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The map label for this gene is gltT [H]

Identifier: 167623533

GI number: 167623533

Start: 1920946

End: 1922271

Strand: Reverse

Name: gltT [H]

Synonym: Shal_1602

Alternate gene names: 167623533

Gene position: 1922271-1920946 (Counterclockwise)

Preceding gene: 167623535

Following gene: 167623523

Centisome position: 36.78

GC content: 45.55

Gene sequence:

>1326_bases
ATGTCTGCTACGAAAACCAAAAAACTCGGTCTCACGAGTAAGATTATAATCGGTATGTTTACCGGTATTATTCTTGGACT
CTTATTACGCAATCTGTTTCCAGAGAGTGACTTTGTCAAAGAGTACATCAGCGAGGGTGTGCTAAATGTAATCGGTACTA
TCTTTATCTCAAGCTTAAAAATGCTTGTTGTTCCTCTTGTCTTTGTTTCACTAGTCTGCGGTACTTGTTCGCTAAGTGAA
CCCTCTAAAGTGGGCCGTTTAGGCGGCAAAACCATCGCGTTTTACCTGTTTACGACTGCAATTGCACTTTCAATGGCGAT
TCTTGTTGCCATTGCGGTTCACCCTGGTAATGCCAGCATGGTGACTGAGGGCATGCAGTTTGACGTCAAGCAGGCGCCAA
GCCTTTCTGATGTACTGATTAACCTTGTCCCGACTAACCCACTGCATGCGATGAGTGAAGGTAATATGCTGCAGATCATC
ATATTTGCAGTAATCTTCGGTTTTGCTATCTCACATATTGGCGAGCGCGGTGCACGCGTTGCAGCGTTGTTTAACGACCT
TAACGAAGTGATCATGCGTGTTGTTACACTGATCATGCAGCTTGCTCCATACGGTGTGTTCGCCCTAATGGCAAAACTTG
CACTCACACTGGGGATGGAAACCTTTGGTAGTGTGGTCAAATACTTCTTCGTTGTACTTGGCGTCTTGTTGATCCATGCA
TTTGTTGTTTACCCAACGTTGCTTAAAGTGTTTTCAGGACTTAACCCGTTGACTTTTATTCGCAAAATTCGCGACGTACA
ACTATTTGCATTCAGCACGGCCAGCTCAAACGCCACATTGCCAGTGACCATTGAAACTGCTGAACACCGTATGGGCGTTG
ATAATAAGATTGCTTCTTTTACCTTGCCACTGGGTGCAACCATTAACATGGATGGCACGGCAATTATGCAAGGCGTCGCA
ACCGTATTTATTGCCCAAGTATTTGGTATCGAACTAACCATTACCGATTACGCCATGGTTGTTGTGACCGCAACGCTTGC
CTCTATCGGTACGGCGGGTGTACCCGGTGTGGGTCTTATCATGTTAGCCATGGTACTAAACCAAGTTGGCTTGCCTGTTG
AAGGTATCGCGCTAATTATTGGTGTGGATAGACTACTTGATATGGTGCGCACCGCAGTTAACGTGACTGGCGATACGGTC
GCAACAGTGGTGATTGCTAAATCTGAGAATGAGTTTAATGAAGCGGTATTTAATGACACCCAAGCAGGTAAAGTCGCTCC
AGGCTTTAACGCTCAGGTACACGCTGAAGAGAATAAACTGAGCTAA

Upstream 100 bases:

>100_bases
TCAATCAAAACTTTAACTTCTACACCATTTCCTCGGTGACACTTTCTTGTTAGGCTTTATGACGCAAATTGAAAAGCATA
AAAATTATACAGGAAGCACT

Downstream 100 bases:

>100_bases
TTTTCATAGCTAAAATGGCTCATTAAGCGAGCAACGCACTGGCTTTAAGAGCTGCATGAATAAAAAGGCATCCAGTTGGA
TGCCTTTTTTGTACTAAATT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSATKTKKLGLTSKIIIGMFTGIILGLLLRNLFPESDFVKEYISEGVLNVIGTIFISSLKMLVVPLVFVSLVCGTCSLSE
PSKVGRLGGKTIAFYLFTTAIALSMAILVAIAVHPGNASMVTEGMQFDVKQAPSLSDVLINLVPTNPLHAMSEGNMLQII
IFAVIFGFAISHIGERGARVAALFNDLNEVIMRVVTLIMQLAPYGVFALMAKLALTLGMETFGSVVKYFFVVLGVLLIHA
FVVYPTLLKVFSGLNPLTFIRKIRDVQLFAFSTASSNATLPVTIETAEHRMGVDNKIASFTLPLGATINMDGTAIMQGVA
TVFIAQVFGIELTITDYAMVVVTATLASIGTAGVPGVGLIMLAMVLNQVGLPVEGIALIIGVDRLLDMVRTAVNVTGDTV
ATVVIAKSENEFNEAVFNDTQAGKVAPGFNAQVHAEENKLS

Sequences:

>Translated_441_residues
MSATKTKKLGLTSKIIIGMFTGIILGLLLRNLFPESDFVKEYISEGVLNVIGTIFISSLKMLVVPLVFVSLVCGTCSLSE
PSKVGRLGGKTIAFYLFTTAIALSMAILVAIAVHPGNASMVTEGMQFDVKQAPSLSDVLINLVPTNPLHAMSEGNMLQII
IFAVIFGFAISHIGERGARVAALFNDLNEVIMRVVTLIMQLAPYGVFALMAKLALTLGMETFGSVVKYFFVVLGVLLIHA
FVVYPTLLKVFSGLNPLTFIRKIRDVQLFAFSTASSNATLPVTIETAEHRMGVDNKIASFTLPLGATINMDGTAIMQGVA
TVFIAQVFGIELTITDYAMVVVTATLASIGTAGVPGVGLIMLAMVLNQVGLPVEGIALIIGVDRLLDMVRTAVNVTGDTV
ATVVIAKSENEFNEAVFNDTQAGKVAPGFNAQVHAEENKLS
>Mature_440_residues
SATKTKKLGLTSKIIIGMFTGIILGLLLRNLFPESDFVKEYISEGVLNVIGTIFISSLKMLVVPLVFVSLVCGTCSLSEP
SKVGRLGGKTIAFYLFTTAIALSMAILVAIAVHPGNASMVTEGMQFDVKQAPSLSDVLINLVPTNPLHAMSEGNMLQIII
FAVIFGFAISHIGERGARVAALFNDLNEVIMRVVTLIMQLAPYGVFALMAKLALTLGMETFGSVVKYFFVVLGVLLIHAF
VVYPTLLKVFSGLNPLTFIRKIRDVQLFAFSTASSNATLPVTIETAEHRMGVDNKIASFTLPLGATINMDGTAIMQGVAT
VFIAQVFGIELTITDYAMVVVTATLASIGTAGVPGVGLIMLAMVLNQVGLPVEGIALIIGVDRLLDMVRTAVNVTGDTVA
TVVIAKSENEFNEAVFNDTQAGKVAPGFNAQVHAEENKLS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=443, Percent_Identity=34.0857787810384, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI40254478, Length=505, Percent_Identity=30.8910891089109, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI66773030, Length=400, Percent_Identity=33.75, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI21314632, Length=414, Percent_Identity=32.6086956521739, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI4827012, Length=334, Percent_Identity=37.7245508982036, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI5032093, Length=375, Percent_Identity=35.7333333333333, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI194239697, Length=292, Percent_Identity=38.013698630137, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI223468566, Length=259, Percent_Identity=39.3822393822394, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=39.6, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI262359914, Length=371, Percent_Identity=32.0754716981132, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI301601644, Length=170, Percent_Identity=41.7647058823529, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1790514, Length=422, Percent_Identity=35.3080568720379, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1789947, Length=439, Percent_Identity=30.2961275626424, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1788024, Length=450, Percent_Identity=30.8888888888889, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789473, Length=394, Percent_Identity=28.6802030456853, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983106, Length=460, Percent_Identity=32.3913043478261, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI71983099, Length=460, Percent_Identity=32.3913043478261, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI193206505, Length=427, Percent_Identity=34.8946135831382, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17537407, Length=419, Percent_Identity=35.5608591885441, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71996953, Length=455, Percent_Identity=33.1868131868132, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193206654, Length=447, Percent_Identity=29.9776286353468, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17541374, Length=392, Percent_Identity=30.6122448979592, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24583025, Length=445, Percent_Identity=31.685393258427, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17137668, Length=445, Percent_Identity=31.685393258427, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24583023, Length=445, Percent_Identity=31.685393258427, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI281360481, Length=448, Percent_Identity=29.4642857142857, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281360483, Length=448, Percent_Identity=29.4642857142857, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17137666, Length=448, Percent_Identity=29.4642857142857, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46895; Mature: 46764

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATKTKKLGLTSKIIIGMFTGIILGLLLRNLFPESDFVKEYISEGVLNVIGTIFISSLK
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MLVVPLVFVSLVCGTCSLSEPSKVGRLGGKTIAFYLFTTAIALSMAILVAIAVHPGNASM
HHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
VTEGMQFDVKQAPSLSDVLINLVPTNPLHAMSEGNMLQIIIFAVIFGFAISHIGERGARV
HHCCCCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
AALFNDLNEVIMRVVTLIMQLAPYGVFALMAKLALTLGMETFGSVVKYFFVVLGVLLIHA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVVYPTLLKVFSGLNPLTFIRKIRDVQLFAFSTASSNATLPVTIETAEHRMGVDNKIASF
HHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCEEEEEEECHHHHCCCCCCHHEE
TLPLGATINMDGTAIMQGVATVFIAQVFGIELTITDYAMVVVTATLASIGTAGVPGVGLI
EECCCCEECCCHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHH
MLAMVLNQVGLPVEGIALIIGVDRLLDMVRTAVNVTGDTVATVVIAKSENEFNEAVFNDT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCC
QAGKVAPGFNAQVHAEENKLS
CCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SATKTKKLGLTSKIIIGMFTGIILGLLLRNLFPESDFVKEYISEGVLNVIGTIFISSLK
CCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MLVVPLVFVSLVCGTCSLSEPSKVGRLGGKTIAFYLFTTAIALSMAILVAIAVHPGNASM
HHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
VTEGMQFDVKQAPSLSDVLINLVPTNPLHAMSEGNMLQIIIFAVIFGFAISHIGERGARV
HHCCCCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
AALFNDLNEVIMRVVTLIMQLAPYGVFALMAKLALTLGMETFGSVVKYFFVVLGVLLIHA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVVYPTLLKVFSGLNPLTFIRKIRDVQLFAFSTASSNATLPVTIETAEHRMGVDNKIASF
HHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCEEEEEEECHHHHCCCCCCHHEE
TLPLGATINMDGTAIMQGVATVFIAQVFGIELTITDYAMVVVTATLASIGTAGVPGVGLI
EECCCCEECCCHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHH
MLAMVLNQVGLPVEGIALIIGVDRLLDMVRTAVNVTGDTVATVVIAKSENEFNEAVFNDT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCC
QAGKVAPGFNAQVHAEENKLS
CCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]