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The map label for this gene is nhaA [H]

Identifier: 167623005

GI number: 167623005

Start: 1311115

End: 1312290

Strand: Direct

Name: nhaA [H]

Synonym: Shal_1071

Alternate gene names: 167623005

Gene position: 1311115-1312290 (Clockwise)

Preceding gene: 167623004

Following gene: 167623006

Centisome position: 25.08

GC content: 46.77

Gene sequence:

>1176_bases
ATGGAACGGGCAATTAGGAATTTTCTAAGCCAGGAATCGGCGGGCGGCATCTTATTGATGATTTCCGTCGTGCTTGCAAT
GTTATTAGCAAACTCACCTTTATCGGGTATGTACCAAGGCTTTCTGGACACAGAAATGCAAGTGCGTGTTGGTAGCCTAG
ATATCGATAAGACACTTATTCACTGGATCAATGATGGCTTGATGGCAATCTTCTTCATGCTTATCGGCTTGGAAGTGAAG
CGAGAGTTGCTTGAAGGTGCATTATCTAGCCGTGCTCAGGCATCTTTGCCTACATTTGCGGCGATCGGCGGTATGGTTTT
CCCTGCTGCTGTATACCTTATTTTTAACTACTCTGATCCCATTACCCAAGTGGGCTGGGCGATTCCAGCTGCGACCGATA
TCGCGTTTGCTTTAGGTATTATGGCGCTACTTGGTAGCCGCGTACCTGTAGCATTGAAGGTGTTCCTATTGGCACTGGCG
ATTATCGATGACCTTGGTGTTGTTGTCATCATTGCACTGTTCTACAGTACAGATCTGTCGACCATTAGCTTAATTGTGGC
TGCAGTGGCGATTCTAGGTCTAGTAGGATTAAACCGCAAAGGTGTCACCGCTCTAGGGCCATATGGTGTACTCGGTCTTA
TTCTGTGGATCGCGGTACTGAAGTCTGGGGTACATGCCACATTGGCCGGCGTAATTATTGCGTTCTGTATTCCGCTTAGA
GCTAAAGATGGCTCCTCACCATCTGAGAGTTTAGAGCATGGTCTTCACCCTTGGAGTACCTTCATTATCTTGCCAATATT
TGCCTTCGCCAATGCTGGTGTTGACTTGGGTGGCATGAGCTTGAGTTCAGTGTTATCGCCTGTACCACTAGGTATTGCAC
TCGGTCTATTAGTGGGTAAGCCATTAGGCATCATGCTATTTAGCTTCGTTGCCGTAAAGCTTAAGCTGGCAGTTCTACCT
GATGGCATGGGCTGGAGACACATCACTCCTGTTGCTGTGATGTGTGGTATCGGTTTCACTATGTCTATGTTTATCTCTTC
GCTTGCCTTTATTGGTGAGGGGCAGATGTACGGTGATTATGCACGGTTAGGTATTTTATTAGGGTCAATAGCATCAGCGA
CGATAGGTTATTTCTGGTTGTCGAAGGTGTTACCTGAGAAAGGAGAGAAAGCATGA

Upstream 100 bases:

>100_bases
ATACTTCGGATATCCCGATGTTTATGGCTGATGCAAACGATTATTCAGGTTAATCGTATTCAGTTACACTCGCGGTATTG
AGATTTTATGGAGCGTAAAA

Downstream 100 bases:

>100_bases
GATTAGGATTATTAGCATTAGTTATTGGTCTTGGGTTTAGCTCTGTTGCAACAGCAAGTCAGATTGAGAGCTGCAATCAA
AATATCGACAGTGTTGTGTG

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MERAIRNFLSQESAGGILLMISVVLAMLLANSPLSGMYQGFLDTEMQVRVGSLDIDKTLIHWINDGLMAIFFMLIGLEVK
RELLEGALSSRAQASLPTFAAIGGMVFPAAVYLIFNYSDPITQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALA
IIDDLGVVVIIALFYSTDLSTISLIVAAVAILGLVGLNRKGVTALGPYGVLGLILWIAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSESLEHGLHPWSTFIILPIFAFANAGVDLGGMSLSSVLSPVPLGIALGLLVGKPLGIMLFSFVAVKLKLAVLP
DGMGWRHITPVAVMCGIGFTMSMFISSLAFIGEGQMYGDYARLGILLGSIASATIGYFWLSKVLPEKGEKA

Sequences:

>Translated_391_residues
MERAIRNFLSQESAGGILLMISVVLAMLLANSPLSGMYQGFLDTEMQVRVGSLDIDKTLIHWINDGLMAIFFMLIGLEVK
RELLEGALSSRAQASLPTFAAIGGMVFPAAVYLIFNYSDPITQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALA
IIDDLGVVVIIALFYSTDLSTISLIVAAVAILGLVGLNRKGVTALGPYGVLGLILWIAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSESLEHGLHPWSTFIILPIFAFANAGVDLGGMSLSSVLSPVPLGIALGLLVGKPLGIMLFSFVAVKLKLAVLP
DGMGWRHITPVAVMCGIGFTMSMFISSLAFIGEGQMYGDYARLGILLGSIASATIGYFWLSKVLPEKGEKA
>Mature_391_residues
MERAIRNFLSQESAGGILLMISVVLAMLLANSPLSGMYQGFLDTEMQVRVGSLDIDKTLIHWINDGLMAIFFMLIGLEVK
RELLEGALSSRAQASLPTFAAIGGMVFPAAVYLIFNYSDPITQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALA
IIDDLGVVVIIALFYSTDLSTISLIVAAVAILGLVGLNRKGVTALGPYGVLGLILWIAVLKSGVHATLAGVIIAFCIPLR
AKDGSSPSESLEHGLHPWSTFIILPIFAFANAGVDLGGMSLSSVLSPVPLGIALGLLVGKPLGIMLFSFVAVKLKLAVLP
DGMGWRHITPVAVMCGIGFTMSMFISSLAFIGEGQMYGDYARLGILLGSIASATIGYFWLSKVLPEKGEKA

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=379, Percent_Identity=60.6860158311346, Blast_Score=418, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 41225; Mature: 41225

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAIRNFLSQESAGGILLMISVVLAMLLANSPLSGMYQGFLDTEMQVRVGSLDIDKTLI
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCHHHHHH
HWINDGLMAIFFMLIGLEVKRELLEGALSSRAQASLPTFAAIGGMVFPAAVYLIFNYSDP
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ITQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALAIIDDLGVVVIIALFYSTDLS
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TISLIVAAVAILGLVGLNRKGVTALGPYGVLGLILWIAVLKSGVHATLAGVIIAFCIPLR
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSESLEHGLHPWSTFIILPIFAFANAGVDLGGMSLSSVLSPVPLGIALGLLVGK
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHCC
PLGIMLFSFVAVKLKLAVLPDGMGWRHITPVAVMCGIGFTMSMFISSLAFIGEGQMYGDY
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ARLGILLGSIASATIGYFWLSKVLPEKGEKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MERAIRNFLSQESAGGILLMISVVLAMLLANSPLSGMYQGFLDTEMQVRVGSLDIDKTLI
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCCCHHHHHH
HWINDGLMAIFFMLIGLEVKRELLEGALSSRAQASLPTFAAIGGMVFPAAVYLIFNYSDP
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ITQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALAIIDDLGVVVIIALFYSTDLS
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TISLIVAAVAILGLVGLNRKGVTALGPYGVLGLILWIAVLKSGVHATLAGVIIAFCIPLR
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
AKDGSSPSESLEHGLHPWSTFIILPIFAFANAGVDLGGMSLSSVLSPVPLGIALGLLVGK
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHCC
PLGIMLFSFVAVKLKLAVLPDGMGWRHITPVAVMCGIGFTMSMFISSLAFIGEGQMYGDY
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ARLGILLGSIASATIGYFWLSKVLPEKGEKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA