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The map label for this gene is csgA [H]

Identifier: 167623997

GI number: 167623997

Start: 2495819

End: 2496511

Strand: Direct

Name: csgA [H]

Synonym: Shal_2071

Alternate gene names: 167623997

Gene position: 2495819-2496511 (Clockwise)

Preceding gene: 167623996

Following gene: 167623998

Centisome position: 47.75

GC content: 44.73

Gene sequence:

>693_bases
GTGAAGCATGTCGTCATCACTGGTGCGAACCGCGGAATTGGTCTTGCCTTTGTTGGGCATTACTTAACAACAGGTTGGCA
GGTCACCGCTTGCTGTCGAAATCTGAATGATGCAGTTGCGTTGCAGCACCAGCAATCAAAATTTACAGCACTAAAGCTTG
TGGAGCTGGATGTCACAATTCCTAGTTCTATCGCAGAATTGAAGCGATCACTAGGCTCTGAAGCTATCGACTTACTGATT
AATAATGCAGGATATTATGGACCAAAGGGAGTGCGCTTTGGTACAACGGATATAAACCAATGGCAGGCGGTGTTAGCGGT
TAACACTATCGCGCCGCTTATCCTGACTGAAACCTTGTATCCTAACTTAAAGATTGCGCAAAACTGTGTTTTGGCATTTA
TCTCCTCAAAGGTTGGAAGCATGCAAGATAATAGCAGTGGTGGCGGCTATTATTACCGCTCCTCAAAAGCAGCATTAAAC
TCAGTTGTTAAGTCTCTTTCAATCGATCTTATTCAAGATGGAATCAAATGTGTGGTACTGCACCCGGGGTGGGTACAAAC
CGAGATGGGCGGACCCAATGCGCTGATTGATACTGACACATCGGTAAAGGGAATGACTCAAGTTATCGATGGCTTAACAC
AAGAACAAAGCGGTCATTTTTATGATTACCAAGGGAAAACCATCCCTTGGTAA

Upstream 100 bases:

>100_bases
GGAAGATTTTCCTGCCTTAGAGTCTGCCTAAGAGGCAGTTACTGCTAAACTAACGATTGGACAGGTTTGTTAGCTAATGG
TTTTTTAGGGAGAGTAATTT

Downstream 100 bases:

>100_bases
AATTTGCTTTATTTTAAAGGGGGTTTTTCATCAGCAGTGCGACTTTGTTTGGTGATTGCCCCGTCACTCAGTTTTATAGC
TGCGCGGAAGGTGAAAAGTT

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKHVVITGANRGIGLAFVGHYLTTGWQVTACCRNLNDAVALQHQQSKFTALKLVELDVTIPSSIAELKRSLGSEAIDLLI
NNAGYYGPKGVRFGTTDINQWQAVLAVNTIAPLILTETLYPNLKIAQNCVLAFISSKVGSMQDNSSGGGYYYRSSKAALN
SVVKSLSIDLIQDGIKCVVLHPGWVQTEMGGPNALIDTDTSVKGMTQVIDGLTQEQSGHFYDYQGKTIPW

Sequences:

>Translated_230_residues
MKHVVITGANRGIGLAFVGHYLTTGWQVTACCRNLNDAVALQHQQSKFTALKLVELDVTIPSSIAELKRSLGSEAIDLLI
NNAGYYGPKGVRFGTTDINQWQAVLAVNTIAPLILTETLYPNLKIAQNCVLAFISSKVGSMQDNSSGGGYYYRSSKAALN
SVVKSLSIDLIQDGIKCVVLHPGWVQTEMGGPNALIDTDTSVKGMTQVIDGLTQEQSGHFYDYQGKTIPW
>Mature_230_residues
MKHVVITGANRGIGLAFVGHYLTTGWQVTACCRNLNDAVALQHQQSKFTALKLVELDVTIPSSIAELKRSLGSEAIDLLI
NNAGYYGPKGVRFGTTDINQWQAVLAVNTIAPLILTETLYPNLKIAQNCVLAFISSKVGSMQDNSSGGGYYYRSSKAALN
SVVKSLSIDLIQDGIKCVVLHPGWVQTEMGGPNALIDTDTSVKGMTQVIDGLTQEQSGHFYDYQGKTIPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=27.8947368421053, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17558994, Length=243, Percent_Identity=32.5102880658436, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17558990, Length=255, Percent_Identity=31.3725490196078, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17559962, Length=251, Percent_Identity=31.8725099601594, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559964, Length=246, Percent_Identity=31.3008130081301, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17532177, Length=247, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193207563, Length=240, Percent_Identity=29.5833333333333, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17558992, Length=241, Percent_Identity=33.195020746888, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17541382, Length=256, Percent_Identity=30.46875, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17558996, Length=254, Percent_Identity=29.1338582677165, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI72001658, Length=248, Percent_Identity=30.6451612903226, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17542178, Length=244, Percent_Identity=29.5081967213115, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=237, Percent_Identity=28.2700421940928, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322779, Length=252, Percent_Identity=28.1746031746032, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640547, Length=248, Percent_Identity=33.8709677419355, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI23397609, Length=212, Percent_Identity=28.7735849056604, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24866; Mature: 24866

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVVITGANRGIGLAFVGHYLTTGWQVTACCRNLNDAVALQHQQSKFTALKLVELDVTI
CCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCEEEEEEEEEEEC
PSSIAELKRSLGSEAIDLLINNAGYYGPKGVRFGTTDINQWQAVLAVNTIAPLILTETLY
CHHHHHHHHHHCHHHHHHEECCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHC
PNLKIAQNCVLAFISSKVGSMQDNSSGGGYYYRSSKAALNSVVKSLSIDLIQDGIKCVVL
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEE
HPGWVQTEMGGPNALIDTDTSVKGMTQVIDGLTQEQSGHFYDYQGKTIPW
CCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCC
>Mature Secondary Structure
MKHVVITGANRGIGLAFVGHYLTTGWQVTACCRNLNDAVALQHQQSKFTALKLVELDVTI
CCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCCEEEEEEEEEEEC
PSSIAELKRSLGSEAIDLLINNAGYYGPKGVRFGTTDINQWQAVLAVNTIAPLILTETLY
CHHHHHHHHHHCHHHHHHEECCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHC
PNLKIAQNCVLAFISSKVGSMQDNSSGGGYYYRSSKAALNSVVKSLSIDLIQDGIKCVVL
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEE
HPGWVQTEMGGPNALIDTDTSVKGMTQVIDGLTQEQSGHFYDYQGKTIPW
CCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]