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The map label for this gene is thrS [H]

Identifier: 167623946

GI number: 167623946

Start: 2437381

End: 2439309

Strand: Direct

Name: thrS [H]

Synonym: Shal_2020

Alternate gene names: 167623946

Gene position: 2437381-2439309 (Clockwise)

Preceding gene: 167623943

Following gene: 167623947

Centisome position: 46.63

GC content: 44.58

Gene sequence:

>1929_bases
ATGCCTGTTATTACACTTCCTGACGGAAGCAAACGTGAGTTTGCTAACCCTGTTTCTACTTTAGATGTTGCTGCCGATAT
TGGTCCTGGTCTTGCTAAAGCGTGTATCGCTGGTCGCGTGAACGGTGAGCTTAAAGATGCGTGCGATATAATTGAAACTG
ATTCAGAACTTTCAATCATCACAGCTAAAGATGAAGAGGGCGTAGAAATTCTTCGTCACTCATGCGCTCACTTGCTTGGA
CATGCGATCAAGCAACTGTTCCCAGAAACCAAAATGGCTATCGGCCCAGTTATCGATAATGGTTTCTACTATGACATTGA
CTTAGATCATAAGTTGACTCAGGAAGACATCGATGCGTTAGAAAAGCGCATGGCAGCACTTGCAAAGACAAACTACGCCG
TTGATAAGCGTGTTGTGAGCTGGCAAGAAGCGCGTGATACCTTTGAAGCGCGTGGTGAAGATTACAAGATGGCGATCTTG
GATGAAAACATCCCGAAAGATTCTACGCCAGCGCTTTATCACCATGAAGAATATATCGACATGTGTCGTGGTCCGCACGT
ACCAAACATGAAGTTCTGTCAGAACTTTAAGTTGATGAGTGTTGCTGGTGCATATTGGCGCGGTAACTCTGACAACAAGA
TGTTGCAGCGTGTTTACGGTACAGCATGGGCAGACAAGAAAGCCCTTAAAGTACACCTTAACCGTCTTGAAGAAGCGGCT
AAGCGTGACCACCGTAAAATTGGTAAGCAGCTTGACCTTTACCATATGCAAGAAGAAGCACCTGGCATGGTGTTCTGGCA
TAACGATGGTTGGAGCCTGTTCCTAGAGCTTGAGAAGTTTATTCGTCAAAAGCTTGGTCAGTACACCTACCAGGAAGTTA
AAGGTCCATTAATGATGGACCGAGTATTGTGGGAACGTAGTGGTCACTGGGATAAGTACTCAGACGCTATGTTTACAACA
AGCTCAGAAAACCGTGAGTACGCTATTAAGCCAATGAACTGCCCTGGCCACGTTCAGATCTTTAACCAAGGTCTTAAGTC
ATACCGTGACTTGCCACTTCGTATGGCTGAATTTGGTTGTTGTCACCGTAATGAGCCATCGGGTTCACTACACGGCCTAA
TGCGCGTTCGTGGCTTTACTCAAGATGACGCACATATTTTCTGTACTGAAGAGCAAGTTCAGCAAGAAGTGAGTGCGTGT
ATCAGGATGGTGTACGACACATACGCAACATTCGGTTTTAGCAATATCGTTGTTAAGCTATCGACTCGCCCTGAAAAGCG
TATCGGTGATGACGATATGTGGGATCGTGCAGAAGAAGCGCTTAAGAAAGCACTTAAAGCAAACGACATCGAATTTGAAA
TTTTACCGGGCGAGGGTGCGTTCTACGGACCTAAAATTGAATTTACATTGCATGACTGTCTAGACAGAGCGTGGCAATGT
GGTACAGTGCAGCTCGATTATGCTCTGCCGGGTCGTTTAGGTGCAACTTATGTTGCTGAAGATAACAGTCGTCAAACACC
TGTTATGATCCACCGTGCGATTTTGGGGTCATTAGAGCGTTTCTTGGGTATTCTAATTGAAGAGTACGCAGGCAAGTTCC
CAGCTTGGTTGTCACCAGTTCAAGTTGTTGTCATGAATATTACCGATAAACAGTCCGATTATGTGGATAATGTCGTTAAT
TTATTTAAAGAACATGGAATTCGTGCAACTAAAGACTTGAGGAATGAGAAGATTGGCTTTAAAATACGTGAACATACTTT
AAGGCGAGTGCCTTATTTGCTGGTCGTTGGCGATCAGGAAATGGAAAATAATGAAGTAGCGGTGCGTACCCGTGAAGGAG
TTGACTTAGGTAAGATGCAACTCGAAGAGTTTGCAACTAAGCTCAAAAACCAGATTTCGCTCCGTAGTCTCAATTTGTTG
GAGGATTAG

Upstream 100 bases:

>100_bases
CACAGACTCCAGTAAGGTCTAGTCCCAGTAGCGTAAACACATACTTAATTTTAAAACCAAGTGGCCCTACGTAGGGGTCA
CCACTGGAAAAGGAATCATC

Downstream 100 bases:

>100_bases
GTCATAAAGATCAAAAAAACAGCAGGGCGCCAGGCGGCCCCGAACAGAATTAACGAGCTCATTACTGGTGTAACAGAAGT
CCGTCTTAACGGTCTTGACG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPVITLPDGSKREFANPVSTLDVAADIGPGLAKACIAGRVNGELKDACDIIETDSELSIITAKDEEGVEILRHSCAHLLG
HAIKQLFPETKMAIGPVIDNGFYYDIDLDHKLTQEDIDALEKRMAALAKTNYAVDKRVVSWQEARDTFEARGEDYKMAIL
DENIPKDSTPALYHHEEYIDMCRGPHVPNMKFCQNFKLMSVAGAYWRGNSDNKMLQRVYGTAWADKKALKVHLNRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELEKFIRQKLGQYTYQEVKGPLMMDRVLWERSGHWDKYSDAMFTT
SSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQQEVSAC
IRMVYDTYATFGFSNIVVKLSTRPEKRIGDDDMWDRAEEALKKALKANDIEFEILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPGRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGKFPAWLSPVQVVVMNITDKQSDYVDNVVN
LFKEHGIRATKDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENNEVAVRTREGVDLGKMQLEEFATKLKNQISLRSLNLL
ED

Sequences:

>Translated_642_residues
MPVITLPDGSKREFANPVSTLDVAADIGPGLAKACIAGRVNGELKDACDIIETDSELSIITAKDEEGVEILRHSCAHLLG
HAIKQLFPETKMAIGPVIDNGFYYDIDLDHKLTQEDIDALEKRMAALAKTNYAVDKRVVSWQEARDTFEARGEDYKMAIL
DENIPKDSTPALYHHEEYIDMCRGPHVPNMKFCQNFKLMSVAGAYWRGNSDNKMLQRVYGTAWADKKALKVHLNRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELEKFIRQKLGQYTYQEVKGPLMMDRVLWERSGHWDKYSDAMFTT
SSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQQEVSAC
IRMVYDTYATFGFSNIVVKLSTRPEKRIGDDDMWDRAEEALKKALKANDIEFEILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPGRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGKFPAWLSPVQVVVMNITDKQSDYVDNVVN
LFKEHGIRATKDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENNEVAVRTREGVDLGKMQLEEFATKLKNQISLRSLNLL
ED
>Mature_641_residues
PVITLPDGSKREFANPVSTLDVAADIGPGLAKACIAGRVNGELKDACDIIETDSELSIITAKDEEGVEILRHSCAHLLGH
AIKQLFPETKMAIGPVIDNGFYYDIDLDHKLTQEDIDALEKRMAALAKTNYAVDKRVVSWQEARDTFEARGEDYKMAILD
ENIPKDSTPALYHHEEYIDMCRGPHVPNMKFCQNFKLMSVAGAYWRGNSDNKMLQRVYGTAWADKKALKVHLNRLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELEKFIRQKLGQYTYQEVKGPLMMDRVLWERSGHWDKYSDAMFTTS
SENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQQEVSACI
RMVYDTYATFGFSNIVVKLSTRPEKRIGDDDMWDRAEEALKKALKANDIEFEILPGEGAFYGPKIEFTLHDCLDRAWQCG
TVQLDYALPGRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGKFPAWLSPVQVVVMNITDKQSDYVDNVVNL
FKEHGIRATKDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENNEVAVRTREGVDLGKMQLEEFATKLKNQISLRSLNLLE
D

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=619, Percent_Identity=40.5492730210016, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI38202255, Length=637, Percent_Identity=38.4615384615385, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI20070344, Length=646, Percent_Identity=36.5325077399381, Blast_Score=394, Evalue=1e-109,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=76.1682242990654, Blast_Score=1055, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=630, Percent_Identity=37.6190476190476, Blast_Score=450, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71984192, Length=630, Percent_Identity=37.6190476190476, Blast_Score=450, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322112, Length=650, Percent_Identity=37.3846153846154, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=37.5314861460957, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24583839, Length=629, Percent_Identity=39.5866454689984, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583842, Length=629, Percent_Identity=39.5866454689984, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI28574141, Length=629, Percent_Identity=39.5866454689984, Blast_Score=472, Evalue=1e-133,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73330; Mature: 73198

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITLPDGSKREFANPVSTLDVAADIGPGLAKACIAGRVNGELKDACDIIETDSELSII
CCEEECCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
TAKDEEGVEILRHSCAHLLGHAIKQLFPETKMAIGPVIDNGFYYDIDLDHKLTQEDIDAL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEECCCEEEEEECCCCCCHHHHHHH
EKRMAALAKTNYAVDKRVVSWQEARDTFEARGEDYKMAILDENIPKDSTPALYHHEEYID
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHCCHHHHH
MCRGPHVPNMKFCQNFKLMSVAGAYWRGNSDNKMLQRVYGTAWADKKALKVHLNRLEEAA
HHCCCCCCCHHHHCCCCHHHHCCHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELEKFIRQKLGQYTYQEVKGPLMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWERSGHWDKYSDAMFTTSSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQQEVSACIRMVYDTYATFGFSNIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGDDDMWDRAEEALKKALKANDIEFEILPGEGAFYGPKIEFTLHDCLDRAWQC
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPGRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGKFPAWLSPV
CCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCE
QVVVMNITDKQSDYVDNVVNLFKEHGIRATKDLRNEKIGFKIREHTLRRVPYLLVVGDQE
EEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
MENNEVAVRTREGVDLGKMQLEEFATKLKNQISLRSLNLLED
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVITLPDGSKREFANPVSTLDVAADIGPGLAKACIAGRVNGELKDACDIIETDSELSII
CEEECCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
TAKDEEGVEILRHSCAHLLGHAIKQLFPETKMAIGPVIDNGFYYDIDLDHKLTQEDIDAL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEECCCEEEEEECCCCCCHHHHHHH
EKRMAALAKTNYAVDKRVVSWQEARDTFEARGEDYKMAILDENIPKDSTPALYHHEEYID
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHCCHHHHH
MCRGPHVPNMKFCQNFKLMSVAGAYWRGNSDNKMLQRVYGTAWADKKALKVHLNRLEEAA
HHCCCCCCCHHHHCCCCHHHHCCHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSLFLELEKFIRQKLGQYTYQEVKGPLMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWERSGHWDKYSDAMFTTSSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQVQQEVSACIRMVYDTYATFGFSNIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
STRPEKRIGDDDMWDRAEEALKKALKANDIEFEILPGEGAFYGPKIEFTLHDCLDRAWQC
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPGRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGKFPAWLSPV
CCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCE
QVVVMNITDKQSDYVDNVVNLFKEHGIRATKDLRNEKIGFKIREHTLRRVPYLLVVGDQE
EEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCC
MENNEVAVRTREGVDLGKMQLEEFATKLKNQISLRSLNLLED
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA