Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 167625818

GI number: 167625818

Start: 4748887

End: 4750131

Strand: Reverse

Name: lysA [H]

Synonym: Shal_3913

Alternate gene names: 167625818

Gene position: 4750131-4748887 (Counterclockwise)

Preceding gene: 167625819

Following gene: 167625817

Centisome position: 90.88

GC content: 48.11

Gene sequence:

>1245_bases
TTGGATCATTTTTTATATCAAGCAGATGAGCTTTATGCGGAGCAATGTCAAGTTGCCGAGCTCGCCAAGCAGCATGGAAC
GCCGCTATATATCTATTCCCGTGCAACCTTAGAACGCCATTGGCACGCCTTTGATAATGCTGTGAGCGATCATCCACACC
TTATCTGTTATGCGGTAAAGGCAAACTCAAACATTGCGGTACTTAACGTATTGGCACGTTTAGGTAGTGGCTTTGATATT
GTCTCTGGTGGCGAGCTGTCTCGAGTGATTGAGGCGGGCGGCGACCCAGCTAAGGTGGTTTTCTCCGGCGTGGGTAAAAC
GGTCGAAGAGATGGAGATGGCGCTTAATCTTGGTATTTATTGTTTTAATGTCGAGTCTGCAGCCGAACTTGAACAGCTCA
ACTTGGTTGCTTTGCGCTTAGGAAAAGTGGCCCCAGTGTCGCTACGAGTGAATCCCGATGTCGATGCGGGCACCCACCCT
TATATCTCAACGGGTCTAAAAGAGAATAAATTTGGTATTGCGATGGAAGGGGCTGAGGCTATCTTTACCCGTGCCAATGA
ATTACCAGGCCTTGAAGTTAAGGGCGTTGATTGCCATATCGGCTCTCAACTTACCGAAATTAAGCCCTTCTTAGATGCGA
TGGATCGTATGCTCGCGCTAATCGATCGCTTAGCAGAACAAGGCATCGAAATTAAGCATTTTGATGTGGGCGGTGGGCTC
GGTGTGACTTATGATGAAGAAGTGCCGCCACAGCCGGACGTCTATGCCGCGGCATTACTTGAGCGATTAGATGGCCGAGA
TCTTAAATTAATATTTGAGCCTGGCCGCGCTATTGCTGCCAACGCCGGCATTTTCGTTACCCAAGTGCTTTACCTTAAAG
AAAACAGCGATAAGCGTTTTGCCTTGGTCGATGGTGCCATGAATGATTTGATCCGCCCATCGCTTTATAGCGCCTGGCAG
AAGATTATTCCTGTGATTGAGCGTGCGGGCGAGATGCAAACCTATGACGTTGTTGGACCCGTGTGTGAAACCGGTGATTT
CCTAGGTAAAGATCGCGAGCTTAATATACTCGCAGGTGATTATCTTGCCATTCGTTCATCGGGAGCCTACGGCTTTACTA
TGTCATCTAATTACAATTCTCGTCCACGTGCAGCAGAGCTGATGGTGGATGGTGATAAAGCCTATGTCATTCGAGAGCGA
GAAAAATTAGCTCAATTATGGCAAGGTGAGCAGATCCTGCCGTAA

Upstream 100 bases:

>100_bases
TTAGAGCGCCTCCGCAAGAAGTTAATCAGCAGGCAACTGATAAGCCGGTGCCTGACGCAGAGCATGAGCAAAGCGAGCAA
AGTAAAAAGGACTAAAGACA

Downstream 100 bases:

>100_bases
ACTAGAATAATACTAAGTAGCGGATGCCAACAAAGCATGCGCTACAGATACTTTTTAAGGATGTCCACCTTGATCCAATT
CACTAAGATGCATGGGTTAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWHAFDNAVSDHPHLICYAVKANSNIAVLNVLARLGSGFDI
VSGGELSRVIEAGGDPAKVVFSGVGKTVEEMEMALNLGIYCFNVESAAELEQLNLVALRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMEGAEAIFTRANELPGLEVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
GVTYDEEVPPQPDVYAAALLERLDGRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFALVDGAMNDLIRPSLYSAWQ
KIIPVIERAGEMQTYDVVGPVCETGDFLGKDRELNILAGDYLAIRSSGAYGFTMSSNYNSRPRAAELMVDGDKAYVIRER
EKLAQLWQGEQILP

Sequences:

>Translated_414_residues
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWHAFDNAVSDHPHLICYAVKANSNIAVLNVLARLGSGFDI
VSGGELSRVIEAGGDPAKVVFSGVGKTVEEMEMALNLGIYCFNVESAAELEQLNLVALRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMEGAEAIFTRANELPGLEVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
GVTYDEEVPPQPDVYAAALLERLDGRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFALVDGAMNDLIRPSLYSAWQ
KIIPVIERAGEMQTYDVVGPVCETGDFLGKDRELNILAGDYLAIRSSGAYGFTMSSNYNSRPRAAELMVDGDKAYVIRER
EKLAQLWQGEQILP
>Mature_414_residues
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWHAFDNAVSDHPHLICYAVKANSNIAVLNVLARLGSGFDI
VSGGELSRVIEAGGDPAKVVFSGVGKTVEEMEMALNLGIYCFNVESAAELEQLNLVALRLGKVAPVSLRVNPDVDAGTHP
YISTGLKENKFGIAMEGAEAIFTRANELPGLEVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
GVTYDEEVPPQPDVYAAALLERLDGRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRFALVDGAMNDLIRPSLYSAWQ
KIIPVIERAGEMQTYDVVGPVCETGDFLGKDRELNILAGDYLAIRSSGAYGFTMSSNYNSRPRAAELMVDGDKAYVIRER
EKLAQLWQGEQILP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=354, Percent_Identity=25.4237288135593, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI22538418, Length=357, Percent_Identity=25.7703081232493, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21361583, Length=357, Percent_Identity=25.7703081232493, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789203, Length=446, Percent_Identity=31.390134529148, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=361, Percent_Identity=22.4376731301939, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=375, Percent_Identity=24.2666666666667, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586474, Length=377, Percent_Identity=24.6684350132626, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45435; Mature: 45435

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWHAFDNAVSDHPHLICYAVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEE
ANSNIAVLNVLARLGSGFDIVSGGELSRVIEAGGDPAKVVFSGVGKTVEEMEMALNLGIY
CCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCEE
CFNVESAAELEQLNLVALRLGKVAPVSLRVNPDVDAGTHPYISTGLKENKFGIAMEGAEA
EEECCCHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHH
IFTRANELPGLEVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
HHHHHCCCCCCEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYDEEVPPQPDVYAAALLERLDGRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
CCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEEEEEEECCCCCEE
ALVDGAMNDLIRPSLYSAWQKIIPVIERAGEMQTYDVVGPVCETGDFLGKDRELNILAGD
EEECCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHCCCCCEEEEEECC
YLAIRSSGAYGFTMSSNYNSRPRAAELMVDGDKAYVIREREKLAQLWQGEQILP
EEEEECCCCEEEEECCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFLYQADELYAEQCQVAELAKQHGTPLYIYSRATLERHWHAFDNAVSDHPHLICYAVK
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEE
ANSNIAVLNVLARLGSGFDIVSGGELSRVIEAGGDPAKVVFSGVGKTVEEMEMALNLGIY
CCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCEE
CFNVESAAELEQLNLVALRLGKVAPVSLRVNPDVDAGTHPYISTGLKENKFGIAMEGAEA
EEECCCHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEECCHHH
IFTRANELPGLEVKGVDCHIGSQLTEIKPFLDAMDRMLALIDRLAEQGIEIKHFDVGGGL
HHHHHCCCCCCEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYDEEVPPQPDVYAAALLERLDGRDLKLIFEPGRAIAANAGIFVTQVLYLKENSDKRF
CCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEEEEEEECCCCCEE
ALVDGAMNDLIRPSLYSAWQKIIPVIERAGEMQTYDVVGPVCETGDFLGKDRELNILAGD
EEECCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHCCCCCEEEEEECC
YLAIRSSGAYGFTMSSNYNSRPRAAELMVDGDKAYVIREREKLAQLWQGEQILP
EEEEECCCCEEEEECCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]