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The map label for this gene is yiaY [H]

Identifier: 167623814

GI number: 167623814

Start: 2262095

End: 2263327

Strand: Direct

Name: yiaY [H]

Synonym: Shal_1884

Alternate gene names: 167623814

Gene position: 2262095-2263327 (Clockwise)

Preceding gene: 167623813

Following gene: 167623816

Centisome position: 43.28

GC content: 51.58

Gene sequence:

>1233_bases
ATGGAACACAATACTAAAAGTAGGCTTTTTCCGCTTCAGGTTTTGGCGTACAAGGGTTATATGAAGGCGTTGAAGCTGGC
GGCCAAGATAATCCCCATGCCGAAGCCAACCCTTTTTACCGGCGAGGGTTCATCATTAGAACTGTGTGATGCCATGGCAC
ATATGGGGATGAAGAGGGTACTTATTGTCACCGACAGCGTTTTGATTAAGTTGGGGCTTTTAGATGCAATTCAAAGCCGC
CTAACGGACAGTAATGTTGAATATGTCATCTATGATGGTGTGCTGCCCGATCCTACCTATACCCAGGTAGAGTCCGGCTT
AGCCCTCTATAATCGTCATCGTTGCGATTCCATTTTGGCCGTCGGCGGGGGCTCGCCGATTGATGCCGCAAAAGTGATCG
CCGCAAGAGTGAATAACCATCGAAAGATAGAGAAGCTCACCGGCCTATTTCGGGTATGGAGAGCGCCTGCGCCGCTGTTT
GCCATACCGACAACGGCGGGGACGGGATCAGAGGTGACTATCGCCGCAGTGGTTTCCGACCCCTTGACTCATAAGAAGAC
ACCACTTATCGATCCAAAGCTTGTGCCTATGATGGCTTCGCTGGATGCGTCGTTAATGACGGGTTTGCCGCCTCATGTGA
CGAGTGCAACGGGGATGGATGCACTGACTCATGCCGTCGAGGCGTTTATCTCTATGAACGCTTCAGCCGATACCGATGCC
TACGCGATAGCGGCGACGCGCCTTATCATGCAGAACTTATCGAAAGTGGTTATGGATGGCAGCGATATCGAGGCGCGGCA
CAATATGGCGATGGCCTCTTATTACGCAGGTCTGGCGTTTACCAAGGCAAGCCTAGGTTATGTGCACGCTATCTCTCATA
ATCTGGGGGCTAAATATGGCACCCCACACGGTCTGGCCAATGCCATCGTCTTGCCCTATGTTCTCGATTATTCAAAGGAG
GAGATAGTGCCCCGTCTGGCCGAACTCTCACGCATCTGCGGTCTTGGTAAGGACTGTGATAGTGATGAGGAGCTGGCGCA
GGTATTTATCGAGCATATTCAGGGGATGCTCAATGAGTATGGCATCGCTTCGCAGCTCGATACCCTTAAGGTTGAAGATG
TGCCAGAGTTAGCTAGGGCGGCGCTGAAGGAGGCGCATTTTAACTATCCGGTGCCCAAATATATGGATCAGCTTCAGTGT
GAGGCGCTTATCAGGCAGATGCTAGTGGTGTAA

Upstream 100 bases:

>100_bases
GGATTACCCCCCAGACATAAATATAGACAGACATAAATATAGACAGGCATAAGCATAGACAGACATAAACATAGACAGAG
TGATACAAGGGACATTTGCC

Downstream 100 bases:

>100_bases
CACCTATCTGCTATCTGCCGTGGCTAATGACAAGACACCTTTTGAAACCGATATTTAAATGAGTGGTGCACTTCTACTTT
GAACAAGGGCTGGAATCGTA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MEHNTKSRLFPLQVLAYKGYMKALKLAAKIIPMPKPTLFTGEGSSLELCDAMAHMGMKRVLIVTDSVLIKLGLLDAIQSR
LTDSNVEYVIYDGVLPDPTYTQVESGLALYNRHRCDSILAVGGGSPIDAAKVIAARVNNHRKIEKLTGLFRVWRAPAPLF
AIPTTAGTGSEVTIAAVVSDPLTHKKTPLIDPKLVPMMASLDASLMTGLPPHVTSATGMDALTHAVEAFISMNASADTDA
YAIAATRLIMQNLSKVVMDGSDIEARHNMAMASYYAGLAFTKASLGYVHAISHNLGAKYGTPHGLANAIVLPYVLDYSKE
EIVPRLAELSRICGLGKDCDSDEELAQVFIEHIQGMLNEYGIASQLDTLKVEDVPELARAALKEAHFNYPVPKYMDQLQC
EALIRQMLVV

Sequences:

>Translated_410_residues
MEHNTKSRLFPLQVLAYKGYMKALKLAAKIIPMPKPTLFTGEGSSLELCDAMAHMGMKRVLIVTDSVLIKLGLLDAIQSR
LTDSNVEYVIYDGVLPDPTYTQVESGLALYNRHRCDSILAVGGGSPIDAAKVIAARVNNHRKIEKLTGLFRVWRAPAPLF
AIPTTAGTGSEVTIAAVVSDPLTHKKTPLIDPKLVPMMASLDASLMTGLPPHVTSATGMDALTHAVEAFISMNASADTDA
YAIAATRLIMQNLSKVVMDGSDIEARHNMAMASYYAGLAFTKASLGYVHAISHNLGAKYGTPHGLANAIVLPYVLDYSKE
EIVPRLAELSRICGLGKDCDSDEELAQVFIEHIQGMLNEYGIASQLDTLKVEDVPELARAALKEAHFNYPVPKYMDQLQC
EALIRQMLVV
>Mature_410_residues
MEHNTKSRLFPLQVLAYKGYMKALKLAAKIIPMPKPTLFTGEGSSLELCDAMAHMGMKRVLIVTDSVLIKLGLLDAIQSR
LTDSNVEYVIYDGVLPDPTYTQVESGLALYNRHRCDSILAVGGGSPIDAAKVIAARVNNHRKIEKLTGLFRVWRAPAPLF
AIPTTAGTGSEVTIAAVVSDPLTHKKTPLIDPKLVPMMASLDASLMTGLPPHVTSATGMDALTHAVEAFISMNASADTDA
YAIAATRLIMQNLSKVVMDGSDIEARHNMAMASYYAGLAFTKASLGYVHAISHNLGAKYGTPHGLANAIVLPYVLDYSKE
EIVPRLAELSRICGLGKDCDSDEELAQVFIEHIQGMLNEYGIASQLDTLKVEDVPELARAALKEAHFNYPVPKYMDQLQC
EALIRQMLVV

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=384, Percent_Identity=23.4375, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI48994951, Length=376, Percent_Identity=39.8936170212766, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789163, Length=352, Percent_Identity=38.0681818181818, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI87082107, Length=339, Percent_Identity=36.5781710914454, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1787493, Length=373, Percent_Identity=34.3163538873995, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1789386, Length=343, Percent_Identity=25.9475218658892, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=414, Percent_Identity=26.0869565217391, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321181, Length=370, Percent_Identity=36.7567567567568, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24657991, Length=419, Percent_Identity=24.582338902148, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 44478; Mature: 44478

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHNTKSRLFPLQVLAYKGYMKALKLAAKIIPMPKPTLFTGEGSSLELCDAMAHMGMKRV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCEE
LIVTDSVLIKLGLLDAIQSRLTDSNVEYVIYDGVLPDPTYTQVESGLALYNRHRCDSILA
EEEEHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VGGGSPIDAAKVIAARVNNHRKIEKLTGLFRVWRAPAPLFAIPTTAGTGSEVTIAAVVSD
ECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEECC
PLTHKKTPLIDPKLVPMMASLDASLMTGLPPHVTSATGMDALTHAVEAFISMNASADTDA
CCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCH
YAIAATRLIMQNLSKVVMDGSDIEARHNMAMASYYAGLAFTKASLGYVHAISHNLGAKYG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TPHGLANAIVLPYVLDYSKEEIVPRLAELSRICGLGKDCDSDEELAQVFIEHIQGMLNEY
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
GIASQLDTLKVEDVPELARAALKEAHFNYPVPKYMDQLQCEALIRQMLVV
CCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHNTKSRLFPLQVLAYKGYMKALKLAAKIIPMPKPTLFTGEGSSLELCDAMAHMGMKRV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHCCCCEE
LIVTDSVLIKLGLLDAIQSRLTDSNVEYVIYDGVLPDPTYTQVESGLALYNRHRCDSILA
EEEEHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VGGGSPIDAAKVIAARVNNHRKIEKLTGLFRVWRAPAPLFAIPTTAGTGSEVTIAAVVSD
ECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEECC
PLTHKKTPLIDPKLVPMMASLDASLMTGLPPHVTSATGMDALTHAVEAFISMNASADTDA
CCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCH
YAIAATRLIMQNLSKVVMDGSDIEARHNMAMASYYAGLAFTKASLGYVHAISHNLGAKYG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TPHGLANAIVLPYVLDYSKEEIVPRLAELSRICGLGKDCDSDEELAQVFIEHIQGMLNEY
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
GIASQLDTLKVEDVPELARAALKEAHFNYPVPKYMDQLQCEALIRQMLVV
CCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]