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The map label for this gene is 16766417

Identifier: 16766417

GI number: 16766417

Start: 3276380

End: 3276814

Strand: Reverse

Name: 16766417

Synonym: STM3117

Alternate gene names: NA

Gene position: 3276814-3276380 (Counterclockwise)

Preceding gene: 16766418

Following gene: 16766415

Centisome position: 67.46

GC content: 37.7

Gene sequence:

>435_bases
ATGCTATTTTTTAATGTAGCATCCCTAAAATATAAACATCATGAGTCTATTCAAATGATAATTGACAGAATTGATCACCT
TGTATTAACGGTATCTGATATATCAACCACAATAAGATTCTACGAAGAGGTACTTGGTTTTTCTGCGGTAACATTTAAAC
AAAACAGAAAAGCGTTAATATTTGGAGCGCAAAAAATTAACCTCCATCAGCAAGAAATGGAGTTCGAACCAAAAGCGAGT
AGACCAACGCCGGGATCTGCCGATTTATGTTTTATTACATCGACACCGATAAATGATGTTGTGTCTGAGATCTTACAGGC
AGGCATTTCCATTGTTGAAGGCCCGGTTGAGAGAACTGGAGCCACAGGCGAGATAATGTCTATCTACATCAGGGACCCTG
ATGGAAACTTAATTGAAATTTCGCAGTATGTTTAA

Upstream 100 bases:

>100_bases
ACCGAGCGTGCGCTCAGCATCATTGAATTGGCACATCCCAATTTTCGGCAGCAACTTAGAGTAGATGCAAAAAAAATGCA
TCTGATTTAAAAGTAGGTTA

Downstream 100 bases:

>100_bases
TGTTAAAACTTACTATTACTGCCTTTATTATGATCACGCATCCGTTTATATTGGTCTAATGGAGATCATATGGCAATAAT
TTCTGGAAAGAGTCTATGTT

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MLFFNVASLKYKHHESIQMIIDRIDHLVLTVSDISTTIRFYEEVLGFSAVTFKQNRKALIFGAQKINLHQQEMEFEPKAS
RPTPGSADLCFITSTPINDVVSEILQAGISIVEGPVERTGATGEIMSIYIRDPDGNLIEISQYV

Sequences:

>Translated_144_residues
MLFFNVASLKYKHHESIQMIIDRIDHLVLTVSDISTTIRFYEEVLGFSAVTFKQNRKALIFGAQKINLHQQEMEFEPKAS
RPTPGSADLCFITSTPINDVVSEILQAGISIVEGPVERTGATGEIMSIYIRDPDGNLIEISQYV
>Mature_144_residues
MLFFNVASLKYKHHESIQMIIDRIDHLVLTVSDISTTIRFYEEVLGFSAVTFKQNRKALIFGAQKINLHQQEMEFEPKAS
RPTPGSADLCFITSTPINDVVSEILQAGISIVEGPVERTGATGEIMSIYIRDPDGNLIEISQYV

Specific function: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidogly

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI254039722, Length=125, Percent_Identity=53.6, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VIR17_SALTY (Q8ZM36)

Other databases:

- EMBL:   AE006468
- RefSeq:   NP_462032.1
- PDB:   3HNQ
- PDB:   3HUH
- PDBsum:   3HNQ
- PDBsum:   3HUH
- ProteinModelPortal:   Q8ZM36
- GeneID:   1254640
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM3117
- NMPDR:   fig|99287.1.peg.3008
- HOGENOM:   HBG704761
- OMA:   MEVVTFK
- ProtClustDB:   CLSK894801
- BioCyc:   STYP99287:STM3117-MONOMER
- GO:   GO:0009405
- InterPro:   IPR004360

Pfam domain/function: PF00903 Glyoxalase

EC number: NA

Molecular weight: Translated: 16147; Mature: 16147

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFFNVASLKYKHHESIQMIIDRIDHLVLTVSDISTTIRFYEEVLGFSAVTFKQNRKALI
CEEEEEEHEEECCHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCEEEEECCCCEEEE
FGAQKINLHQQEMEFEPKASRPTPGSADLCFITSTPINDVVSEILQAGISIVEGPVERTG
EEEEECCCCHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCHHHHCCCHHHCC
ATGEIMSIYIRDPDGNLIEISQYV
CCCEEEEEEEECCCCCEEEEECCC
>Mature Secondary Structure
MLFFNVASLKYKHHESIQMIIDRIDHLVLTVSDISTTIRFYEEVLGFSAVTFKQNRKALI
CEEEEEEHEEECCHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCEEEEECCCCEEEE
FGAQKINLHQQEMEFEPKASRPTPGSADLCFITSTPINDVVSEILQAGISIVEGPVERTG
EEEEECCCCHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCHHHHCCCHHHCC
ATGEIMSIYIRDPDGNLIEISQYV
CCCEEEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609