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The map label for this gene is sifB

Identifier: 16764946

GI number: 16764946

Start: 1692181

End: 1693131

Strand: Direct

Name: sifB

Synonym: STM1602

Alternate gene names: 16764946

Gene position: 1692181-1693131 (Clockwise)

Preceding gene: 16764939

Following gene: 16764947

Centisome position: 34.84

GC content: 37.85

Gene sequence:

>951_bases
ATGCCAATTACTATCGGGAGAGGATTTTTAAAGAGTGAGATGTTTTCTCAAAGTGCTATCTCTCAACGCTCTTTCTTTAC
GTTACTATGGGAAAAGATTAAAGATTTTTTTTGTGACACGCAAAGATCCACTGCCGATCAATATATAAAGGAATTATGTG
ATGTTGCCTCTCCGCCTGACGCGCAACGTTTATTTGATTTATTTTGCAAGTTATATGAATTATCATCACCGTCATGCAGA
GGAAATTTCCATTTTCAGCACTATAAAGATGCTGAGTGTCAGTATACAAATCTCTGTATTAAAGATGGCGAAGATATTCC
GTTATGTATTATGATACGTCAGGATCACTACTATTATGAGATAATGAATAGAACAGTGCTCTGTGTTGATACTCAGTCTG
CCCACCTGAAAAGATATTCTGATATTAATATAAAAGCTAGCACTTATGTTTGTGAACCGCTATGTTGCTTGTTCCCTGAG
CGGTTACAACTCTCGCTATCCGGCGGTATAACATTTTCCGTTGACCTAAAAAATATAGAAGAGACGCTTATCGCCATGGC
AGAAAAGGGTAATTTATGTGACTGGAAGGAACAGGAAAGAAAAGCCGCCATCTCCTCCAGGATTAATCTGGGCATCGCCC
AGGCAGGTGTAACAGCTATTGACGACGCTATCAAAAACAAAATAGCCGCAAAGGTTATTGAGAATACTAACTTAAAGAAT
GCAGCGTTTGAACCAAATTATGCACAAAGCTCAGTTACTCAAATTGTTTATTCATGTTTGTTTAAGAATGAGATACTAAT
GAATATGCTGGAAGAAAGTTCCTCTCATGGCCTGCTATGTTTAAACGAGCTTACTGAATATGTAGCGCTACAAGTTCATA
ACAGCCTTTTTTCTGAAGATTTATCTTCACTCGTTGAAACAACAAAAAATGAGGCTCATCACCAGAGTTGA

Upstream 100 bases:

>100_bases
TGTTTCACCGATAGGCAAACCGATGGGCAACATGGGATAATATTTCGAATACCACCTATTCCAGTAATGAAGTATCATAT
AATCACTTGTGGTCTACATT

Downstream 100 bases:

>100_bases
TCACACCATAAATAGTATGGATTTACAATCCCCTGGCAATACCAAAACCATCTAATACAATAACTTTAAATATATACTCC
CAGGGAATAATGGATTTACT

Product: secreted effector protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCDTQRSTADQYIKELCDVASPPDAQRLFDLFCKLYELSSPSCR
GNFHFQHYKDAECQYTNLCIKDGEDIPLCIMIRQDHYYYEIMNRTVLCVDTQSAHLKRYSDINIKASTYVCEPLCCLFPE
RLQLSLSGGITFSVDLKNIEETLIAMAEKGNLCDWKEQERKAAISSRINLGIAQAGVTAIDDAIKNKIAAKVIENTNLKN
AAFEPNYAQSSVTQIVYSCLFKNEILMNMLEESSSHGLLCLNELTEYVALQVHNSLFSEDLSSLVETTKNEAHHQS

Sequences:

>Translated_316_residues
MPITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCDTQRSTADQYIKELCDVASPPDAQRLFDLFCKLYELSSPSCR
GNFHFQHYKDAECQYTNLCIKDGEDIPLCIMIRQDHYYYEIMNRTVLCVDTQSAHLKRYSDINIKASTYVCEPLCCLFPE
RLQLSLSGGITFSVDLKNIEETLIAMAEKGNLCDWKEQERKAAISSRINLGIAQAGVTAIDDAIKNKIAAKVIENTNLKN
AAFEPNYAQSSVTQIVYSCLFKNEILMNMLEESSSHGLLCLNELTEYVALQVHNSLFSEDLSSLVETTKNEAHHQS
>Mature_315_residues
PITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCDTQRSTADQYIKELCDVASPPDAQRLFDLFCKLYELSSPSCRG
NFHFQHYKDAECQYTNLCIKDGEDIPLCIMIRQDHYYYEIMNRTVLCVDTQSAHLKRYSDINIKASTYVCEPLCCLFPER
LQLSLSGGITFSVDLKNIEETLIAMAEKGNLCDWKEQERKAAISSRINLGIAQAGVTAIDDAIKNKIAAKVIENTNLKNA
AFEPNYAQSSVTQIVYSCLFKNEILMNMLEESSSHGLLCLNELTEYVALQVHNSLFSEDLSSLVETTKNEAHHQS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. Localizes to the Salmonella-containing vacuole (SCV) at early time points following invasion and subsequently traffics away from t

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Sif family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SIFB_SALTY (Q9KIB9)

Other databases:

- EMBL:   AF236076
- EMBL:   AE006468
- RefSeq:   NP_460561.1
- GeneID:   1253120
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1602
- NMPDR:   fig|99287.1.peg.1550
- HOGENOM:   HBG671280
- OMA:   WKEQERK
- ProtClustDB:   PRK09499
- BioCyc:   STYP99287:STM1602-MONOMER
- GO:   GO:0009405
- InterPro:   IPR010637

Pfam domain/function: PF06767 Sif

EC number: NA

Molecular weight: Translated: 35908; Mature: 35777

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCDTQRSTADQYIKELCDVASPPD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
AQRLFDLFCKLYELSSPSCRGNFHFQHYKDAECQYTNLCIKDGEDIPLCIMIRQDHYYYE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCEEH
IMNRTVLCVDTQSAHLKRYSDINIKASTYVCEPLCCLFPERLQLSLSGGITFSVDLKNIE
HHCCEEEEEECCHHHHHHHCCCCEEEHHHHHHHHHHHCHHHHEEEECCCEEEEEEHHHHH
ETLIAMAEKGNLCDWKEQERKAAISSRINLGIAQAGVTAIDDAIKNKIAAKVIENTNLKN
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCC
AAFEPNYAQSSVTQIVYSCLFKNEILMNMLEESSSHGLLCLNELTEYVALQVHNSLFSED
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LSSLVETTKNEAHHQS
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PITIGRGFLKSEMFSQSAISQRSFFTLLWEKIKDFFCDTQRSTADQYIKELCDVASPPD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
AQRLFDLFCKLYELSSPSCRGNFHFQHYKDAECQYTNLCIKDGEDIPLCIMIRQDHYYYE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCEEH
IMNRTVLCVDTQSAHLKRYSDINIKASTYVCEPLCCLFPERLQLSLSGGITFSVDLKNIE
HHCCEEEEEECCHHHHHHHCCCCEEEHHHHHHHHHHHCHHHHEEEECCCEEEEEEHHHHH
ETLIAMAEKGNLCDWKEQERKAAISSRINLGIAQAGVTAIDDAIKNKIAAKVIENTNLKN
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCC
AAFEPNYAQSSVTQIVYSCLFKNEILMNMLEESSSHGLLCLNELTEYVALQVHNSLFSED
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LSSLVETTKNEAHHQS
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10861017; 11677609