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The map label for this gene is clpP [H]

Identifier: 167624686

GI number: 167624686

Start: 3359655

End: 3360266

Strand: Reverse

Name: clpP [H]

Synonym: Shal_2768

Alternate gene names: 167624686

Gene position: 3360266-3359655 (Counterclockwise)

Preceding gene: 167624687

Following gene: 167624685

Centisome position: 64.29

GC content: 44.93

Gene sequence:

>612_bases
ATGCACAAAGCGCCAGAATCAGTACTTAACGCACTCGTTCCTATGGTTGTCGAACAGACGGCTAAAGGTGAACGTTCATA
TGATATTTATTCTCGCCTGTTAAAAGAGCGAGTGATCTTTCTCGTTGGCCAAGTTGAAGAACATATGGCTAACCTTATCG
TTGCTCAGTTACTGTTTTTGGAATCAGAGAGCCCAGATAAGGATATCTACCTATACATCAACTCACCAGGCGGCAGCGTA
ACTGCAGGTATGGCAATTTATGACACTATGCAGTTCATTAAGCCTAATGTGAGTACCGTGTGTATTGGTCAAGCGGCGAG
CATGGGCGCATTTTTATTGGCAGGCGGTGCAGAAGGCAAACGCCATTGCTTACCAAACTCAAGAGTGATGATCCATCAGC
CATTAGGTGGTTTCCAAGGTCAAGCGTCAGATATCGCTATTCATGCTCAAGAGATCTTGGGTATTAAGAATAAACTTAAT
ACTATGCTTGCAGAGCACACAGGCCAGCCTCTTGAAGTGATCGAACGTGATACAGACCGTGATAACTTCATGAGCGCGAC
AGAAGCCGCTGAATACGGATTAGTCGATTCAGTGATAGCAAAACGAAGCTGA

Upstream 100 bases:

>100_bases
TCGCGCGTAACCATCGCTTGACTTAAATGGCTATTAGCCATTTATAATGGCTCGTATGAGGTTCCTCATGCGGGCCATTT
TTATTTAGGGAAGTTTAATC

Downstream 100 bases:

>100_bases
TTTTTACTTCGCTCTGAGCTATGCTCAAATAAGAAGTAACGAAAAGATTTAGGCAGTGAAAATACTGCAAATAGAGGTAA
AGTAATGGGTGAAGACAAAG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESESPDKDIYLYINSPGGSV
TAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLN
TMLAEHTGQPLEVIERDTDRDNFMSATEAAEYGLVDSVIAKRS

Sequences:

>Translated_203_residues
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESESPDKDIYLYINSPGGSV
TAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLN
TMLAEHTGQPLEVIERDTDRDNFMSATEAAEYGLVDSVIAKRS
>Mature_203_residues
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESESPDKDIYLYINSPGGSV
TAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLN
TMLAEHTGQPLEVIERDTDRDNFMSATEAAEYGLVDSVIAKRS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=59.0425531914894, Blast_Score=244, Evalue=4e-65,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=76.6839378238342, Blast_Score=325, Evalue=9e-91,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.9139784946236, Blast_Score=222, Evalue=9e-59,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=56.9148936170213, Blast_Score=234, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22134; Mature: 22134

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESESPDKDIYLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGK
CCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEECCHHCCCEEEEECCCCCC
RHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLNTMLAEHTGQPLEVIERDTDR
CCCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCH
DNFMSATEAAEYGLVDSVIAKRS
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFL
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESESPDKDIYLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGK
CCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCEEEECCHHCCCEEEEECCCCCC
RHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLNTMLAEHTGQPLEVIERDTDR
CCCCCCCCEEEECCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCH
DNFMSATEAAEYGLVDSVIAKRS
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA