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The map label for this gene is lacA [H]

Identifier: 167623523

GI number: 167623523

Start: 1909833

End: 1910399

Strand: Reverse

Name: lacA [H]

Synonym: Shal_1592

Alternate gene names: 167623523

Gene position: 1910399-1909833 (Counterclockwise)

Preceding gene: 167623533

Following gene: 167623514

Centisome position: 36.55

GC content: 38.62

Gene sequence:

>567_bases
ATGAGTATGTGTAAAAAAGTTAGTCTGCGACGAAAGTTGAAAAATCTTTCTATCAAATTCTTTTGTAAAAGAAAGAAGGT
TATGATTGATAGCATCCCGATATTCAGTGGAGCATGGCCGGAAATACATAACAAAGGTATTATGCGTATTGGTAATCAAT
GCTCATTTCGCTCTTTTCGCCTACGTCAAAGTATTACGGTTCAAACTGGTGCAATATTAGAGATAGGTGAAGGTTCATTT
TTTAATGACGGAGTCAATATTTGTGCTACACAGTCGATCAAAATCGGTCATCACACTAAGGTAGGTGATATGACTTACAT
TTTTGATACCGACTTCCATCAGTTATCTCCTGAGCGAGAGATGAAAAATGCCCCCATTATTATTGGAAATAATGTGTGGG
TTGGTGCGAATTCAATGATCCTTGCAGGTTCTTCTATTGGCAATAATTCTGTCATTGCCGCCGGTTCGATAGTTGTTGGA
GAAATTCCACCAAATTGCTTAGCAGCAGGCACCCCAGCAAAAGTGATAAGGTCACTCAATATTCCAGATGGTTGGTTAAG
GCAATAA

Upstream 100 bases:

>100_bases
CCGAGCACTCAGGGGGATTCCAAAGAGTCCCATAGAGAGTTAATCATCACTCCACTGTCACCACCAGTCTTAGTTAGTCA
TCTAGTATAAATATTCGGAA

Downstream 100 bases:

>100_bases
CCCCGCTGAAACTCAAACAGATAACCAATCCACATTATAGGCCTTCGTAGCCATATATTAATAAGTTAGCTTCGTAACTG
TCCGAGTCAACTCTGCTGAA

Product: acetyltransferase

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSMCKKVSLRRKLKNLSIKFFCKRKKVMIDSIPIFSGAWPEIHNKGIMRIGNQCSFRSFRLRQSITVQTGAILEIGEGSF
FNDGVNICATQSIKIGHHTKVGDMTYIFDTDFHQLSPEREMKNAPIIIGNNVWVGANSMILAGSSIGNNSVIAAGSIVVG
EIPPNCLAAGTPAKVIRSLNIPDGWLRQ

Sequences:

>Translated_188_residues
MSMCKKVSLRRKLKNLSIKFFCKRKKVMIDSIPIFSGAWPEIHNKGIMRIGNQCSFRSFRLRQSITVQTGAILEIGEGSF
FNDGVNICATQSIKIGHHTKVGDMTYIFDTDFHQLSPEREMKNAPIIIGNNVWVGANSMILAGSSIGNNSVIAAGSIVVG
EIPPNCLAAGTPAKVIRSLNIPDGWLRQ
>Mature_187_residues
SMCKKVSLRRKLKNLSIKFFCKRKKVMIDSIPIFSGAWPEIHNKGIMRIGNQCSFRSFRLRQSITVQTGAILEIGEGSFF
NDGVNICATQSIKIGHHTKVGDMTYIFDTDFHQLSPEREMKNAPIIIGNNVWVGANSMILAGSSIGNNSVIAAGSIVVGE
IPPNCLAAGTPAKVIRSLNIPDGWLRQ

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=126, Percent_Identity=37.3015873015873, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788345, Length=111, Percent_Identity=35.1351351351351, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1788367, Length=118, Percent_Identity=27.9661016949153, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786664, Length=91, Percent_Identity=35.1648351648352, Blast_Score=63, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322243, Length=165, Percent_Identity=30.9090909090909, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 20647; Mature: 20516

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMCKKVSLRRKLKNLSIKFFCKRKKVMIDSIPIFSGAWPEIHNKGIMRIGNQCSFRSFR
CCHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCCCCCCHHHCCCCCEEECCCCCCCEEE
LRQSITVQTGAILEIGEGSFFNDGVNICATQSIKIGHHTKVGDMTYIFDTDFHQLSPERE
ECEEEEEECCCEEEECCCCEECCCCCEEEECEEECCCCCCCCCEEEEEECCHHHCCCHHH
MKNAPIIIGNNVWVGANSMILAGSSIGNNSVIAAGSIVVGEIPPNCLAAGTPAKVIRSLN
HCCCCEEECCCEEECCCCEEEEECCCCCCCEEEECCEEEECCCCCCCCCCCHHHHHEECC
IPDGWLRQ
CCCHHHCC
>Mature Secondary Structure 
SMCKKVSLRRKLKNLSIKFFCKRKKVMIDSIPIFSGAWPEIHNKGIMRIGNQCSFRSFR
CHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCCCCCCHHHCCCCCEEECCCCCCCEEE
LRQSITVQTGAILEIGEGSFFNDGVNICATQSIKIGHHTKVGDMTYIFDTDFHQLSPERE
ECEEEEEECCCEEEECCCCEECCCCCEEEECEEECCCCCCCCCEEEEEECCHHHCCCHHH
MKNAPIIIGNNVWVGANSMILAGSSIGNNSVIAAGSIVVGEIPPNCLAAGTPAKVIRSLN
HCCCCEEECCCEEECCCCEEEEECCCCCCCEEEECCEEEECCCCCCCCCCCHHHHHEECC
IPDGWLRQ
CCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]