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The map label for this gene is poxB [H]

Identifier: 169627239

GI number: 169627239

Start: 131476

End: 133215

Strand: Reverse

Name: poxB [H]

Synonym: MAB_0134c

Alternate gene names: 169627239

Gene position: 133215-131476 (Counterclockwise)

Preceding gene: 169627244

Following gene: 169627236

Centisome position: 2.63

GC content: 63.91

Gene sequence:

>1740_bases
ATGGCACGCACCGTTTCCCAGCTCATCCTCGACACTGTGAAAGCCGCTGGTGTCCAACGTATTTATGGCCTACCTGGAGA
CTCGCTCAACGGCTTTACCGAGGCACTGCGGCGCGACGGAACCCTGGAGTGGGTGCACGTGCGGCACGAGGAATCTGCCG
CGTTCGCCGCCGGCGCCGAGGCCGCGCTCACGGGCAATCTTGCGGTCTGTGCAGCAAGCTGCGGTCCCGGGAACCTGCAT
CTGATCAACGGCCTCTTCGATGCTCATCGCAGCCGGGTGCCCGTACTCGCGATCGCATCGCATATTCCCAGCGCCGAGAT
AGGCAGCGGCTACTTCCAGGAGACTCACCCGCAGAATCTGTTCGCCGAGTGCAGCGTCTACAGCGAGCTGGTGAGCAGTG
TCGAGCAGCTGCCATATGTCCTCGACACCGCCATCCGTGCGGCCCTCGATCAACAGGGGGTGGCGGTCTTGACGATCCCC
GGAGACATCCTGAGCGCCAAGGTCGACCTGGCACCGCCCTCTGCTCCCCTCGTCGCCGGGGCCGGGATCAGGCTGCCCGG
TACGTCCTGCTTGGAACGAGCCGTGCGGGAGCTGAACGGTTCGAACGCGATCACCATCCTGGCCGGGGCGGGGTGCGAGG
GCGCCCATGCGGAACTGCTGACCGCGGCCCACGCGCTCCAGGCACCCATCGTGCACACGCTGCGCGGCAAGGAATTCGTC
GAATACGACAATCCCTTCGACGTCGGTATGACGGGCCTGCTCGGCTTCCGCTCCGGTTACGACGCACTGGAAGACACCGA
GGTGCTGCTCATGCTCGGAACGGACTTCCCGTACCGGCAGTTCTACCCACCGAAGGCCACCGTCATTCAGGTCGACATCC
GCGGTGAGCACATCGGCCGGCGCACCCGAGTAGATGTCGCACTCGTCGGTACGGTGAAAGATACTTTACAACAACTTAAT
TCGATGATTCAGCCGCATTCGGACAGGAGACACCTGGAGCGCGCCAGAGAGAACTACACACGCACACGAGCTCAGCTCGA
TCGCTTGGCCGTGGACGACCGCAACCAGACGCCGGTGCGTCCCGAGCTTGTCGCCCGCCGAATCGACGAGCTGGCGGCCG
ACGACGCGGTCTTCATCGCCGATGTCGGCACACCCGTGATCTGGGCGGCGCGATACCTGTCGATGAACGGCCGGCGCCGA
TTGCTCGGCTCGTTCAACCACGGCAGCATGGCGAATGCCGTACCCCAAGCGATCGGCGCACAGGCATCGCATCGCGATCG
CCAGATTGTCACCCTCTCCGGTGACGGTGGTCTCACCATGATGCTCGGCGACCTCATCACGCTGACCCAGTCCCAACTGC
CGGTCAAAATGGTCGTCTTCAACAACGGTGCGCTCAGCTTTGTCGAGCTCGAAATGAAGGCCGCCGGTATCGTCAATTAC
GGTACCGCCCTGGATAATCCGGTGTTTGCAGATGTCGCAAAGGCTCTCGGGATCCATGGGCTCCGGGTCGAGCGCCCCGA
CCAGCTGGACGGCGCCCTTTCGGAAGCCTTTGACCACCCCGGGCCCGTGCTCGTGGAGGTTCTCACCGCGCGCCAGGAGC
TGTCGATTCCCCCGACCATCACCGCCGCGCAAGTTGCGGGATTCTCATTGTGGGCCACCCGAACGCTGCTGTCCGGGCGT
GGCGACGAGCTCATCGATTTGGCCAAGACCAATCTCGGAGCACGCCTGCGCCGCAAGTGA

Upstream 100 bases:

>100_bases
TCCGCGATCGTTGCGCGCGGCATCCCTGCCTGCCATGGTCGCTAGCATCGATTGCATCAGGTCTGATCCGTCCAGCCGCC
AAGCGATCCGGAGCACACTC

Downstream 100 bases:

>100_bases
TGGGTGCGCCTCCTGCCAGCCGGAAGATCAAACAGACAGGGAGCGGACCCCGCGCGGTTACGCCGACTTGTCGGTATCCG
GTGTTACAACAGAGGTATGA

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MARTVSQLILDTVKAAGVQRIYGLPGDSLNGFTEALRRDGTLEWVHVRHEESAAFAAGAEAALTGNLAVCAASCGPGNLH
LINGLFDAHRSRVPVLAIASHIPSAEIGSGYFQETHPQNLFAECSVYSELVSSVEQLPYVLDTAIRAALDQQGVAVLTIP
GDILSAKVDLAPPSAPLVAGAGIRLPGTSCLERAVRELNGSNAITILAGAGCEGAHAELLTAAHALQAPIVHTLRGKEFV
EYDNPFDVGMTGLLGFRSGYDALEDTEVLLMLGTDFPYRQFYPPKATVIQVDIRGEHIGRRTRVDVALVGTVKDTLQQLN
SMIQPHSDRRHLERARENYTRTRAQLDRLAVDDRNQTPVRPELVARRIDELAADDAVFIADVGTPVIWAARYLSMNGRRR
LLGSFNHGSMANAVPQAIGAQASHRDRQIVTLSGDGGLTMMLGDLITLTQSQLPVKMVVFNNGALSFVELEMKAAGIVNY
GTALDNPVFADVAKALGIHGLRVERPDQLDGALSEAFDHPGPVLVEVLTARQELSIPPTITAAQVAGFSLWATRTLLSGR
GDELIDLAKTNLGARLRRK

Sequences:

>Translated_579_residues
MARTVSQLILDTVKAAGVQRIYGLPGDSLNGFTEALRRDGTLEWVHVRHEESAAFAAGAEAALTGNLAVCAASCGPGNLH
LINGLFDAHRSRVPVLAIASHIPSAEIGSGYFQETHPQNLFAECSVYSELVSSVEQLPYVLDTAIRAALDQQGVAVLTIP
GDILSAKVDLAPPSAPLVAGAGIRLPGTSCLERAVRELNGSNAITILAGAGCEGAHAELLTAAHALQAPIVHTLRGKEFV
EYDNPFDVGMTGLLGFRSGYDALEDTEVLLMLGTDFPYRQFYPPKATVIQVDIRGEHIGRRTRVDVALVGTVKDTLQQLN
SMIQPHSDRRHLERARENYTRTRAQLDRLAVDDRNQTPVRPELVARRIDELAADDAVFIADVGTPVIWAARYLSMNGRRR
LLGSFNHGSMANAVPQAIGAQASHRDRQIVTLSGDGGLTMMLGDLITLTQSQLPVKMVVFNNGALSFVELEMKAAGIVNY
GTALDNPVFADVAKALGIHGLRVERPDQLDGALSEAFDHPGPVLVEVLTARQELSIPPTITAAQVAGFSLWATRTLLSGR
GDELIDLAKTNLGARLRRK
>Mature_578_residues
ARTVSQLILDTVKAAGVQRIYGLPGDSLNGFTEALRRDGTLEWVHVRHEESAAFAAGAEAALTGNLAVCAASCGPGNLHL
INGLFDAHRSRVPVLAIASHIPSAEIGSGYFQETHPQNLFAECSVYSELVSSVEQLPYVLDTAIRAALDQQGVAVLTIPG
DILSAKVDLAPPSAPLVAGAGIRLPGTSCLERAVRELNGSNAITILAGAGCEGAHAELLTAAHALQAPIVHTLRGKEFVE
YDNPFDVGMTGLLGFRSGYDALEDTEVLLMLGTDFPYRQFYPPKATVIQVDIRGEHIGRRTRVDVALVGTVKDTLQQLNS
MIQPHSDRRHLERARENYTRTRAQLDRLAVDDRNQTPVRPELVARRIDELAADDAVFIADVGTPVIWAARYLSMNGRRRL
LGSFNHGSMANAVPQAIGAQASHRDRQIVTLSGDGGLTMMLGDLITLTQSQLPVKMVVFNNGALSFVELEMKAAGIVNYG
TALDNPVFADVAKALGIHGLRVERPDQLDGALSEAFDHPGPVLVEVLTARQELSIPPTITAAQVAGFSLWATRTLLSGRG
DELIDLAKTNLGARLRRK

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=575, Percent_Identity=24.5217391304348, Blast_Score=129, Evalue=8e-30,
Organism=Escherichia coli, GI1787096, Length=574, Percent_Identity=54.8780487804878, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1790104, Length=554, Percent_Identity=26.7148014440433, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87081685, Length=528, Percent_Identity=26.3257575757576, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786717, Length=547, Percent_Identity=25.2285191956124, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788716, Length=548, Percent_Identity=21.5328467153285, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17531299, Length=552, Percent_Identity=23.731884057971, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17531301, Length=552, Percent_Identity=23.731884057971, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323755, Length=565, Percent_Identity=23.1858407079646, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320816, Length=550, Percent_Identity=21.6363636363636, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922626, Length=485, Percent_Identity=25.979381443299, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 62171; Mature: 62039

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTVSQLILDTVKAAGVQRIYGLPGDSLNGFTEALRRDGTLEWVHVRHEESAAFAAGAE
CCHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCCC
AALTGNLAVCAASCGPGNLHLINGLFDAHRSRVPVLAIASHIPSAEIGSGYFQETHPQNL
CEEECCEEEEEECCCCCCEEEEHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCCCHH
FAECSVYSELVSSVEQLPYVLDTAIRAALDQQGVAVLTIPGDILSAKVDLAPPSAPLVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHEEEEECCCCCCCEEEC
AGIRLPGTSCLERAVRELNGSNAITILAGAGCEGAHAELLTAAHALQAPIVHTLRGKEFV
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCEEE
EYDNPFDVGMTGLLGFRSGYDALEDTEVLLMLGTDFPYRQFYPPKATVIQVDIRGEHIGR
CCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHCCCCCCEEEEEEECCCCCCC
RTRVDVALVGTVKDTLQQLNSMIQPHSDRRHLERARENYTRTRAQLDRLAVDDRNQTPVR
EEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PELVARRIDELAADDAVFIADVGTPVIWAARYLSMNGRRRLLGSFNHGSMANAVPQAIGA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCC
QASHRDRQIVTLSGDGGLTMMLGDLITLTQSQLPVKMVVFNNGALSFVELEMKAAGIVNY
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEHHCCEEEC
GTALDNPVFADVAKALGIHGLRVERPDQLDGALSEAFDHPGPVLVEVLTARQELSIPPTI
CCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
TAAQVAGFSLWATRTLLSGRGDELIDLAKTNLGARLRRK
CHHHHHCHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
ARTVSQLILDTVKAAGVQRIYGLPGDSLNGFTEALRRDGTLEWVHVRHEESAAFAAGAE
CHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCCC
AALTGNLAVCAASCGPGNLHLINGLFDAHRSRVPVLAIASHIPSAEIGSGYFQETHPQNL
CEEECCEEEEEECCCCCCEEEEHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCCCHH
FAECSVYSELVSSVEQLPYVLDTAIRAALDQQGVAVLTIPGDILSAKVDLAPPSAPLVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHEEEEECCCCCCCEEEC
AGIRLPGTSCLERAVRELNGSNAITILAGAGCEGAHAELLTAAHALQAPIVHTLRGKEFV
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHCCCEEE
EYDNPFDVGMTGLLGFRSGYDALEDTEVLLMLGTDFPYRQFYPPKATVIQVDIRGEHIGR
CCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHCCCCCCEEEEEEECCCCCCC
RTRVDVALVGTVKDTLQQLNSMIQPHSDRRHLERARENYTRTRAQLDRLAVDDRNQTPVR
EEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PELVARRIDELAADDAVFIADVGTPVIWAARYLSMNGRRRLLGSFNHGSMANAVPQAIGA
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCC
QASHRDRQIVTLSGDGGLTMMLGDLITLTQSQLPVKMVVFNNGALSFVELEMKAAGIVNY
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEHHCCEEEC
GTALDNPVFADVAKALGIHGLRVERPDQLDGALSEAFDHPGPVLVEVLTARQELSIPPTI
CCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
TAAQVAGFSLWATRTLLSGRGDELIDLAKTNLGARLRRK
CHHHHHCHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]