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The map label for this gene is proA

Identifier: 167625081

GI number: 167625081

Start: 3870319

End: 3871587

Strand: Reverse

Name: proA

Synonym: Shal_3169

Alternate gene names: 167625081

Gene position: 3871587-3870319 (Counterclockwise)

Preceding gene: 167625082

Following gene: 167625079

Centisome position: 74.07

GC content: 47.52

Gene sequence:

>1269_bases
ATGAATAACGACGAATATTTAACGGCTTTAGGCCAAAATGCAAAGCAGGCGAGCTATGCCTTGGCCACGCTTTCGGGTCA
ACAGAAGTCAGCGCTATTACGCTGTATTGCCGATAAGCTTACGGCAGCTAAAGCTGACATAGTGAGTGCTAACCAACAAG
ATGTTGCAGATGCAAAAGCGAACGGCTTATCTGATGCGATGATCGATCGCTTGTTACTCGATGAAACAAGATTGATGGGC
GTGATTAGCGACATTGATAACGTGATTGGTCTGACCGATCCTGTTGGTAGCGAAATCGATAGTCGCCTGTTAGATAATGG
CTTGCGCTTATCTCGCAGACGTGTGCCACTCGGGGTTATCGGCGTTATTTACGAAGCTCGCCCAAATGTCACCGTCGATA
TCGCAGTATTGGCCCTTAAAACTGGTAATGCAGTTATTCTGCGTGGCGGCAAAGAGACGCTAGCGTCGAACAAAGCCTTA
TGCACAGTGATCCGTAGTGCCATGGTATCGCAAGGCTTATCAGAAGATTGCGTACAGCTTATCGATAACCCTGATAGAAG
CTTGGTATCAGGGCTATTAAAGCTCGATAAGTATGTCGATATGATAGTGCCGCGTGGCGGGCAAAACTTGCAGCGTCTGT
GCGCCGAGCAAGCCACTATTCCAGTGATCTTGGGCGGTATTGGTATTTGCCATATCTACGTTGATGCTGAGGCTAACCTC
GAAAAAGCGGTTTCAGTGATTGAAAATGCCAAAGTACAACGACCGACAGTTTGTAATGCGCTCGATACCGTGCTTATTCA
TCAAAGCCATGCGAAGCAGTTTATCCCTGTATTAGCTAAGCACCTTAGTGGTTTAGGGGTTAATTTTTATGGCTGCGATC
AGACACAAGCTATCTTAACAGCAGAAGGTCTAGATGTTTCTGCGGCAACCGATGAGAGCTTCGCAACAGAGTGGTTGTCA
CTGACTCTAGGCATTAGAGTTGTTGCTGACCTTGATGGCGCGGTTGAACATATCCGTCAATTCTCAAGTGGCCACTCAGA
GTCGATTTTGACCGATAACATTCATACCGCGAGCGACTTTATGAACGCTATCGACTCGGCTGCCGTCTACGTTAATGCCA
GTACCCGCTTCACCGATGGCGGTGAGTTTGGCTTAGGCGCAGAAGTTGCAGTAAGTACGCAAAAATTGCATGCTCGTGGA
CCTATGGGTCTAGAAGCGCTAACAACCTATAAATGGTTAGCGTGGGGCGATTATACGATTCGTGGTTAA

Upstream 100 bases:

>100_bases
ATGTCAGTAAGATTGCTGGTAAGCACTCTGATAACATCGAAGAGATACTAGGCTACGATTATGGTGATGCAGTAGTTCAC
CGCAACGACATGGTGGTGTT

Downstream 100 bases:

>100_bases
ACAGGGTTTACTTGATCTGTTTTAAGTCCACATAAAAAGCCGCATTGAGCGGCTTTTTTTATGACATATTTCCGGGGAGG
AATGCCGTTAAGTGGTTAAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIADKLTAAKADIVSANQQDVADAKANGLSDAMIDRLLLDETRLMG
VISDIDNVIGLTDPVGSEIDSRLLDNGLRLSRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLASNKAL
CTVIRSAMVSQGLSEDCVQLIDNPDRSLVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAEANL
EKAVSVIENAKVQRPTVCNALDTVLIHQSHAKQFIPVLAKHLSGLGVNFYGCDQTQAILTAEGLDVSAATDESFATEWLS
LTLGIRVVADLDGAVEHIRQFSSGHSESILTDNIHTASDFMNAIDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARG
PMGLEALTTYKWLAWGDYTIRG

Sequences:

>Translated_422_residues
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIADKLTAAKADIVSANQQDVADAKANGLSDAMIDRLLLDETRLMG
VISDIDNVIGLTDPVGSEIDSRLLDNGLRLSRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLASNKAL
CTVIRSAMVSQGLSEDCVQLIDNPDRSLVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAEANL
EKAVSVIENAKVQRPTVCNALDTVLIHQSHAKQFIPVLAKHLSGLGVNFYGCDQTQAILTAEGLDVSAATDESFATEWLS
LTLGIRVVADLDGAVEHIRQFSSGHSESILTDNIHTASDFMNAIDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARG
PMGLEALTTYKWLAWGDYTIRG
>Mature_422_residues
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIADKLTAAKADIVSANQQDVADAKANGLSDAMIDRLLLDETRLMG
VISDIDNVIGLTDPVGSEIDSRLLDNGLRLSRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLASNKAL
CTVIRSAMVSQGLSEDCVQLIDNPDRSLVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAEANL
EKAVSVIENAKVQRPTVCNALDTVLIHQSHAKQFIPVLAKHLSGLGVNFYGCDQTQAILTAEGLDVSAATDESFATEWLS
LTLGIRVVADLDGAVEHIRQFSSGHSESILTDNIHTASDFMNAIDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARG
PMGLEALTTYKWLAWGDYTIRG

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=408, Percent_Identity=36.7647058823529, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI21361368, Length=408, Percent_Identity=36.7647058823529, Blast_Score=254, Evalue=8e-68,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=58.7951807228916, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17569969, Length=412, Percent_Identity=35.9223300970874, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17569967, Length=412, Percent_Identity=35.9223300970874, Blast_Score=265, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=37.3831775700935, Blast_Score=265, Evalue=9e-72,
Organism=Drosophila melanogaster, GI21357643, Length=410, Percent_Identity=35.1219512195122, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_SHEHH (B0TQC4)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675375.1
- ProteinModelPortal:   B0TQC4
- SMR:   B0TQC4
- GeneID:   5904756
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_3169
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   SHAL458817:SHAL_3169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45042; Mature: 45042

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIADKLTAAKADIVSANQQDVADAKA
CCCCCEEHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
NGLSDAMIDRLLLDETRLMGVISDIDNVIGLTDPVGSEIDSRLLDNGLRLSRRRVPLGVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHCCCEEEE
GVIYEARPNVTVDIAVLALKTGNAVILRGGKETLASNKALCTVIRSAMVSQGLSEDCVQL
EEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
IDNPDRSLVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAEANL
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECEEEEEEEEECCCCH
EKAVSVIENAKVQRPTVCNALDTVLIHQSHAKQFIPVLAKHLSGLGVNFYGCDQTQAILT
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEE
AEGLDVSAATDESFATEWLSLTLGIRVVADLDGAVEHIRQFSSGHSESILTDNIHTASDF
ECCCCCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHCCCCCCEECCCCHHHHHH
MNAIDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTYKWLAWGDYTI
HHHHCCCEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHEEEECCEEE
RG
CC
>Mature Secondary Structure
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIADKLTAAKADIVSANQQDVADAKA
CCCCCEEHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
NGLSDAMIDRLLLDETRLMGVISDIDNVIGLTDPVGSEIDSRLLDNGLRLSRRRVPLGVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHCCCEEEE
GVIYEARPNVTVDIAVLALKTGNAVILRGGKETLASNKALCTVIRSAMVSQGLSEDCVQL
EEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
IDNPDRSLVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAEANL
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECEEEEEEEEECCCCH
EKAVSVIENAKVQRPTVCNALDTVLIHQSHAKQFIPVLAKHLSGLGVNFYGCDQTQAILT
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEE
AEGLDVSAATDESFATEWLSLTLGIRVVADLDGAVEHIRQFSSGHSESILTDNIHTASDF
ECCCCCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHCCCCCCEECCCCHHHHHH
MNAIDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTYKWLAWGDYTI
HHHHCCCEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHEEEECCEEE
RG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA