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The map label for this gene is thiM [H]

Identifier: 16765476

GI number: 16765476

Start: 2241048

End: 2241845

Strand: Reverse

Name: thiM [H]

Synonym: STM2147

Alternate gene names: 16765476

Gene position: 2241845-2241048 (Counterclockwise)

Preceding gene: 16765478

Following gene: 16765475

Centisome position: 46.15

GC content: 61.03

Gene sequence:

>798_bases
ATGCAGCCTGACCTGCACTGCCGCACGCTTGCGGCGCATACGTTAAAACACTTTCGCGCGCTCTCCCCGCTTACGCACTG
TATGACGAATGACGTCGTACAAACGTTTACCGCCAATACGTTGCTGGCGCTGGGCGCTTCACCCGCCATGGTGATTGATC
CTGTCGAGGCCAGACCGTTTGCCGCCATCGCCAACGCCTTGCTGATTAATGTCGGAACATTAACTGCCTCACGCGCTGAC
GCGATGCGTGCGGCGGTAGAAAGCGCTTATGATGCCAAAACGCCGTGGACGCTTGATCCTGTCGCGGTGGGCGCGCTGGA
ATTTCGTCGGCGATTTTGCCTGGATCTCTTGTCCCTGCGCCCGGCGGCAATACGCGGCAACGCCTCGGAAATCCTGGCGT
TATCCGGCATGGCGCTGGGCGGACGTGGCGTAGATACCACCGAGGCGGCGTTGGCCGCACTGCCTGCGGCGCAGGCGCTG
GCGCGTCAGATAGACTGCATCGTTGTGGTTACCGGAGAGATAGATTACGTCACTAATGGTCAGCGCACGCTGAGCATTCC
CGGCGGCGATCCGTTAATGACTCGCATTGTAGGCACCGGCTGCGCGTTGTCGGCGGTCGTCGCCGCCAGTTGCGCGTTAC
CGGGCGCCGCGCTGGACAATGTCGCGTCGGCCTGCTGCTGGATGAAACTGGCTGGACAGGCCGCGGCAGAGCGTAGCGAA
GGACCGGGTAGCTTCATCCCGGCTTTTCTTGATGCGCTCTATCATCTGGATGTGGAGGCGGCCAATGCAACGAATTAA

Upstream 100 bases:

>100_bases
GAAGGCTGAGAAATACCCGTACCACCTGATCTGGATAATGCCAGCGTAGGGAAGTCTGACACTGCTCGTGTCCCTTCTTC
ACGCGGGCAGGAGCTGAACC

Downstream 100 bases:

>100_bases
CGCGCTGACGATTGCCGGCACCGATCCCAGCGGCGGGGCCGGTATCCAGGCGGATCTCAAGACCTTTTCCGCGCTGGGCG
CATATGGCTGTTCGGTCATC

Product: hydroxyethylthiazole kinase

Products: NA

Alternate protein names: 4-methyl-5-beta-hydroxyethylthiazole kinase; TH kinase; Thz kinase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MQPDLHCRTLAAHTLKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPFAAIANALLINVGTLTASRAD
AMRAAVESAYDAKTPWTLDPVAVGALEFRRRFCLDLLSLRPAAIRGNASEILALSGMALGGRGVDTTEAALAALPAAQAL
ARQIDCIVVVTGEIDYVTNGQRTLSIPGGDPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSE
GPGSFIPAFLDALYHLDVEAANATN

Sequences:

>Translated_265_residues
MQPDLHCRTLAAHTLKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPFAAIANALLINVGTLTASRAD
AMRAAVESAYDAKTPWTLDPVAVGALEFRRRFCLDLLSLRPAAIRGNASEILALSGMALGGRGVDTTEAALAALPAAQAL
ARQIDCIVVVTGEIDYVTNGQRTLSIPGGDPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSE
GPGSFIPAFLDALYHLDVEAANATN
>Mature_265_residues
MQPDLHCRTLAAHTLKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPFAAIANALLINVGTLTASRAD
AMRAAVESAYDAKTPWTLDPVAVGALEFRRRFCLDLLSLRPAAIRGNASEILALSGMALGGRGVDTTEAALAALPAAQAL
ARQIDCIVVVTGEIDYVTNGQRTLSIPGGDPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSE
GPGSFIPAFLDALYHLDVEAANATN

Specific function: Thiamine biosynthesis. [C]

COG id: COG2145

COG function: function code H; Hydroxyethylthiazole kinase, sugar kinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Thz kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788421, Length=259, Percent_Identity=71.8146718146718, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6325042, Length=265, Percent_Identity=34.3396226415094, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000417 [H]

Pfam domain/function: PF02110 HK [H]

EC number: =2.7.1.50 [H]

Molecular weight: Translated: 27422; Mature: 27422

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPDLHCRTLAAHTLKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCHH
AAIANALLINVGTLTASRADAMRAAVESAYDAKTPWTLDPVAVGALEFRRRFCLDLLSLR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PAAIRGNASEILALSGMALGGRGVDTTEAALAALPAAQALARQIDCIVVVTGEIDYVTNG
CHHHCCCHHHHHEECCCEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECC
QRTLSIPGGDPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSE
CEEEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
GPGSFIPAFLDALYHLDVEAANATN
CCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQPDLHCRTLAAHTLKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCHH
AAIANALLINVGTLTASRADAMRAAVESAYDAKTPWTLDPVAVGALEFRRRFCLDLLSLR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PAAIRGNASEILALSGMALGGRGVDTTEAALAALPAAQALARQIDCIVVVTGEIDYVTNG
CHHHCCCHHHHHEECCCEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECC
QRTLSIPGGDPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSE
CEEEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
GPGSFIPAFLDALYHLDVEAANATN
CCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA