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The map label for this gene is alsR [H]

Identifier: 169627130

GI number: 169627130

Start: 23501

End: 24418

Strand: Direct

Name: alsR [H]

Synonym: MAB_0023

Alternate gene names: 169627130

Gene position: 23501-24418 (Clockwise)

Preceding gene: 169627128

Following gene: 169627132

Centisome position: 0.46

GC content: 63.51

Gene sequence:

>918_bases
ATGGAGATCGAGTTGCGTTGGCTGCGTTACGTGGTGGCAGTAGCAGATCACGGTGGCATGCAGCGGGCTGCGGACGCGCT
CCACATGACTCAGCCTCCGCTTAGTCGACAGATCCGTGAACTCGAGCGGCGACTAGGGACATCGCTGTTCACCCGCCGCC
CGGTCTCCCTCACCGCGGCGGGTGCCGTATTCGTCGAACACGCGCGGGAGGTTCTCTCGTCTGTCGACAACCTTGTCACG
GCGACGCGCAGTACCGCGACGGGAGAGGCGGGCGAACTCGCGGTCGGGTACATCCTGTCCGGGGCCTACGATACGATTCC
GCGCCTGCGCGAAGCATCAACAGCCGCATACCCCGGGCTGCGGCTCGACTCCAGGGAACTCTGGCCCGCCCAGCTCGACG
CAGGATTACTCGACGGTGAGCTGGACCTCGTGATCGCGCACACCATGCCTGTCCGACCGGAATTTCGTCGTGAACGACTA
CGCACTGACCCCTTGGTTGCCGTCACCCGACCCAAGAATCCCGCGGCGTCGGGAGCTGGCCCAGTGCGACTCGGCGAAGC
CTTCGACGGGCAGACATTCGTGTTCTACGACCCAAAGTACGCACCCGAGCACTACGCCGTCCTCACCAAGGCGCTCGATG
CGGGCGGCGGATCCCATGCTGTCCGCCTCGACATGACACCAGGCTTACGTAACATCGTCCTCCCCGACGACTACAGCTTT
ACGCTGATCCCCGAGTCCATGAAACCCTTTCTGCCCCGCACTGTCCGCGAGGTTCCGCTAGACACCAGCGCGCTTCCCGC
TCTAGAGGTCGAACTCGTGTGGCATCGAGAACGCGAATCACCGGGCCTGCTGCGATTCCTTGCTATTGCTCGAGAGGTGA
GTGCCGGGCGCGACTGGTTGACCGCTTCATATACCTGA

Upstream 100 bases:

>100_bases
CTCGCGGGCCCCTGTGCTGAATTCTTCACGGCTTCAACTCTGCGCGTCCGCAGGCCACGGGTCGAAGACCCATCCGGAGC
GAACTCGATACCTTGAAGGT

Downstream 100 bases:

>100_bases
CCCGGTGCGGGAGTGTCGCCTTACGGTTGCGGTTGCGGATCCACGCTCGGTGCCAGCGGTGACGGCTCGGGTTGCCCAGA
GCGCCGCAGCACGCTGAACG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MEIELRWLRYVVAVADHGGMQRAADALHMTQPPLSRQIRELERRLGTSLFTRRPVSLTAAGAVFVEHAREVLSSVDNLVT
ATRSTATGEAGELAVGYILSGAYDTIPRLREASTAAYPGLRLDSRELWPAQLDAGLLDGELDLVIAHTMPVRPEFRRERL
RTDPLVAVTRPKNPAASGAGPVRLGEAFDGQTFVFYDPKYAPEHYAVLTKALDAGGGSHAVRLDMTPGLRNIVLPDDYSF
TLIPESMKPFLPRTVREVPLDTSALPALEVELVWHRERESPGLLRFLAIAREVSAGRDWLTASYT

Sequences:

>Translated_305_residues
MEIELRWLRYVVAVADHGGMQRAADALHMTQPPLSRQIRELERRLGTSLFTRRPVSLTAAGAVFVEHAREVLSSVDNLVT
ATRSTATGEAGELAVGYILSGAYDTIPRLREASTAAYPGLRLDSRELWPAQLDAGLLDGELDLVIAHTMPVRPEFRRERL
RTDPLVAVTRPKNPAASGAGPVRLGEAFDGQTFVFYDPKYAPEHYAVLTKALDAGGGSHAVRLDMTPGLRNIVLPDDYSF
TLIPESMKPFLPRTVREVPLDTSALPALEVELVWHRERESPGLLRFLAIAREVSAGRDWLTASYT
>Mature_305_residues
MEIELRWLRYVVAVADHGGMQRAADALHMTQPPLSRQIRELERRLGTSLFTRRPVSLTAAGAVFVEHAREVLSSVDNLVT
ATRSTATGEAGELAVGYILSGAYDTIPRLREASTAAYPGLRLDSRELWPAQLDAGLLDGELDLVIAHTMPVRPEFRRERL
RTDPLVAVTRPKNPAASGAGPVRLGEAFDGQTFVFYDPKYAPEHYAVLTKALDAGGGSHAVRLDMTPGLRNIVLPDDYSF
TLIPESMKPFLPRTVREVPLDTSALPALEVELVWHRERESPGLLRFLAIAREVSAGRDWLTASYT

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=205, Percent_Identity=36.5853658536585, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788887, Length=298, Percent_Identity=30.8724832214765, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI2367136, Length=141, Percent_Identity=36.8794326241135, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790399, Length=177, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI157672245, Length=173, Percent_Identity=34.6820809248555, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787601, Length=179, Percent_Identity=29.608938547486, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788297, Length=165, Percent_Identity=30.3030303030303, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787530, Length=148, Percent_Identity=30.4054054054054, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081904, Length=181, Percent_Identity=32.0441988950276, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33633; Mature: 33633

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIELRWLRYVVAVADHGGMQRAADALHMTQPPLSRQIRELERRLGTSLFTRRPVSLTAA
CCEEHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHCCCCEEEHH
GAVFVEHAREVLSSVDNLVTATRSTATGEAGELAVGYILSGAYDTIPRLREASTAAYPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHECCHHHHHHHHHHHHHHCCCCC
RLDSRELWPAQLDAGLLDGELDLVIAHTMPVRPEFRRERLRTDPLVAVTRPKNPAASGAG
CCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCC
PVRLGEAFDGQTFVFYDPKYAPEHYAVLTKALDAGGGSHAVRLDMTPGLRNIVLPDDYSF
CEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCEE
TLIPESMKPFLPRTVREVPLDTSALPALEVELVWHRERESPGLLRFLAIAREVSAGRDWL
EEECHHHCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
TASYT
EECCC
>Mature Secondary Structure
MEIELRWLRYVVAVADHGGMQRAADALHMTQPPLSRQIRELERRLGTSLFTRRPVSLTAA
CCEEHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHCCCCEEEHH
GAVFVEHAREVLSSVDNLVTATRSTATGEAGELAVGYILSGAYDTIPRLREASTAAYPGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHECCHHHHHHHHHHHHHHCCCCC
RLDSRELWPAQLDAGLLDGELDLVIAHTMPVRPEFRRERLRTDPLVAVTRPKNPAASGAG
CCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCC
PVRLGEAFDGQTFVFYDPKYAPEHYAVLTKALDAGGGSHAVRLDMTPGLRNIVLPDDYSF
CEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCEE
TLIPESMKPFLPRTVREVPLDTSALPALEVELVWHRERESPGLLRFLAIAREVSAGRDWL
EEECHHHCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
TASYT
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]