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The map label for this gene is norW [H]

Identifier: 167625644

GI number: 167625644

Start: 4535819

End: 4537012

Strand: Reverse

Name: norW [H]

Synonym: Shal_3739

Alternate gene names: 167625644

Gene position: 4537012-4535819 (Counterclockwise)

Preceding gene: 167625645

Following gene: 167625643

Centisome position: 86.8

GC content: 48.16

Gene sequence:

>1194_bases
ATGTATTTCAGCCTATTGCAGGAGTCTAACAATATGCTTCAATCAATCGATGCACCTATTGTCATTATCGGCAGTGGTTT
TGCGGCTTACCAGTTGATTAGGGCGATTCGACGCACAGATGCTTCGACACCGATCCAAGTTTTTACGGCAGATGAGGGGC
ATGACTATAATAAACCTGACTTAAGTCATGTGTTTTCAAAGAGGCAATTAGCTAGCGATCTGGTGAGATCTCAAGGCTCA
GAGATAGCCAATGAGCTTAATTTTGAGCTATATGCTAACACCTATGTTGAGGCTATCATCCCGCAGCGGCATAGCCTTAT
TGCGGCTGGGCGTGAATTCCCTTACGCAAAATTAGTATTGGCGACCGGTGCGCGTGCTTTTGTTCCACCAATGCTTGGCA
ATGCCGTGGACAAGGTTGTGACGCTTAATAGTCTGCAAGAATACCAAGCGGCGGAGTCTGATTTAGCGCTTGCTAAGCGG
GTACTCGTCATTGGCGGCGGCCTGATAGGCACCGAGCTATCGATGGATCTGGCGAGTGCAGGTAAAAAGGTGATCACTGT
CGACCCTTGCATGCAGCTGATGGCCAGCTTACTGCCGGAGTATATCGCGACTCAGCTTGGCAAACAGATGCAGCGTCAAG
GTGTATATCTTGCACTCAATAACAGCGTGAATTCACTCAATACTGCAGCAGATCAGGCGACGATTGTGGCGACGCTGGCA
TCTGCCGAGCAGTTAGAGGTTGATATGGTTATTTCTGCGGCGGGATTATTACCAAATATTCAACTGGCCCAGCAGGCGGG
GATCTCCGTTGGTCGTGGTGTGCTGGTCAATGATTACATGGAAACATCGGCCAAAGATATTTTTGCCTTAGGTGATTGCG
CCGAAATTAACGGTAAAGTATTAGCTTACTTACAGCCCGCACTGCTAAGTGCCAACGCGTTAGCGAAAACCTTACTCGGT
CAACCTACAAAGCTCAGCATGCCAGCGATGCTGGTTAAGGTAAAAACGCCCCATTACCCCATTCAATTAGCGGGGCAAGC
TGTCGATGGTGTTTATCGCTGGCAGATGGATATTGATGCACAGGGAAGTAGCGTCAAGGCCTTCGCCCATAATGGTGATT
TACAAGGTTTTGTGGTTGCCGAGCAGCATATGAATAACGCCTTTAGCTTACTAAAAGCATTACCGAGAACTTAA

Upstream 100 bases:

>100_bases
GATCCCGCAATCGGTGAGCCTAATCAGGGCGTAACGCCGGGAACAACTTGGGCTGATATAGCTGAAGATTTTCTCTGCCC
TGAATGTGGCTTAGGAAAAG

Downstream 100 bases:

>100_bases
TCCCTATATTGCTGCTGTGCTATTGGCTGGCAGCATCCGTATTTGCATTAGGAGAAGATGATGAGTCATTTACGCATCCC
TAAAAATTGGACAATTCAGC

Product: nitric oxide reductase

Products: NAD; reduced flavorubredoxin; H2O [C]

Alternate protein names: Flavorubredoxin reductase; FlRd-reductase; FlavoRb reductase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MYFSLLQESNNMLQSIDAPIVIIGSGFAAYQLIRAIRRTDASTPIQVFTADEGHDYNKPDLSHVFSKRQLASDLVRSQGS
EIANELNFELYANTYVEAIIPQRHSLIAAGREFPYAKLVLATGARAFVPPMLGNAVDKVVTLNSLQEYQAAESDLALAKR
VLVIGGGLIGTELSMDLASAGKKVITVDPCMQLMASLLPEYIATQLGKQMQRQGVYLALNNSVNSLNTAADQATIVATLA
SAEQLEVDMVISAAGLLPNIQLAQQAGISVGRGVLVNDYMETSAKDIFALGDCAEINGKVLAYLQPALLSANALAKTLLG
QPTKLSMPAMLVKVKTPHYPIQLAGQAVDGVYRWQMDIDAQGSSVKAFAHNGDLQGFVVAEQHMNNAFSLLKALPRT

Sequences:

>Translated_397_residues
MYFSLLQESNNMLQSIDAPIVIIGSGFAAYQLIRAIRRTDASTPIQVFTADEGHDYNKPDLSHVFSKRQLASDLVRSQGS
EIANELNFELYANTYVEAIIPQRHSLIAAGREFPYAKLVLATGARAFVPPMLGNAVDKVVTLNSLQEYQAAESDLALAKR
VLVIGGGLIGTELSMDLASAGKKVITVDPCMQLMASLLPEYIATQLGKQMQRQGVYLALNNSVNSLNTAADQATIVATLA
SAEQLEVDMVISAAGLLPNIQLAQQAGISVGRGVLVNDYMETSAKDIFALGDCAEINGKVLAYLQPALLSANALAKTLLG
QPTKLSMPAMLVKVKTPHYPIQLAGQAVDGVYRWQMDIDAQGSSVKAFAHNGDLQGFVVAEQHMNNAFSLLKALPRT
>Mature_397_residues
MYFSLLQESNNMLQSIDAPIVIIGSGFAAYQLIRAIRRTDASTPIQVFTADEGHDYNKPDLSHVFSKRQLASDLVRSQGS
EIANELNFELYANTYVEAIIPQRHSLIAAGREFPYAKLVLATGARAFVPPMLGNAVDKVVTLNSLQEYQAAESDLALAKR
VLVIGGGLIGTELSMDLASAGKKVITVDPCMQLMASLLPEYIATQLGKQMQRQGVYLALNNSVNSLNTAADQATIVATLA
SAEQLEVDMVISAAGLLPNIQLAQQAGISVGRGVLVNDYMETSAKDIFALGDCAEINGKVLAYLQPALLSANALAKTLLG
QPTKLSMPAMLVKVKTPHYPIQLAGQAVDGVYRWQMDIDAQGSSVKAFAHNGDLQGFVVAEQHMNNAFSLLKALPRT

Specific function: One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI22202629, Length=200, Percent_Identity=26.5, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4757732, Length=200, Percent_Identity=26.5, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21389617, Length=321, Percent_Identity=24.2990654205607, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI226437568, Length=321, Percent_Identity=24.2990654205607, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI65787454, Length=321, Percent_Identity=24.2990654205607, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789065, Length=376, Percent_Identity=47.3404255319149, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI1789765, Length=332, Percent_Identity=27.1084337349398, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788892, Length=279, Percent_Identity=27.2401433691756, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559934, Length=331, Percent_Identity=25.3776435045317, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581020, Length=312, Percent_Identity=25.3205128205128, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573993, Length=317, Percent_Identity=24.9211356466877, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24639257, Length=287, Percent_Identity=22.9965156794425, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281359715, Length=287, Percent_Identity=22.9965156794425, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281359713, Length=287, Percent_Identity=22.9965156794425, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639250, Length=287, Percent_Identity=22.9965156794425, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18543267, Length=287, Percent_Identity=22.9965156794425, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639252, Length=287, Percent_Identity=22.9965156794425, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: NA

Molecular weight: Translated: 42637; Mature: 42637

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFSLLQESNNMLQSIDAPIVIIGSGFAAYQLIRAIRRTDASTPIQVFTADEGHDYNKPD
CCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCH
LSHVFSKRQLASDLVRSQGSEIANELNFELYANTYVEAIIPQRHSLIAAGREFPYAKLVL
HHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEEHHHHHHHCCCCHHHHHCCCCCCCEEEEE
ATGARAFVPPMLGNAVDKVVTLNSLQEYQAAESDLALAKRVLVIGGGLIGTELSMDLASA
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHC
GKKVITVDPCMQLMASLLPEYIATQLGKQMQRQGVYLALNNSVNSLNTAADQATIVATLA
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHH
SAEQLEVDMVISAAGLLPNIQLAQQAGISVGRGVLVNDYMETSAKDIFALGDCAEINGKV
CHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEHHHHHCCHHEEEECCCHHCCCCE
LAYLQPALLSANALAKTLLGQPTKLSMPAMLVKVKTPHYPIQLAGQAVDGVYRWQMDIDA
EEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEECCCHHCCEEEEEEEECC
QGSSVKAFAHNGDLQGFVVAEQHMNNAFSLLKALPRT
CCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYFSLLQESNNMLQSIDAPIVIIGSGFAAYQLIRAIRRTDASTPIQVFTADEGHDYNKPD
CCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCH
LSHVFSKRQLASDLVRSQGSEIANELNFELYANTYVEAIIPQRHSLIAAGREFPYAKLVL
HHHHHHHHHHHHHHHHCCCHHHHHHCCEEEEEHHHHHHHCCCCHHHHHCCCCCCCEEEEE
ATGARAFVPPMLGNAVDKVVTLNSLQEYQAAESDLALAKRVLVIGGGLIGTELSMDLASA
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHC
GKKVITVDPCMQLMASLLPEYIATQLGKQMQRQGVYLALNNSVNSLNTAADQATIVATLA
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHH
SAEQLEVDMVISAAGLLPNIQLAQQAGISVGRGVLVNDYMETSAKDIFALGDCAEINGKV
CHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEHHHHHCCHHEEEECCCHHCCCCE
LAYLQPALLSANALAKTLLGQPTKLSMPAMLVKVKTPHYPIQLAGQAVDGVYRWQMDIDA
EEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEECCCHHCCEEEEEEEECC
QGSSVKAFAHNGDLQGFVVAEQHMNNAFSLLKALPRT
CCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; oxidized flavorubredoxin; O2 [C]

Specific reaction: NADH + oxidized flavorubredoxin + O2 = NAD + reduced flavorubredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA