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The map label for this gene is eco

Identifier: 16765590

GI number: 16765590

Start: 2360059

End: 2360553

Strand: Direct

Name: eco

Synonym: STM2262

Alternate gene names: 16765590

Gene position: 2360059-2360553 (Clockwise)

Preceding gene: 16765574

Following gene: 16765596

Centisome position: 48.59

GC content: 54.95

Gene sequence:

>495_bases
ATGAAGATGTTTGTCCCTGCCGTCGTCTTCGCCGCCCTCGCCAGCGCCTCTGCCTGGGCTAACAATGGCGATACCGCCCA
GCCGCTGGAAAAAATCGCCCCCTATCCGCAGGCGGAAAAAGGAATGAAGCGGCAAGTGATAACCCTTACCCCTCAGCAGG
ATGAATCTACCCTCAAAGTGGAACTGTTGATTGGCCAAACGCTGAATGTGGATTGTAACCAGCATCGCCTCGGCGGCACG
CTGGAAACAAAAACGCTGGAAGGCTGGGGCTATGACTATTATGTCTTTGATAACGTCACCTCTCCGGTATCAACCATGAT
GGCCTGCCCTGAAGGTAAGAAAGAGCAAAAATTCGTCACCGCCTGGCTGGGTGAAGACGGGATGCTGCGCTACAACAGCA
AGCTGCCGATCGTGGTGTATACCCCGGCGAATGTGGACGTGAAATACCGCATCTGGAAAGCGGACGCTAACGTACAGAAC
GCCGTCGCGCGATGA

Upstream 100 bases:

>100_bases
GAAAATATGAGTAAATACAGATTAATAGATAATATGAATGTGTTAATCTGTTGTCAGTGAATACCGAAAACAGCAGAAAG
GAAATACTGTGAACAATCAA

Downstream 100 bases:

>100_bases
TGTTACGCTGCCCGGTCACACTTACCGGGCATCTGAACACGCCGACTCACGCAGCGCTCCGGGGTTCTTTTTAAAACACG
TCTGGAAACCCGCTCGCCCG

Product: ecotin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MKMFVPAVVFAALASASAWANNGDTAQPLEKIAPYPQAEKGMKRQVITLTPQQDESTLKVELLIGQTLNVDCNQHRLGGT
LETKTLEGWGYDYYVFDNVTSPVSTMMACPEGKKEQKFVTAWLGEDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQN
AVAR

Sequences:

>Translated_164_residues
MKMFVPAVVFAALASASAWANNGDTAQPLEKIAPYPQAEKGMKRQVITLTPQQDESTLKVELLIGQTLNVDCNQHRLGGT
LETKTLEGWGYDYYVFDNVTSPVSTMMACPEGKKEQKFVTAWLGEDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQN
AVAR
>Mature_164_residues
MKMFVPAVVFAALASASAWANNGDTAQPLEKIAPYPQAEKGMKRQVITLTPQQDESTLKVELLIGQTLNVDCNQHRLGGT
LETKTLEGWGYDYYVFDNVTSPVSTMMACPEGKKEQKFVTAWLGEDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQN
AVAR

Specific function: General inhibitor of pancreatic serine proteases:inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases

COG id: COG4574

COG function: function code R; Serine protease inhibitor ecotin

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protease inhibitor I11 (ecotin) family

Homologues:

Organism=Escherichia coli, GI1788538, Length=164, Percent_Identity=79.2682926829268, Blast_Score=276, Evalue=5e-76,

Paralogues:

None

Copy number: 260 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): ECOT_SALEP (B5R236)

Other databases:

- EMBL:   AM933172
- RefSeq:   YP_002244333.1
- ProteinModelPortal:   B5R236
- SMR:   B5R236
- PRIDE:   B5R236
- GeneID:   6949721
- GenomeReviews:   AM933172_GR
- KEGG:   set:SEN2245
- HOGENOM:   HBG710412
- OMA:   RYDSRLP
- ProtClustDB:   PRK03719
- HAMAP:   MF_00706
- InterPro:   IPR005658
- InterPro:   IPR023189
- InterPro:   IPR023084
- Gene3D:   G3DSA:2.60.40.550
- PIRSF:   PIRSF006865

Pfam domain/function: PF03974 Ecotin; SSF49772 Prot_inh_ecotin

EC number: NA

Molecular weight: Translated: 18218; Mature: 18218

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMFVPAVVFAALASASAWANNGDTAQPLEKIAPYPQAEKGMKRQVITLTPQQDESTLKV
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEE
ELLIGQTLNVDCNQHRLGGTLETKTLEGWGYDYYVFDNVTSPVSTMMACPEGKKEQKFVT
EEEECCEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCEEEE
AWLGEDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQNAVAR
EEECCCCEEEECCCCCEEEECCCCCEEEEEEEECCCCHHHHHCC
>Mature Secondary Structure
MKMFVPAVVFAALASASAWANNGDTAQPLEKIAPYPQAEKGMKRQVITLTPQQDESTLKV
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEE
ELLIGQTLNVDCNQHRLGGTLETKTLEGWGYDYYVFDNVTSPVSTMMACPEGKKEQKFVT
EEEECCEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCEEEE
AWLGEDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQNAVAR
EEECCCCEEEECCCCCEEEECCCCCEEEEEEEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA