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The map label for this gene is deoA

Identifier: 167625047

GI number: 167625047

Start: 3825715

End: 3827046

Strand: Reverse

Name: deoA

Synonym: Shal_3135

Alternate gene names: 167625047

Gene position: 3827046-3825715 (Counterclockwise)

Preceding gene: 167625048

Following gene: 167625046

Centisome position: 73.22

GC content: 46.7

Gene sequence:

>1332_bases
ATGTTTTTAGCTCAAGAAATTATTCGTAAAAAACGTAATGCTGAAGTCCTTTCGACTGAAGAGATCCAATTCTTCGTCAA
CGGTATCACCAACAATACTGTTTCAGAAGGTCAGATCGCAGCCTTTGGTATGGCGGTCTATTTCAATGACATGAACATGG
ATGAACGTATTGCGCTGACTACAGCGATGCGTGACTCTGGTACAGTGCTAGACTGGAAATCGCTCGATCTTAATGGTCCA
ATTATTGATAAGCACTCAACTGGTGGTGTGGGAGATGTCATTAGTTTGATGTTAGGCCCAATGGCTGCTGCTTGTGGTGG
TTATGTGCCGATGATCTCTGGTCGTGGTTTAGGCCATACTGGCGGTACGCTCGACAAGTTTGATGCCATTCCTGGTTATA
ACACCGAACCCGACAGTGCGCTGTTCCGCAAAGTTGTAAAAGAAGCCGGTGTGGCCATTATTGGTCAAACGGGCGATCTT
GTTCCTGCCGATAAGCGTTTCTATTCTATTCGCGATAATACCGCTACGGTTGAGTCTATCTCTTTAATCACAGCCTCCAT
TCTTTCTAAAAAGCTTGCTGCTGGTCTTGATGCTTTGGCGATGGACGTTAAAGTCGGTACTGGCGCGTTTATGCCTACCT
ACGAATTATCAGAAGAGTTGGCTCGCAGTATTACTGCTGTCGCAAACGGTGCAGGCACTAAGACAACGGCATTACTTACG
GATATGAACCAAGTTCTGGCTTCATGTGCGGGTAATGCGGTAGAGGTGAAAGAAGCGGTAGACTTTATGACAGGTGCTTA
CCGTAACCCTCGTCTATATGAAGTGACTATGGGTCTTTGTGCCGAAATGTTAGTACTGGGCGGGATCGCAAGTAACGAAG
CCGAAGCGCGCGTAAAACTAAACGCTGTACTGGATAACGGTAAAGCGGCAGAGATCTTTGGTCGTATGGTGTCAGGCCTA
GGTGGTCCAGCAGATTTCGTTGAGAACTACAGCAAGTACCTACCTGATTCTCAAATTATTCGTCCAGTGTATGCGGACAG
AGCCGGTTTTGCATCGGCAATGGATACCCGTGAACTTGGACTTGCAGTCGTTACCTTAGGTGGCGGTCGTCGTAAGCCAG
GAGATGTTCTGGACTATAGTGTCGGACTTTCTAAGGTCTGTGCGCTAGGCGATGAGATCAATGCCGATAAGCCGATTGCA
TTTATTCATGCTCAATCTGAAGGTGCCTTTGCTGAAGCTGAAGCTGCAGTAAAGAAAGCGATTCATATTGGCGATACCAA
ACCAGACAAAACTCCGGAAATTTATCGTTATATCCGCGAGTCTGATCTGTAA

Upstream 100 bases:

>100_bases
GTTAGTATGTAACAATATTACGGCTTTTGATTCACTTTAGCGGAATGCTAACTGAGGGTTCTGTTTATTCGAAACTCAGT
TACACTCTTGGAGGTAGTAC

Downstream 100 bases:

>100_bases
CGGAGCACAGTTTATGAAACGTACTATAATCATGATGCTAGATTCGTTCGGCATCGGCGAGGCGCACGACGCGCATGCCT
TTGGTGATGTGGGTTCAAAC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLAQEIIRKKRNAEVLSTEEIQFFVNGITNNTVSEGQIAAFGMAVYFNDMNMDERIALTTAMRDSGTVLDWKSLDLNGP
IIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGTGAFMPTYELSEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGIASNEAEARVKLNAVLDNGKAAEIFGRMVSGL
GGPADFVENYSKYLPDSQIIRPVYADRAGFASAMDTRELGLAVVTLGGGRRKPGDVLDYSVGLSKVCALGDEINADKPIA
FIHAQSEGAFAEAEAAVKKAIHIGDTKPDKTPEIYRYIRESDL

Sequences:

>Translated_443_residues
MFLAQEIIRKKRNAEVLSTEEIQFFVNGITNNTVSEGQIAAFGMAVYFNDMNMDERIALTTAMRDSGTVLDWKSLDLNGP
IIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGTGAFMPTYELSEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGIASNEAEARVKLNAVLDNGKAAEIFGRMVSGL
GGPADFVENYSKYLPDSQIIRPVYADRAGFASAMDTRELGLAVVTLGGGRRKPGDVLDYSVGLSKVCALGDEINADKPIA
FIHAQSEGAFAEAEAAVKKAIHIGDTKPDKTPEIYRYIRESDL
>Mature_443_residues
MFLAQEIIRKKRNAEVLSTEEIQFFVNGITNNTVSEGQIAAFGMAVYFNDMNMDERIALTTAMRDSGTVLDWKSLDLNGP
IIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGTGAFMPTYELSEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGIASNEAEARVKLNAVLDNGKAAEIFGRMVSGL
GGPADFVENYSKYLPDSQIIRPVYADRAGFASAMDTRELGLAVVTLGGGRRKPGDVLDYSVGLSKVCALGDEINADKPIA
FIHAQSEGAFAEAEAAVKKAIHIGDTKPDKTPEIYRYIRESDL

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=442, Percent_Identity=38.0090497737557, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI4503445, Length=442, Percent_Identity=38.0090497737557, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI166158922, Length=442, Percent_Identity=38.0090497737557, Blast_Score=266, Evalue=2e-71,
Organism=Escherichia coli, GI1790842, Length=440, Percent_Identity=68.4090909090909, Blast_Score=626, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_SHEHH (B0TQ90)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675341.1
- ProteinModelPortal:   B0TQ90
- SMR:   B0TQ90
- GeneID:   5905584
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_3135
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- BioCyc:   SHAL458817:SHAL_3135-MONOMER
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 47020; Mature: 47020

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRNAEVLSTEEIQFFVNGITNNTVSEGQIAAFGMAVYFNDMNMDERIALT
CCHHHHHHHHHCCCCCCCHHHHEEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLDWKSLDLNGPIIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLAAGLDALAMDVKVGTGAFMPTYELSEELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGIASNEAEARVKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEEE
NAVLDNGKAAEIFGRMVSGLGGPADFVENYSKYLPDSQIIRPVYADRAGFASAMDTRELG
EEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCHHHCC
LAVVTLGGGRRKPGDVLDYSVGLSKVCALGDEINADKPIAFIHAQSEGAFAEAEAAVKKA
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
IHIGDTKPDKTPEIYRYIRESDL
HCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFLAQEIIRKKRNAEVLSTEEIQFFVNGITNNTVSEGQIAAFGMAVYFNDMNMDERIALT
CCHHHHHHHHHCCCCCCCHHHHEEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLDWKSLDLNGPIIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLAAGLDALAMDVKVGTGAFMPTYELSEELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGIASNEAEARVKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEEE
NAVLDNGKAAEIFGRMVSGLGGPADFVENYSKYLPDSQIIRPVYADRAGFASAMDTRELG
EEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCHHHCC
LAVVTLGGGRRKPGDVLDYSVGLSKVCALGDEINADKPIAFIHAQSEGAFAEAEAAVKKA
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
IHIGDTKPDKTPEIYRYIRESDL
HCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA