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The map label for this gene is thiC [H]

Identifier: 16767418

GI number: 16767418

Start: 4380491

End: 4382386

Strand: Reverse

Name: thiC [H]

Synonym: STM4164

Alternate gene names: 16767418

Gene position: 4382386-4380491 (Counterclockwise)

Preceding gene: 16767419

Following gene: 16767417

Centisome position: 90.22

GC content: 58.07

Gene sequence:

>1896_bases
ATGTCTACAACAACGTTAACCCGCCGCGAGCAGCGCGCTAAAGCCCAGCATTTTATCGATACGCTGGAAGGCACCGCGTT
TCCCAACTCGAAACGCATCTACGTGACCGGTTCGCAGCATGATATTCGCGTACCGATGCGCGAAATTCAACTTAGCCCCA
CGCTCATCGGCGGCAGTAAAGACAACCCGCAGTTTGAAGAGAACGAAGCCGTACCGGTATACGACACCTCCGGCCCCTAT
GGCGATCCTGAGGTGGCGATTAACGTCCAGCAGGGTCTGGCGAAACTGCGCCAGCCATGGATTGACGCACGTAACGATAG
CGAAGAATTAGACGACCGTAGCTCGGCTTATACCAGAGAACGTCTGGCCGACGATGGCCTGGACGATCTGCGTTTTACCG
GCCTGCTGACGCCAAAACGCGCTAAAGCGGGCAAGCGCGTCACCCAGTTACACTACGCCCGCAAGGGGATCGTCACTCCC
GAAATGGAGTTCATCGCCATCCGTGAAAATATGGGCCGTGAGCGCATTCGCAGTGAAGTGCTGCGCCACCAGCATCCGGG
GATGAACTTTGGCGCGCGCCTGCCGGAAAACATTACGCCGGAATTCGTGCGTGATGAAGTCGCCGCGGGCCGCGCGATTA
TTCCCGCCAACATCAACCACCCGGAATCGGAGCCGATGATTATCGGCCGCAACTTCCTGGTCAAAGTGAATGCCAACATC
GGTAACTCGGCGGTCACCTCCTCCATCGAAGAAGAGGTGGAAAAACTGGTGTGGTCAACCCGCTGGGGCGCGGACACGGT
GATGGACCTCTCCACCGGTCGCTATATTCATGAAACCCGCGAATGGATCCTGCGTAACAGCCCGGTACCGATCGGCACCG
TCCCGATCTACCAGGCGCTGGAGAAGGTCAACGGGATCGCCGAAGATCTTACCTGGGAAGCGTTCCGCGACACGCTACTG
GAGCAGGCTGAACAGGGCGTCGACTACTTCACCATTCACGCGGGCGTGCTGCTGCGCTACGTGCCAATGACCGCCAAACG
CCTGACCGGGATTGTCTCACGCGGCGGTTCCATCATGGCAAAGTGGTGTCTCTCCCATCACAAAGAGAACTTCCTGTTCG
AACATTTCCGCGAGATTTGTGAAATTTGCGCCGCCTACGACGTCTCCTTGTCGCTGGGCGACGGCCTGCGCCCCGGCTCC
ATTCAGGATGCCAACGACGAAGCGCAGTTCTCCGAGCTGCATACGCTGGGCGAATTGACCAAAATCGCCTGGGAATACGA
CGTGCAGGTGATGATTGAAGGCCCGGGCCACGTACCCATGCATATGATCCAGCGCAACATGACCGAAGAGCTGGAGAGCT
GCCATGAAGCACCGTTCTACACCTTAGGGCCATTGACCACCGATATCGCGCCGGGCTATGACCACTTCACCTCCGGGATC
GGTGCCGCGATGATCGGCTGGTTTGGCTGCGCGATGCTGTGTTATGTGACGCCGAAAGAACACCTCGGCCTGCCGAACAA
AGAAGATGTGAAGCAGGGGCTAATCACCTACAAAATCGCCGCCCACGCCGCGGATTTAGCCAAAGGACATCCGGGCGCGC
AGATCCGCGATAACGCCATGTCGAAAGCGCGCTTTGAATTCCGCTGGGAAGATCAGTTTAACCTCGCGCTCGACCCGTTC
ACCGCCCGCGCTTATCACGATGAAACCCTGCCGCAGGAGTCCGGCAAGGTTGCCCACTTCTGCTCCATGTGCGGGCCGAA
GTTCTGCTCGATGAAAATCAGCCAGGAGGTCCGCGACTACGCCGCCGCACAAACTATTGAAATCGGCATGGCGGATATGT
CAGAGGACTTCCGCGCCAAAGGCGGCGAAATTTATCTCAAGCGGGAGGAAGCCTGA

Upstream 100 bases:

>100_bases
AGAGTAATTCTGCTTTATGCTGCTGCCTTTACGGGCGGCGCACATCCATTACTCCATCCGTCGTCTGACAAGCCACGTCC
TTAATTTTTTGGAATGAGCT

Downstream 100 bases:

>100_bases
TGTATCAGCCTGATTTCCCCACCGTGCCGTTCCGCCTCGGGCTTTACCCGGTGGTGGACAGCGTTGAATGGATTGAGCGT
TTACTGGAGTCGGGCGTGCG

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MSTTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSKDNPQFEENEAVPVYDTSGPY
GDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRERLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARKGIVTP
EMEFIAIRENMGRERIRSEVLRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANI
GNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLL
EQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGS
IQDANDEAQFSELHTLGELTKIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGI
GAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPF
TARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAAAQTIEIGMADMSEDFRAKGGEIYLKREEA

Sequences:

>Translated_631_residues
MSTTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSKDNPQFEENEAVPVYDTSGPY
GDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRERLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARKGIVTP
EMEFIAIRENMGRERIRSEVLRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANI
GNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLL
EQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGS
IQDANDEAQFSELHTLGELTKIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGI
GAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPF
TARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAAAQTIEIGMADMSEDFRAKGGEIYLKREEA
>Mature_630_residues
STTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSKDNPQFEENEAVPVYDTSGPYG
DPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRERLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARKGIVTPE
MEFIAIRENMGRERIRSEVLRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIG
NSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLLE
QAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGSI
QDANDEAQFSELHTLGELTKIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGIG
AAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPFT
ARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAAAQTIEIGMADMSEDFRAKGGEIYLKREEA

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=631, Percent_Identity=93.026941362916, Blast_Score=1247, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 70846; Mature: 70715

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSK
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEECCHHHHEECCEEECCCC
DNPQFEENEAVPVYDTSGPYGDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRE
CCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
RLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARKGIVTPEMEFIAIRENMGRERIRSEV
HHHCCCCCHHEEEECCCCHHHHHCHHHHHHHHHHCCCCCCCHHEEEEHHHCCHHHHHHHH
LRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANI
HHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCEEEEEEECCC
GNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQAL
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
EKVNGIAEDLTWEAFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGSIQDANDEAQFSELHTLGELT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGI
HHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHH
GAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAM
HHHHHHHHHHHHHHEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SKARFEFRWEDQFNLALDPFTARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDY
HHCEEEEEECCCCCEEECCCHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
AAAQTIEIGMADMSEDFRAKGGEIYLKREEA
HHHHHHEECHHHCCHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
STTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEECCHHHHEECCEEECCCC
DNPQFEENEAVPVYDTSGPYGDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRE
CCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
RLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARKGIVTPEMEFIAIRENMGRERIRSEV
HHHCCCCCHHEEEECCCCHHHHHCHHHHHHHHHHCCCCCCCHHEEEEHHHCCHHHHHHHH
LRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANI
HHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEECCEEEEEEECCC
GNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQAL
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
EKVNGIAEDLTWEAFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGSIQDANDEAQFSELHTLGELT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGI
HHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHH
GAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAM
HHHHHHHHHHHHHHEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SKARFEFRWEDQFNLALDPFTARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDY
HHCEEEEEECCCCCEEECCCHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
AAAQTIEIGMADMSEDFRAKGGEIYLKREEA
HHHHHHEECHHHCCHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA