTGA
GCATCCCCCGCGGGCAGTGGGAGGCGGCCTCCAGCCTGGGGATGAGCTACAGCACCACGTTGTGGCGGATCGTCATTCCG
CAGGCCAGCCGGGTGGCGGTGCCCCCGCTGTCGAACACCTTGATCTCCCTGGTGAAGGACACCTCGCTGGCCTCGGCGAT
CCTGGTGACGGACGTGATGCGTACGGCACAGGTCGCCGCCGCGCCGACCTTTCAGTTCTTCACGCTCTACGTCACCGCCG
GCGTCTACTACTGGATTGTCTGCATGGCGATGTCGGCGGTGCAGGACCGGCTGGAGCAGCGTCTGGAGAAATCCGTCGCG
CGCTAA

Upstream 100 bases:

>100_bases
TGCGCCAGTTCGATGCCGGACGTATCCCGCGCGAGCCGTGGATATACCCGGGCTGATCCGAAGCTGCCTAGATGGACCCG
AAACGTGTTAGCCTCCCGCG

Downstream 100 bases:

>100_bases
CCCTTCAGCGCCGACACGCCGTGTTTCGATCTAAACGCCGAGAGCCGCGCGCAGAACACGGCGTGTCGGCGGCATCTAGG
CGATGCTCACCGGAAGCTCG

Product: amino acid ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MFRAIVLALLALVAVAGCAAPTQEPLRVGTEGVYAPFSFHDGHTGELTGYDVDVARAVGEKLGRPVEFVEIPWDAIFAGL
DAERFDVVANQVTITPARKAKYDISTPYAVGEGVIVTRADDNSIHSLSDVRGKVAAENATSNWSQIARDAGARVEAVEGF
TQSITLLSQGRVDVVINDSIAVYAYLASTGDPAVKIAGATGQRSEQGFAARKNSGLLPDLDKALDQLAADGTLTRISQKY
LKTDASGTTKPQAGKGDSGSTRSDTQLVLDNLWPMARAMITVTLPLTAISFVIGLVIALGVALARMSGHRVVTGLARIYI
SVIRGTPLLLQLFLIFFALPEFGVKISPFPAAVIAFSLNVGGYAAEIIRSSILSIPRGQWEAASSLGMSYSTTLWRIVIP
QASRVAVPPLSNTLISLVKDTSLASAILVTDVMRTAQVAAAPTFQFFTLYVTAGVYYWIVCMAMSAVQDRLEQRLEKSVA
R

Sequences:

>Translated_481_residues
MFRAIVLALLALVAVAGCAAPTQEPLRVGTEGVYAPFSFHDGHTGELTGYDVDVARAVGEKLGRPVEFVEIPWDAIFAGL
DAERFDVVANQVTITPARKAKYDISTPYAVGEGVIVTRADDNSIHSLSDVRGKVAAENATSNWSQIARDAGARVEAVEGF
TQSITLLSQGRVDVVINDSIAVYAYLASTGDPAVKIAGATGQRSEQGFAARKNSGLLPDLDKALDQLAADGTLTRISQKY
LKTDASGTTKPQAGKGDSGSTRSDTQLVLDNLWPMARAMITVTLPLTAISFVIGLVIALGVALARMSGHRVVTGLARIYI
SVIRGTPLLLQLFLIFFALPEFGVKISPFPAAVIAFSLNVGGYAAEIIRSSILSIPRGQWEAASSLGMSYSTTLWRIVIP
QASRVAVPPLSNTLISLVKDTSLASAILVTDVMRTAQVAAAPTFQFFTLYVTAGVYYWIVCMAMSAVQDRLEQRLEKSVA
R
>Mature_481_residues
MFRAIVLALLALVAVAGCAAPTQEPLRVGTEGVYAPFSFHDGHTGELTGYDVDVARAVGEKLGRPVEFVEIPWDAIFAGL
DAERFDVVANQVTITPARKAKYDISTPYAVGEGVIVTRADDNSIHSLSDVRGKVAAENATSNWSQIARDAGARVEAVEGF
TQSITLLSQGRVDVVINDSIAVYAYLASTGDPAVKIAGATGQRSEQGFAARKNSGLLPDLDKALDQLAADGTLTRISQKY
LKTDASGTTKPQAGKGDSGSTRSDTQLVLDNLWPMARAMITVTLPLTAISFVIGLVIALGVALARMSGHRVVTGLARIYI
SVIRGTPLLLQLFLIFFALPEFGVKISPFPAAVIAFSLNVGGYAAEIIRSSILSIPRGQWEAASSLGMSYSTTLWRIVIP
QASRVAVPPLSNTLISLVKDTSLASAILVTDVMRTAQVAAAPTFQFFTLYVTAGVYYWIVCMAMSAVQDRLEQRLEKSVA
R

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=216, Percent_Identity=45.8333333333333, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788228, Length=260, Percent_Identity=31.9230769230769, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1787030, Length=210, Percent_Identity=37.1428571428571, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI87082239, Length=203, Percent_Identity=34.4827586206897, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787087, Length=230, Percent_Identity=28.2608695652174, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788645, Length=210, Percent_Identity=32.3809523809524, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787085, Length=242, Percent_Identity=27.6859504132231, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787086, Length=202, Percent_Identity=31.1881188118812, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786873, Length=203, Percent_Identity=32.0197044334975, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788646, Length=211, Percent_Identity=29.8578199052133, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786874, Length=164, Percent_Identity=27.4390243902439, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788648, Length=240, Percent_Identity=26.25, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787031, Length=244, Percent_Identity=26.2295081967213, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994930, Length=163, Percent_Identity=36.1963190184049, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787088, Length=253, Percent_Identity=26.8774703557312, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788649, Length=260, Percent_Identity=25.3846153846154, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 51241; Mature: 51241

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50928 ABC_TM1 ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRAIVLALLALVAVAGCAAPTQEPLRVGTEGVYAPFSFHDGHTGELTGYDVDVARAVGE
CHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEECEECCCCCCCCCCCCCHHHHHHHHH
KLGRPVEFVEIPWDAIFAGLDAERFDVVANQVTITPARKAKYDISTPYAVGEGVIVTRAD
HHCCCEEEEECCHHHHHHCCCHHHHHHHHCEEEECCCHHCCCCCCCCCCCCCCEEEEECC
DNSIHSLSDVRGKVAAENATSNWSQIARDAGARVEAVEGFTQSITLLSQGRVDVVINDSI
CCCHHHHHHHHCHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCE
AVYAYLASTGDPAVKIAGATGQRSEQGFAARKNSGLLPDLDKALDQLAADGTLTRISQKY
EEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
LKTDASGTTKPQAGKGDSGSTRSDTQLVLDNLWPMARAMITVTLPLTAISFVIGLVIALG
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHH
VALARMSGHRVVTGLARIYISVIRGTPLLLQLFLIFFALPEFGVKISPFPAAVIAFSLNV
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEECC
GGYAAEIIRSSILSIPRGQWEAASSLGMSYSTTLWRIVIPQASRVAVPPLSNTLISLVKD
CHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHCEEEEEEECCCCCEECCCHHHHHHHHHHH
TSLASAILVTDVMRTAQVAAAPTFQFFTLYVTAGVYYWIVCMAMSAVQDRLEQRLEKSVA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
R
C
>Mature Secondary Structure
MFRAIVLALLALVAVAGCAAPTQEPLRVGTEGVYAPFSFHDGHTGELTGYDVDVARAVGE
CHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEECEECCCCCCCCCCCCCHHHHHHHHH
KLGRPVEFVEIPWDAIFAGLDAERFDVVANQVTITPARKAKYDISTPYAVGEGVIVTRAD
HHCCCEEEEECCHHHHHHCCCHHHHHHHHCEEEECCCHHCCCCCCCCCCCCCCEEEEECC
DNSIHSLSDVRGKVAAENATSNWSQIARDAGARVEAVEGFTQSITLLSQGRVDVVINDSI
CCCHHHHHHHHCHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCE
AVYAYLASTGDPAVKIAGATGQRSEQGFAARKNSGLLPDLDKALDQLAADGTLTRISQKY
EEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
LKTDASGTTKPQAGKGDSGSTRSDTQLVLDNLWPMARAMITVTLPLTAISFVIGLVIALG
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHH
VALARMSGHRVVTGLARIYISVIRGTPLLLQLFLIFFALPEFGVKISPFPAAVIAFSLNV
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEECC
GGYAAEIIRSSILSIPRGQWEAASSLGMSYSTTLWRIVIPQASRVAVPPLSNTLISLVKD
CHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHCEEEEEEECCCCCEECCCHHHHHHHHHHH
TSLASAILVTDVMRTAQVAAAPTFQFFTLYVTAGVYYWIVCMAMSAVQDRLEQRLEKSVA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]