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The map label for this gene is purE [H]

Identifier: 167623179

GI number: 167623179

Start: 1518032

End: 1518535

Strand: Direct

Name: purE [H]

Synonym: Shal_1245

Alternate gene names: 167623179

Gene position: 1518032-1518535 (Clockwise)

Preceding gene: 167623177

Following gene: 167623180

Centisome position: 29.04

GC content: 49.21

Gene sequence:

>504_bases
ATGAGCAAACCATTTGTTGCAGTATTAATGGGATCTGATTCAGATCTGCCCACAATGCAAGCCACCCTCGATGTGCTTAG
AACTTTCGAAATCAACTTTGAAGCAAAGGTCACTTCAGCGCACCGTACGCCAGCCGCGACCCATGCTTATGTAACCGATG
CTGAAGCGCGGGGTTGTAAAGTCTTTATTTGTGCTGCAGGTCTTGCTGCGCACCTAGCTGGCGCTGTTGCTGGTATTACT
ACTCGCCCTGTTATTGGTGTGCCAATTGATTGTGGTCCACTAAAAGGCCACGATGCGCTTTTATCAACAGTAATGATGCC
TGGCGGCGTCCCTGTAGCGACCGTTGCTATCGGTAGTGCTGGTGCTAAGAACGCTGGCTATCTAGCGGCACAAATGTTAG
CTGTTGGTGATGAAGCACTGGCTGTAGCCGTTAAAGAAGAACGTGCTAAGTCTGCTGAAGCCGTTCAAGCTAAAGATGCA
GCGCTACAAGCTAAACTAGCTTAA

Upstream 100 bases:

>100_bases
TTACGCCGCAGGCTTGGGGGAAGTCTGTTTACTAAGCGTGCTAATTTTCATTATAATGCGCGCAATTATAATAATGTACC
GCCCTACTCAAGGACTTAAA

Downstream 100 bases:

>100_bases
TTAAACAGGCATTTGCCTGTCGACATCAAATGCCGCCTAGAAAATTTTTTAGGTGGCATTTTTGTTTGATCTGTTTGCAT
TTTACCTCCTTATCTCAACT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MSKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCKVFICAAGLAAHLAGAVAGIT
TRPVIGVPIDCGPLKGHDALLSTVMMPGGVPVATVAIGSAGAKNAGYLAAQMLAVGDEALAVAVKEERAKSAEAVQAKDA
ALQAKLA

Sequences:

>Translated_167_residues
MSKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCKVFICAAGLAAHLAGAVAGIT
TRPVIGVPIDCGPLKGHDALLSTVMMPGGVPVATVAIGSAGAKNAGYLAAQMLAVGDEALAVAVKEERAKSAEAVQAKDA
ALQAKLA
>Mature_166_residues
SKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCKVFICAAGLAAHLAGAVAGITT
RPVIGVPIDCGPLKGHDALLSTVMMPGGVPVATVAIGSAGAKNAGYLAAQMLAVGDEALAVAVKEERAKSAEAVQAKDAA
LQAKLA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=43.8709677419355, Blast_Score=94, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=163, Percent_Identity=46.6257668711656, Blast_Score=131, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16883; Mature: 16752

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCK
CCCCEEEEEECCCCCCCHHHHHHHHHHHEECCEEEEEECCCCCCCCCEEEEECCCCCCCE
VFICAAGLAAHLAGAVAGITTRPVIGVPIDCGPLKGHDALLSTVMMPGGVPVATVAIGSA
EEEEECCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
GAKNAGYLAAQMLAVGDEALAVAVKEERAKSAEAVQAKDAALQAKLA
CCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
SKPFVAVLMGSDSDLPTMQATLDVLRTFEINFEAKVTSAHRTPAATHAYVTDAEARGCK
CCCEEEEEECCCCCCCHHHHHHHHHHHEECCEEEEEECCCCCCCCCEEEEECCCCCCCE
VFICAAGLAAHLAGAVAGITTRPVIGVPIDCGPLKGHDALLSTVMMPGGVPVATVAIGSA
EEEEECCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCC
GAKNAGYLAAQMLAVGDEALAVAVKEERAKSAEAVQAKDAALQAKLA
CCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]