Click here to switch to the map view.

The map label for this gene is hapE [H]

Identifier: 169627245

GI number: 169627245

Start: 136824

End: 138371

Strand: Reverse

Name: hapE [H]

Synonym: MAB_0140c

Alternate gene names: 169627245

Gene position: 138371-136824 (Counterclockwise)

Preceding gene: 169627246

Following gene: 169627244

Centisome position: 2.73

GC content: 62.66

Gene sequence:

>1548_bases
GTGAGCACGCATACCCTCCCGCAGCACGAGGTCCTCGTGGTAGGCGCCGGATTCGGCGGCATAGCCGCAGGCGTCAGACT
CCGCCGGGCAGGTATCGATGATTTTGTCATCGTCGACAAGCATCCGTCGGTGGGCGGGACTTGGTTCGTCAACAAGTACC
CCGGTGTGGCCGTGGATATTCCGTCGTTCATCTACAGCTTCTCCTTTGCCCAGACGGGTAAGTGGAGTCGCCTGTTCGCA
CCGGGCGAGGAACTCCAGCAATACGCCGAGGATGTCGTCGACGGACACGGCCTGCGTGACAAGCTCCGGCTGGGAACCAC
CGTGTTGGGCAGCAGATTCGACGAAGACACCGACATCTGGCATGTCGAGACCGACCGCGGCGAAATCACCGCCCGCCATG
TGATCGTCGGGATCGGTGGGCTGGAAGTGCCGAATCTGCCCGACATTCCCGGCATCGGGTCGTTCGGCGGCAAGCTTCTG
CACACCACCGCGTGGGACCATGACTACGACCTCACCGGCAAGCGCGTGGCGGTCATCGGCACCGGCGCTACCGCACTGCA
ATTGGTTCCGGCGATCGCCGACCAGGTCAGTCGGCTTACGGTCTTTCAGCGCACCGCCATCTGGGTGGCGCCAAAACTCG
ATTTCAAGACGGGGCCCGTCAGCCGGTTCGTCTTCGGCAATCGTCTACTGCGGACTCCCCTTCGCGGTGTCGGGATGGCG
CTCGTCGAACTGGGGCTAGGTGGGGCCCTGCTCGGGGGCCAGCTGCTGGGGCAGCGCCTTTACAAGACGGTGCTGCAGGG
CGTGGGACTTGCACTGAGAGGCTGGATGTGGACACAGCTGCCCCACGATCCCGAACTGCGCAAGAAACTCACGCCGACCT
ACGCCTTCGGGTGCAAACGGCCTTCCATGCACAACGAATGGTTCTCGACATTCACCAAGCCCAATGTCGACTTGATAACC
GAGCCCATCGAGCGCATCACCGAGAACTCTGTCATCACCGCCGACGGAACCGAGCACGAGATAGACGTCTTGGTGTGCGC
CACCGGTTTCAAGGTCATGGAGAAGGGCGCGACGCCGCCATTCCCCTGCCTCGGCCGGGGCGGCACCGATCTCAACACGT
GGTGGGACGAGAATCGCTACCAGGCGTACCAGGGGGTGACCGTTCCCGGCTGGCCCAACGCGTACATGCTGATCGGCCCG
TGGGCATATTCGCCCGGCTCGTACCTGGTCCTGTTGGAATCGACAGTTGCGCATGCCGTGCGGGCCATCACAGAAACCCG
GCGCCGCGGCGCCACCCGCTGTGAGGTGCGTCAAGAACCGCATGACAAGTATTGGCAGCAGATGCTTTCCCGGGCGGCAA
AGAGCCATCTACTCACACCGCTGTGTGCCGGATCGAACACCTACTACATCAACTACCAAGGTGACGCCGCGGCCTACCGT
CCGTCCACCAATACCGAAATGCGCCTGCAAAACCGGTACTTCCCGTTCAGTGACTACGAATTCACCACTACGCAGGCACG
GCAGCTCGTCGCGGAGAGCGTCGGATGA

Upstream 100 bases:

>100_bases
TCGGCGCCGATCTCTTGCCCGATGCCCGTGCCGCGGTCGGCGATATGGCGCATTTCATCTATCGGATCACCGACCCCGAC
AATCTCAAGGCAGGTACACC

Downstream 100 bases:

>100_bases
CATCAGCACGGTTCACATTCCGCGGTGACACACTCGCCTACAGCCGCACTGGCACCGGCCCGCCAATTCTGTTCCTGCAC
AACGGCGGGTCTGCCAAGGA

Product: monooxygenase

Products: NA

Alternate protein names: HAPMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSTHTLPQHEVLVVGAGFGGIAAGVRLRRAGIDDFVIVDKHPSVGGTWFVNKYPGVAVDIPSFIYSFSFAQTGKWSRLFA
PGEELQQYAEDVVDGHGLRDKLRLGTTVLGSRFDEDTDIWHVETDRGEITARHVIVGIGGLEVPNLPDIPGIGSFGGKLL
HTTAWDHDYDLTGKRVAVIGTGATALQLVPAIADQVSRLTVFQRTAIWVAPKLDFKTGPVSRFVFGNRLLRTPLRGVGMA
LVELGLGGALLGGQLLGQRLYKTVLQGVGLALRGWMWTQLPHDPELRKKLTPTYAFGCKRPSMHNEWFSTFTKPNVDLIT
EPIERITENSVITADGTEHEIDVLVCATGFKVMEKGATPPFPCLGRGGTDLNTWWDENRYQAYQGVTVPGWPNAYMLIGP
WAYSPGSYLVLLESTVAHAVRAITETRRRGATRCEVRQEPHDKYWQQMLSRAAKSHLLTPLCAGSNTYYINYQGDAAAYR
PSTNTEMRLQNRYFPFSDYEFTTTQARQLVAESVG

Sequences:

>Translated_515_residues
MSTHTLPQHEVLVVGAGFGGIAAGVRLRRAGIDDFVIVDKHPSVGGTWFVNKYPGVAVDIPSFIYSFSFAQTGKWSRLFA
PGEELQQYAEDVVDGHGLRDKLRLGTTVLGSRFDEDTDIWHVETDRGEITARHVIVGIGGLEVPNLPDIPGIGSFGGKLL
HTTAWDHDYDLTGKRVAVIGTGATALQLVPAIADQVSRLTVFQRTAIWVAPKLDFKTGPVSRFVFGNRLLRTPLRGVGMA
LVELGLGGALLGGQLLGQRLYKTVLQGVGLALRGWMWTQLPHDPELRKKLTPTYAFGCKRPSMHNEWFSTFTKPNVDLIT
EPIERITENSVITADGTEHEIDVLVCATGFKVMEKGATPPFPCLGRGGTDLNTWWDENRYQAYQGVTVPGWPNAYMLIGP
WAYSPGSYLVLLESTVAHAVRAITETRRRGATRCEVRQEPHDKYWQQMLSRAAKSHLLTPLCAGSNTYYINYQGDAAAYR
PSTNTEMRLQNRYFPFSDYEFTTTQARQLVAESVG
>Mature_514_residues
STHTLPQHEVLVVGAGFGGIAAGVRLRRAGIDDFVIVDKHPSVGGTWFVNKYPGVAVDIPSFIYSFSFAQTGKWSRLFAP
GEELQQYAEDVVDGHGLRDKLRLGTTVLGSRFDEDTDIWHVETDRGEITARHVIVGIGGLEVPNLPDIPGIGSFGGKLLH
TTAWDHDYDLTGKRVAVIGTGATALQLVPAIADQVSRLTVFQRTAIWVAPKLDFKTGPVSRFVFGNRLLRTPLRGVGMAL
VELGLGGALLGGQLLGQRLYKTVLQGVGLALRGWMWTQLPHDPELRKKLTPTYAFGCKRPSMHNEWFSTFTKPNVDLITE
PIERITENSVITADGTEHEIDVLVCATGFKVMEKGATPPFPCLGRGGTDLNTWWDENRYQAYQGVTVPGWPNAYMLIGPW
AYSPGSYLVLLESTVAHAVRAITETRRRGATRCEVRQEPHDKYWQQMLSRAAKSHLLTPLCAGSNTYYINYQGDAAAYRP
STNTEMRLQNRYFPFSDYEFTTTQARQLVAESVG

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Can oxidize a wide range of acetophenone derivatives. Highest activity occurs with co

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.84 [H]

Molecular weight: Translated: 56939; Mature: 56808

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHTLPQHEVLVVGAGFGGIAAGVRLRRAGIDDFVIVDKHPSVGGTWFVNKYPGVAVDI
CCCCCCCCCCEEEEECCCCHHHHHHHHEECCCCCEEEEECCCCCCCEEEEECCCCCEEEH
PSFIYSFSFAQTGKWSRLFAPGEELQQYAEDVVDGHGLRDKLRLGTTVLGSRFDEDTDIW
HHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHCHHHHCCCCCCCCCEE
HVETDRGEITARHVIVGIGGLEVPNLPDIPGIGSFGGKLLHTTAWDHDYDLTGKRVAVIG
EEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEE
TGATALQLVPAIADQVSRLTVFQRTAIWVAPKLDFKTGPVSRFVFGNRLLRTPLRGVGMA
CCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHCCHHHHCCHHHHHHH
LVELGLGGALLGGQLLGQRLYKTVLQGVGLALRGWMWTQLPHDPELRKKLTPTYAFGCKR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCEEECCCCCCHHHHHHCCCCCEECCCC
PSMHNEWFSTFTKPNVDLITEPIERITENSVITADGTEHEIDVLVCATGFKVMEKGATPP
CCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEECCHHHHHCCCCCC
FPCLGRGGTDLNTWWDENRYQAYQGVTVPGWPNAYMLIGPWAYSPGSYLVLLESTVAHAV
CCCCCCCCCCCCCCCCCCCEEHCCCEECCCCCCCEEEEEEEEECCCCEEEEEEHHHHHHH
RAITETRRRGATRCEVRQEPHDKYWQQMLSRAAKSHLLTPLCAGSNTYYINYQGDAAAYR
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCEEC
PSTNTEMRLQNRYFPFSDYEFTTTQARQLVAESVG
CCCCCCEEEECCCCCCCCCEECHHHHHHHHHHHCC
>Mature Secondary Structure 
STHTLPQHEVLVVGAGFGGIAAGVRLRRAGIDDFVIVDKHPSVGGTWFVNKYPGVAVDI
CCCCCCCCCEEEEECCCCHHHHHHHHEECCCCCEEEEECCCCCCCEEEEECCCCCEEEH
PSFIYSFSFAQTGKWSRLFAPGEELQQYAEDVVDGHGLRDKLRLGTTVLGSRFDEDTDIW
HHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHCHHHHCCCCCCCCCEE
HVETDRGEITARHVIVGIGGLEVPNLPDIPGIGSFGGKLLHTTAWDHDYDLTGKRVAVIG
EEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEE
TGATALQLVPAIADQVSRLTVFQRTAIWVAPKLDFKTGPVSRFVFGNRLLRTPLRGVGMA
CCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHCCHHHHCCHHHHHHH
LVELGLGGALLGGQLLGQRLYKTVLQGVGLALRGWMWTQLPHDPELRKKLTPTYAFGCKR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCEEECCCCCCHHHHHHCCCCCEECCCC
PSMHNEWFSTFTKPNVDLITEPIERITENSVITADGTEHEIDVLVCATGFKVMEKGATPP
CCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEECCHHHHHCCCCCC
FPCLGRGGTDLNTWWDENRYQAYQGVTVPGWPNAYMLIGPWAYSPGSYLVLLESTVAHAV
CCCCCCCCCCCCCCCCCCCEEHCCCEECCCCCCCEEEEEEEEECCCCEEEEEEHHHHHHH
RAITETRRRGATRCEVRQEPHDKYWQQMLSRAAKSHLLTPLCAGSNTYYINYQGDAAAYR
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCEEC
PSTNTEMRLQNRYFPFSDYEFTTTQARQLVAESVG
CCCCCCEEEECCCCCCCCCEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11322873 [H]