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The map label for this gene is ald [H]

Identifier: 167624143

GI number: 167624143

Start: 2683580

End: 2684695

Strand: Direct

Name: ald [H]

Synonym: Shal_2219

Alternate gene names: 167624143

Gene position: 2683580-2684695 (Clockwise)

Preceding gene: 167624135

Following gene: 167624148

Centisome position: 51.34

GC content: 44.98

Gene sequence:

>1116_bases
ATGATTATAGGTGTTCCAAAAGAAATCAAAAATCACGAATATCGTGTTGGTATGGTCCCATCAAGTGTTCGTGAATTGAC
GTCACGTGGTCATGAGGTTTTTATTGAAACAAATGCTGGCTCAGGCATTGGTTTTGCTGATCAAGATTATATCGAAGTCG
GTGCAAAAATACTGCAAACAGCTGCCGAGGTATTTGCTCAATCTGAGATGATTGTAAAAGTAAAAGAGCCTCAAGCTGTT
GAACGTGCAATGTTACGTGAAGACCAGTTACTATTTACCTACCTTCATTTAGCACCCGATCTTCCACAAACTGAAGATCT
CGTGAAAAGTGGTTCTGTTTGTATTGCATACGAAACCGTTACCGATGATCGCGGTGCGCTTCCGCTACTTGCACCTATGT
CTGAAGTCGCTGGCCGTATGTCTATTCAAGCAGGTGCGATGGCGCTAGAGAAATCTATGGGTGGCCGCGGTATGTTACTC
GGTGGCGTTCCTGGTGTTGAACCTGCAAAGGTTGTGATCATTGGCGGCGGCATGGTTGGTACAAACGCAGCGCAGATGGC
TGTTGGTCTTGGTGCCGATGTTGTTATTCTAGATAGAAGTATTGATGCTCTTCGTCGCCTTAACGCTCAATTCGATAATA
AAGTTAAAGCCATTTACTCAACGGCTGATGCCATTGAAAAACATGTACTTGAGGCTGACCTTGTGATCGGCGGCGTGCTT
GTTCCTGGAGCCGCGGCACCGAAACTTGTGACTAAAGAACATATCAAACGCATGAAGCCGGGCTCTGCCATCGTTGATGT
TGCAATTGACCAAGGTGGTTGTATCGAAACATCGCACGCAACGACTCACCAAGATCCAACTTATATCGTTGATGACGTTG
TTCATTACTGTGTTGCTAACATGCCTGGTGCGGTTGCCCGTACTTCGACATTTGCACTAAACAACGCAACCTTGCCATAC
ATCATTAAGCTGGCTCAACTGGGTTATAGAGAAGCGCTGTTACAAGACAAGCACTTACTAAACGGTCTTAATGTAATGCA
CGGTAAGATCACTTGTGCCGAAGTTGCTGAAGCACTAAACCTTGAGTTTGTCGATCCACAAATATTACTTAAGTAA

Upstream 100 bases:

>100_bases
ATACTATACTAGATTTCCCTGCAACATTCACGTTCAGGCAATACAATATAACAATTACACCCATATAAAATGGGTTTTTA
TGCAAATTTGAGGCTCGAAG

Downstream 100 bases:

>100_bases
CTCGAAAAACTAGTTACTTAAGTAATATGTAGGGAGCCGCAGGCTCCCTTTTAAGTTCCCTAATATTATACCAATCAGTA
TAAAGATTTAGTCGCTCAGC

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MIIGVPKEIKNHEYRVGMVPSSVRELTSRGHEVFIETNAGSGIGFADQDYIEVGAKILQTAAEVFAQSEMIVKVKEPQAV
ERAMLREDQLLFTYLHLAPDLPQTEDLVKSGSVCIAYETVTDDRGALPLLAPMSEVAGRMSIQAGAMALEKSMGGRGMLL
GGVPGVEPAKVVIIGGGMVGTNAAQMAVGLGADVVILDRSIDALRRLNAQFDNKVKAIYSTADAIEKHVLEADLVIGGVL
VPGAAAPKLVTKEHIKRMKPGSAIVDVAIDQGGCIETSHATTHQDPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPY
IIKLAQLGYREALLQDKHLLNGLNVMHGKITCAEVAEALNLEFVDPQILLK

Sequences:

>Translated_371_residues
MIIGVPKEIKNHEYRVGMVPSSVRELTSRGHEVFIETNAGSGIGFADQDYIEVGAKILQTAAEVFAQSEMIVKVKEPQAV
ERAMLREDQLLFTYLHLAPDLPQTEDLVKSGSVCIAYETVTDDRGALPLLAPMSEVAGRMSIQAGAMALEKSMGGRGMLL
GGVPGVEPAKVVIIGGGMVGTNAAQMAVGLGADVVILDRSIDALRRLNAQFDNKVKAIYSTADAIEKHVLEADLVIGGVL
VPGAAAPKLVTKEHIKRMKPGSAIVDVAIDQGGCIETSHATTHQDPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPY
IIKLAQLGYREALLQDKHLLNGLNVMHGKITCAEVAEALNLEFVDPQILLK
>Mature_371_residues
MIIGVPKEIKNHEYRVGMVPSSVRELTSRGHEVFIETNAGSGIGFADQDYIEVGAKILQTAAEVFAQSEMIVKVKEPQAV
ERAMLREDQLLFTYLHLAPDLPQTEDLVKSGSVCIAYETVTDDRGALPLLAPMSEVAGRMSIQAGAMALEKSMGGRGMLL
GGVPGVEPAKVVIIGGGMVGTNAAQMAVGLGADVVILDRSIDALRRLNAQFDNKVKAIYSTADAIEKHVLEADLVIGGVL
VPGAAAPKLVTKEHIKRMKPGSAIVDVAIDQGGCIETSHATTHQDPTYIVDDVVHYCVANMPGAVARTSTFALNNATLPY
IIKLAQLGYREALLQDKHLLNGLNVMHGKITCAEVAEALNLEFVDPQILLK

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=347, Percent_Identity=30.2593659942363, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI122939153, Length=347, Percent_Identity=30.2593659942363, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI1787887, Length=298, Percent_Identity=30.5369127516779, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550456, Length=348, Percent_Identity=29.5977011494253, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39611; Mature: 39611

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGVPKEIKNHEYRVGMVPSSVRELTSRGHEVFIETNAGSGIGFADQDYIEVGAKILQT
CEECCCHHHCCCCEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AAEVFAQSEMIVKVKEPQAVERAMLREDQLLFTYLHLAPDLPQTEDLVKSGSVCIAYETV
HHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEE
TDDRGALPLLAPMSEVAGRMSIQAGAMALEKSMGGRGMLLGGVPGVEPAKVVIIGGGMVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
TNAAQMAVGLGADVVILDRSIDALRRLNAQFDNKVKAIYSTADAIEKHVLEADLVIGGVL
CCHHHHHHCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHEEEEEE
VPGAAAPKLVTKEHIKRMKPGSAIVDVAIDQGGCIETSHATTHQDPTYIVDDVVHYCVAN
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTFALNNATLPYIIKLAQLGYREALLQDKHLLNGLNVMHGKITCAEVAEALN
CCCCHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEHHHHHHHHC
LEFVDPQILLK
CEEECHHEECC
>Mature Secondary Structure
MIIGVPKEIKNHEYRVGMVPSSVRELTSRGHEVFIETNAGSGIGFADQDYIEVGAKILQT
CEECCCHHHCCCCEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AAEVFAQSEMIVKVKEPQAVERAMLREDQLLFTYLHLAPDLPQTEDLVKSGSVCIAYETV
HHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEE
TDDRGALPLLAPMSEVAGRMSIQAGAMALEKSMGGRGMLLGGVPGVEPAKVVIIGGGMVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
TNAAQMAVGLGADVVILDRSIDALRRLNAQFDNKVKAIYSTADAIEKHVLEADLVIGGVL
CCHHHHHHCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHEEEEEE
VPGAAAPKLVTKEHIKRMKPGSAIVDVAIDQGGCIETSHATTHQDPTYIVDDVVHYCVAN
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTFALNNATLPYIIKLAQLGYREALLQDKHLLNGLNVMHGKITCAEVAEALN
CCCCHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEHHHHHHHHC
LEFVDPQILLK
CEEECHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]