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The map label for this gene is mmgC [H]

Identifier: 167624070

GI number: 167624070

Start: 2585127

End: 2586335

Strand: Direct

Name: mmgC [H]

Synonym: Shal_2146

Alternate gene names: 167624070

Gene position: 2585127-2586335 (Clockwise)

Preceding gene: 167624069

Following gene: 167624071

Centisome position: 49.46

GC content: 41.94

Gene sequence:

>1209_bases
ATGGATTTTACCTTTACAGAAGAACAAGAAATGATCCGTGATACAGCCGTTTCTTTTCTTGCTGATATATCCGCGAGTAA
TCAAGTACGTTTGGTAATGGAAACACAAACCGGTTATGACAAAACACTTTGGAAAAAAGTTTGTGAAGAGATGTTTTGGC
AAGGTGTTACGGTACCTGAAGCTTATGGTGGCTTAGGACTTGGCTATGTAGAACTTGTTGCTTTGTTAGAAAAAATGGGA
GAACGACTGTTTTGTTCACCTTTTTATTCCACGATTGCTTTAGCTGCAAATGCATTATTAATTGCAGGCAATGAGCAGCA
AAAAAAACGTTATTTTGAAATTATTCTGGCGGGTGCTACTGCGACAGTTGCCTATACTGGAGCAAATGGTAGGTGGGATG
CGAAAGCGGTAGAAGCGCTGTGTGTCAAAGAGAATGGTCAATATAAATTAAATGGATGCTATCGATACGTTGTTGACGGT
CATAGCGCTAATTTCTTGATTGTTGCCGCAAGAAGCCTTGGCAGTGTCGGTGAGGAAGGAATAAGTTTGTTTGTTGTTGA
TGCTAACGCTGAAGGTGTGCAGCGCAATTGGCTACCGACCATGGATCAAACCCGTAAACAGGCTGAAGTTGTTTTTGAAA
ACGTTATAGTTGAGCCCTGTGCGTTACTAGGTGAGTTTGAACAAGGTTGGCAGAATCTATCGATTGTCATCGATTTAGCC
ACAATCGCAATTGCTGCCGATCAGGTCGGTGGCGCTCAAGCAGCGTTAGATCAAAGTGTAGATTACACCAAACAACGAGT
TCAATTTGGAAGAACTATCGCGTCATTTCAAGCGATTAAACACAAAGCTGCAGATATGATGCTCAAAGCTGAAGCTGCGC
GTTCATCAATATATTATGCAGCATGCGTTGCCGACCAATTTCTAAATTATAACGGCCAAGATGTTGATGGCATGCCTACT
CAGACGATAAACCCTTTGCGCAAAGAGTTAAGCGAAGTAGCGAGTATCGCGAAAGCCTATTGCAGTGATGCATATTTTTT
TAACGCTGGTTGCGGGATCCAACTTCACGGTGGCGTTGGTTTTACTCAAGAGTATGATATTCAACTTTATTTTAAACGAG
CCAAATCTACCGAGACATATTTAGGAAATAGCGCTTATCACCGTGAGCGTTTAGCCAATCTTATCCTCAAGCCAGGAGCT
TTATTATGA

Upstream 100 bases:

>100_bases
GACTCTATGCGTGCATTTTGGGGGCCGGGAAATGTTAAATCAGTTTCGAAGCCAGCTCCAATAACGGCTTAACGACTCAA
GAATAAATGGAGCCTAATAA

Downstream 100 bases:

>100_bases
AACTGAACTTTGATAAAGCGGATGAGTGCTTTCGTCACGAGGTTAGTCAATGGCTTAGTGAAAACTTGAGCGGAGAATTT
GAATGTGTTCGTGGCCGAGG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDFTFTEEQEMIRDTAVSFLADISASNQVRLVMETQTGYDKTLWKKVCEEMFWQGVTVPEAYGGLGLGYVELVALLEKMG
ERLFCSPFYSTIALAANALLIAGNEQQKKRYFEIILAGATATVAYTGANGRWDAKAVEALCVKENGQYKLNGCYRYVVDG
HSANFLIVAARSLGSVGEEGISLFVVDANAEGVQRNWLPTMDQTRKQAEVVFENVIVEPCALLGEFEQGWQNLSIVIDLA
TIAIAADQVGGAQAALDQSVDYTKQRVQFGRTIASFQAIKHKAADMMLKAEAARSSIYYAACVADQFLNYNGQDVDGMPT
QTINPLRKELSEVASIAKAYCSDAYFFNAGCGIQLHGGVGFTQEYDIQLYFKRAKSTETYLGNSAYHRERLANLILKPGA
LL

Sequences:

>Translated_402_residues
MDFTFTEEQEMIRDTAVSFLADISASNQVRLVMETQTGYDKTLWKKVCEEMFWQGVTVPEAYGGLGLGYVELVALLEKMG
ERLFCSPFYSTIALAANALLIAGNEQQKKRYFEIILAGATATVAYTGANGRWDAKAVEALCVKENGQYKLNGCYRYVVDG
HSANFLIVAARSLGSVGEEGISLFVVDANAEGVQRNWLPTMDQTRKQAEVVFENVIVEPCALLGEFEQGWQNLSIVIDLA
TIAIAADQVGGAQAALDQSVDYTKQRVQFGRTIASFQAIKHKAADMMLKAEAARSSIYYAACVADQFLNYNGQDVDGMPT
QTINPLRKELSEVASIAKAYCSDAYFFNAGCGIQLHGGVGFTQEYDIQLYFKRAKSTETYLGNSAYHRERLANLILKPGA
LL
>Mature_402_residues
MDFTFTEEQEMIRDTAVSFLADISASNQVRLVMETQTGYDKTLWKKVCEEMFWQGVTVPEAYGGLGLGYVELVALLEKMG
ERLFCSPFYSTIALAANALLIAGNEQQKKRYFEIILAGATATVAYTGANGRWDAKAVEALCVKENGQYKLNGCYRYVVDG
HSANFLIVAARSLGSVGEEGISLFVVDANAEGVQRNWLPTMDQTRKQAEVVFENVIVEPCALLGEFEQGWQNLSIVIDLA
TIAIAADQVGGAQAALDQSVDYTKQRVQFGRTIASFQAIKHKAADMMLKAEAARSSIYYAACVADQFLNYNGQDVDGMPT
QTINPLRKELSEVASIAKAYCSDAYFFNAGCGIQLHGGVGFTQEYDIQLYFKRAKSTETYLGNSAYHRERLANLILKPGA
LL

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=403, Percent_Identity=27.5434243176179, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI226958412, Length=400, Percent_Identity=25.25, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557231, Length=405, Percent_Identity=27.4074074074074, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI187960098, Length=401, Percent_Identity=27.1820448877805, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226958414, Length=361, Percent_Identity=25.7617728531856, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557233, Length=345, Percent_Identity=25.7971014492754, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4501857, Length=398, Percent_Identity=23.1155778894472, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21361497, Length=370, Percent_Identity=25.4054054054054, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI7656849, Length=402, Percent_Identity=22.3880597014925, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI76496475, Length=353, Percent_Identity=24.6458923512748, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4557235, Length=353, Percent_Identity=24.6458923512748, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786223, Length=406, Percent_Identity=23.1527093596059, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=23.7597911227154, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=349, Percent_Identity=27.2206303724928, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17506239, Length=407, Percent_Identity=25.5528255528256, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17538396, Length=365, Percent_Identity=27.1232876712329, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17569725, Length=420, Percent_Identity=27.3809523809524, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17534899, Length=407, Percent_Identity=27.027027027027, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17570075, Length=415, Percent_Identity=28.6746987951807, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71990804, Length=270, Percent_Identity=27.037037037037, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=27.1551724137931, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982178, Length=253, Percent_Identity=27.6679841897233, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71985184, Length=335, Percent_Identity=23.8805970149254, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17533517, Length=357, Percent_Identity=20.7282913165266, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356377, Length=353, Percent_Identity=28.6118980169972, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24646207, Length=357, Percent_Identity=29.4117647058824, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24666513, Length=400, Percent_Identity=25, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355753, Length=393, Percent_Identity=25.6997455470738, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24660351, Length=401, Percent_Identity=24.1895261845387, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363737, Length=379, Percent_Identity=23.2189973614776, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 44222; Mature: 44222

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTFTEEQEMIRDTAVSFLADISASNQVRLVMETQTGYDKTLWKKVCEEMFWQGVTVPE
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCH
AYGGLGLGYVELVALLEKMGERLFCSPFYSTIALAANALLIAGNEQQKKRYFEIILAGAT
HHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHCEEEEECCHHHHHHHHHHEEECCE
ATVAYTGANGRWDAKAVEALCVKENGQYKLNGCYRYVVDGHSANFLIVAARSLGSVGEEG
EEEEEECCCCCCCHHHHHHHEEECCCCEEECCEEEEEEECCCCCEEEEEECHHCCCCCCC
ISLFVVDANAEGVQRNWLPTMDQTRKQAEVVFENVIVEPCALLGEFEQGWQNLSIVIDLA
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEH
TIAIAADQVGGAQAALDQSVDYTKQRVQFGRTIASFQAIKHKAADMMLKAEAARSSIYYA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACVADQFLNYNGQDVDGMPTQTINPLRKELSEVASIAKAYCSDAYFFNAGCGIQLHGGVG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCC
FTQEYDIQLYFKRAKSTETYLGNSAYHRERLANLILKPGALL
CCEECCEEEEEEECCCCHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDFTFTEEQEMIRDTAVSFLADISASNQVRLVMETQTGYDKTLWKKVCEEMFWQGVTVPE
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCH
AYGGLGLGYVELVALLEKMGERLFCSPFYSTIALAANALLIAGNEQQKKRYFEIILAGAT
HHCCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHCEEEEECCHHHHHHHHHHEEECCE
ATVAYTGANGRWDAKAVEALCVKENGQYKLNGCYRYVVDGHSANFLIVAARSLGSVGEEG
EEEEEECCCCCCCHHHHHHHEEECCCCEEECCEEEEEEECCCCCEEEEEECHHCCCCCCC
ISLFVVDANAEGVQRNWLPTMDQTRKQAEVVFENVIVEPCALLGEFEQGWQNLSIVIDLA
CEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEH
TIAIAADQVGGAQAALDQSVDYTKQRVQFGRTIASFQAIKHKAADMMLKAEAARSSIYYA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACVADQFLNYNGQDVDGMPTQTINPLRKELSEVASIAKAYCSDAYFFNAGCGIQLHGGVG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCC
FTQEYDIQLYFKRAKSTETYLGNSAYHRERLANLILKPGALL
CCEECCEEEEEEECCCCHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]