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The map label for this gene is dinB

Identifier: 167625088

GI number: 167625088

Start: 3882284

End: 3883360

Strand: Reverse

Name: dinB

Synonym: Shal_3176

Alternate gene names: 167625088

Gene position: 3883360-3882284 (Counterclockwise)

Preceding gene: 167625089

Following gene: 167625086

Centisome position: 74.3

GC content: 47.35

Gene sequence:

>1077_bases
TTGCAAAAAATTATTCACGTCGACATGGATTGCTTCTACGCCGCAGTGGAAATGCGCGACTTTCCTGAACTAAGAGGAAA
ACCTATTGCGGTGGGCGGACGCAGCGATCGCCGTGGAGTGATCAGTACCTGTAACTACGAGGCACGTCAGTTTGGAGTCC
GCTCTGCGATGGCATCGGGGTACGCCCTTAAGTTATGTCCCGATTTGATTTTGGTTCCTGGGCGGATGCAGGTTTATAAA
GAGGTATCAAACCAGATCCGAGCCGTATTTGAGCGTTATACCGACTTAATTGAGCCCTTATCTCTGGATGAGGCTTACCT
TGATGTGACAGAGAGTTCTCATTGTAAAGGCTCTGCTACCTTGATGGCAGAGGCTATTCGTGCCGAGATCTTGGCTGAGA
CGGGACTAACCGCATCGGCAGGCATCGCACCGGTTAAGTTTCTTGCCAAGATAGCATCTGATTTAAATAAACCGAATGGA
CAATATGTGATCCGCCCTGAGATGATTGAAGAGTTTGTAAAAACCTTACCGCTGATAAAAATACCTGGAGTGGGAAAGGT
CACGGCTAAAAAACTTGCCGATCTGGGGCTACATACTTGTAGCGATATTCAGGCTTACCCAGAGCCTAAGTTGGTTGAGC
GTTTTGGCAAATTCGGTAGCGTGCTCATTGAGCGATCTAAGGGAATAGATAAGCGTGCTATTTTGCCCAACCGAGAGAGA
AAGTCGGTTGGGGTTGAAACTACATTAGCTAAAGATATTCACACCCTAGAGCAGTGTCGGGCGGTGATGCCGCAGCTTAT
TCAAGAACTCGGTGCTCGCGTGAGTCGTAGCGCTAAAGATAGAGCGATCAATAAGCAGGTGGTTAAACTTAAGTTTGAAG
ACTTTAAACAGACCACGATTGAGCATAGAAGTGATGAAATTTCAGTAAACCTGTTTTACCAGTTGCTTGAGCAAGCGATG
GAAAGGCAGCATGAGCGAGGTATTCGCCTCTTGGGGGTTTCCGTTGGACTCGCTTCTAATAGCATTGCTTCGGAACAGGC
AGATGTAGACAGCTCGCAGATGGATTTAGGGTTTTAG

Upstream 100 bases:

>100_bases
TTTTACTAACCGCCAATTTCAAAAGTTAGCATTTGATCTGTGTGCTTTATATTGAATACTGTTTTTATATACAGTAATAT
TCTTTTCGGAGGATATTGGC

Downstream 100 bases:

>100_bases
GCGTGTCGCGAGAAATAGCTCAGATTCTAGAAATAATAAAGGCCACTTATGACTAAGTGGCCTTATTCTTATAAACCTGT
TTTATTGGTTAACCTTTAAC

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MQKIIHVDMDCFYAAVEMRDFPELRGKPIAVGGRSDRRGVISTCNYEARQFGVRSAMASGYALKLCPDLILVPGRMQVYK
EVSNQIRAVFERYTDLIEPLSLDEAYLDVTESSHCKGSATLMAEAIRAEILAETGLTASAGIAPVKFLAKIASDLNKPNG
QYVIRPEMIEEFVKTLPLIKIPGVGKVTAKKLADLGLHTCSDIQAYPEPKLVERFGKFGSVLIERSKGIDKRAILPNRER
KSVGVETTLAKDIHTLEQCRAVMPQLIQELGARVSRSAKDRAINKQVVKLKFEDFKQTTIEHRSDEISVNLFYQLLEQAM
ERQHERGIRLLGVSVGLASNSIASEQADVDSSQMDLGF

Sequences:

>Translated_358_residues
MQKIIHVDMDCFYAAVEMRDFPELRGKPIAVGGRSDRRGVISTCNYEARQFGVRSAMASGYALKLCPDLILVPGRMQVYK
EVSNQIRAVFERYTDLIEPLSLDEAYLDVTESSHCKGSATLMAEAIRAEILAETGLTASAGIAPVKFLAKIASDLNKPNG
QYVIRPEMIEEFVKTLPLIKIPGVGKVTAKKLADLGLHTCSDIQAYPEPKLVERFGKFGSVLIERSKGIDKRAILPNRER
KSVGVETTLAKDIHTLEQCRAVMPQLIQELGARVSRSAKDRAINKQVVKLKFEDFKQTTIEHRSDEISVNLFYQLLEQAM
ERQHERGIRLLGVSVGLASNSIASEQADVDSSQMDLGF
>Mature_358_residues
MQKIIHVDMDCFYAAVEMRDFPELRGKPIAVGGRSDRRGVISTCNYEARQFGVRSAMASGYALKLCPDLILVPGRMQVYK
EVSNQIRAVFERYTDLIEPLSLDEAYLDVTESSHCKGSATLMAEAIRAEILAETGLTASAGIAPVKFLAKIASDLNKPNG
QYVIRPEMIEEFVKTLPLIKIPGVGKVTAKKLADLGLHTCSDIQAYPEPKLVERFGKFGSVLIERSKGIDKRAILPNRER
KSVGVETTLAKDIHTLEQCRAVMPQLIQELGARVSRSAKDRAINKQVVKLKFEDFKQTTIEHRSDEISVNLFYQLLEQAM
ERQHERGIRLLGVSVGLASNSIASEQADVDSSQMDLGF

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=324, Percent_Identity=33.0246913580247, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI7706681, Length=325, Percent_Identity=32.6153846153846, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI154350220, Length=247, Percent_Identity=34.8178137651822, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI5729982, Length=362, Percent_Identity=30.1104972375691, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI7705344, Length=108, Percent_Identity=51.8518518518518, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1786425, Length=338, Percent_Identity=59.7633136094675, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1787432, Length=207, Percent_Identity=29.4685990338164, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193205700, Length=398, Percent_Identity=30.1507537688442, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17537959, Length=302, Percent_Identity=29.1390728476821, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI115534089, Length=366, Percent_Identity=25.1366120218579, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI193205702, Length=339, Percent_Identity=27.1386430678466, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324921, Length=205, Percent_Identity=31.7073170731707, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19923006, Length=337, Percent_Identity=31.7507418397626, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21355641, Length=363, Percent_Identity=29.2011019283747, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24644984, Length=363, Percent_Identity=29.2011019283747, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24668444, Length=117, Percent_Identity=39.3162393162393, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_SHEHH (B0TQD1)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675382.1
- ProteinModelPortal:   B0TQD1
- SMR:   B0TQD1
- GeneID:   5904414
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_3176
- HOGENOM:   HBG734504
- OMA:   VICAASY
- ProtClustDB:   PRK02406
- BioCyc:   SHAL458817:SHAL_3176-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- InterPro:   IPR003583
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076
- SMART:   SM00278

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 39757; Mature: 39757

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIIHVDMDCFYAAVEMRDFPELRGKPIAVGGRSDRRGVISTCNYEARQFGVRSAMASG
CCCEEEECHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHCC
YALKLCPDLILVPGRMQVYKEVSNQIRAVFERYTDLIEPLSLDEAYLDVTESSHCKGSAT
CEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHH
LMAEAIRAEILAETGLTASAGIAPVKFLAKIASDLNKPNGQYVIRPEMIEEFVKTLPLIK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCEEE
IPGVGKVTAKKLADLGLHTCSDIQAYPEPKLVERFGKFGSVLIERSKGIDKRAILPNRER
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
KSVGVETTLAKDIHTLEQCRAVMPQLIQELGARVSRSAKDRAINKQVVKLKFEDFKQTTI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHH
EHRSDEISVNLFYQLLEQAMERQHERGIRLLGVSVGLASNSIASEQADVDSSQMDLGF
HHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQKIIHVDMDCFYAAVEMRDFPELRGKPIAVGGRSDRRGVISTCNYEARQFGVRSAMASG
CCCEEEECHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHCC
YALKLCPDLILVPGRMQVYKEVSNQIRAVFERYTDLIEPLSLDEAYLDVTESSHCKGSAT
CEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCHHH
LMAEAIRAEILAETGLTASAGIAPVKFLAKIASDLNKPNGQYVIRPEMIEEFVKTLPLIK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHCCEEE
IPGVGKVTAKKLADLGLHTCSDIQAYPEPKLVERFGKFGSVLIERSKGIDKRAILPNRER
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
KSVGVETTLAKDIHTLEQCRAVMPQLIQELGARVSRSAKDRAINKQVVKLKFEDFKQTTI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHH
EHRSDEISVNLFYQLLEQAMERQHERGIRLLGVSVGLASNSIASEQADVDSSQMDLGF
HHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA