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The map label for this gene is rtcR [H]

Identifier: 16766809

GI number: 16766809

Start: 3684868

End: 3686451

Strand: Direct

Name: rtcR [H]

Synonym: STM3522

Alternate gene names: 16766809

Gene position: 3684868-3686451 (Clockwise)

Preceding gene: 16766803

Following gene: 16766813

Centisome position: 75.86

GC content: 60.16

Gene sequence:

>1584_bases
ATGCGAAAAACGGTGGCCTTTGGTTTTGTCGGTACGGTACTCGACTATGCAGGACGCGGCAGTCAACGTTGGGAAAAATG
GCGCCCTACTTTGTGTCTGTGCCAGCAGGAGACGCTGGTCGTTCACCGCCTGGAACTGCTGTACGATGCCCGCTCTCGCT
CGCTGTTTGAAGGATTAAAGAAGGATATCGCCAGCGTCTCGCCGGAAACGGAAGTCGTCGGCGTAGAAATCGCGATCCGC
AACCCGTGGGACTTCGAAGAGGTTTACGCCTGCCTGCACGATTTCGCCCGCAGCCATACCTTTCATCCCGAAGATGAAGA
CTATCTGATTCACATCACCACCGGCACCCACGTCGCGCAGATCTGCTGGTTCCTGCTGGCGGAGGCGCGCTATCTTCCGG
CGCGATTAGCGCAGACCTCGCCGCCGCGCAAAAAAGATAAACCGCATAGCACGGGCGACGTGACGATTATTGACCTCGAC
CTCAGCCGCTACAATGATATCGCCACCCGCTTCGCCCAGGAGCGGGAGGAGACGCTCAACTTCCTGAAGTCCGGCATTGC
AACCCGCAACCCGTGTTTCAACCGGATGATTGAGCAAATTGAGCGCGTCGCGATACGCTCCCGTTCGCCAATCCTGCTCA
ATGGCCCGACCGGCGCGGGCAAGTCGTTTCTCGCCCGTCGCATCTATGAACTAAAACTGGCCCGCCACCAGTTCAGCGGC
CCGTTTGTCGAAGTGAACTGCGCCACCCTGCGCGGCGACACGGCGATGTCGGCGCTGTTCGGCCACGTTAAGGGGGCGTT
TACCGGCGCGAGAGAGGAGCGTGCAGGGCTGCTGCGCAGCGCCGACGGCGGCATGTTGTTTCTTGACGAAGTGGGAGAAC
TGGGCGCGGATGAACAGGCCATGTTGCTGAAAGCCATTGAAGAAAAACGCTTTTACCCTTTCGGCAGCGACCAGCAGGTC
AGCAGCGATTTCCAGTTGATTGCCGGCACGGTGCGCGACCTGCGCCAGCGGGTGGCGGAGGGGACATTCCGCGAAGACCT
GTACGCGCGTATTAATCTCTGGACCTTCGAACTACCGGGCCTGCGTCAGCGCCAGGAAGATATTGAGCCAAACCTTGACT
ACGAACTGGAACGCCACGCGGCGCTAACCGGCGACAGCGTGCGTTTTAATACCGAAGCGCGCCGCGCCTGGCTGAGCTTC
GCCACCTCGCCGCAGGCCGCCTGGCGCGGTAACTTCCGCGAACTCTCCGCCAGCGTCACCCGCATGGCGACGCTGGCGGA
CAACGGGCGAATCACGGTCGAAACGGTAGACGATGAAATCGCGCGTTTGCGCTATAGCTGGAATGACCATCGCCCCTCCG
CGCTCGACGGACTGCCGGGCATTGACGCAACGGCGCTGGATCTGTTTGACCGTATGCAACTGGAAAACGTCGTTGCGGTC
TGCCGCCAGGCGAAAACCCTTTCCGACGCCGGGCGGCAGCTATTCAACGTTTCCCGTCAGGGGAAAGCCACGGTGAATGA
CGCTGACCGGCTGCGTAAGTACCTGGCGCGTTTTGGGCTGACGTGGGACGTTTTACAGAATTAA

Upstream 100 bases:

>100_bases
AATTGATTTATTTCTTTAGCGTTCAAGTGAAAGAAAAATGCCTGCACGGTAGTCATTAAAAAGCGATAAAATTATCTCGT
CTTTTAGAAGGAAATCTAAG

Downstream 100 bases:

>100_bases
CACAGCTCCAGTTGAATATGGTTCTCCGTCAACACCTGCATCACGCCCGGCGGCGGCAGGGTATCGGTGTAGACCGCATC
GACCATACTAATGCTGCCCA

Product: sigma N

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MRKTVAFGFVGTVLDYAGRGSQRWEKWRPTLCLCQQETLVVHRLELLYDARSRSLFEGLKKDIASVSPETEVVGVEIAIR
NPWDFEEVYACLHDFARSHTFHPEDEDYLIHITTGTHVAQICWFLLAEARYLPARLAQTSPPRKKDKPHSTGDVTIIDLD
LSRYNDIATRFAQEREETLNFLKSGIATRNPCFNRMIEQIERVAIRSRSPILLNGPTGAGKSFLARRIYELKLARHQFSG
PFVEVNCATLRGDTAMSALFGHVKGAFTGAREERAGLLRSADGGMLFLDEVGELGADEQAMLLKAIEEKRFYPFGSDQQV
SSDFQLIAGTVRDLRQRVAEGTFREDLYARINLWTFELPGLRQRQEDIEPNLDYELERHAALTGDSVRFNTEARRAWLSF
ATSPQAAWRGNFRELSASVTRMATLADNGRITVETVDDEIARLRYSWNDHRPSALDGLPGIDATALDLFDRMQLENVVAV
CRQAKTLSDAGRQLFNVSRQGKATVNDADRLRKYLARFGLTWDVLQN

Sequences:

>Translated_527_residues
MRKTVAFGFVGTVLDYAGRGSQRWEKWRPTLCLCQQETLVVHRLELLYDARSRSLFEGLKKDIASVSPETEVVGVEIAIR
NPWDFEEVYACLHDFARSHTFHPEDEDYLIHITTGTHVAQICWFLLAEARYLPARLAQTSPPRKKDKPHSTGDVTIIDLD
LSRYNDIATRFAQEREETLNFLKSGIATRNPCFNRMIEQIERVAIRSRSPILLNGPTGAGKSFLARRIYELKLARHQFSG
PFVEVNCATLRGDTAMSALFGHVKGAFTGAREERAGLLRSADGGMLFLDEVGELGADEQAMLLKAIEEKRFYPFGSDQQV
SSDFQLIAGTVRDLRQRVAEGTFREDLYARINLWTFELPGLRQRQEDIEPNLDYELERHAALTGDSVRFNTEARRAWLSF
ATSPQAAWRGNFRELSASVTRMATLADNGRITVETVDDEIARLRYSWNDHRPSALDGLPGIDATALDLFDRMQLENVVAV
CRQAKTLSDAGRQLFNVSRQGKATVNDADRLRKYLARFGLTWDVLQN
>Mature_527_residues
MRKTVAFGFVGTVLDYAGRGSQRWEKWRPTLCLCQQETLVVHRLELLYDARSRSLFEGLKKDIASVSPETEVVGVEIAIR
NPWDFEEVYACLHDFARSHTFHPEDEDYLIHITTGTHVAQICWFLLAEARYLPARLAQTSPPRKKDKPHSTGDVTIIDLD
LSRYNDIATRFAQEREETLNFLKSGIATRNPCFNRMIEQIERVAIRSRSPILLNGPTGAGKSFLARRIYELKLARHQFSG
PFVEVNCATLRGDTAMSALFGHVKGAFTGAREERAGLLRSADGGMLFLDEVGELGADEQAMLLKAIEEKRFYPFGSDQQV
SSDFQLIAGTVRDLRQRVAEGTFREDLYARINLWTFELPGLRQRQEDIEPNLDYELERHAALTGDSVRFNTEARRAWLSF
ATSPQAAWRGNFRELSASVTRMATLADNGRITVETVDDEIARLRYSWNDHRPSALDGLPGIDATALDLFDRMQLENVVAV
CRQAKTLSDAGRQLFNVSRQGKATVNDADRLRKYLARFGLTWDVLQN

Specific function: Transcriptional repressor of the rtcAB genes. Interacts with sigma-54 [H]

COG id: COG4650

COG function: function code KT; Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789828, Length=527, Percent_Identity=84.4402277039848, Blast_Score=932, Evalue=0.0,
Organism=Escherichia coli, GI1788905, Length=252, Percent_Identity=38.0952380952381, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790437, Length=248, Percent_Identity=39.5161290322581, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1788550, Length=254, Percent_Identity=38.1889763779528, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789233, Length=254, Percent_Identity=35.8267716535433, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1790299, Length=289, Percent_Identity=33.5640138408304, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87082117, Length=257, Percent_Identity=36.9649805447471, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789087, Length=260, Percent_Identity=36.1538461538462, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87082152, Length=247, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786524, Length=237, Percent_Identity=36.2869198312236, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787583, Length=249, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=35.7758620689655, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87081858, Length=251, Percent_Identity=29.4820717131474, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR002078
- InterPro:   IPR009715
- InterPro:   IPR017183 [H]

Pfam domain/function: PF06956 RtcR; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 59741; Mature: 59741

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTVAFGFVGTVLDYAGRGSQRWEKWRPTLCLCQQETLVVHRLELLYDARSRSLFEGLK
CCCEEEHHHHHHHHHHCCCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
KDIASVSPETEVVGVEIAIRNPWDFEEVYACLHDFARSHTFHPEDEDYLIHITTGTHVAQ
HHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHH
ICWFLLAEARYLPARLAQTSPPRKKDKPHSTGDVTIIDLDLSRYNDIATRFAQEREETLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
FLKSGIATRNPCFNRMIEQIERVAIRSRSPILLNGPTGAGKSFLARRIYELKLARHQFSG
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
PFVEVNCATLRGDTAMSALFGHVKGAFTGAREERAGLLRSADGGMLFLDEVGELGADEQA
CEEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCHHH
MLLKAIEEKRFYPFGSDQQVSSDFQLIAGTVRDLRQRVAEGTFREDLYARINLWTFELPG
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEEEECCC
LRQRQEDIEPNLDYELERHAALTGDSVRFNTEARRAWLSFATSPQAAWRGNFRELSASVT
CHHHHHCCCCCCCCCHHHHHCCCCCCEEECHHHHHHHHHHCCCCCHHHCCCHHHHHHHHH
RMATLADNGRITVETVDDEIARLRYSWNDHRPSALDGLPGIDATALDLFDRMQLENVVAV
HHHHCCCCCEEEEEECCHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHH
CRQAKTLSDAGRQLFNVSRQGKATVNDADRLRKYLARFGLTWDVLQN
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MRKTVAFGFVGTVLDYAGRGSQRWEKWRPTLCLCQQETLVVHRLELLYDARSRSLFEGLK
CCCEEEHHHHHHHHHHCCCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
KDIASVSPETEVVGVEIAIRNPWDFEEVYACLHDFARSHTFHPEDEDYLIHITTGTHVAQ
HHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHH
ICWFLLAEARYLPARLAQTSPPRKKDKPHSTGDVTIIDLDLSRYNDIATRFAQEREETLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
FLKSGIATRNPCFNRMIEQIERVAIRSRSPILLNGPTGAGKSFLARRIYELKLARHQFSG
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
PFVEVNCATLRGDTAMSALFGHVKGAFTGAREERAGLLRSADGGMLFLDEVGELGADEQA
CEEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCHHH
MLLKAIEEKRFYPFGSDQQVSSDFQLIAGTVRDLRQRVAEGTFREDLYARINLWTFELPG
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEEEECCC
LRQRQEDIEPNLDYELERHAALTGDSVRFNTEARRAWLSFATSPQAAWRGNFRELSASVT
CHHHHHCCCCCCCCCHHHHHCCCCCCEEECHHHHHHHHHHCCCCCHHHCCCHHHHHHHHH
RMATLADNGRITVETVDDEIARLRYSWNDHRPSALDGLPGIDATALDLFDRMQLENVVAV
HHHHCCCCCEEEEEECCHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHH
CRQAKTLSDAGRQLFNVSRQGKATVNDADRLRKYLARFGLTWDVLQN
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 3045764; 7984428; 7920643; 9738023 [H]