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The map label for this gene is ilvD [H]

Identifier: 16766817

GI number: 16766817

Start: 3695271

End: 3696986

Strand: Direct

Name: ilvD [H]

Synonym: STM3531

Alternate gene names: 16766817

Gene position: 3695271-3696986 (Clockwise)

Preceding gene: 16766813

Following gene: 16766818

Centisome position: 76.07

GC content: 53.73

Gene sequence:

>1716_bases
ATGAGCCAAAAATGTCAACATGCTCGCGACCTGTGGTCGCAGCTCGACGCCCTGCGTCTTGGAATGAATTACAGCAAAGA
AGATGTCAATAAACTGCAGGTCCTGGTGGATGATTGCTATGGTGAAAGTCATCCGGGCAGTTTCCATCTTAACCAACTGG
GCGATGAAGCCGTGCTGGGTGTTCATGAAAGCGGCGGTCGCGCGGTCCGTCACCATGTGACGGATATCTGCGACGGCTGG
GGTCAGGGCCACGATGGGATGAACTACATCCTGGCATCTCGCGAAGCCATTGCCAACATGGTCGAAATTCATGCCTCAGT
GGTGCCTTATGATGCCGGTATTCTGATCTCAAGCTGCGATAAATCTATCCCGGCGCATCTGATTGCCGCCGCACGCCTGA
ACCTGCCGCTACTGCATATTCCCGGCGGTTCTATGCGTCCGGCACCGAATATGAGTACTTCTGACCTCGGTGGGATCACT
GCTAAGTTGAGGAAAGGCGAAATCGGCATTCAGCAAGTGGAAGCCATGCAGCAATGCGGTTGCCCCACCGCCGGAGCCTG
CCAGTTTATGGGAACGGCCAGTACCATGCAGTGCATGTCGGAGGCCTTGGGGCTGGCCCTGCCAGGCAGCGCTTTGCTGC
CATCGACCCTGGCGGAAATTCGCCGCGTTGCCAGAACTGCAGGCCACCAGGCGCTGTATCTGGCGGAGAAAAATATCACC
ACCCATAAGATCCTGACTCCTGCGGCGTTTGAAAATGCTATCAAAGTCCATGCTGCTATTGGTGGCAGCACCAATGCGAT
GATCCACCTTCCGGCCATCGCTCATGAACTTGGATGGGAGCTGAAGCCCGAACTGTTTGATCGGATCAATAACGAAATCC
CTTATCTGACCAATATTCAGCCCAGCGGTGAATACGTTACCGAAATGATGTGGTTCGCTGGCGGCGTGCCAATGGTGCAA
TGGTATCTGCGCGATTATCTGGATCTTGATGTGCTTACCGTGACTGGCCGTACGCTCGGCGACAACCTGGAAATGCTCCA
TCAATCCGGCTTCTTTACCCGCAACCACGGTTACCTCAACAATTACAAAGTCAGTCCGGAGGAGGTGATCCGTAAACCAG
AAAATGCCACCAAAAAAGGGTCGATTGCGGTACTGAAAGGCAACATCGCGCCTGAAGGAGCGGTCATTAAATACGCGGCC
TGTGCGCCGGATATGCACCACCATACCGGTCCTGCTCGGGTCTTTAACTCCGAAGAAGACGCTCAGCAGGCCATCATCCA
TAACCATATCGAACCCGGCGACGTCATTTTCATTCGCTACGAAGGCGCAAAAGGCTCTGGCGCACCGGAAATGCTGATGA
CTACCGATGCCATAGTGTATGACAAACGCCTCGACGGAAAAGTCGCATTGATTACCGACGGTCGTTTCTCTGGAGCGACC
AGCGGGCCATGTGTCGGACACGTCTCGCCAGAAGCCGCTGATGGGGGGCCGATTGCCCTGGTGGAAGATGGTGATTTAAT
CGAAATGGATGTGAAAGGCCGCAAGCTCAATATTGTAGGGATCGACGGGATGCCTAAAACAGAAGAGGAAATACGCCGCT
GTCTTGAAGAGCGTCGAGCAAGCTGGAAGAAACCTGATTATTCAAACCGTCGCGGCGTCTTTAAACAGTTCACCGCTAAT
GCAACATCATTAATGGCCGGAGCCTGGCTTAAATAA

Upstream 100 bases:

>100_bases
TTTTCAGCTTACCTTCTGTTACCGCTCGTCCTGCAGGTAGCAGCAACACCCCTAACACCTCGACGCCGGGTGCGTCACTT
AAACAGGAAGGAATCGCCAA

Downstream 100 bases:

>100_bases
TATCCCTGGCGGGCTACGGCTCGCCTGTTTTAAGGATCAATACATGACTCAGATTACGAAATTTCACGGCGTATTTCCGC
CAGTTCCGACCATTGTTAAT

Product: dihydroxyacid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MSQKCQHARDLWSQLDALRLGMNYSKEDVNKLQVLVDDCYGESHPGSFHLNQLGDEAVLGVHESGGRAVRHHVTDICDGW
GQGHDGMNYILASREAIANMVEIHASVVPYDAGILISSCDKSIPAHLIAAARLNLPLLHIPGGSMRPAPNMSTSDLGGIT
AKLRKGEIGIQQVEAMQQCGCPTAGACQFMGTASTMQCMSEALGLALPGSALLPSTLAEIRRVARTAGHQALYLAEKNIT
THKILTPAAFENAIKVHAAIGGSTNAMIHLPAIAHELGWELKPELFDRINNEIPYLTNIQPSGEYVTEMMWFAGGVPMVQ
WYLRDYLDLDVLTVTGRTLGDNLEMLHQSGFFTRNHGYLNNYKVSPEEVIRKPENATKKGSIAVLKGNIAPEGAVIKYAA
CAPDMHHHTGPARVFNSEEDAQQAIIHNHIEPGDVIFIRYEGAKGSGAPEMLMTTDAIVYDKRLDGKVALITDGRFSGAT
SGPCVGHVSPEAADGGPIALVEDGDLIEMDVKGRKLNIVGIDGMPKTEEEIRRCLEERRASWKKPDYSNRRGVFKQFTAN
ATSLMAGAWLK

Sequences:

>Translated_571_residues
MSQKCQHARDLWSQLDALRLGMNYSKEDVNKLQVLVDDCYGESHPGSFHLNQLGDEAVLGVHESGGRAVRHHVTDICDGW
GQGHDGMNYILASREAIANMVEIHASVVPYDAGILISSCDKSIPAHLIAAARLNLPLLHIPGGSMRPAPNMSTSDLGGIT
AKLRKGEIGIQQVEAMQQCGCPTAGACQFMGTASTMQCMSEALGLALPGSALLPSTLAEIRRVARTAGHQALYLAEKNIT
THKILTPAAFENAIKVHAAIGGSTNAMIHLPAIAHELGWELKPELFDRINNEIPYLTNIQPSGEYVTEMMWFAGGVPMVQ
WYLRDYLDLDVLTVTGRTLGDNLEMLHQSGFFTRNHGYLNNYKVSPEEVIRKPENATKKGSIAVLKGNIAPEGAVIKYAA
CAPDMHHHTGPARVFNSEEDAQQAIIHNHIEPGDVIFIRYEGAKGSGAPEMLMTTDAIVYDKRLDGKVALITDGRFSGAT
SGPCVGHVSPEAADGGPIALVEDGDLIEMDVKGRKLNIVGIDGMPKTEEEIRRCLEERRASWKKPDYSNRRGVFKQFTAN
ATSLMAGAWLK
>Mature_570_residues
SQKCQHARDLWSQLDALRLGMNYSKEDVNKLQVLVDDCYGESHPGSFHLNQLGDEAVLGVHESGGRAVRHHVTDICDGWG
QGHDGMNYILASREAIANMVEIHASVVPYDAGILISSCDKSIPAHLIAAARLNLPLLHIPGGSMRPAPNMSTSDLGGITA
KLRKGEIGIQQVEAMQQCGCPTAGACQFMGTASTMQCMSEALGLALPGSALLPSTLAEIRRVARTAGHQALYLAEKNITT
HKILTPAAFENAIKVHAAIGGSTNAMIHLPAIAHELGWELKPELFDRINNEIPYLTNIQPSGEYVTEMMWFAGGVPMVQW
YLRDYLDLDVLTVTGRTLGDNLEMLHQSGFFTRNHGYLNNYKVSPEEVIRKPENATKKGSIAVLKGNIAPEGAVIKYAAC
APDMHHHTGPARVFNSEEDAQQAIIHNHIEPGDVIFIRYEGAKGSGAPEMLMTTDAIVYDKRLDGKVALITDGRFSGATS
GPCVGHVSPEAADGGPIALVEDGDLIEMDVKGRKLNIVGIDGMPKTEEEIRRCLEERRASWKKPDYSNRRGVFKQFTANA
TSLMAGAWLK

Specific function: Unknown

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1786464, Length=520, Percent_Identity=38.6538461538462, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI2367371, Length=490, Percent_Identity=40.6122448979592, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=34.4884488448845, Blast_Score=280, Evalue=3e-76,
Organism=Escherichia coli, GI1788157, Length=463, Percent_Identity=30.6695464362851, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=33.8078291814947, Blast_Score=269, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62014; Mature: 61882

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKCQHARDLWSQLDALRLGMNYSKEDVNKLQVLVDDCYGESHPGSFHLNQLGDEAVLG
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCEEEE
VHESGGRAVRHHVTDICDGWGQGHDGMNYILASREAIANMVEIHASVVPYDAGILISSCD
EECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
KSIPAHLIAAARLNLPLLHIPGGSMRPAPNMSTSDLGGITAKLRKGEIGIQQVEAMQQCG
CCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCC
CPTAGACQFMGTASTMQCMSEALGLALPGSALLPSTLAEIRRVARTAGHQALYLAEKNIT
CCCCCCHHCCCCHHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
THKILTPAAFENAIKVHAAIGGSTNAMIHLPAIAHELGWELKPELFDRINNEIPYLTNIQ
HHEEECHHHHHCCEEEEEEECCCCCEEEECCHHHHHHCCCCCHHHHHHHCCCCCEEECCC
PSGEYVTEMMWFAGGVPMVQWYLRDYLDLDVLTVTGRTLGDNLEMLHQSGFFTRNHGYLN
CCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHCCCEEECCCCCC
NYKVSPEEVIRKPENATKKGSIAVLKGNIAPEGAVIKYAACAPDMHHHTGPARVFNSEED
CCCCCHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHCCCCHHH
AQQAIIHNHIEPGDVIFIRYEGAKGSGAPEMLMTTDAIVYDKRLDGKVALITDGRFSGAT
HHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEECCEEEEECCCCCEEEEEECCCCCCCC
SGPCVGHVSPEAADGGPIALVEDGDLIEMDVKGRKLNIVGIDGMPKTEEEIRRCLEERRA
CCCEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHH
SWKKPDYSNRRGVFKQFTANATSLMAGAWLK
CCCCCCCCCCCCHHHHHHCCHHHHHHCCCCC
>Mature Secondary Structure 
SQKCQHARDLWSQLDALRLGMNYSKEDVNKLQVLVDDCYGESHPGSFHLNQLGDEAVLG
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCEEEE
VHESGGRAVRHHVTDICDGWGQGHDGMNYILASREAIANMVEIHASVVPYDAGILISSCD
EECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
KSIPAHLIAAARLNLPLLHIPGGSMRPAPNMSTSDLGGITAKLRKGEIGIQQVEAMQQCG
CCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCC
CPTAGACQFMGTASTMQCMSEALGLALPGSALLPSTLAEIRRVARTAGHQALYLAEKNIT
CCCCCCHHCCCCHHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
THKILTPAAFENAIKVHAAIGGSTNAMIHLPAIAHELGWELKPELFDRINNEIPYLTNIQ
HHEEECHHHHHCCEEEEEEECCCCCEEEECCHHHHHHCCCCCHHHHHHHCCCCCEEECCC
PSGEYVTEMMWFAGGVPMVQWYLRDYLDLDVLTVTGRTLGDNLEMLHQSGFFTRNHGYLN
CCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHCCCEEECCCCCC
NYKVSPEEVIRKPENATKKGSIAVLKGNIAPEGAVIKYAACAPDMHHHTGPARVFNSEED
CCCCCHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCHHCCCCHHH
AQQAIIHNHIEPGDVIFIRYEGAKGSGAPEMLMTTDAIVYDKRLDGKVALITDGRFSGAT
HHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEECCEEEEECCCCCEEEEEECCCCCCCC
SGPCVGHVSPEAADGGPIALVEDGDLIEMDVKGRKLNIVGIDGMPKTEEEIRRCLEERRA
CCCEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHH
SWKKPDYSNRRGVFKQFTANATSLMAGAWLK
CCCCCCCCCCCCHHHHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA