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The map label for this gene is ptsA [H]

Identifier: 16767376

GI number: 16767376

Start: 4324491

End: 4326992

Strand: Reverse

Name: ptsA [H]

Synonym: STM4110

Alternate gene names: 16767376

Gene position: 4326992-4324491 (Counterclockwise)

Preceding gene: 16767382

Following gene: 16767375

Centisome position: 89.08

GC content: 57.83

Gene sequence:

>2502_bases
ATGCCCCTGATTGTGGAATTTACCTGTGAACTGCCGAATGGCGTACATGCGCGCCCGGCAAGCCACGTAGAAACGCTGTG
TAATACCTTCACGTCGCAAATTGAGTGGCACAACCTGCGCACCGATCGCAAAGGCAGCGCCAAAAGCGCGCTGGCGCTGA
TTGGCACCGACACGCTGGCTGGCGACCACTGTCAGCTGGTGATTTCCGGTGCCGATGAACAGGTTGCCTGTCAGCGTCTG
AGTCAATGGCTGCGCGATGAATTCCCACTCTGCGACGCGCCGCTGGCGGAGATTAAAAACAGCGAACTGGAGCCGCTTCC
GGCGTCGTTGACCCAGCTGAATCCGCAGATTTACCGCGCCCGTAGCGTGTGTAGCGGCAGCGCGGGCGGCGTACTGACGC
CACTCTCTTCCCTGGATCTCAATGCGCTCGGCGAACTCCCGACCGCCAACGACACAGAGACGGAACAAGCCGCGCTGGAC
AATGGCTTAGCGATGTTGATAAAGCATATTGAGTTTCGTCAGCTCGACAGTGACGGTGCCGCCAGCGCGATTCTGGAAGC
CCATCGTTCACTGGCAGGCGACGCTTCACTGCGTCAGCATTTACTGGACGGCGTTCTGCGCGGTTTAAGCTGCGCGCAGG
CAATCGTGGAAAGCGCGAACCATTTCTGCAATGAGTTCGCTCGCGCCAGCAGCAGCTATTTACAGGAACGCGCGCTGGAT
GTTCGTGACGTTTGCTTCCAGTTACTGCAACACATTTACGGTGGGCAGCGCTTTCCGGCGCCGGGCCAGTTGACCCGGCC
ATCTATCTGTATGGCGGAAGAGTTGACGCCAAGCCAGTTCCTCGAACTGGATAAAACCTTTCTCAAAGGTCTGCTGTTAA
AAAGCGGCGGCACCACTTCGCACACGGTGATTCTCGCCCGCTCATTCAACATTCCCACCCTGGTTGGCGTGGAGATTGAG
GCCTTAACACCGTGGCGTCAGCAGACGGTTTATATTGACGGCAACGCAGGCGCGATTGTCGTTGCGCCTGACGAGCCTGT
CACTCGTTACTATCAGCAGGAAGCCCGCGTGCAAGACGCCCTGCGCGAACAGCAGCGCATCTGGCTGACCCAGGAAGCGC
GCACCGCTGACGGCATCCGCATGGAGGTCGCCGCCAACATCGCGCACTCCGTCGAGGCGCAAGCGGCCTTTAGTAACGGC
GCGGAAGCGGTTGGCCTGTTCCGCACAGAAATGCTGTATATGGACCGCGCCTGCGCGCCGGACGAAAACGAGCTGTACAA
TATTTTTTGCCAGGCTCTGGAGTCCGCAAAGGGACGCAGCATTATTGTGCGCACAATGGATATAGGCGGCGATAAGCCCG
TTGATTATCTGAATATTCCTGCCGAAGCCAACCCATTCCTCGGCTATCGCGCCGTCCGTATTTATGAAGAGTACGCTTCT
CTGTTTACCACCCAGCTACGCTCGATCCTCCGCGCGTCCGCCCACGGCAACCTGAAAATCATGATCCCGATGATCTCCTC
TATGGAAGAGATTCTGTGGGTCAAAGAGAAGCTGGCGGAAGCCAAACAGCAGCTGCGTAATGAACATATCCCGTTCGATG
AGAAGATCCCACTCGGCATTATGCTGGAAGTGCCGTCGGTGATGTTCATCATCGATCAATGCTGTGAAGAGATTGATTTC
TTTAGTATTGGTAGTAACGATCTAACACAATACCTGCTGGCGGTAGACCGTGATAACGCCAAAGTCACTCGTCACTACAA
CAGCCTGAATCCCGCCTTCCTGCGCGCGTTGGATTTCGCGGTGCAGGCGGTACATCGTCAGGGCAAATGGATTGGTCTGT
GCGGCGAACTGGGGGCCAAAGGTTCGGTTCTGCCATTGCTGGTAGGTCTGGGGCTGGACGAGATCAGCATGGGCGCGCCG
TCGATTCCCGCCGCCAAAGCGCGGATGGCACAACTCGACAGCCGAGCCTGCCGCCAGTTGTTGAATCAGGCGATGGCCTG
CCGCACCTCGCTGGAGGTGGAGCATCTGCTGGCGCAGTTCCGCATGTCGCAGCAGGATGCCCCGCTGGTTACCGCCCAAT
GCATAACGCTTGATAGCGACTGGCGCAGCAAAGAGGAGGTGATTAAAGGCATGACCGACAATCTGCTGCTGGCGGGCCGC
TGCCGCTACCCGCGCAAACTGGAAGCCGATCTATGGGCGCGCGAGGCGGTATTCTCCACCGGACTGGGCTTTAGCTTTGC
CATTCCGCACAGCAAATCGGAACATATCGAACAGTCCACCATCAGCGTGGCGCGCCTGAACGCGCCGGTACGCTGGGGAG
ATGACGAGGCGCAGTTCATCATTATGCTGACGCTTAACAAACACGCCGCGGGCGACCAGCATATGCGTATTTTCTCGCGC
CTGGCCCGCCGCATCATGCACGAAGAATTCCGCAACACGCTGGTTAACGCCGCTTCCGCCGACGCTATCGCCAGCCTGCT
GCAACATGAACTTGAACTGTAA

Upstream 100 bases:

>100_bases
CTACATTACATTTATCCAGCTTTTGACAGATTTGTCACATGGCGTATTCCGGCTACCTCCTTTTATGCTGTAGCGAGAGA
ATCGTTATGGGAGAGAGGCA

Downstream 100 bases:

>100_bases
AGGAAAGACTATGGAACTCTATCTGGATACCGCTAACGTGGCGGAAGTTGAACGTCTGGCGCGCATTTTCCCGATTGCCG
GCGTCACCACCAATCCAAGC

Product: PEP-protein phosphotransferase

Products: NA

Alternate protein names: MTP 2; Phosphoenolpyruvate-protein phosphotransferase; Enzyme I-Ani; Phosphotransferase system enzyme I; Phosphocarrier protein HPr; Protein H; Fructose-like phosphotransferase enzyme IIA component; PTS system fructose-like EIIA component [H]

Number of amino acids: Translated: 833; Mature: 832

Protein sequence:

>833_residues
MPLIVEFTCELPNGVHARPASHVETLCNTFTSQIEWHNLRTDRKGSAKSALALIGTDTLAGDHCQLVISGADEQVACQRL
SQWLRDEFPLCDAPLAEIKNSELEPLPASLTQLNPQIYRARSVCSGSAGGVLTPLSSLDLNALGELPTANDTETEQAALD
NGLAMLIKHIEFRQLDSDGAASAILEAHRSLAGDASLRQHLLDGVLRGLSCAQAIVESANHFCNEFARASSSYLQERALD
VRDVCFQLLQHIYGGQRFPAPGQLTRPSICMAEELTPSQFLELDKTFLKGLLLKSGGTTSHTVILARSFNIPTLVGVEIE
ALTPWRQQTVYIDGNAGAIVVAPDEPVTRYYQQEARVQDALREQQRIWLTQEARTADGIRMEVAANIAHSVEAQAAFSNG
AEAVGLFRTEMLYMDRACAPDENELYNIFCQALESAKGRSIIVRTMDIGGDKPVDYLNIPAEANPFLGYRAVRIYEEYAS
LFTTQLRSILRASAHGNLKIMIPMISSMEEILWVKEKLAEAKQQLRNEHIPFDEKIPLGIMLEVPSVMFIIDQCCEEIDF
FSIGSNDLTQYLLAVDRDNAKVTRHYNSLNPAFLRALDFAVQAVHRQGKWIGLCGELGAKGSVLPLLVGLGLDEISMGAP
SIPAAKARMAQLDSRACRQLLNQAMACRTSLEVEHLLAQFRMSQQDAPLVTAQCITLDSDWRSKEEVIKGMTDNLLLAGR
CRYPRKLEADLWAREAVFSTGLGFSFAIPHSKSEHIEQSTISVARLNAPVRWGDDEAQFIIMLTLNKHAAGDQHMRIFSR
LARRIMHEEFRNTLVNAASADAIASLLQHELEL

Sequences:

>Translated_833_residues
MPLIVEFTCELPNGVHARPASHVETLCNTFTSQIEWHNLRTDRKGSAKSALALIGTDTLAGDHCQLVISGADEQVACQRL
SQWLRDEFPLCDAPLAEIKNSELEPLPASLTQLNPQIYRARSVCSGSAGGVLTPLSSLDLNALGELPTANDTETEQAALD
NGLAMLIKHIEFRQLDSDGAASAILEAHRSLAGDASLRQHLLDGVLRGLSCAQAIVESANHFCNEFARASSSYLQERALD
VRDVCFQLLQHIYGGQRFPAPGQLTRPSICMAEELTPSQFLELDKTFLKGLLLKSGGTTSHTVILARSFNIPTLVGVEIE
ALTPWRQQTVYIDGNAGAIVVAPDEPVTRYYQQEARVQDALREQQRIWLTQEARTADGIRMEVAANIAHSVEAQAAFSNG
AEAVGLFRTEMLYMDRACAPDENELYNIFCQALESAKGRSIIVRTMDIGGDKPVDYLNIPAEANPFLGYRAVRIYEEYAS
LFTTQLRSILRASAHGNLKIMIPMISSMEEILWVKEKLAEAKQQLRNEHIPFDEKIPLGIMLEVPSVMFIIDQCCEEIDF
FSIGSNDLTQYLLAVDRDNAKVTRHYNSLNPAFLRALDFAVQAVHRQGKWIGLCGELGAKGSVLPLLVGLGLDEISMGAP
SIPAAKARMAQLDSRACRQLLNQAMACRTSLEVEHLLAQFRMSQQDAPLVTAQCITLDSDWRSKEEVIKGMTDNLLLAGR
CRYPRKLEADLWAREAVFSTGLGFSFAIPHSKSEHIEQSTISVARLNAPVRWGDDEAQFIIMLTLNKHAAGDQHMRIFSR
LARRIMHEEFRNTLVNAASADAIASLLQHELEL
>Mature_832_residues
PLIVEFTCELPNGVHARPASHVETLCNTFTSQIEWHNLRTDRKGSAKSALALIGTDTLAGDHCQLVISGADEQVACQRLS
QWLRDEFPLCDAPLAEIKNSELEPLPASLTQLNPQIYRARSVCSGSAGGVLTPLSSLDLNALGELPTANDTETEQAALDN
GLAMLIKHIEFRQLDSDGAASAILEAHRSLAGDASLRQHLLDGVLRGLSCAQAIVESANHFCNEFARASSSYLQERALDV
RDVCFQLLQHIYGGQRFPAPGQLTRPSICMAEELTPSQFLELDKTFLKGLLLKSGGTTSHTVILARSFNIPTLVGVEIEA
LTPWRQQTVYIDGNAGAIVVAPDEPVTRYYQQEARVQDALREQQRIWLTQEARTADGIRMEVAANIAHSVEAQAAFSNGA
EAVGLFRTEMLYMDRACAPDENELYNIFCQALESAKGRSIIVRTMDIGGDKPVDYLNIPAEANPFLGYRAVRIYEEYASL
FTTQLRSILRASAHGNLKIMIPMISSMEEILWVKEKLAEAKQQLRNEHIPFDEKIPLGIMLEVPSVMFIIDQCCEEIDFF
SIGSNDLTQYLLAVDRDNAKVTRHYNSLNPAFLRALDFAVQAVHRQGKWIGLCGELGAKGSVLPLLVGLGLDEISMGAPS
IPAAKARMAQLDSRACRQLLNQAMACRTSLEVEHLLAQFRMSQQDAPLVTAQCITLDSDWRSKEEVIKGMTDNLLLAGRC
RYPRKLEADLWAREAVFSTGLGFSFAIPHSKSEHIEQSTISVARLNAPVRWGDDEAQFIIMLTLNKHAAGDQHMRIFSRL
ARRIMHEEFRNTLVNAASADAIASLLQHELEL

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane [H]

COG id: COG1080

COG function: function code G; Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIA type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI48994992, Length=833, Percent_Identity=89.9159663865546, Blast_Score=1536, Evalue=0.0,
Organism=Escherichia coli, GI1788726, Length=836, Percent_Identity=44.7368421052632, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1788756, Length=449, Percent_Identity=39.8663697104677, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI1789193, Length=518, Percent_Identity=31.8532818532818, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1787994, Length=190, Percent_Identity=31.5789473684211, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786951, Length=153, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008279
- InterPro:   IPR006318
- InterPro:   IPR018274
- InterPro:   IPR023151
- InterPro:   IPR000121
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR001020
- InterPro:   IPR005698
- InterPro:   IPR000032
- InterPro:   IPR008731
- InterPro:   IPR015813 [H]

Pfam domain/function: PF05524 PEP-utilisers_N; PF00391 PEP-utilizers; PF02896 PEP-utilizers_C; PF00381 PTS-HPr; PF00359 PTS_EIIA_2 [H]

EC number: =2.7.3.9 [H]

Molecular weight: Translated: 92084; Mature: 91953

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00369 PTS_HPR_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS00370 PEP_ENZYMES_PHOS_SITE ; PS00742 PEP_ENZYMES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIVEFTCELPNGVHARPASHVETLCNTFTSQIEWHNLRTDRKGSAKSALALIGTDTLA
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCC
GDHCQLVISGADEQVACQRLSQWLRDEFPLCDAPLAEIKNSELEPLPASLTQLNPQIYRA
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHCCHHHHHH
RSVCSGSAGGVLTPLSSLDLNALGELPTANDTETEQAALDNGLAMLIKHIEFRQLDSDGA
HHHCCCCCCCCCCCHHHCCHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCH
ASAILEAHRSLAGDASLRQHLLDGVLRGLSCAQAIVESANHFCNEFARASSSYLQERALD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VRDVCFQLLQHIYGGQRFPAPGQLTRPSICMAEELTPSQFLELDKTFLKGLLLKSGGTTS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
HTVILARSFNIPTLVGVEIEALTPWRQQTVYIDGNAGAIVVAPDEPVTRYYQQEARVQDA
EEEEEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHH
LREQQRIWLTQEARTADGIRMEVAANIAHSVEAQAAFSNGAEAVGLFRTEMLYMDRACAP
HHHHHHEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
DENELYNIFCQALESAKGRSIIVRTMDIGGDKPVDYLNIPAEANPFLGYRAVRIYEEYAS
CHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
LFTTQLRSILRASAHGNLKIMIPMISSMEEILWVKEKLAEAKQQLRNEHIPFDEKIPLGI
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
MLEVPSVMFIIDQCCEEIDFFSIGSNDLTQYLLAVDRDNAKVTRHYNSLNPAFLRALDFA
EECCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCCCEEHHCCCCCHHHHHHHHHH
VQAVHRQGKWIGLCGELGAKGSVLPLLVGLGLDEISMGAPSIPAAKARMAQLDSRACRQL
HHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LNQAMACRTSLEVEHLLAQFRMSQQDAPLVTAQCITLDSDWRSKEEVIKGMTDNLLLAGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHCCCCCCEEEECC
CRYPRKLEADLWAREAVFSTGLGFSFAIPHSKSEHIEQSTISVARLNAPVRWGDDEAQFI
CCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHEECCCCEECCCCCCEE
IMLTLNKHAAGDQHMRIFSRLARRIMHEEFRNTLVNAASADAIASLLQHELEL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLIVEFTCELPNGVHARPASHVETLCNTFTSQIEWHNLRTDRKGSAKSALALIGTDTLA
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEECCCCC
GDHCQLVISGADEQVACQRLSQWLRDEFPLCDAPLAEIKNSELEPLPASLTQLNPQIYRA
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCHHHHHCCHHHHHH
RSVCSGSAGGVLTPLSSLDLNALGELPTANDTETEQAALDNGLAMLIKHIEFRQLDSDGA
HHHCCCCCCCCCCCHHHCCHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCH
ASAILEAHRSLAGDASLRQHLLDGVLRGLSCAQAIVESANHFCNEFARASSSYLQERALD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VRDVCFQLLQHIYGGQRFPAPGQLTRPSICMAEELTPSQFLELDKTFLKGLLLKSGGTTS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
HTVILARSFNIPTLVGVEIEALTPWRQQTVYIDGNAGAIVVAPDEPVTRYYQQEARVQDA
EEEEEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHH
LREQQRIWLTQEARTADGIRMEVAANIAHSVEAQAAFSNGAEAVGLFRTEMLYMDRACAP
HHHHHHEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
DENELYNIFCQALESAKGRSIIVRTMDIGGDKPVDYLNIPAEANPFLGYRAVRIYEEYAS
CHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
LFTTQLRSILRASAHGNLKIMIPMISSMEEILWVKEKLAEAKQQLRNEHIPFDEKIPLGI
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
MLEVPSVMFIIDQCCEEIDFFSIGSNDLTQYLLAVDRDNAKVTRHYNSLNPAFLRALDFA
EECCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCCCEEHHCCCCCHHHHHHHHHH
VQAVHRQGKWIGLCGELGAKGSVLPLLVGLGLDEISMGAPSIPAAKARMAQLDSRACRQL
HHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LNQAMACRTSLEVEHLLAQFRMSQQDAPLVTAQCITLDSDWRSKEEVIKGMTDNLLLAGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCHHHHHCCCCCCEEEECC
CRYPRKLEADLWAREAVFSTGLGFSFAIPHSKSEHIEQSTISVARLNAPVRWGDDEAQFI
CCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHEECCCCEECCCCCCEE
IMLTLNKHAAGDQHMRIFSRLARRIMHEEFRNTLVNAASADAIASLLQHELEL
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 7773398 [H]