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The map label for this gene is pipB

Identifier: 16764446

GI number: 16764446

Start: 1176450

End: 1177325

Strand: Reverse

Name: pipB

Synonym: STM1088

Alternate gene names: 16764446

Gene position: 1177325-1176450 (Counterclockwise)

Preceding gene: 16764448

Following gene: 16764445

Centisome position: 24.24

GC content: 39.38

Gene sequence:

>876_bases
ATGCCAATAACTAACGCGTCCCCAGAAAATATATTAAGATATTTGCATGCGGCCGGTACCGGTACGAAAGAAGCAATGAA
AAGTGCAACTTCACCACGCGGTATACTGGAATGGTTTGTCAATTTTTTTACCTGTGGTGGAGTAAGAAGAAGCAATGAAA
GATGGTTTCGGGAGGTAATTGGAAAACTGACCACATCATTATTATATGTAAATAAAAATGCTTTCTTCGATGGTAATAAA
ATATTTCTGGAGGATGTCAACGGGTGTACTATATGTCTGTCATGTGGAGCAGCATCCGAAAATACGGATCCCATGGTCAT
TATTGAAGTGAACAAAAATGGAAAAACTGTAACGGATAAAGTTGATAGTGAGAGATTTTGGAATGTATGTCGAATGTTAA
AACTGATGAGTAAACATAATATACAACAGCCTGATTCACTTATAACCGAGGATGGTTTTCTGAACCTGCGCGGAGTAAAC
CTGGCTCATAAAGATTTCCAGGGGGAAGATTTGTCAAAAATAGATGCTTCTAATGCAGATTTCCGTGAAACAACTCTATC
TAATGTAAATTTAGTCGGTGCAAATTTGTGTTGTGCAAATCTACACGCTGTAAATCTAATGGGTTCAAACATGACTAAAG
CAAACCTGACTCACGCAGACCTGACTTGCGCTAACATGTCCGGTGTAAACTTAACCGCTGCAATTCTATTCGGCTCAGAC
TTAACTGACACCAAACTAAATGGTGCGAAATTAGATAAGATAGCTCTAACTTTAGCGAAAGCATTAACAGGAGCCGATCT
GACAGGTAGTCAACATACCCCTACTCCACTCCCGGATTACAATGATAGAACTCTTTTCCCCCATCCGATATTTTAG

Upstream 100 bases:

>100_bases
TACAAAAATCACCTTATATCTTTTTTTATTATTCCTTGTATAAATGTGACTTGACTCACACCTATAAGGAGTCGGCTCAC
TTCCATAAGAAGGAATCAAA

Downstream 100 bases:

>100_bases
TCGAGATAAAGGGATTTTATAAACAAGAAGTATTCAAACAGAGGCCCCCTTGTTTTATTAAATAAACCCCGCCCCTAAGT
TTCATTATAAATAACATTTT

Product: secreted effector protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVIGKLTTSLLYVNKNAFFDGNK
IFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDKVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVN
LAHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF

Sequences:

>Translated_291_residues
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVIGKLTTSLLYVNKNAFFDGNK
IFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDKVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVN
LAHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF
>Mature_290_residues
PITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVIGKLTTSLLYVNKNAFFDGNKI
FLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDKVDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNL
AHKDFQGEDLSKIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDL
TDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Does not appear to be required for the formation or the maintenance of either Salmonella-containing vacuole (SCV) or the Salmonella-induced filaments

COG id: COG1357

COG function: function code S; Uncharacterized low-complexity proteins

Gene ontology:

Cell location: Secreted. Host membrane. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cell. Concentrates in detergent-resistant microdomains (DRMs) that are present on the membranes of Salmonella-containing vacuole (SCV) and Sal

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 pentapeptide repeat domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIPB_SALTY (Q8ZQ59)

Other databases:

- EMBL:   AE006468
- RefSeq:   NP_460061.1
- ProteinModelPortal:   Q8ZQ59
- SMR:   Q8ZQ59
- PRIDE:   Q8ZQ59
- GeneID:   1252606
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM1088
- NMPDR:   fig|99287.1.peg.1054
- HOGENOM:   HBG671710
- OMA:   NERCFRE
- ProtClustDB:   PRK15197
- BioCyc:   STYP99287:STM1088-MONOMER
- GO:   GO:0016020
- GO:   GO:0009405
- InterPro:   IPR001646

Pfam domain/function: PF00805 Pentapeptide

EC number: NA

Molecular weight: Translated: 31806; Mature: 31674

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVI
CCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GKLTTSLLYVNKNAFFDGNKIFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDK
HHHHHHEEEEECCCEECCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCEECCC
VDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNLAHKDFQGEDLSKIDASNAD
CCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECCEECCCCCCCCHHHCCCCCCC
FRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
HHHHHHCCCEEEECCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEECCC
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PITNASPENILRYLHAAGTGTKEAMKSATSPRGILEWFVNFFTCGGVRRSNERWFREVI
CCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GKLTTSLLYVNKNAFFDGNKIFLEDVNGCTICLSCGAASENTDPMVIIEVNKNGKTVTDK
HHHHHHEEEEECCCEECCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCEECCC
VDSERFWNVCRMLKLMSKHNIQQPDSLITEDGFLNLRGVNLAHKDFQGEDLSKIDASNAD
CCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECCEECCCCCCCCHHHCCCCCCC
FRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSD
HHHHHHCCCEEEECCEEECCCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEECCC
LTDTKLNGAKLDKIALTLAKALTGADLTGSQHTPTPLPDYNDRTLFPHPIF
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677609; 12864852