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The map label for this gene is ribA

Identifier: 167624607

GI number: 167624607

Start: 3262000

End: 3262629

Strand: Reverse

Name: ribA

Synonym: Shal_2689

Alternate gene names: 167624607

Gene position: 3262629-3262000 (Counterclockwise)

Preceding gene: 167624608

Following gene: 167624606

Centisome position: 62.42

GC content: 44.29

Gene sequence:

>630_bases
ATGTCGATTAAATATATAGCGTCTTCAAAATTACCGACCCCTTGGGGTGTTTTCGAAATGCATGGTTTTGAAGATAGTGA
GACGGGTAAAGAGCACGTTGCGCTTACCTTTGGTACACTTTCTCCAGATGCACCCATCCTCGGGCGTATTCACTCAGAAT
GTTTAACTGGTGATGCATTGTTTAGTCTGCGTTGTGACTGTGGTTTTCAGCTGCAAACAGCAATGCAAAATGTAGCTGAA
GAAGGGCAAGGCTTTATTCTTTATCTACGCCAAGAAGGCCGTGGCATTGGTTTGCTGAATAAAATCCGTGCTTATGAGCT
ACAAGATCAAGGCGCGAATACAGTAGAAGCCAACGAACGCTTAGGCTTTGAAGCCGATATGCGTAAATACGACATGATCA
TTCCGATGATGGAGAAGATTGGTGTCGCTAAAGTTCGCCTAATGACCAATAACCCTCGTAAAGTGAAGGCGATGCAAAGC
TTTGGTTTAGAGGTCGTTGAGCGAGTGCCATTGCAAGTGGGTAAAAATCGCTATAACGAAGGTTACCTCAAGACAAAGTC
GACCGAGTTAGGCCACATGATGTCTGAGCACCACTTTACTGACGCTGATACTGAAGCAAAGAAAGATTAA

Upstream 100 bases:

>100_bases
ATTTGATCATTGAGCTAGCAAGAGTATCGTCTCAAGCATTTATTTTCTTTATCAGGACGTTTGCAGTCTCATGGAGTGAG
AGTTGTCGTTAAGGTTTTTC

Downstream 100 bases:

>100_bases
TCCCTTTCGGTAAAAGTGTTAGTTTTCATGGATTTTACCCTGCAATACCGCTATATTCGGGCTATCGATTAGAGTTTAAT
TAAGTTTAAAGTCAATTTAT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTLSPDAPILGRIHSECLTGDALFSLRCDCGFQLQTAMQNVAE
EGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANERLGFEADMRKYDMIIPMMEKIGVAKVRLMTNNPRKVKAMQS
FGLEVVERVPLQVGKNRYNEGYLKTKSTELGHMMSEHHFTDADTEAKKD

Sequences:

>Translated_209_residues
MSIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTLSPDAPILGRIHSECLTGDALFSLRCDCGFQLQTAMQNVAE
EGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANERLGFEADMRKYDMIIPMMEKIGVAKVRLMTNNPRKVKAMQS
FGLEVVERVPLQVGKNRYNEGYLKTKSTELGHMMSEHHFTDADTEAKKD
>Mature_208_residues
SIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTLSPDAPILGRIHSECLTGDALFSLRCDCGFQLQTAMQNVAEE
GQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANERLGFEADMRKYDMIIPMMEKIGVAKVRLMTNNPRKVKAMQSF
GLEVVERVPLQVGKNRYNEGYLKTKSTELGHMMSEHHFTDADTEAKKD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=59.1836734693878, Blast_Score=254, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319438, Length=195, Percent_Identity=41.025641025641, Blast_Score=128, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_SHEHH (B0TL40)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674901.1
- ProteinModelPortal:   B0TL40
- SMR:   B0TL40
- GeneID:   5905110
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2689
- HOGENOM:   HBG735778
- OMA:   QGFILYL
- ProtClustDB:   PRK00393
- BioCyc:   SHAL458817:SHAL_2689-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 23481; Mature: 23350

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 128-128 BINDING 70-70 BINDING 114-114 BINDING 149-149 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTLSPDAPILGRIHSECLTGDAL
CCEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCE
FSLRCDCGFQLQTAMQNVAEEGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANER
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCEECCCHH
LGFEADMRKYDMIIPMMEKIGVAKVRLMTNNPRKVKAMQSFGLEVVERVPLQVGKNRYNE
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCHHHHHHHHHHHCCCCCCC
GYLKTKSTELGHMMSEHHFTDADTEAKKD
CEEEECCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SIKYIASSKLPTPWGVFEMHGFEDSETGKEHVALTFGTLSPDAPILGRIHSECLTGDAL
CEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCE
FSLRCDCGFQLQTAMQNVAEEGQGFILYLRQEGRGIGLLNKIRAYELQDQGANTVEANER
EEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHEEECCCCCCEECCCHH
LGFEADMRKYDMIIPMMEKIGVAKVRLMTNNPRKVKAMQSFGLEVVERVPLQVGKNRYNE
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCHHHHHHHHHHHCCCCCCC
GYLKTKSTELGHMMSEHHFTDADTEAKKD
CEEEECCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA