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The map label for this gene is tetA [H]

Identifier: 16764890

GI number: 16764890

Start: 1621409

End: 1622650

Strand: Reverse

Name: tetA [H]

Synonym: STM1545

Alternate gene names: 16764890

Gene position: 1622650-1621409 (Counterclockwise)

Preceding gene: 16764891

Following gene: 16764889

Centisome position: 33.41

GC content: 49.36

Gene sequence:

>1242_bases
ATGAATACTAATGTCTATGAGAACACCGACAGCGAAACTATCACCCCGCTCAACAAGCGGCGTATTTTGCCTGTTTTCCT
GCTTGTCGGCCTTTACGCCGCCAGTACCGCGGCTGTAATGTCGGTACTGCCTTTTTATATCCGCGAGATGGGCGGTTCGC
CGCTTATCATTGGAATCATCATCGCCACTGAAGCTTTTAGCCAATTTTGTGCGGCGCCCCTGATTGGCCACCTTTCCGAT
CGCGTTGGCCGCAAGCGAATACTGATTGTCACGCTGGCTATTGCGGCGATAAGTTTACTATTACTCGCCAACGCGCAATG
TATCCTGTTTATCCTGCTCGCCCGCACGCTTTTTGGCATTAGCGCCGGGAATTTGTCAGCCGCCGCAGCCTATATTGCCG
ATTGTACGCACGTCAGAAATCGGCGTCAGGCAATCGGTATCCTCACAGGCTGCATTGGTTTAGGCGGTATTGTCGGGGCA
GGCGTTTCCGGGTGGTTATCGCGTATCAGTCTGAGCGCGCCGATCTACGCCGCCTTTATACTTGTCCTTGGGTCTGCCCT
GGTCGCGATTTGGGGGTTAAAAGACCCTTCCACAACATCACGTACCACAGATAAAATAGCGGCGTTCTCTGCCCGCGCTA
TTTTAAAGATGCCTGTCCTTCGCGTCTTAATCATCGTAATGCTTTGTCATTTCTTCGCCTATGGCATGTACTCTTCACAA
TTACCTGTTTTTCTTTCTGACACCTTCATCTGGAATGGGCTTCCCTTTGGGCCAAAAGCGTTAAGCTATCTGTTAATGGC
GGACGGGGTTATTAATATTTTCGTTCAGCTATTTCTGTTAGGTTGGGTGAGCCAATATTTTTCGGAGCGAAAGCTAATTA
TCCTCATCTTCGCCCTTCTTTGTACTGGATTTCTCACTGCGGGTATCGCCACGACCATACCTGTGCTTGTTTTTGCTATC
GTTTGTATTAGCATCGCTGATGCGCTAGCCAAACCCACTTATCTTGCCGCCTTGTCCGTCCATGTATCGCCTGCCCGACA
AGGTATCGTCATCGGAACGGCGCAGGCATTAATCGCAATCGCTGATTTTATATCCCCCGTATTGGGCGGATTTGTCCTGG
GTTATGCTCTGTATGGCGTCTGGATCGGTATAGCTATCTCTGTCGCCATTATTGGTCTGGTGACGGCAATGATTTACCTT
TCAAAAAGTTCAGTGCTAATAGTGAAACCAGAAACAGAATAA

Upstream 100 bases:

>100_bases
GTGCTGATCCGACCCGATGGCTATGTCGGCGCATTCTTTCACGGCAAACAGAGCAACGATATTGAAAATTATCTCTCTCG
TTTTGCCATAGGGATTAAAG

Downstream 100 bases:

>100_bases
TGTGACAACGTCACAAACATTATTGTTCCCTTCTTCCGTTATTTATCAAAAGTATTGTACTTATATTGAATGTTTAAGAG
GTATTTATGGAAATTATGCT

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(G) [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNTNVYENTDSETITPLNKRRILPVFLLVGLYAASTAAVMSVLPFYIREMGGSPLIIGIIIATEAFSQFCAAPLIGHLSD
RVGRKRILIVTLAIAAISLLLLANAQCILFILLARTLFGISAGNLSAAAAYIADCTHVRNRRQAIGILTGCIGLGGIVGA
GVSGWLSRISLSAPIYAAFILVLGSALVAIWGLKDPSTTSRTTDKIAAFSARAILKMPVLRVLIIVMLCHFFAYGMYSSQ
LPVFLSDTFIWNGLPFGPKALSYLLMADGVINIFVQLFLLGWVSQYFSERKLIILIFALLCTGFLTAGIATTIPVLVFAI
VCISIADALAKPTYLAALSVHVSPARQGIVIGTAQALIAIADFISPVLGGFVLGYALYGVWIGIAISVAIIGLVTAMIYL
SKSSVLIVKPETE

Sequences:

>Translated_413_residues
MNTNVYENTDSETITPLNKRRILPVFLLVGLYAASTAAVMSVLPFYIREMGGSPLIIGIIIATEAFSQFCAAPLIGHLSD
RVGRKRILIVTLAIAAISLLLLANAQCILFILLARTLFGISAGNLSAAAAYIADCTHVRNRRQAIGILTGCIGLGGIVGA
GVSGWLSRISLSAPIYAAFILVLGSALVAIWGLKDPSTTSRTTDKIAAFSARAILKMPVLRVLIIVMLCHFFAYGMYSSQ
LPVFLSDTFIWNGLPFGPKALSYLLMADGVINIFVQLFLLGWVSQYFSERKLIILIFALLCTGFLTAGIATTIPVLVFAI
VCISIADALAKPTYLAALSVHVSPARQGIVIGTAQALIAIADFISPVLGGFVLGYALYGVWIGIAISVAIIGLVTAMIYL
SKSSVLIVKPETE
>Mature_413_residues
MNTNVYENTDSETITPLNKRRILPVFLLVGLYAASTAAVMSVLPFYIREMGGSPLIIGIIIATEAFSQFCAAPLIGHLSD
RVGRKRILIVTLAIAAISLLLLANAQCILFILLARTLFGISAGNLSAAAAYIADCTHVRNRRQAIGILTGCIGLGGIVGA
GVSGWLSRISLSAPIYAAFILVLGSALVAIWGLKDPSTTSRTTDKIAAFSARAILKMPVLRVLIIVMLCHFFAYGMYSSQ
LPVFLSDTFIWNGLPFGPKALSYLLMADGVINIFVQLFLLGWVSQYFSERKLIILIFALLCTGFLTAGIATTIPVLVFAI
VCISIADALAKPTYLAALSVHVSPARQGIVIGTAQALIAIADFISPVLGGFVLGYALYGVWIGIAISVAIIGLVTAMIYL
SKSSVLIVKPETE

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=409, Percent_Identity=25.6723716381418, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17738085, Length=375, Percent_Identity=24.2666666666667, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43918; Mature: 43918

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1479961 [H]