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The map label for this gene is yngJ [H]

Identifier: 167624055

GI number: 167624055

Start: 2566040

End: 2567116

Strand: Direct

Name: yngJ [H]

Synonym: Shal_2131

Alternate gene names: 167624055

Gene position: 2566040-2567116 (Clockwise)

Preceding gene: 167624054

Following gene: 167624056

Centisome position: 49.09

GC content: 47.26

Gene sequence:

>1077_bases
ATGGACTTTACATTCACAGAAGACGAACTCGCATTTCGAGAAGCCATCAGTCGATTTTTAATGACGGAAGCGGCGCCTGA
AGCATTAAGAGAGATTTGGGAGACTGATACGGGGCGATCTCCTGAACTGCGCAATAAAATTGCCGAGCAAGGCTTAACTG
CTCTATCTATTCCCGAAGAGAGCGGAGGCTTGGGCCTTGGTGACGTCGCATGGTCTTTAATGACCCAAGAGTTGGGTTAT
TACGGGATCCCCGATAGCTTAGCCGATACCGCATATCTTGCTGCTGGTGTGCTGTCTGCACTGCCGCAAACTGACAATGC
AGAACGCAATGAGCAGATTAAGCAATGGCTAGTAGCTATAGGCGAAGGCAGTATTCGTGTTGCTGTTGGCCACCCAGTTA
ATCCGCTCGTGGCCGACGCTGCAGTAGCGGATCTGTTAATCCTGCTCGATGGTGATGATGTACATGCCGTTACACGTAAA
GATATTGATGTAGTGCTCCGTCCAAGTATCGATTCATCAAGACGGCTTGCTAAGGTCAGTTGGCAACCTAGCAGCGATAG
TTTGCTTGCTACAGGTGAAGTCGGCAAAGCGATTCAACAGCAAATATTAAACCGCGGCGCTCTATCAGCGGCAGGGCAGT
TGTTAGGGTTAGCGCAACGCATGCTGGATCTGTCTATTGATTATGTTGCACAGCGCAAGCAATTTGGACGTGTAATCGGC
AGTTTTCAAGCCGTTAAACATCACTTGGCGGATGTGGCATCAAAAATTGAGATGGCAAAACCCGTGTTATACCGTGCAGC
AAAAGAGTTTGAGCAAGGATGTTGCGATTCTTCAGTCTATATTTCTCAAGCCAAGGTTTTTTGCGCTGAAGCTGCGCACT
TGGCAGCAAGAAATGGTATTCAAGTTCATGGCGCAATGGGATACACCTGGGAAGTTGATTTACAGATGTTTATGAAACGC
ACTTGGGTTTTAGAATCAACCTGGGGAGATGTGAGCTTTCATAAAGCCAGAGTCAATGAGTTTGTATTTGATCAAAATTG
CAAAATTGGCCCAGGCCAAACCTTTGGGAGAACGTAA

Upstream 100 bases:

>100_bases
TATTTGCGCAAGCGGGTCCTATTTATGCGGGCTCTAATGAAATTCAACGCAACATTATTGCTGAACGTATGCTTGGCCTG
CCACGAGCCTAGGGGGAATT

Downstream 100 bases:

>100_bases
TGCCAAATGCATATATTGTTGATGCACTTCGAACGCCAACAGGGCGTCGTAAAGGAGGCTTGTCTCATATACACGCCATT
GATTTAGCGGCTCACTCATT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MDFTFTEDELAFREAISRFLMTEAAPEALREIWETDTGRSPELRNKIAEQGLTALSIPEESGGLGLGDVAWSLMTQELGY
YGIPDSLADTAYLAAGVLSALPQTDNAERNEQIKQWLVAIGEGSIRVAVGHPVNPLVADAAVADLLILLDGDDVHAVTRK
DIDVVLRPSIDSSRRLAKVSWQPSSDSLLATGEVGKAIQQQILNRGALSAAGQLLGLAQRMLDLSIDYVAQRKQFGRVIG
SFQAVKHHLADVASKIEMAKPVLYRAAKEFEQGCCDSSVYISQAKVFCAEAAHLAARNGIQVHGAMGYTWEVDLQMFMKR
TWVLESTWGDVSFHKARVNEFVFDQNCKIGPGQTFGRT

Sequences:

>Translated_358_residues
MDFTFTEDELAFREAISRFLMTEAAPEALREIWETDTGRSPELRNKIAEQGLTALSIPEESGGLGLGDVAWSLMTQELGY
YGIPDSLADTAYLAAGVLSALPQTDNAERNEQIKQWLVAIGEGSIRVAVGHPVNPLVADAAVADLLILLDGDDVHAVTRK
DIDVVLRPSIDSSRRLAKVSWQPSSDSLLATGEVGKAIQQQILNRGALSAAGQLLGLAQRMLDLSIDYVAQRKQFGRVIG
SFQAVKHHLADVASKIEMAKPVLYRAAKEFEQGCCDSSVYISQAKVFCAEAAHLAARNGIQVHGAMGYTWEVDLQMFMKR
TWVLESTWGDVSFHKARVNEFVFDQNCKIGPGQTFGRT
>Mature_358_residues
MDFTFTEDELAFREAISRFLMTEAAPEALREIWETDTGRSPELRNKIAEQGLTALSIPEESGGLGLGDVAWSLMTQELGY
YGIPDSLADTAYLAAGVLSALPQTDNAERNEQIKQWLVAIGEGSIRVAVGHPVNPLVADAAVADLLILLDGDDVHAVTRK
DIDVVLRPSIDSSRRLAKVSWQPSSDSLLATGEVGKAIQQQILNRGALSAAGQLLGLAQRMLDLSIDYVAQRKQFGRVIG
SFQAVKHHLADVASKIEMAKPVLYRAAKEFEQGCCDSSVYISQAKVFCAEAAHLAARNGIQVHGAMGYTWEVDLQMFMKR
TWVLESTWGDVSFHKARVNEFVFDQNCKIGPGQTFGRT

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=362, Percent_Identity=23.7569060773481, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4557231, Length=364, Percent_Identity=26.6483516483516, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI187960098, Length=364, Percent_Identity=26.6483516483516, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI226958412, Length=369, Percent_Identity=23.0352303523035, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4557233, Length=319, Percent_Identity=25.3918495297806, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21361497, Length=136, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI226958414, Length=360, Percent_Identity=22.5, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17570075, Length=371, Percent_Identity=25.6064690026954, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506239, Length=367, Percent_Identity=23.9782016348774, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=393, Percent_Identity=23.4096692111959, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=343, Percent_Identity=23.3236151603499, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508101, Length=170, Percent_Identity=29.4117647058824, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71990804, Length=84, Percent_Identity=41.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=315, Percent_Identity=26.984126984127, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24666513, Length=344, Percent_Identity=24.1279069767442, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=24.1286863270777, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 39140; Mature: 39140

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTFTEDELAFREAISRFLMTEAAPEALREIWETDTGRSPELRNKIAEQGLTALSIPEE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCC
SGGLGLGDVAWSLMTQELGYYGIPDSLADTAYLAAGVLSALPQTDNAERNEQIKQWLVAI
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GEGSIRVAVGHPVNPLVADAAVADLLILLDGDDVHAVTRKDIDVVLRPSIDSSRRLAKVS
CCCCEEEEECCCCCHHHHHHHHHHEEEEECCCCEEHHHHCCCCEEEECCCCCCCCEEEEE
WQPSSDSLLATGEVGKAIQQQILNRGALSAAGQLLGLAQRMLDLSIDYVAQRKQFGRVIG
CCCCCCCEEECCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFQAVKHHLADVASKIEMAKPVLYRAAKEFEQGCCDSSVYISQAKVFCAEAAHLAARNGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
QVHGAMGYTWEVDLQMFMKRTWVLESTWGDVSFHKARVNEFVFDQNCKIGPGQTFGRT
EEEECCCCEEEHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFTFTEDELAFREAISRFLMTEAAPEALREIWETDTGRSPELRNKIAEQGLTALSIPEE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCC
SGGLGLGDVAWSLMTQELGYYGIPDSLADTAYLAAGVLSALPQTDNAERNEQIKQWLVAI
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GEGSIRVAVGHPVNPLVADAAVADLLILLDGDDVHAVTRKDIDVVLRPSIDSSRRLAKVS
CCCCEEEEECCCCCHHHHHHHHHHEEEEECCCCEEHHHHCCCCEEEECCCCCCCCEEEEE
WQPSSDSLLATGEVGKAIQQQILNRGALSAAGQLLGLAQRMLDLSIDYVAQRKQFGRVIG
CCCCCCCEEECCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFQAVKHHLADVASKIEMAKPVLYRAAKEFEQGCCDSSVYISQAKVFCAEAAHLAARNGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
QVHGAMGYTWEVDLQMFMKRTWVLESTWGDVSFHKARVNEFVFDQNCKIGPGQTFGRT
EEEECCCCEEEHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]