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The map label for this gene is cadB [H]

Identifier: 16765878

GI number: 16765878

Start: 2698536

End: 2699867

Strand: Direct

Name: cadB [H]

Synonym: STM2558

Alternate gene names: 16765878

Gene position: 2698536-2699867 (Clockwise)

Preceding gene: 16765877

Following gene: 16765879

Centisome position: 55.55

GC content: 53.68

Gene sequence:

>1332_bases
ATGAGTTCTGTCAAAAAGATCGGGCTATTTGCCTGTACTGGCGTCGTTGCCGGTAATATGATGGGGAGCGGGATTGCATT
ATTACCCGCCAACCTTGCCAGTATTGGTGGCATTGCCATCTGGGGCTGGGTAATTTCTATTATTGGGGCAATGTCGCTGG
CTTATGTTTATGCGAGGCTGGCAACCAAAAACCCTCAACAGGGTGGCCCTATCGCTTATGCTGGGGAAATATCTCCGGCG
TTTGGTTTCCAGACCGGCGTTCTTTATTATCACGCAAACTGGATTGGTAACTTAGCCATCGGTATTACCGCGGTTTCTTA
TCTTTCTACGTTCTTCCCGGCATTAAATAATCCAATACCGGCAGGTATTGCCTGTATTGCTATCGTCTGGCTGTTCACCT
TTATTAATATGCTGGGTGGGGCCTGGGTCAGCCGCTTGACAACGATTGGCCTATTCCTGGTGCTGATCCCGGTAGTCTTG
ACCGCAGTCGCCGGCTGGCATTGGTTCGATATCGCGACCTATCACGCGAACTGGAACACGTCCACGACGACCGACTCTCA
CGCCATTGTTAAAAGTATTCTGCTCTGCCTGTGGGCGTTCGTTGGCGTTGAGTCTGCCGCCGTCAGCACCGGCATGGTGA
AAAACCCGAAACGCACCGTACCGCTGGCAACCATGCTGGGTACCGCGCTGGCAGGCATCATCTATATCGCTGCGACTCAG
GTTATCGCCGGGATGTTCCCAGCTTCCGTTATGGCCTCTTCCGGCGCGCCGTTCGCTATCAGTACCTCCACGATTCTGGG
TGGCTGGGCTGCGCCGCTGGTTTCCGCCTTTACCGCTTTCGCCTGCCTGACGTCTCTGGGCTCCTGGATGATGCTGGTCG
GCCAGGCTGGGGTTCGCGCCGCCAACGACGGCAACTTCCCGAAAATTTACGGTGAAATGGATAAAAACGGTATTCCGAAA
AAAGGTCTGCTGTTGGCTGCGGTGAAAATGACGGCGCTGATGATTCTGATCACCATCATGAACTCCAGCGGCGGTAAAGC
GTCCGACCTGTTCGGCGAACTGACCGGGATTGCCGTACTGCTTACCATGCTGCCGTACTTCTACTCCTGTGTTGACCTGA
TTCGCTTCGAAGGGTTCAACATCCGTAACTCGGTAAGCCTGATTTGTTCTGTACTGGGCTGCGCATTTTGCTTCATCGCA
CTGATGGGCGCCAGCTCCTTCGAACTCTCCGGCACCTTTATCGTCAGTCTGATCATCCTGATGTTCTACGGTCGCAAAAT
GCACCAGCGCCAGAACAACGACAGCGACAACAATACGGCTGAAGCGCTTTAA

Upstream 100 bases:

>100_bases
ATCTCAACCCATTCGTTAATCTTGTCGACAGTTGAACGGGCACGCAGCATATATGAAGCATAAGCCCGGTTCTTAAAAAT
ACAGCTCAGGAGAAATGAAC

Downstream 100 bases:

>100_bases
CCGCTAACTCCTTTTTCTCAAAGCCCCTTTCGTCACCTGCTATAGCGTAGCGGGAGGGGCCCACTTTACCAGGAACAAGA
CTATGAACGTTATTGCTATC

Product: lysine/cadaverine antiporter

Products: cadaverine [Cytoplasm]; L-lysine [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSSVKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPIPAGIACIAIVWLFTFINMLGGAWVSRLTTIGLFLVLIPVVL
TAVAGWHWFDIATYHANWNTSTTTDSHAIVKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
VIAGMFPASVMASSGAPFAISTSTILGGWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKIYGEMDKNGIPK
KGLLLAAVKMTALMILITIMNSSGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGFNIRNSVSLICSVLGCAFCFIA
LMGASSFELSGTFIVSLIILMFYGRKMHQRQNNDSDNNTAEAL

Sequences:

>Translated_443_residues
MSSVKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPIPAGIACIAIVWLFTFINMLGGAWVSRLTTIGLFLVLIPVVL
TAVAGWHWFDIATYHANWNTSTTTDSHAIVKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
VIAGMFPASVMASSGAPFAISTSTILGGWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKIYGEMDKNGIPK
KGLLLAAVKMTALMILITIMNSSGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGFNIRNSVSLICSVLGCAFCFIA
LMGASSFELSGTFIVSLIILMFYGRKMHQRQNNDSDNNTAEAL
>Mature_442_residues
SSVKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPAF
GFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPIPAGIACIAIVWLFTFINMLGGAWVSRLTTIGLFLVLIPVVLT
AVAGWHWFDIATYHANWNTSTTTDSHAIVKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQV
IAGMFPASVMASSGAPFAISTSTILGGWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKIYGEMDKNGIPKK
GLLLAAVKMTALMILITIMNSSGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGFNIRNSVSLICSVLGCAFCFIAL
MGASSFELSGTFIVSLIILMFYGRKMHQRQNNDSDNNTAEAL

Specific function: Probable cadaverine/lysine antiporter or part of it [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790575, Length=441, Percent_Identity=90.0226757369615, Blast_Score=783, Evalue=0.0,
Organism=Escherichia coli, GI2367353, Length=435, Percent_Identity=39.0804597701149, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1786908, Length=436, Percent_Identity=31.8807339449541, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1787890, Length=442, Percent_Identity=23.9819004524887, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082250, Length=334, Percent_Identity=26.9461077844311, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787768, Length=331, Percent_Identity=25.0755287009063, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982608, Length=345, Percent_Identity=24.9275362318841, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71982612, Length=345, Percent_Identity=24.9275362318841, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321492, Length=321, Percent_Identity=22.7414330218069, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221331183, Length=298, Percent_Identity=27.1812080536913, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17647653, Length=298, Percent_Identity=27.1812080536913, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664379, Length=298, Percent_Identity=27.1812080536913, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46679; Mature: 46547

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARL
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPIP
HCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWLFTFINMLGGAWVSRLTTIGLFLVLIPVVLTAVAGWHWFDIATYHANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCC
STTTDSHAIVKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VIAGMFPASVMASSGAPFAISTSTILGGWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKIYGEMDKNGIPKKGLLLAAVKMTALMILITIMNSSGGKASDLFGELTGIAVL
CCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGFNIRNSVSLICSVLGCAFCFIALMGASSFELSGTFIVSLIIL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MFYGRKMHQRQNNDSDNNTAEAL
HHHCHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure 
SSVKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARL
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPALNNPIP
HCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGIACIAIVWLFTFINMLGGAWVSRLTTIGLFLVLIPVVLTAVAGWHWFDIATYHANWNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCC
STTTDSHAIVKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTALAGIIYIAATQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VIAGMFPASVMASSGAPFAISTSTILGGWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRA
HHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ANDGNFPKIYGEMDKNGIPKKGLLLAAVKMTALMILITIMNSSGGKASDLFGELTGIAVL
CCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTMLPYFYSCVDLIRFEGFNIRNSVSLICSVLGCAFCFIALMGASSFELSGTFIVSLIIL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MFYGRKMHQRQNNDSDNNTAEAL
HHHCHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cadaverine [Cytoplasm]; Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: cadaverine [Cytoplasm] + Proton [Periplasm] + L-lysine [Periplasm] = cadaverine [Cytoplasm] + L-lysine [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]