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The map label for this gene is uppS [H]

Identifier: 167624891

GI number: 167624891

Start: 3621758

End: 3622558

Strand: Reverse

Name: uppS [H]

Synonym: Shal_2977

Alternate gene names: 167624891

Gene position: 3622558-3621758 (Counterclockwise)

Preceding gene: 167624892

Following gene: 167624890

Centisome position: 69.31

GC content: 46.44

Gene sequence:

>801_bases
ATGTCAATCGATTCCCAGTCTGACACTGAAGTGACAGAGACCTTACCAAGCGAAATATCCGACTTGGTAAAACAGTCGAT
CCCCAAACATGTTGCTATCATTATGGATGGCAATGGACGTTGGGCACAGGCTCAGGGAAAGCCGCGAGTTCTCGGCCATA
AAGCTGGGGTCAAGGCCGTTAGGCGAGCAGTCAGTACGGCCCGTAACTTAGGGGTTGAATCATTAACCTTGTTTGCGTTT
TCTAGTGAAAACTGGCGCAGACCTGACAAAGAAGTCAGCTTGTTAATGGAGCTATTTTTTACCGTGCTGCAGCGCGAACT
TAAGTTGCTGCACAAGAATGGGGTTCGCCTCAATATTATCGGTGATATCAGTCGATTTTCTCCGCGGTTGCAAAAGCAAA
TTGCAGCGGCAGAAGAGAAAACGGCGGACAATAAAGATTTAGTGCTTAATGTGGCGGCTAACTATGGTGGACGCTGGGAC
ATTTTGCAGGCAGCACAAAAAATGGCTGTTAAGGTCGAATCTGGTGAAATGAGCAGCACTCAGTTTACCGAAGAGGCCCT
AAGTGAGCATTTGTGCATGCAAAATCAAGCCGAAGTTGATTTAATGATCCGCACTGGTGGTGACTATCGTATTAGCAACT
TTGTCTTGTGGCAAGCCGCTTATGCCGAGTTAGTCTTTACTGACACTTTGTGGCCGGATTTTAATGAGGATGCGTTTAAA
GACGCGATTGCTATTTTTGCTAATCGTCAGCGTCGATTCGGTTTGACAGGAACTCAAATCGATACCATCCGCTCTTTGTA
A

Upstream 100 bases:

>100_bases
CGGACAAAAATTAAACTCGAATGGACAACATGCCCTAGAGTTCAGACGCCGTGTAGAGTTATACTACACGGCGTTTGTCT
ATTTTTAAGGGTTGTAATAG

Downstream 100 bases:

>100_bases
TAATTAGTGAGGGAAGTTTTTTGCTAAAACAACGAATAATAACAGCAATATGGTTAATCCCCTTAGTTTTTGGTGCCATC
TTCGGTTTACCGACTGAGTA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSIDSQSDTEVTETLPSEISDLVKQSIPKHVAIIMDGNGRWAQAQGKPRVLGHKAGVKAVRRAVSTARNLGVESLTLFAF
SSENWRRPDKEVSLLMELFFTVLQRELKLLHKNGVRLNIIGDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWD
ILQAAQKMAVKVESGEMSSTQFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFNEDAFK
DAIAIFANRQRRFGLTGTQIDTIRSL

Sequences:

>Translated_266_residues
MSIDSQSDTEVTETLPSEISDLVKQSIPKHVAIIMDGNGRWAQAQGKPRVLGHKAGVKAVRRAVSTARNLGVESLTLFAF
SSENWRRPDKEVSLLMELFFTVLQRELKLLHKNGVRLNIIGDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWD
ILQAAQKMAVKVESGEMSSTQFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFNEDAFK
DAIAIFANRQRRFGLTGTQIDTIRSL
>Mature_265_residues
SIDSQSDTEVTETLPSEISDLVKQSIPKHVAIIMDGNGRWAQAQGKPRVLGHKAGVKAVRRAVSTARNLGVESLTLFAFS
SENWRRPDKEVSLLMELFFTVLQRELKLLHKNGVRLNIIGDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWDI
LQAAQKMAVKVESGEMSSTQFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFNEDAFKD
AIAIFANRQRRFGLTGTQIDTIRSL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=35.8744394618834, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=35.8744394618834, Blast_Score=141, Evalue=5e-34,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=62.719298245614, Blast_Score=302, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI71993029, Length=215, Percent_Identity=32.093023255814, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=35.8139534883721, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=35.4545454545455, Blast_Score=122, Evalue=5e-29,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=35.8851674641148, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29832; Mature: 29701

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDSQSDTEVTETLPSEISDLVKQSIPKHVAIIMDGNGRWAQAQGKPRVLGHKAGVKAV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCEECCHHHHHHH
RRAVSTARNLGVESLTLFAFSSENWRRPDKEVSLLMELFFTVLQRELKLLHKNGVRLNII
HHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
GDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWDILQAAQKMAVKVESGEMSST
ECHHHHCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEEEECCCCCCCH
QFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFNEDAFK
HHHHHHHHHHHHCCCCCCEEEEEEECCCEEEHHEEHHHHHHHHHHEECCCCCCCCHHHHH
DAIAIFANRQRRFGLTGTQIDTIRSL
HHHHHHHCCCHHCCCCCCHHHHHHCC
>Mature Secondary Structure 
SIDSQSDTEVTETLPSEISDLVKQSIPKHVAIIMDGNGRWAQAQGKPRVLGHKAGVKAV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCEECCHHHHHHH
RRAVSTARNLGVESLTLFAFSSENWRRPDKEVSLLMELFFTVLQRELKLLHKNGVRLNII
HHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
GDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWDILQAAQKMAVKVESGEMSST
ECHHHHCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHEEEECCCCCCCH
QFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFNEDAFK
HHHHHHHHHHHHCCCCCCEEEEEEECCCEEEHHEEHHHHHHHHHHEECCCCCCCCHHHHH
DAIAIFANRQRRFGLTGTQIDTIRSL
HHHHHHHCCCHHCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]