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The map label for this gene is pphA

Identifier: 16765194

GI number: 16765194

Start: 1950689

End: 1951339

Strand: Reverse

Name: pphA

Synonym: STM1853

Alternate gene names: 16765194

Gene position: 1951339-1950689 (Counterclockwise)

Preceding gene: 16765195

Following gene: 16765188

Centisome position: 40.17

GC content: 52.53

Gene sequence:

>651_bases
ATGATGCGGCCTGAAGAGATTTATCAGCGAATAGAGGCAAAGAATTGGCGGCATGTCTGGGTGGTTGGCGATATTCACGG
CTGTTTTTCAATGTTAATGAAAAGGTTACGTGAGTGTCGATTTGATCCGCAACAAGACTTGTTAGTTTCTGTGGGCGATC
TCATTGATAGAGGCCCGGACAGCCTGGGCTGCCTGGCTTTACTGCGTGAGTCCTGGATGACGGCGGTTCGCGGCAATCAT
GAACAAATGGCGCTGGATGCGCGGGCCTCATCGCAGTCGACGCTGTGGTTGATGAATGGTGGCGACTGGTTTACCCGCCT
GACGGCTGAACACGCTGCGCAAGCTGAAGCGCTTTTTATTCTTTGTCAGCGGCTGCCCTGGATACTGGAAGTTCGTTGCC
GCCATAGCACGCATGTGATCGCTCATGCAGATTATCCCGCGTCAACCTATCAATGGCAAAAAAAGGTCGACTTACATCAG
GTTCTCTGGAGCCGCGAACGGCTCATAAATAAGCGCGGCGGGATTAGCGGAGCCGATCATTTTTGGTTTGGCCATACGCC
GTTGCGTCGGCGCATGGATTTTGCCAACGTACACTATATTGATACGGGCGCGGTATTTGGCGGGCAATTGACGTTAGCGC
GGATACAATAG

Upstream 100 bases:

>100_bases
GTGAAATTCGCTATTTACAACAGCGCACGCTTACTAAGCAAAAAAATCTGCACACGCTATCTTTTTATATCTGTCCTGGA
TAATGAACGACAGGAAAAAC

Downstream 100 bases:

>100_bases
CGGTATCAGCGACCAGGGTTAAAAATCGCTATATTGCTGCGCAGGTCGCCAGAAGCCGTCGATAAAATCCTCTACCGGAA
AACAGCCGCCATGGCGAATC

Product: serine/threonine protein phosphatase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNH
EQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQ
VLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ

Sequences:

>Translated_216_residues
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNH
EQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQ
VLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ
>Mature_216_residues
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPDSLGCLALLRESWMTAVRGNH
EQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFILCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQ
VLWSRERLINKRGGISGADHFWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ

Specific function: Can hydrolyze phosphorylated Ser-, Thr- or Tyr- substrates in vitro. The natural substrate is unknown

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily

Homologues:

Organism=Escherichia coli, GI87081988, Length=218, Percent_Identity=62.8440366972477, Blast_Score=290, Evalue=5e-80,
Organism=Escherichia coli, GI1789090, Length=217, Percent_Identity=43.778801843318, Blast_Score=192, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRP1_SALTY (Q8ZNY9)

Other databases:

- EMBL:   AY049950
- EMBL:   AE006468
- RefSeq:   NP_460809.1
- ProteinModelPortal:   Q8ZNY9
- SMR:   Q8ZNY9
- PptaseDB:   P3D0411148
- GeneID:   1253372
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1853
- NMPDR:   fig|99287.1.peg.1794
- HOGENOM:   HBG724457
- OMA:   QWSRRRL
- ProtClustDB:   PRK11439
- BioCyc:   STYP99287:STM1853-MONOMER
- BRENDA:   3.1.3.16
- InterPro:   IPR004843
- InterPro:   IPR006186
- PANTHER:   PTHR11668

Pfam domain/function: PF00149 Metallophos

EC number: =3.1.3.16

Molecular weight: Translated: 25037; Mature: 25037

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPD
CCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
SLGCLALLRESWMTAVRGNHEQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFI
HHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
LCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQVLWSRERLINKRGGISGADH
HHHHCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ
EEECCCHHHHHCCCCCEEEEECCCEECCEEEEEEEC
>Mature Secondary Structure
MMRPEEIYQRIEAKNWRHVWVVGDIHGCFSMLMKRLRECRFDPQQDLLVSVGDLIDRGPD
CCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
SLGCLALLRESWMTAVRGNHEQMALDARASSQSTLWLMNGGDWFTRLTAEHAAQAEALFI
HHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
LCQRLPWILEVRCRHSTHVIAHADYPASTYQWQKKVDLHQVLWSRERLINKRGGISGADH
HHHHCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FWFGHTPLRRRMDFANVHYIDTGAVFGGQLTLARIQ
EEECCCHHHHHCCCCCEEEEECCCEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11717262; 11677609