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The map label for this gene is serS

Identifier: 167624137

GI number: 167624137

Start: 2676410

End: 2677696

Strand: Reverse

Name: serS

Synonym: Shal_2213

Alternate gene names: 167624137

Gene position: 2677696-2676410 (Counterclockwise)

Preceding gene: 167624138

Following gene: 167624136

Centisome position: 51.23

GC content: 45.07

Gene sequence:

>1287_bases
ATGTTAGATCCAAAATTTTTACGTAATGAATTAGAAGTTACCGCAGAGCGTTTAGCGACTCGCGGATTTATTTTAGATGT
AGAGCGCCTAGGCAAGCTTGAAGACAAGCGTAAGTCATTACAGGTCGCGACCGAAGAATTACAAGCATCACGTAACGCTA
TCTCCAAGTCGATTGGTCAAGCTAAAGCTAAAGGCGAAGATGTTGCACCAATCATGGCTCAAGTGGGCTCACTAGGCGAA
GAGCTTGATGCAAAGAAAGCTGAGCTTGCATCTTTACTCGACGAGCTAAACTCAATCGCAATGAGCGTTCCTAACCTACC
TGATGAGTCAGCACCTATTGGCGCAGATGAATCAGAGAACGTAGAAGTTCGTCGTTGGGGCACGCCTAAAGAGTATGATT
TTGAAGTTAAAGATCATGTTGAACTCGGTGAGAACATTGGTGGTCTAGATTTTAAGAATGCGGTTAAGATCACCGGTTCG
CGCTTTATCGTGATGAAAGGCCAAATCGCTCGCATGCACCGCGCATTAGCCCAGTTTATGTTAGATCTACACACCACTGA
ACATGGTTATACAGAAGCGTACGTGCCTTTATTAGTTAATGAAGACAGCTTAATGGGTACAGGCCAACTACCAAAGTTTG
GTGAAGACCTGTTCCACACTAAGCCTGCTACTGAAGAAGGCCAAGGCCTAAGTCTTATTCCAACGGCAGAGGTTCCGCTA
ACTAACCTAGTTCGCGATACCATCGTTGATGAAGAAGAGTTACCAATTAAGCTAACCGCGCATACACCATGTTTCAGAAG
TGAAGCTGGTTCTTATGGTCGTGATACTCGTGGCTTGATCCGTCAGCATCAGTTTGACAAAGTAGAGCTAGTACAGCTTG
TAAAGCCTGAAAATTCTATGCAGGCATTGGAAGAGTTAACTGCTCATGCGGAAACTGTACTGCAAAAGCTAGGTCTACCG
TACCGTACTGTTGTGCTTTGTACTGGTGATATGGGCTTCGGTTCAAGCAAGACCTACGATATCGAAGTTTGGTTGCCAGC
GCAAAACACCTTTAGAGAGATCTCATCTTGCAGTAACATGCAGGACTTCCAGGCTCGTCGTATGCAAGCTCGCTATAAGG
CTAAAACTGATAAGAAGCCAAGCTTACTGCACACTCTGAATGGTTCTGGTTTAGCTGTAGGTCGTACATTGGTAGCGGTT
ATTGAAAACTACCAAAATGCAGATGGTTCTATCACAGTGCCTGAAGCATTACGCGGATACATGGGCGGCCTAGAAAAAAT
CGGCTAA

Upstream 100 bases:

>100_bases
CGTATTGAATGTTGTTGTTAATGTTGGCGTCTGTATATTCGTCGTCTATCTAGGACAGCAATTGGTGTTTTCTCGTTTTT
AACTATTAAGATAATAAAAT

Downstream 100 bases:

>100_bases
TATTGAGCCGGCCCAATCGCAAAAAGCCTTCACTAACGTGAAGGCTTTTTTGTTTTCTCGAAAATAATAGCTACTATCGA
TTTAACCGCTAACTCCTGTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDPKFLRNELEVTAERLATRGFILDVERLGKLEDKRKSLQVATEELQASRNAISKSIGQAKAKGEDVAPIMAQVGSLGE
ELDAKKAELASLLDELNSIAMSVPNLPDESAPIGADESENVEVRRWGTPKEYDFEVKDHVELGENIGGLDFKNAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTTEHGYTEAYVPLLVNEDSLMGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDTIVDEEELPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPENSMQALEELTAHAETVLQKLGLP
YRTVVLCTGDMGFGSSKTYDIEVWLPAQNTFREISSCSNMQDFQARRMQARYKAKTDKKPSLLHTLNGSGLAVGRTLVAV
IENYQNADGSITVPEALRGYMGGLEKIG

Sequences:

>Translated_428_residues
MLDPKFLRNELEVTAERLATRGFILDVERLGKLEDKRKSLQVATEELQASRNAISKSIGQAKAKGEDVAPIMAQVGSLGE
ELDAKKAELASLLDELNSIAMSVPNLPDESAPIGADESENVEVRRWGTPKEYDFEVKDHVELGENIGGLDFKNAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTTEHGYTEAYVPLLVNEDSLMGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDTIVDEEELPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPENSMQALEELTAHAETVLQKLGLP
YRTVVLCTGDMGFGSSKTYDIEVWLPAQNTFREISSCSNMQDFQARRMQARYKAKTDKKPSLLHTLNGSGLAVGRTLVAV
IENYQNADGSITVPEALRGYMGGLEKIG
>Mature_428_residues
MLDPKFLRNELEVTAERLATRGFILDVERLGKLEDKRKSLQVATEELQASRNAISKSIGQAKAKGEDVAPIMAQVGSLGE
ELDAKKAELASLLDELNSIAMSVPNLPDESAPIGADESENVEVRRWGTPKEYDFEVKDHVELGENIGGLDFKNAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTTEHGYTEAYVPLLVNEDSLMGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDTIVDEEELPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPENSMQALEELTAHAETVLQKLGLP
YRTVVLCTGDMGFGSSKTYDIEVWLPAQNTFREISSCSNMQDFQARRMQARYKAKTDKKPSLLHTLNGSGLAVGRTLVAV
IENYQNADGSITVPEALRGYMGGLEKIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=463, Percent_Identity=31.9654427645788, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI225579074, Length=403, Percent_Identity=29.0322580645161, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI8923421, Length=336, Percent_Identity=31.25, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=71.6279069767442, Blast_Score=656, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=441, Percent_Identity=29.2517006802721, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=28.7878787878788, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321799, Length=414, Percent_Identity=30.1932367149758, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6320226, Length=400, Percent_Identity=30.75, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24581334, Length=338, Percent_Identity=34.6153846153846, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17737985, Length=358, Percent_Identity=31.0055865921788, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SHEHH (B0TUP4)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674431.1
- ProteinModelPortal:   B0TUP4
- SMR:   B0TUP4
- GeneID:   5906176
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2213
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- ProtClustDB:   PRK05431
- BioCyc:   SHAL458817:SHAL_2213-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47240; Mature: 47240

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPKFLRNELEVTAERLATRGFILDVERLGKLEDKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGEDVAPIMAQVGSLGEELDAKKAELASLLDELNSIAMSVPNLPDESAPIGADESEN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGTPKEYDFEVKDHVELGENIGGLDFKNAVKITGSRFIVMKGQIARMHRALAQFM
EEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEDSLMGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDTIVDEEELPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPENSM
HHHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCHHH
QALEELTAHAETVLQKLGLPYRTVVLCTGDMGFGSSKTYDIEVWLPAQNTFREISSCSNM
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHCCH
QDFQARRMQARYKAKTDKKPSLLHTLNGSGLAVGRTLVAVIENYQNADGSITVPEALRGY
HHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLEKIG
HHHHHHCC
>Mature Secondary Structure
MLDPKFLRNELEVTAERLATRGFILDVERLGKLEDKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGEDVAPIMAQVGSLGEELDAKKAELASLLDELNSIAMSVPNLPDESAPIGADESEN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGTPKEYDFEVKDHVELGENIGGLDFKNAVKITGSRFIVMKGQIARMHRALAQFM
EEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEDSLMGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDTIVDEEELPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVELVQLVKPENSM
HHHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCHHH
QALEELTAHAETVLQKLGLPYRTVVLCTGDMGFGSSKTYDIEVWLPAQNTFREISSCSNM
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHCCH
QDFQARRMQARYKAKTDKKPSLLHTLNGSGLAVGRTLVAVIENYQNADGSITVPEALRGY
HHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLEKIG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA