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The map label for this gene is catF [H]

Identifier: 167624056

GI number: 167624056

Start: 2567116

End: 2568270

Strand: Direct

Name: catF [H]

Synonym: Shal_2132

Alternate gene names: 167624056

Gene position: 2567116-2568270 (Clockwise)

Preceding gene: 167624055

Following gene: 167624057

Centisome position: 49.11

GC content: 47.36

Gene sequence:

>1155_bases
ATGCCAAATGCATATATTGTTGATGCACTTCGAACGCCAACAGGGCGTCGTAAAGGAGGCTTGTCTCATATACACGCCAT
TGATTTAGCGGCTCACTCATTAAAGGCATTAGTAGAACGTAATGCTATTCCTGCAGCAGATTATGACGACGTTATTTTTG
GTTGTGTCGATACTATCGGTTCACAAGCTGGCAATATTGCACGTACTTCATGGCTAGCTGCAGGGTTACCGCTGAATGTA
CCCGGCACCACGGTAGACCGCCAATGCGGCTCGTCACAACAAGCAATACATTTTGCAGCCCAAGCAGTGATGAGCGGCAC
CCAAGATGTGATTGCTGTGGGGGGCGTGCAGACGATGACACAAATACCGATATCTTCTGCAATGTTAGCTGGCCAACCTC
TGGGATTTAGCACGCCATTTGCAGAAAGTGAGCTGTGGCATAAACGCTTTGGTGATGCACCTGTCGATCAGTTTTATGCG
GCGCAGCGTATCGCAGATAAATGGCAACTTAGTCGAGACATGATGGAGTCATTTTCACTAGAGAGCCATAACCGCGCATT
AGCCGCGATTAAAGAAGGCTACTTTGACCGAGAGATTGTGCCATTAGCCGGGGTCACTCAAGATGAAACCCCAAGGGTAT
CAAGCCTTGAGAAAATGGCGTCTCTTGAACCTGTAGGCGATGCGTATCCGTCAATTACAGCAGCAGTGTCGAGTCAAACC
TGTGATGCTTCGGCAGCCATGTTAATTGTCTCTGAAGAGGCGTTGGCTAAGTATCAACTTAAACCTCGTGCTCGCATTCA
TCATCTAAGTGTACTTGGTGATGATCCTATCTGGCATTTAACTGCACCTATTGCTGCAACGAAAGCGGCATTACAAAAAG
CTGGCATGACTCTAGATGATATTGATTTAGTTGAAATCAATGAAGCTTTTGCATCGGTTGCGATGGCTTGGCTTAAAGAA
ACAGGTTACAGCCATGATAAAACCAATGTTAATGGTGGTGCAATTGCACTTGGGCATCCTTTAGGCGCGACAGGAGTTCG
CTTAATGACAGGTTTGTTACACGAGCTAGAGCGGCGCGGTGGGCGCTTTGGGTTACAAACAATGTGTGAGGGCGGTGGCC
TTGCCAATGTCACCATTATTGAGCGTTTGTCATAA

Upstream 100 bases:

>100_bases
CAACCTGGGGAGATGTGAGCTTTCATAAAGCCAGAGTCAATGAGTTTGTATTTGATCAAAATTGCAAAATTGGCCCAGGC
CAAACCTTTGGGAGAACGTA

Downstream 100 bases:

>100_bases
GCGACTTGAGCCAATACAAAAACAATAAAAGTTAGTGCAATTGAGGGAGCATAGAATGAAAGCATGTAATTCGAGAACCG
TAATTATTACCGGCAGTGGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MPNAYIVDALRTPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIGSQAGNIARTSWLAAGLPLNV
PGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMTQIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYA
AQRIADKWQLSRDMMESFSLESHNRALAAIKEGYFDREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CDASAAMLIVSEEALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDDIDLVEINEAFASVAMAWLKE
TGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRGGRFGLQTMCEGGGLANVTIIERLS

Sequences:

>Translated_384_residues
MPNAYIVDALRTPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIGSQAGNIARTSWLAAGLPLNV
PGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMTQIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYA
AQRIADKWQLSRDMMESFSLESHNRALAAIKEGYFDREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CDASAAMLIVSEEALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDDIDLVEINEAFASVAMAWLKE
TGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRGGRFGLQTMCEGGGLANVTIIERLS
>Mature_383_residues
PNAYIVDALRTPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIGSQAGNIARTSWLAAGLPLNVP
GTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMTQIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYAA
QRIADKWQLSRDMMESFSLESHNRALAAIKEGYFDREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQTC
DASAAMLIVSEEALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDDIDLVEINEAFASVAMAWLKET
GYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRGGRFGLQTMCEGGGLANVTIIERLS

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=36.2944162436548, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=36.5038560411311, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=31.2182741116751, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=32.9439252336449, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=31.8987341772152, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI194353979, Length=383, Percent_Identity=26.8929503916449, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=39.5989974937343, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=38.4615384615385, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=38.0710659898477, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=37.6237623762376, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=31.2039312039312, Blast_Score=148, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=33.502538071066, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=31.1392405063291, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=396, Percent_Identity=31.5656565656566, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=434, Percent_Identity=30.4147465437788, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=28.6783042394015, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=34.0740740740741, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6322031, Length=389, Percent_Identity=29.8200514138817, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24655093, Length=395, Percent_Identity=36.4556962025316, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=35.0383631713555, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24640423, Length=395, Percent_Identity=32.6582278481013, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=32.4009324009324, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 40939; Mature: 40808

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNAYIVDALRTPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIG
CCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SQAGNIARTSWLAAGLPLNVPGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMT
HCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
QIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYAAQRIADKWQLSRDMMESFSL
HCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ESHNRALAAIKEGYFDREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCC
CDASAAMLIVSEEALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDD
CCCCEEEEEEEHHHHHHHCCCCCHHEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCCCC
IDLVEINEAFASVAMAWLKETGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
GRFGLQTMCEGGGLANVTIIERLS
CCCCHHHHHCCCCEEEEEEEEECC
>Mature Secondary Structure 
PNAYIVDALRTPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIG
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SQAGNIARTSWLAAGLPLNVPGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMT
HCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
QIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYAAQRIADKWQLSRDMMESFSL
HCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ESHNRALAAIKEGYFDREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCC
CDASAAMLIVSEEALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDD
CCCCEEEEEEEHHHHHHHCCCCCHHEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCCCC
IDLVEINEAFASVAMAWLKETGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
GRFGLQTMCEGGGLANVTIIERLS
CCCCHHHHHCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]