Click here to switch to the map view.

The map label for this gene is acsA

Identifier: 167623628

GI number: 167623628

Start: 2034792

End: 2036744

Strand: Reverse

Name: acsA

Synonym: Shal_1697

Alternate gene names: 167623628

Gene position: 2036744-2034792 (Counterclockwise)

Preceding gene: 167623630

Following gene: 167623627

Centisome position: 38.97

GC content: 47.11

Gene sequence:

>1953_bases
ATGAGCACGCAGTCTCTCTATAAAGTTCCAAGTGAAATCGCTGCAAACGCACTTGTAAACGATGAACAATATAAAAAAAT
GTACCAGGAGTCGATTGTAAACCCTGAAGGTTTCTGGAGAGAACACGGCAACCGTATCGACTGGATAAAGCCCTTTACTA
AGGTAAAGAAAACCTCTTTCGATGACCACAACTTATTTATTAAGTGGTTCTACGATGGCACGCTTAACGCGTCTGCAAAC
TGTTTAGATAGACACCTAGAAAACAATGCCGATAAGCTGGCCATTATTTGGGAAGGTGATGACGCTAAAGATCAGCGTAC
GCTGACTTACGGCCAATTACATACGCAAGTCTGTAAATTTGCTAATGCACTGCGTAGCCAAGGTGTACGCCGTGGTGACG
TCGTCACTATATACATGCCTATGGTACCTGAAGCGGCTGTTGCTATGCTTGCATGTGCCCGTATTGGTGCCATTCACTCT
GTTGTCTTTGGTGGTTTCTCACCCGACTCGATTGCCTCACGTGTGATTGACGGTAATTCAAAAGTGGTTATCACGGCCGA
TGAAGGTGTGCGTGCTGGTCGTATCATTCCACTTAAAGCCAATATCGATGAAGCCCTTTCTCATCCTGATGTAAACTGCG
TTGAAAAAGTCATCGTGATGAAACGCACGGGTGGAGATATCAACTGGGTTGAAGGTCGTGATATCTGGTGGGACTCCTTA
ATGGATACTGCATCAGAGCATTGCATTGCTGAAGAGATGGGCGCAGAAGATCCGCTGTTCCTGCTCTATACATCAGGCTC
AACTGGTAACCCTAAAGGTGTGCTTCATACCACGGGTGGTTACATGGTTTACGCAGCCATGACCCACGAATATGTATTCG
ATTACAAAGAGAATGAAGTTTATTGGTGTACGGCAGATGTAGGCTGGATCACCGGTCACTCTTACATGGTTTACGGACCA
CTAGCCAATGGCGCAACAGTGCTTATTCATGAAGGCGTACCAAACTATCCAAGCCCAGCCCGTTTAGGTGAGATGGTTGA
CCGTCATAAAGTAAACATTCTTTATACGGCTCCAACGCTTATTCGCGCACTAATGGCTGAAGGAAAAGAGCAGTTTGCAG
GCTTTGATGGTAGCTCACTGCGGATTATGGGCTCGGTGGGTGAGCCTATTAATCCTGAAGCTTGGCGCTGGTATAACGAT
GTTATTGGTCATGAGAAATGCCCAATTGTTGATACTTGGTGGCAAACGGAAACTGGCGGGATTTTGATTAGCCCACTGCC
AGGTGCAACGGATACCAAACCAGGCTCTGCAACCCGTCCATTCTTTGGCGTACAACCAGCACTTGTCGATAATATGGGTA
ATATCGTTGACGGTGCTAGCGAAGGTAACTTAGTTATCTTAGATTCTTGGCCGGGGCAGATGCGTACCGTATTTGGCGAT
CACGACCGATTCGTACTGACTTACTTTAAAACATTTAGAGGCATGTACTTTACCGGTGATGGTGCTAAGCGTGACGAAGA
CGGTTACTACTGGATCACCGGACGTGTCGATGATGTGATTAACGTATCGGGTCACCGTTTAGGTACCGCTGAAGTTGAAA
GTGCATTAGTTGCTCACGAGTTCGTAGCAGAGGCTGCTGTTGTAGGTTATCCGCACGATATTAAGGGACAAGGGATCTAC
GCCTATGTCACCTTGACCAAAGGGTCGGTTGAAACCGAAGAGCTGCGCCAAGAGTTAAGACAATGGGTAAGAAAAGAGAT
TGGTGCCCTTGCGACCCCAGATCTTATCCAGTGGGCAGGCGGTTTACCTAAAACACGCTCGGGCAAAATTATGCGCCGTT
TCCTACGCAAGATTGCGGCTAATGAGGTCAGCAACTTAGGTGACTCTTCGACACTCGCGGATCCTGCCGTTATCGATACA
CTGATTGAGACGCGTCTTAATCGTAGCGAATAA

Upstream 100 bases:

>100_bases
AAAAAATAAGGAAAATATTTTACTAGACCAAGGTCTAATAGAGAAACCCCCCTCTCCCAATCCATACTCAACTTACGCAT
TATTAGATAAGGGAAGCCCA

Downstream 100 bases:

>100_bases
ACATATACGCAAGATATTAAGTTCTACAGTTTGACTCCCTAGCCCCTCACAGAGGGGCTTTTTTTGTCCCATTTTTACCT
CAAACACGACAAAAAAAGGA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASAN
CLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHTQVCKFANALRSQGVRRGDVVTIYMPMVPEAAVAMLACARIGAIHS
VVFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWDSL
MDTASEHCIAEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGP
LANGATVLIHEGVPNYPSPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFAGFDGSSLRIMGSVGEPINPEAWRWYND
VIGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNMGNIVDGASEGNLVILDSWPGQMRTVFGD
HDRFVLTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHEFVAEAAVVGYPHDIKGQGIY
AYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVSNLGDSSTLADPAVIDT
LIETRLNRSE

Sequences:

>Translated_650_residues
MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASAN
CLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHTQVCKFANALRSQGVRRGDVVTIYMPMVPEAAVAMLACARIGAIHS
VVFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWDSL
MDTASEHCIAEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGP
LANGATVLIHEGVPNYPSPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFAGFDGSSLRIMGSVGEPINPEAWRWYND
VIGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNMGNIVDGASEGNLVILDSWPGQMRTVFGD
HDRFVLTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHEFVAEAAVVGYPHDIKGQGIY
AYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVSNLGDSSTLADPAVIDT
LIETRLNRSE
>Mature_649_residues
STQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASANC
LDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHTQVCKFANALRSQGVRRGDVVTIYMPMVPEAAVAMLACARIGAIHSV
VFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWDSLM
DTASEHCIAEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGPL
ANGATVLIHEGVPNYPSPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFAGFDGSSLRIMGSVGEPINPEAWRWYNDV
IGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNMGNIVDGASEGNLVILDSWPGQMRTVFGDH
DRFVLTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHEFVAEAAVVGYPHDIKGQGIYA
YVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVSNLGDSSTLADPAVIDTL
IETRLNRSE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=670, Percent_Identity=51.7910447761194, Blast_Score=681, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=683, Percent_Identity=50.805270863836, Blast_Score=676, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=623, Percent_Identity=47.9935794542536, Blast_Score=613, Evalue=1e-175,
Organism=Homo sapiens, GI13375727, Length=631, Percent_Identity=36.4500792393027, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=29.1353383458647, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI122937307, Length=550, Percent_Identity=28.1818181818182, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI38505220, Length=515, Percent_Identity=29.5145631067961, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI115511026, Length=535, Percent_Identity=28.5981308411215, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI31982927, Length=639, Percent_Identity=25.508607198748, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=27.0955165692008, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI157311624, Length=494, Percent_Identity=26.7206477732794, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI157311622, Length=494, Percent_Identity=26.7206477732794, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI195947378, Length=423, Percent_Identity=25.531914893617, Blast_Score=106, Evalue=9e-23,
Organism=Homo sapiens, GI187761345, Length=390, Percent_Identity=27.1794871794872, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI187761343, Length=390, Percent_Identity=27.1794871794872, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI42544134, Length=350, Percent_Identity=25.4285714285714, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI156151445, Length=575, Percent_Identity=22.4347826086957, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1790505, Length=645, Percent_Identity=68.5271317829457, Blast_Score=956, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=638, Percent_Identity=37.9310344827586, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788107, Length=589, Percent_Identity=23.9388794567063, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=21.780303030303, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI145693145, Length=524, Percent_Identity=22.5190839694656, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786810, Length=559, Percent_Identity=21.2880143112701, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=661, Percent_Identity=50.6807866868381, Blast_Score=629, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71982997, Length=663, Percent_Identity=50.5279034690799, Blast_Score=629, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17569507, Length=618, Percent_Identity=22.168284789644, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17558820, Length=530, Percent_Identity=23.7735849056604, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32563687, Length=547, Percent_Identity=23.0347349177331, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17560308, Length=566, Percent_Identity=23.8515901060071, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=137, Percent_Identity=32.8467153284672, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=376, Percent_Identity=22.0744680851064, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=127, Percent_Identity=33.8582677165354, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=48.9891135303266, Blast_Score=623, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=45.7231726283048, Blast_Score=565, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319699, Length=377, Percent_Identity=22.5464190981432, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=51.6566265060241, Blast_Score=667, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=55.1601423487544, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=55.5769230769231, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI21355225, Length=646, Percent_Identity=34.5201238390093, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI18859661, Length=540, Percent_Identity=23.3333333333333, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581924, Length=545, Percent_Identity=22.0183486238532, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358303, Length=561, Percent_Identity=20.4991087344029, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656500, Length=537, Percent_Identity=22.5325884543762, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_SHEHH (B0TPY4)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673922.1
- ProteinModelPortal:   B0TPY4
- SMR:   B0TPY4
- GeneID:   5903133
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1697
- HOGENOM:   HBG547964
- OMA:   ETASEHC
- ProtClustDB:   PRK00174
- BioCyc:   SHAL458817:SHAL_1697-MONOMER
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 72065; Mature: 71934

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 517-517

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSF
CCCCHHHHCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCCC
DDHNLFIKWFYDGTLNASANCLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHTQVCKF
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANALRSQGVRRGDVVTIYMPMVPEAAVAMLACARIGAIHSVVFGGFSPDSIASRVIDGNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
KVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWDSL
EEEEECCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHEEEECCCCEEEECCCCCHHHHH
MDTASEHCIAEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEV
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPSPARLGEMVDRHKVNILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGKEQFAGFDGSSLRIMGSVGEPINPEAWRWYNDVIGHEKCPIVDTWWQTETGG
HHHHHHCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
ILISPLPGATDTKPGSATRPFFGVQPALVDNMGNIVDGASEGNLVILDSWPGQMRTVFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCCEEEEECCCCCEEHEECC
HDRFVLTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHE
CCCCCEEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
FVAEAAVVGYPHDIKGQGIYAYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAG
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
GLPKTRSGKIMRRFLRKIAANEVSNLGDSSTLADPAVIDTLIETRLNRSE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSF
CCCHHHHCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCCC
DDHNLFIKWFYDGTLNASANCLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHTQVCKF
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANALRSQGVRRGDVVTIYMPMVPEAAVAMLACARIGAIHSVVFGGFSPDSIASRVIDGNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
KVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWDSL
EEEEECCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHEEEECCCCEEEECCCCCHHHHH
MDTASEHCIAEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEV
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPSPARLGEMVDRHKVNILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGKEQFAGFDGSSLRIMGSVGEPINPEAWRWYNDVIGHEKCPIVDTWWQTETGG
HHHHHHCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
ILISPLPGATDTKPGSATRPFFGVQPALVDNMGNIVDGASEGNLVILDSWPGQMRTVFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCCEEEEECCCCCEEHEECC
HDRFVLTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHE
CCCCCEEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
FVAEAAVVGYPHDIKGQGIYAYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAG
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
GLPKTRSGKIMRRFLRKIAANEVSNLGDSSTLADPAVIDTLIETRLNRSE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA