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The map label for this gene is uxuB [H]

Identifier: 16766384

GI number: 16766384

Start: 3244366

End: 3245838

Strand: Reverse

Name: uxuB [H]

Synonym: STM3083

Alternate gene names: 16766384

Gene position: 3245838-3244366 (Counterclockwise)

Preceding gene: 39546359

Following gene: 16766383

Centisome position: 66.82

GC content: 51.46

Gene sequence:

>1473_bases
ATGGACACCATAGCTCGCCAGTTAGACGCCGCAAGGCACCAATTCAAAACGACTTATTCACGTCAGGGAATGGAAGCCAA
CATCGTACATATTGGATTTGGCGCCTTTCACCGTGGTCATCAGGCTGTTTATAACGATCTCACGAATGAGATAACCGGCA
ACCGCTGGGGGATTTTTGAACTGAATCTGTTCGGCGATGCGGAGCTGGTGGATGCGCTAAATGCGCAACAGGGGCTGTTT
TCAGTGGTGGAAACGTCAGCCAGCGCCATCAATAGTCGCCTGGTTCGTACCATCACCGGCGCGTTGCATACGCCGAAGTC
AGGTATTCAGGCGGCGATCGAGAAGCTGACTGAGCCGCAGGTAAAAATTGTTTCGTTGACGATAACGGAAAAAGGTTACT
GCACCGATCCACGGTCCAGAACGCTCGATCTCAGCCATCCGCTCATCAAACACGATCTTGCCGATCCTGAACATCCCCGG
TCAGCACTCGGACTGATCGTCGAAGCGCTACGGATACGCCGCCAGCAAGGGCTTCCCCCGTTTAGTGTACTGTCGTGCGA
TAACATTCCGGAAAACGGTCATTTGACCAAAACGGCGATCGTTACGTTTGCCGATAATCTCGATCCGCAACTGGCGGCCT
GGATAGCGAAGCATGTCACCTTTCCTGGCACCATGGTCGATCGCATCGTGCCGGCAATGACGCCAGAGCAATTTGACATG
ATTAAAGACCAGATCGGTTTTGCCGATCCCTGCGGCATCGTATGCGAGGATTTCCGTCAGTGGGTTATCGAAGATAATTT
CGTTGCCGGTCGTCCTGACTGGGATAAAGCAGGGGCGATGTTCGTCTCGGACGTGCTTCCCTATGAAGAAATGAAACTTC
GTATGCTGAATGGCAGCCATTCGTTTCTCGCCTATAACGGCAGCCTGGCCGGATATGAGTTTATCTATCAGTGCATGGAA
GACGACGCTTTTAAAACCGCCGTACATCATTTAATGACGGAAGAGCAGGCAAAATCGCTGCGCCCGAATTTGGCGGTAGA
TGTACATCAATATGCGCAGTTGCTCATTGATCGATTCAGCAACCCGAATATTAAACATAAGACCGGACAGATTGCGATGG
ACGGTTCTCAGAAGCTGCCTCAGCGGGCCGTCGATCCTTATCTGACGCTCCAGGCGCGCGGTGTTAAGGGCAGGGCGTTA
GCGACGCTGATTGCGGGCTGGCTCCATTACGTCATTAATACGCTCTCTCAGGGGCAGAGCGTGGCCGACCCGCTCAATGA
TACCTTCAATGCGGCTATTAAAAATAAAAACACGCGATGGGAACAAGCGCTGTCTTTGCTGCAGATAAATAGCATCTTTG
GAACGCTGGCCAGCGACAACGCAGACTTTTTAAACAACATTCAGCAGGCCTTTAACCATATTGAATTACATGGCGTCACG
GCCACCATTCACCGTTTATCTTCAAAGGGTTAA

Upstream 100 bases:

>100_bases
CCATGGTAAAGAATCTGGTGCCATGAGTGTGATCATATTCACGGATTTTGGTATGGTGTTTAAGCAGAATTGGTAAACAA
AACAGGAGTGGGAAAAATTC

Downstream 100 bases:

>100_bases
GTATGAAAACGCTTATCTGTAATAATCCGGGAAATATCGAATACATTGAAAGGGATATTCCTCATTTAAAAGACGATGAA
GTACTGTTAAAAATTAAAGC

Product: mannitol dehydrogenase

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MDTIARQLDAARHQFKTTYSRQGMEANIVHIGFGAFHRGHQAVYNDLTNEITGNRWGIFELNLFGDAELVDALNAQQGLF
SVVETSASAINSRLVRTITGALHTPKSGIQAAIEKLTEPQVKIVSLTITEKGYCTDPRSRTLDLSHPLIKHDLADPEHPR
SALGLIVEALRIRRQQGLPPFSVLSCDNIPENGHLTKTAIVTFADNLDPQLAAWIAKHVTFPGTMVDRIVPAMTPEQFDM
IKDQIGFADPCGIVCEDFRQWVIEDNFVAGRPDWDKAGAMFVSDVLPYEEMKLRMLNGSHSFLAYNGSLAGYEFIYQCME
DDAFKTAVHHLMTEEQAKSLRPNLAVDVHQYAQLLIDRFSNPNIKHKTGQIAMDGSQKLPQRAVDPYLTLQARGVKGRAL
ATLIAGWLHYVINTLSQGQSVADPLNDTFNAAIKNKNTRWEQALSLLQINSIFGTLASDNADFLNNIQQAFNHIELHGVT
ATIHRLSSKG

Sequences:

>Translated_490_residues
MDTIARQLDAARHQFKTTYSRQGMEANIVHIGFGAFHRGHQAVYNDLTNEITGNRWGIFELNLFGDAELVDALNAQQGLF
SVVETSASAINSRLVRTITGALHTPKSGIQAAIEKLTEPQVKIVSLTITEKGYCTDPRSRTLDLSHPLIKHDLADPEHPR
SALGLIVEALRIRRQQGLPPFSVLSCDNIPENGHLTKTAIVTFADNLDPQLAAWIAKHVTFPGTMVDRIVPAMTPEQFDM
IKDQIGFADPCGIVCEDFRQWVIEDNFVAGRPDWDKAGAMFVSDVLPYEEMKLRMLNGSHSFLAYNGSLAGYEFIYQCME
DDAFKTAVHHLMTEEQAKSLRPNLAVDVHQYAQLLIDRFSNPNIKHKTGQIAMDGSQKLPQRAVDPYLTLQARGVKGRAL
ATLIAGWLHYVINTLSQGQSVADPLNDTFNAAIKNKNTRWEQALSLLQINSIFGTLASDNADFLNNIQQAFNHIELHGVT
ATIHRLSSKG
>Mature_490_residues
MDTIARQLDAARHQFKTTYSRQGMEANIVHIGFGAFHRGHQAVYNDLTNEITGNRWGIFELNLFGDAELVDALNAQQGLF
SVVETSASAINSRLVRTITGALHTPKSGIQAAIEKLTEPQVKIVSLTITEKGYCTDPRSRTLDLSHPLIKHDLADPEHPR
SALGLIVEALRIRRQQGLPPFSVLSCDNIPENGHLTKTAIVTFADNLDPQLAAWIAKHVTFPGTMVDRIVPAMTPEQFDM
IKDQIGFADPCGIVCEDFRQWVIEDNFVAGRPDWDKAGAMFVSDVLPYEEMKLRMLNGSHSFLAYNGSLAGYEFIYQCME
DDAFKTAVHHLMTEEQAKSLRPNLAVDVHQYAQLLIDRFSNPNIKHKTGQIAMDGSQKLPQRAVDPYLTLQARGVKGRAL
ATLIAGWLHYVINTLSQGQSVADPLNDTFNAAIKNKNTRWEQALSLLQINSIFGTLASDNADFLNNIQQAFNHIELHGVT
ATIHRLSSKG

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=475, Percent_Identity=48.6315789473684, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1788497, Length=476, Percent_Identity=49.5798319327731, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1787823, Length=474, Percent_Identity=47.2573839662447, Blast_Score=450, Evalue=1e-127,
Organism=Escherichia coli, GI1790028, Length=261, Percent_Identity=26.4367816091954, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI48994885, Length=397, Percent_Identity=25.1889168765743, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324401, Length=477, Percent_Identity=37.9454926624738, Blast_Score=312, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6320765, Length=477, Percent_Identity=37.9454926624738, Blast_Score=312, Evalue=9e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 54418; Mature: 54418

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIARQLDAARHQFKTTYSRQGMEANIVHIGFGAFHRGHQAVYNDLTNEITGNRWGIFE
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEE
LNLFGDAELVDALNAQQGLFSVVETSASAINSRLVRTITGALHTPKSGIQAAIEKLTEPQ
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
VKIVSLTITEKGYCTDPRSRTLDLSHPLIKHDLADPEHPRSALGLIVEALRIRRQQGLPP
EEEEEEEEECCCCCCCCCCCEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FSVLSCDNIPENGHLTKTAIVTFADNLDPQLAAWIAKHVTFPGTMVDRIVPAMTPEQFDM
EEEEECCCCCCCCCEEHEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHH
IKDQIGFADPCGIVCEDFRQWVIEDNFVAGRPDWDKAGAMFVSDVLPYEEMKLRMLNGSH
HHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCHHHHHEEEECCCC
SFLAYNGSLAGYEFIYQCMEDDAFKTAVHHLMTEEQAKSLRPNLAVDVHQYAQLLIDRFS
CEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCC
NPNIKHKTGQIAMDGSQKLPQRAVDPYLTLQARGVKGRALATLIAGWLHYVINTLSQGQS
CCCCCCCCCCEEECCCHHCHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCH
VADPLNDTFNAAIKNKNTRWEQALSLLQINSIFGTLASDNADFLNNIQQAFNHIELHGVT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEHHHHH
ATIHRLSSKG
HHHHHHHCCC
>Mature Secondary Structure
MDTIARQLDAARHQFKTTYSRQGMEANIVHIGFGAFHRGHQAVYNDLTNEITGNRWGIFE
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEE
LNLFGDAELVDALNAQQGLFSVVETSASAINSRLVRTITGALHTPKSGIQAAIEKLTEPQ
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
VKIVSLTITEKGYCTDPRSRTLDLSHPLIKHDLADPEHPRSALGLIVEALRIRRQQGLPP
EEEEEEEEECCCCCCCCCCCEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FSVLSCDNIPENGHLTKTAIVTFADNLDPQLAAWIAKHVTFPGTMVDRIVPAMTPEQFDM
EEEEECCCCCCCCCEEHEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHH
IKDQIGFADPCGIVCEDFRQWVIEDNFVAGRPDWDKAGAMFVSDVLPYEEMKLRMLNGSH
HHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCHHHHHEEEECCCC
SFLAYNGSLAGYEFIYQCMEDDAFKTAVHHLMTEEQAKSLRPNLAVDVHQYAQLLIDRFS
CEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCC
NPNIKHKTGQIAMDGSQKLPQRAVDPYLTLQARGVKGRALATLIAGWLHYVINTLSQGQS
CCCCCCCCCCEEECCCHHCHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCH
VADPLNDTFNAAIKNKNTRWEQALSLLQINSIFGTLASDNADFLNNIQQAFNHIELHGVT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEHHHHH
ATIHRLSSKG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]