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The map label for this gene is fhs

Identifier: 167625711

GI number: 167625711

Start: 4621473

End: 4623185

Strand: Reverse

Name: fhs

Synonym: Shal_3806

Alternate gene names: 167625711

Gene position: 4623185-4621473 (Counterclockwise)

Preceding gene: 167625712

Following gene: 167625709

Centisome position: 88.45

GC content: 47.81

Gene sequence:

>1713_bases
ATGCAGTCAGATATTGAAATTTCGCGCCAACATACTTGTTTACCTATCACCGAAATCGCAAAAGATCTCGGACTGAATCC
AGATGAGTTTTCTCCTTGTGGTGTTAACAAGGCTAAAGTCTCACAGTCAGTCGCTAGAAGATTAGCCGATAAAAAAAATG
CCAAGTTAGTGATTGTAACTGCCGTTACTCCGACGCCTTTTGGTGAAGGTAAAACCGTGACCACCATTGGCCTAACTCAA
GCCATGAACCTCAATGGTATTAAAACTTGCGCCTGTATTCGTCAGCCGAGCATGGGACCTGTATTTGGCACCAAAGGTGG
CGCTGCGGGCGGTGGCTACGCGCAAGTCGTACCGATGGAAGAGCTTAATCTGCACCTGACCGGTGATATTCATGCGGTGA
GTAGTGCTCATAACTTAGCGGCCGCCGCAATCGATGCTCGTCTATTCCATGAACATCGTTTGGGAGCTGAAGTCTTTGCT
CAAGAGTCAGGCTTAAGTGCGCTCAATATCGATTCTGAGAATATCCTCTGGCGTCGAGTGGTCGACCATAACGAGCGTAG
CCTAAGACAGATTAAAGTCGGGTATGGCAAAGTTAACGGTCCGGTTCATGAATCAGGGTTCGATATTACTGCGGCGTCAG
AGCTGATGGCTATCTTGGCGCTAAGCCAAGATCTGAAGGATCTAAGGCAGCGTATTGGCCGCTTGGTGTTGGCACTTAAT
ACCCAAGGTGAGCCGATTACCGCTGAAGAGTTAGGCGTTGCAGGGGCAATGACGGTAATTATGGCCGATGCGATTGAGCC
AACCTTGATGCAAACCTTATCTGGTGACCCTTGTTTCATTCATGCAGGGCCATTTGCCAATATCGCTCATGGCAACTCCT
CTATTATTGCCGACACCATTGCAGCAAAGCTAGCCGATGTAGTTATCACTGAGGCGGGCTTTGGCTCCGATATGGGCTTT
GAAAAGTTTAGTAATATCAAGGTGAGAGAGTCGGGCTATGCGCCCAGTGCATCTGTGGTTGTCGTGACGCTTAAGGCACT
TAAAGCTAACAGTGGCATCGAGTCTGACAAAGATATTAATCAGCCTGATATGGAGCGTCTACAAGCAGGTTTTGCCAACC
TAGAGTGGCATATCAACAACGTAAGCCAATATGGTGTACCTGTTGTGGTTGCGATTAACCGCTTCCCAACCGATACCGAT
GAGGAGCTTGAGTGGCTTAAGCAGGCTGTTGAGCAAACTAAGGCCTTTGGTAGCGAGATCAGTGAAGCCTTTGGTAAAGG
TGCCGAGGGAGCAACTAAACTAGCGGATATGGTTTATCATGCCACACAAACGCCGTCGGACTTTAAGTTACTTTATCAAA
GCGACACAAGCTTAGAAGCTAAGCTAATGACCCTCGCAGAAGTTGGCTATGGTGCATCGAGCGTGACGTTATCCGATAAG
GCCAAGTCACAGCTACACTGGCTAACCAAACATAATTATGGCCAGCTACCTATCTGCGTGGCTAAAACGCCGATGTCGAT
AAGTCATGACCCCAGTATTAAAGGGATCCCGACAGAATTTGAGTTACCAATCACCGAGCTAAGACTGAATGCGGGAGCCG
GTTTTGTTACAGCATTAGTTGGCCAAGTGATGACCATGCCGGGTCTTGGAATTAAACCGGGTTATCTCAATGTCGATATT
AATGATGATGGCGAGATTATTGGCCTAGCTTAA

Upstream 100 bases:

>100_bases
AAGCTAAAATAACAACGCATTGTTATTTTCTCGATATCAGAGATGACCTATATTGCAGCGGTAACTACCCTACATAATAA
TAGATTGTGGAGCCATAAGC

Downstream 100 bases:

>100_bases
GATTGCAATAGCTAATAAAAAGCCCCGGCAACCTAAGTTATCGGGGCTTTTTTAATTTTATCTTTAGAGCGACAGGATTT
ATTTCTCTAAGGCAGTTTGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MQSDIEISRQHTCLPITEIAKDLGLNPDEFSPCGVNKAKVSQSVARRLADKKNAKLVIVTAVTPTPFGEGKTVTTIGLTQ
AMNLNGIKTCACIRQPSMGPVFGTKGGAAGGGYAQVVPMEELNLHLTGDIHAVSSAHNLAAAAIDARLFHEHRLGAEVFA
QESGLSALNIDSENILWRRVVDHNERSLRQIKVGYGKVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
TQGEPITAEELGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTIAAKLADVVITEAGFGSDMGF
EKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDKDINQPDMERLQAGFANLEWHINNVSQYGVPVVVAINRFPTDTD
EELEWLKQAVEQTKAFGSEISEAFGKGAEGATKLADMVYHATQTPSDFKLLYQSDTSLEAKLMTLAEVGYGASSVTLSDK
AKSQLHWLTKHNYGQLPICVAKTPMSISHDPSIKGIPTEFELPITELRLNAGAGFVTALVGQVMTMPGLGIKPGYLNVDI
NDDGEIIGLA

Sequences:

>Translated_570_residues
MQSDIEISRQHTCLPITEIAKDLGLNPDEFSPCGVNKAKVSQSVARRLADKKNAKLVIVTAVTPTPFGEGKTVTTIGLTQ
AMNLNGIKTCACIRQPSMGPVFGTKGGAAGGGYAQVVPMEELNLHLTGDIHAVSSAHNLAAAAIDARLFHEHRLGAEVFA
QESGLSALNIDSENILWRRVVDHNERSLRQIKVGYGKVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
TQGEPITAEELGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTIAAKLADVVITEAGFGSDMGF
EKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDKDINQPDMERLQAGFANLEWHINNVSQYGVPVVVAINRFPTDTD
EELEWLKQAVEQTKAFGSEISEAFGKGAEGATKLADMVYHATQTPSDFKLLYQSDTSLEAKLMTLAEVGYGASSVTLSDK
AKSQLHWLTKHNYGQLPICVAKTPMSISHDPSIKGIPTEFELPITELRLNAGAGFVTALVGQVMTMPGLGIKPGYLNVDI
NDDGEIIGLA
>Mature_570_residues
MQSDIEISRQHTCLPITEIAKDLGLNPDEFSPCGVNKAKVSQSVARRLADKKNAKLVIVTAVTPTPFGEGKTVTTIGLTQ
AMNLNGIKTCACIRQPSMGPVFGTKGGAAGGGYAQVVPMEELNLHLTGDIHAVSSAHNLAAAAIDARLFHEHRLGAEVFA
QESGLSALNIDSENILWRRVVDHNERSLRQIKVGYGKVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
TQGEPITAEELGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTIAAKLADVVITEAGFGSDMGF
EKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDKDINQPDMERLQAGFANLEWHINNVSQYGVPVVVAINRFPTDTD
EELEWLKQAVEQTKAFGSEISEAFGKGAEGATKLADMVYHATQTPSDFKLLYQSDTSLEAKLMTLAEVGYGASSVTLSDK
AKSQLHWLTKHNYGQLPICVAKTPMSISHDPSIKGIPTEFELPITELRLNAGAGFVTALVGQVMTMPGLGIKPGYLNVDI
NDDGEIIGLA

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=612, Percent_Identity=46.2418300653595, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI36796743, Length=612, Percent_Identity=44.4444444444444, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=44.4444444444444, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=618, Percent_Identity=47.0873786407767, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568739, Length=618, Percent_Identity=47.0873786407767, Blast_Score=503, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=43.84, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=42.6073131955485, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI62472483, Length=617, Percent_Identity=44.8946515397083, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=617, Percent_Identity=44.8946515397083, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24645718, Length=617, Percent_Identity=44.8946515397083, Blast_Score=467, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17137370, Length=617, Percent_Identity=44.8946515397083, Blast_Score=467, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_SHEHH (B0TVP3)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001676005.1
- ProteinModelPortal:   B0TVP3
- SMR:   B0TVP3
- GeneID:   5904001
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_3806
- HOGENOM:   HBG677721
- OMA:   LEWHINN
- ProtClustDB:   PRK13506
- BioCyc:   SHAL458817:SHAL_3806-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60794; Mature: 60794

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSDIEISRQHTCLPITEIAKDLGLNPDEFSPCGVNKAKVSQSVARRLADKKNAKLVIVT
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEE
AVTPTPFGEGKTVTTIGLTQAMNLNGIKTCACIRQPSMGPVFGTKGGAAGGGYAQVVPME
EECCCCCCCCCEEEEEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLAAAAIDARLFHEHRLGAEVFAQESGLSALNIDSENILWRRV
HCCEEEECCEEEHHCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCHHHHHH
VDHNERSLRQIKVGYGKVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
HCCCHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
TQGEPITAEELGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTI
CCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCHHHHHH
AAKLADVVITEAGFGSDMGFEKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDKDIN
HHHHHHHHEECCCCCCCCCHHHHCCEEEEECCCCCCCCEEEEEEEHHHCCCCCCCCCCCC
QPDMERLQAGFANLEWHINNVSQYGVPVVVAINRFPTDTDEELEWLKQAVEQTKAFGSEI
CHHHHHHHCCCCCEEEEECCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
SEAFGKGAEGATKLADMVYHATQTPSDFKLLYQSDTSLEAKLMTLAEVGYGASSVTLSDK
HHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEECHH
AKSQLHWLTKHNYGQLPICVAKTPMSISHDPSIKGIPTEFELPITELRLNAGAGFVTALV
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCHHHHHHH
GQVMTMPGLGIKPGYLNVDINDDGEIIGLA
HHHHHCCCCCCCCCEEEEEECCCCCEEEEC
>Mature Secondary Structure
MQSDIEISRQHTCLPITEIAKDLGLNPDEFSPCGVNKAKVSQSVARRLADKKNAKLVIVT
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEE
AVTPTPFGEGKTVTTIGLTQAMNLNGIKTCACIRQPSMGPVFGTKGGAAGGGYAQVVPME
EECCCCCCCCCEEEEEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSSAHNLAAAAIDARLFHEHRLGAEVFAQESGLSALNIDSENILWRRV
HCCEEEECCEEEHHCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCHHHHHH
VDHNERSLRQIKVGYGKVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALN
HCCCHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
TQGEPITAEELGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTI
CCCCCCCHHHHCCHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCHHHHHH
AAKLADVVITEAGFGSDMGFEKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDKDIN
HHHHHHHHEECCCCCCCCCHHHHCCEEEEECCCCCCCCEEEEEEEHHHCCCCCCCCCCCC
QPDMERLQAGFANLEWHINNVSQYGVPVVVAINRFPTDTDEELEWLKQAVEQTKAFGSEI
CHHHHHHHCCCCCEEEEECCHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
SEAFGKGAEGATKLADMVYHATQTPSDFKLLYQSDTSLEAKLMTLAEVGYGASSVTLSDK
HHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEECHH
AKSQLHWLTKHNYGQLPICVAKTPMSISHDPSIKGIPTEFELPITELRLNAGAGFVTALV
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCHHHHHHH
GQVMTMPGLGIKPGYLNVDINDDGEIIGLA
HHHHHCCCCCCCCCEEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA