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The map label for this gene is mtnN

Identifier: 167622985

GI number: 167622985

Start: 1283577

End: 1284269

Strand: Reverse

Name: mtnN

Synonym: Shal_1051

Alternate gene names: 167622985

Gene position: 1284269-1283577 (Counterclockwise)

Preceding gene: 167622988

Following gene: 167622984

Centisome position: 24.57

GC content: 48.92

Gene sequence:

>693_bases
ATGAAAATCGGTATTATTGGCGCTATGGAGCCGGAAGTTGCACATTTAGTTGAGTCGATGGAAAACCCAAGCTCTACAAC
CATCGCCGGTATCGAGTTTGTTGCAGGTCAGCTAGCGGGCAAAGACGTTATCGTTACTCGTTCAGGCATTGGTAAAGTAA
CAGCCAGCATTGCGACGACGCTGCTTATCGAAAAGTATGCACCTGATGTGATTATTAACACAGGTTCTGCTGGCGGCTTC
GCCGACGAACTTGCCATTGGCGATATCGTGATCTCATCTGAAGTGCGTCACCATGATGTTGACGTGACTGCGTTCGGTTA
TGAGATTGGCCAGATGGCGCAGCAACCTGCAGCGTTTATCCCTGATGCTAAGCTTGTGGCTGCGGCGCAAAAAGCGGTTG
CTAGCCTTGGTGAAGTCAAAGCCATTGAAGGTTTAATCTGTACAGGCGATAGCTTTATTTGCGATCCCGTTCGCACCAAG
ACCATGCTAGAGAACTTCCCAACGATGGCGGCGTGTGAAATGGAAGGCGCAGCGATTGCTCAGGTTTGTCACCAGTTTGG
TGTACCGTTTGTGGTTATCCGCTCTCTGTCCGACAATGCTAACAACGACTCGCCTGTAGATTTTGACGAATACATTGTTA
AAGCAGGCCACCACTCTGCATTGATGGTTATCGCTCTGCTTAAGCAACTTTAA

Upstream 100 bases:

>100_bases
AGCCTTACTTCTCATCTTATCTTCAAGGCTTTTTCACTAACGCCAAGTGCCGTGGTATATTAGCGCCCATATTCATTCAG
GTAGTTAAAAAGGTCATTAA

Downstream 100 bases:

>100_bases
GCTAAGCTGCTTTAAGTTAAAAAAGCTCTAAGCTAAAAAGCTTTTAATTAAAGACGAGTAAAGCAACACAAGGATAGCGC
AGCAATATGGTTCCAGAGTT

Product: adenosylhomocysteine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKIGIIGAMEPEVAHLVESMENPSSTTIAGIEFVAGQLAGKDVIVTRSGIGKVTASIATTLLIEKYAPDVIINTGSAGGF
ADELAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFIPDAKLVAAAQKAVASLGEVKAIEGLICTGDSFICDPVRTK
TMLENFPTMAACEMEGAAIAQVCHQFGVPFVVIRSLSDNANNDSPVDFDEYIVKAGHHSALMVIALLKQL

Sequences:

>Translated_230_residues
MKIGIIGAMEPEVAHLVESMENPSSTTIAGIEFVAGQLAGKDVIVTRSGIGKVTASIATTLLIEKYAPDVIINTGSAGGF
ADELAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFIPDAKLVAAAQKAVASLGEVKAIEGLICTGDSFICDPVRTK
TMLENFPTMAACEMEGAAIAQVCHQFGVPFVVIRSLSDNANNDSPVDFDEYIVKAGHHSALMVIALLKQL
>Mature_230_residues
MKIGIIGAMEPEVAHLVESMENPSSTTIAGIEFVAGQLAGKDVIVTRSGIGKVTASIATTLLIEKYAPDVIINTGSAGGF
ADELAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFIPDAKLVAAAQKAVASLGEVKAIEGLICTGDSFICDPVRTK
TMLENFPTMAACEMEGAAIAQVCHQFGVPFVVIRSLSDNANNDSPVDFDEYIVKAGHHSALMVIALLKQL

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily

Homologues:

Organism=Escherichia coli, GI1786354, Length=230, Percent_Identity=52.1739130434783, Blast_Score=207, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNN_SHEHH (B0TIS5)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673279.1
- ProteinModelPortal:   B0TIS5
- SMR:   B0TIS5
- GeneID:   5905752
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1051
- HOGENOM:   HBG367723
- OMA:   LEHFPTM
- ProtClustDB:   CLSK906203
- BioCyc:   SHAL458817:SHAL_1051-MONOMER
- HAMAP:   MF_01684
- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01704

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =3.2.2.9

Molecular weight: Translated: 24128; Mature: 24128

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: ACT_SITE 12-12 BINDING 78-78 BINDING 153-153 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIIGAMEPEVAHLVESMENPSSTTIAGIEFVAGQLAGKDVIVTRSGIGKVTASIATT
CEEEEECCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
LLIEKYAPDVIINTGSAGGFADELAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFI
HHHHHCCCCEEEECCCCCCCHHHHHHHHEEEECCCHHCCCCEEEECHHHHHHHCCCHHCC
PDAKLVAAAQKAVASLGEVKAIEGLICTGDSFICDPVRTKTMLENFPTMAACEMEGAAIA
CCHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEECCHHHHHHHHHCCCCEECCCCCHHHH
QVCHQFGVPFVVIRSLSDNANNDSPVDFDEYIVKAGHHSALMVIALLKQL
HHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MKIGIIGAMEPEVAHLVESMENPSSTTIAGIEFVAGQLAGKDVIVTRSGIGKVTASIATT
CEEEEECCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHH
LLIEKYAPDVIINTGSAGGFADELAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFI
HHHHHCCCCEEEECCCCCCCHHHHHHHHEEEECCCHHCCCCEEEECHHHHHHHCCCHHCC
PDAKLVAAAQKAVASLGEVKAIEGLICTGDSFICDPVRTKTMLENFPTMAACEMEGAAIA
CCHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEECCHHHHHHHHHCCCCEECCCCCHHHH
QVCHQFGVPFVVIRSLSDNANNDSPVDFDEYIVKAGHHSALMVIALLKQL
HHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA