Click here to switch to the map view.

The map label for this gene is moeB

Identifier: 16764207

GI number: 16764207

Start: 914962

End: 915711

Strand: Reverse

Name: moeB

Synonym: STM0845

Alternate gene names: 16764207

Gene position: 915711-914962 (Counterclockwise)

Preceding gene: 308065968

Following gene: 16764206

Centisome position: 18.85

GC content: 57.47

Gene sequence:

>750_bases
ATGGCGGAACTTAGCGACCAGGAGATGCTGCGCTATAACCGACAAATTATTCTGCGCGGCTTCGATTTTGAAGGGCAGGA
AGCGTTAAAAGATGCGCGGGTATTAGTGGTCGGGCTGGGCGGGCTCGGCTGCGCGGCAACGCAGTATCTGGCTGGCGCTG
GCGTCGGGCAACTGACGCTACTCGATTTTGATACCGTTTCCGTTTCCAATCTCCAGCGTCAAACCTTGCACAGCGACGCC
ACGGTCGGGCAGCCGAAGGTAGAGTCCGCCCGCGACGCGCTGGCGCGTATCAACCCACATATTACCATTACGCCCGTTAA
CGCGCGGCTGGACGACGACGCTATGACCAGCCTGATTGCCGGGCATTCGCTGGTGCTGGACTGTACCGATAACGTTAGCG
TACGTAATCAACTTAACGCCGGGTGCTATACCGCGAAAGTGCCGCTAATCTCCGGCGCGGCCATTCGTATGGAAGGACAA
GTTACCGTCTTTACGTATCGGGAAAACGAACCCTGTTACCGCTGCCTGAGCCGTCTGTTTGGCGAAAACGCTCTGACCTG
CGTAGAGGCAGGGGTGATGGCGCCGCTGATTGGCGTGATCGGTTCGCTACAGGCAATGGAGGCCATTAAGCTACTGGCGC
ATTACGGTCAGCCTGCCAGCGGAAAAATCGTCATGTACGATGCGATGACCTGTCAGTTCCGCGAAATGAAGTTAATGCGC
AACCCCGGCTGTGAGGTCTGCGGGCAGTAG

Upstream 100 bases:

>100_bases
TGGGCAACTGCTTTATTGTGCTGGAGCGTGAACGCGGCAATGTTGAGCCGGGAGAATGGGTGGAAGTCGAGCCGTTTAAT
GCTCTGTTCGGAGGCCTGTA

Downstream 100 bases:

>100_bases
CCACTTTACGGATAAACATACCAAAGCACGGTTTATGGCCGTGCTGTATCAACAGATAATTACTGTCATCAGACGCAAAG
CCAGCTTACCCAAGCTCCGA

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MAELSDQEMLRYNRQIILRGFDFEGQEALKDARVLVVGLGGLGCAATQYLAGAGVGQLTLLDFDTVSVSNLQRQTLHSDA
TVGQPKVESARDALARINPHITITPVNARLDDDAMTSLIAGHSLVLDCTDNVSVRNQLNAGCYTAKVPLISGAAIRMEGQ
VTVFTYRENEPCYRCLSRLFGENALTCVEAGVMAPLIGVIGSLQAMEAIKLLAHYGQPASGKIVMYDAMTCQFREMKLMR
NPGCEVCGQ

Sequences:

>Translated_249_residues
MAELSDQEMLRYNRQIILRGFDFEGQEALKDARVLVVGLGGLGCAATQYLAGAGVGQLTLLDFDTVSVSNLQRQTLHSDA
TVGQPKVESARDALARINPHITITPVNARLDDDAMTSLIAGHSLVLDCTDNVSVRNQLNAGCYTAKVPLISGAAIRMEGQ
VTVFTYRENEPCYRCLSRLFGENALTCVEAGVMAPLIGVIGSLQAMEAIKLLAHYGQPASGKIVMYDAMTCQFREMKLMR
NPGCEVCGQ
>Mature_248_residues
AELSDQEMLRYNRQIILRGFDFEGQEALKDARVLVVGLGGLGCAATQYLAGAGVGQLTLLDFDTVSVSNLQRQTLHSDAT
VGQPKVESARDALARINPHITITPVNARLDDDAMTSLIAGHSLVLDCTDNVSVRNQLNAGCYTAKVPLISGAAIRMEGQV
TVFTYRENEPCYRCLSRLFGENALTCVEAGVMAPLIGVIGSLQAMEAIKLLAHYGQPASGKIVMYDAMTCQFREMKLMRN
PGCEVCGQ

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family

Homologues:

Organism=Homo sapiens, GI7657339, Length=251, Percent_Identity=41.4342629482072, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4885649, Length=158, Percent_Identity=35.4430379746835, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI23510338, Length=169, Percent_Identity=30.1775147928994, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI23510340, Length=169, Percent_Identity=30.1775147928994, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI38045948, Length=165, Percent_Identity=32.7272727272727, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI38045942, Length=159, Percent_Identity=31.4465408805031, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI38045944, Length=159, Percent_Identity=31.4465408805031, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=88.7550200803213, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI87082356, Length=245, Percent_Identity=43.265306122449, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1789177, Length=131, Percent_Identity=35.8778625954198, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540406, Length=251, Percent_Identity=37.4501992031873, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193203301, Length=161, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71984476, Length=116, Percent_Identity=32.7586206896552, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=253, Percent_Identity=37.9446640316205, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322639, Length=176, Percent_Identity=28.9772727272727, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=42.741935483871, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24660640, Length=159, Percent_Identity=35.8490566037736, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573937, Length=163, Percent_Identity=31.2883435582822, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOEB_SALTY (Q56067)

Other databases:

- EMBL:   U53178
- EMBL:   AE006468
- RefSeq:   NP_459822.1
- ProteinModelPortal:   Q56067
- SMR:   Q56067
- PRIDE:   Q56067
- GeneID:   1252364
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM0845
- HOGENOM:   HBG535305
- OMA:   CYHCLYG
- ProtClustDB:   PRK05690
- BioCyc:   STYP99287:STM0845-MONOMER
- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR02355

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF; SSF69572 MoeB

EC number: NA

Molecular weight: Translated: 26903; Mature: 26772

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: BINDING 41-41 BINDING 62-62 BINDING 86-86

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELSDQEMLRYNRQIILRGFDFEGQEALKDARVLVVGLGGLGCAATQYLAGAGVGQLTL
CCCCCHHHHHHHCCEEEEEECCCCCHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCEEEE
LDFDTVSVSNLQRQTLHSDATVGQPKVESARDALARINPHITITPVNARLDDDAMTSLIA
EEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHC
GHSLVLDCTDNVSVRNQLNAGCYTAKVPLISGAAIRMEGQVTVFTYRENEPCYRCLSRLF
CCEEEEECCCCCCHHHHCCCCEEEEECCEECCCEEEEECEEEEEEEECCCHHHHHHHHHH
GENALTCVEAGVMAPLIGVIGSLQAMEAIKLLAHYGQPASGKIVMYDAMTCQFREMKLMR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHC
NPGCEVCGQ
CCCCCCCCC
>Mature Secondary Structure 
AELSDQEMLRYNRQIILRGFDFEGQEALKDARVLVVGLGGLGCAATQYLAGAGVGQLTL
CCCCHHHHHHHCCEEEEEECCCCCHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCEEEE
LDFDTVSVSNLQRQTLHSDATVGQPKVESARDALARINPHITITPVNARLDDDAMTSLIA
EEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHC
GHSLVLDCTDNVSVRNQLNAGCYTAKVPLISGAAIRMEGQVTVFTYRENEPCYRCLSRLF
CCEEEEECCCCCCHHHHCCCCEEEEECCEECCCEEEEECEEEEEEEECCCHHHHHHHHHH
GENALTCVEAGVMAPLIGVIGSLQAMEAIKLLAHYGQPASGKIVMYDAMTCQFREMKLMR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHC
NPGCEVCGQ
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609