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The map label for this gene is fadI [H]

Identifier: 167624589

GI number: 167624589

Start: 3240561

End: 3241871

Strand: Reverse

Name: fadI [H]

Synonym: Shal_2671

Alternate gene names: 167624589

Gene position: 3241871-3240561 (Counterclockwise)

Preceding gene: 167624606

Following gene: 167624588

Centisome position: 62.02

GC content: 48.51

Gene sequence:

>1311_bases
ATGAGTGATAGACAACAGGTGACAAATGCGAGAGGCGAACGTATCGCGATTGTTTCGGGATTGCGTACACCATTTGCTAA
ACAAGCCACCGCTTTTCACGGGGTGTCGGCATTAGATATGGGCAAGATGGTAGTCAATGAGCTATTGTCTCGTTCTGAAC
TTAATCCTAAAGAAATTGAACAGCTTGTTTATGGTCAAGTTGTTCAGATGCCAGCTGCGCCCAATATTGCTCGTGAAATT
GTATTAGGCACGGGTATGGATGTGAGTACCGACGCTTACAGTGTGACAAGGGCTTGTGCGACCAGCTTTCAGTCAACGGT
AAATGTCGCTGAGTCTATCATGACGGGCAATATGGATATCGGTATTGCTGGTGGCGCCGACTCTTCATCTGTATTGCCGA
TTGGCGTCTCTAAGAAACTTGCCCATGCCTTGGTTGATCTCAATAAGGCGCGCAGTTTTGGTCAGAAGTTAGCAATCTTT
CGCAGATTAGGCTTAAAAGATTTACTACCAGTGCCACCTGCGGTTGCCGAGTATTCGACAGGTTTGTCGATGGGGCAAAC
CGCAGAGCAGATGGCAAAGACTTACAATATCAGCCGCGCCGATCAAGATGCATTAGCTCACCGTTCACATACCTTAGCCA
CAGAAACGTGGAATGCAGGAAAGCTTGCAGAAGAGGTGATGGCTGCTCATGTCCCACCTTATAAGTCATTTATCGACCGT
GATAATAATATTCGTGAAAACTCAACGCTAGAGTCTTACGCAAAATTACGTCCGGCTTTCGATCGTAAACACGGCTCAGT
GACAGCGGCTAATAGCACGCCGTTAACCGACGGTGCATCGGCCGTACTCTTGATGAGTGAAGGGCGCGCCAAAGCCCTTG
GTTACACGCCTATCGGTTACATTAAGAGTTATGCCTTTACAGCCATTGATGTATGGCAAGATATGTTGATGGGGCCTTCA
TACGCAACACCACTCGCGCTTAAACGTGCAGGAATGGAACTTGAAGATCTGACCTTGATTGAGATGCATGAAGCGTTTGC
CGCACAGACTCTGGCAAACATGCAGATGTTTGCTTCGAAAAAGTTTGCCGAAGAGAAACTTGGCCGCAACCGTGCGATTG
GTGAAATCGATATGAGTAAGTTTAACGTACTCGGTGGCTCGCTTGCTTATGGCCACCCATTTGCGGCAACGGGAACACGA
TTGGTGACGCAGGTGTGTCACGAGCTTAAACGCCGTGGTGGTGGAACGGGTCTCGCAACAGCATGTGCTGCGGGTGGTTT
GGGTGCAGCAATGATTGTTGAAGTGGAGTAA

Upstream 100 bases:

>100_bases
CTTTAATGGTCAGACCTGTTTAATTGAAAGCAAATAGGTTTCTCAAGGATATAAGAAAGCGCGCAACGATAAGTGAGCGA
GCAGAATAAGAGGGCGAAAA

Downstream 100 bases:

>100_bases
TCACATGGACATGGAAAAGACATTTAATTTAACGCGCCGCGATGATGGTATTGCCATATTAACTATGGATGTGCCGGGCG
AAACTATGAATACCCTGCGT

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELNPKEIEQLVYGQVVQMPAAPNIAREI
VLGTGMDVSTDAYSVTRACATSFQSTVNVAESIMTGNMDIGIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLAIF
RRLGLKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLATETWNAGKLAEEVMAAHVPPYKSFIDR
DNNIRENSTLESYAKLRPAFDRKHGSVTAANSTPLTDGASAVLLMSEGRAKALGYTPIGYIKSYAFTAIDVWQDMLMGPS
YATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTR
LVTQVCHELKRRGGGTGLATACAAGGLGAAMIVEVE

Sequences:

>Translated_436_residues
MSDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELNPKEIEQLVYGQVVQMPAAPNIAREI
VLGTGMDVSTDAYSVTRACATSFQSTVNVAESIMTGNMDIGIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLAIF
RRLGLKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLATETWNAGKLAEEVMAAHVPPYKSFIDR
DNNIRENSTLESYAKLRPAFDRKHGSVTAANSTPLTDGASAVLLMSEGRAKALGYTPIGYIKSYAFTAIDVWQDMLMGPS
YATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTR
LVTQVCHELKRRGGGTGLATACAAGGLGAAMIVEVE
>Mature_435_residues
SDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELNPKEIEQLVYGQVVQMPAAPNIAREIV
LGTGMDVSTDAYSVTRACATSFQSTVNVAESIMTGNMDIGIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLAIFR
RLGLKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLATETWNAGKLAEEVMAAHVPPYKSFIDRD
NNIRENSTLESYAKLRPAFDRKHGSVTAANSTPLTDGASAVLLMSEGRAKALGYTPIGYIKSYAFTAIDVWQDMLMGPSY
ATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTRL
VTQVCHELKRRGGGTGLATACAAGGLGAAMIVEVE

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=420, Percent_Identity=41.4285714285714, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI4557237, Length=434, Percent_Identity=29.0322580645161, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI167614485, Length=423, Percent_Identity=32.1513002364066, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI148539872, Length=431, Percent_Identity=30.6264501160093, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4501853, Length=430, Percent_Identity=30, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=73.4741784037559, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=426, Percent_Identity=33.0985915492958, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788554, Length=425, Percent_Identity=34.5882352941176, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI48994986, Length=429, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1787663, Length=424, Percent_Identity=32.0754716981132, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=40.3800475059382, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI133906874, Length=427, Percent_Identity=32.3185011709602, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=422, Percent_Identity=28.6729857819905, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535921, Length=425, Percent_Identity=28.2352941176471, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=431, Percent_Identity=23.8979118329466, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6325229, Length=430, Percent_Identity=29.0697674418605, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322031, Length=444, Percent_Identity=29.954954954955, Blast_Score=166, Evalue=6e-42,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=40.7834101382488, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24655093, Length=424, Percent_Identity=30.6603773584906, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17648125, Length=430, Percent_Identity=29.5348837209302, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24640423, Length=424, Percent_Identity=25.9433962264151, Blast_Score=157, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46593; Mature: 46462

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELNPKEIE
CCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLVYGQVVQMPAAPNIAREIVLGTGMDVSTDAYSVTRACATSFQSTVNVAESIMTGNMDI
HHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
GIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLAIFRRLGLKDLLPVPPAVAEYST
EEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHC
GLSMGQTAEQMAKTYNISRADQDALAHRSHTLATETWNAGKLAEEVMAAHVPPYKSFIDR
CCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCC
DNNIRENSTLESYAKLRPAFDRKHGSVTAANSTPLTDGASAVLLMSEGRAKALGYTPIGY
CCCCCCCCHHHHHHHHCHHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCHHH
IKSYAFTAIDVWQDMLMGPSYATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTRLVTQVCHELKRRGGGTGLAT
HHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMIVEVE
HHHCCCCCEEEEEEEC
>Mature Secondary Structure 
SDRQQVTNARGERIAIVSGLRTPFAKQATAFHGVSALDMGKMVVNELLSRSELNPKEIE
CCHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
QLVYGQVVQMPAAPNIAREIVLGTGMDVSTDAYSVTRACATSFQSTVNVAESIMTGNMDI
HHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
GIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLAIFRRLGLKDLLPVPPAVAEYST
EEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHC
GLSMGQTAEQMAKTYNISRADQDALAHRSHTLATETWNAGKLAEEVMAAHVPPYKSFIDR
CCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCC
DNNIRENSTLESYAKLRPAFDRKHGSVTAANSTPLTDGASAVLLMSEGRAKALGYTPIGY
CCCCCCCCHHHHHHHHCHHHHCCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCHHH
IKSYAFTAIDVWQDMLMGPSYATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTRLVTQVCHELKRRGGGTGLAT
HHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
ACAAGGLGAAMIVEVE
HHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA