Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 167622941

GI number: 167622941

Start: 1231929

End: 1233206

Strand: Direct

Name: gabT [H]

Synonym: Shal_1002

Alternate gene names: 167622941

Gene position: 1231929-1233206 (Clockwise)

Preceding gene: 167622940

Following gene: 167622947

Centisome position: 23.57

GC content: 52.19

Gene sequence:

>1278_bases
ATGACAACTAATGAGTCACTTATGGTGCGCCGCCAAGCGGCGGTCGCTAATGGCGTTGGACAAATTCACCCTATCTATAC
CCAGCGCGCCGAAAACGCTACGGTGTGGGATGTAGAAGGGCGAGAGTTTATCGACTTTGCTGGTGGTATCGCGGTGCTCA
ATACCGGGCATCTTCACGATAAAGTCAAAGCTGCGGTGGCGGAGCAACTCGAGCTATTTTCTCATACCTGCTTTATGGTG
CTGGGCTATGAGAATTACATTCAAGTGTGTGAGAAACTTAATCACCTAGTGCCAGGCGACTTCGCCAAGAAAACGGCATT
GTTTACCAGTGGCTCAGAGGCGGTTGAGAATGCGGTCAAAGTGGCGCGTGCTTATACCAAGCGCAGCGGTGTTATCGCCT
TTACCTCCGGTTATCATGGCCGCACCATGGCGGCGTTAGCACTGACAGGCAAGGTCGCGCCTTACAGTAAAGGCATGGGT
TTGATGTCGGCCAATGTGTTTAGAGCCGAGTTCCCCTGTGCGCTCCATGGCGTGACAGATGACGATGCCATCGCATCGAT
TGAACGTATTTTTAAAAATGATGCCGAGCCCGATGATATCGCAGCAATTATTATCGAGCCAGTGCAAGGCGAGGGAGGCT
TTTACCATACCTCTGTCGAGTTTATGCAGCGTTTACGTCAATTATGCCATAAGCACGGTATTATGCTGATTGCCGATGAG
GTGCAAACAGGCGCTGGGCGAACTGGAACCTTCTTTGCTATGGAGCAGATGGGCGTGAGCGCGGATATCACCACCTTTGC
TAAGTCTATCGCCGGAGGTTTTCCGTTATCGGGGATCACCGGCCGAGCCGAAGTGATGGATTCCATCGGTGCTGGTGGCT
TAGGTGGCACCTATGGCGGTAGCCCACTAGCTTGTGCTGCCGCACTCGCGGTGATTGAGGTGTTTGAAGAAGAACAGCTA
CTTCAAAGAGCAAATGCGCTTGGCGCTAAGCTTAAAGAGTCACTCAAAGCTATGGCAGCAAAGCATGAGCAAATTTTTGA
TGTGCGCGGTCTTGGCGCCATGATAGCGGTCGAGCTCATGCAAGAGGGCAAACCCGCGCCAGAGCTGTGCGCGCAAATGC
TTAAAGAGGCGCGAGACAAAGGGCTTATACTGCTCTCTTGCGGTACCTACGGTAACGTACTACGTATCCTTGTGCCGCTT
ACGGCGCCCGATGAGCTGGTTGACAGGGGACTGGAGATCATTCGTGCCTGTTTTGATGTTGTATTGAAGCCTGTTTAA

Upstream 100 bases:

>100_bases
AGTTTGGTATCGAAGAGTACTTGGAGATGAAATACATCTGCATGTCTGTTTAATACTTGAAGATTAAGTTCATCAGTATG
TCAGTTAAAAGGAAATCGTT

Downstream 100 bases:

>100_bases
TACCAATTGGCATCATCAGTAAAAGGTGGGCTGAGTATAATGCGTGCGGAAATCCGAGAGCCGTTTTTGGTCTCGGATTT
TTTACTTTCTAATTGCACTA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTTNESLMVRRQAAVANGVGQIHPIYTQRAENATVWDVEGREFIDFAGGIAVLNTGHLHDKVKAAVAEQLELFSHTCFMV
LGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMG
LMSANVFRAEFPCALHGVTDDDAIASIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCHKHGIMLIADE
VQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGGSPLACAAALAVIEVFEEEQL
LQRANALGAKLKESLKAMAAKHEQIFDVRGLGAMIAVELMQEGKPAPELCAQMLKEARDKGLILLSCGTYGNVLRILVPL
TAPDELVDRGLEIIRACFDVVLKPV

Sequences:

>Translated_425_residues
MTTNESLMVRRQAAVANGVGQIHPIYTQRAENATVWDVEGREFIDFAGGIAVLNTGHLHDKVKAAVAEQLELFSHTCFMV
LGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMG
LMSANVFRAEFPCALHGVTDDDAIASIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCHKHGIMLIADE
VQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGGSPLACAAALAVIEVFEEEQL
LQRANALGAKLKESLKAMAAKHEQIFDVRGLGAMIAVELMQEGKPAPELCAQMLKEARDKGLILLSCGTYGNVLRILVPL
TAPDELVDRGLEIIRACFDVVLKPV
>Mature_424_residues
TTNESLMVRRQAAVANGVGQIHPIYTQRAENATVWDVEGREFIDFAGGIAVLNTGHLHDKVKAAVAEQLELFSHTCFMVL
GYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMGL
MSANVFRAEFPCALHGVTDDDAIASIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCHKHGIMLIADEV
QTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGGSPLACAAALAVIEVFEEEQLL
QRANALGAKLKESLKAMAAKHEQIFDVRGLGAMIAVELMQEGKPAPELCAQMLKEARDKGLILLSCGTYGNVLRILVPLT
APDELVDRGLEIIRACFDVVLKPV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=31.2039312039312, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI13994255, Length=428, Percent_Identity=30.1401869158879, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI37574042, Length=402, Percent_Identity=29.6019900497512, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI226442705, Length=402, Percent_Identity=29.3532338308458, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI226442709, Length=370, Percent_Identity=30, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI284507298, Length=318, Percent_Identity=31.7610062893082, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=27.5058275058275, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI188536080, Length=396, Percent_Identity=25.7575757575758, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38679950, Length=396, Percent_Identity=25.7575757575758, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38679946, Length=396, Percent_Identity=25.7575757575758, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=69.9052132701422, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI1787560, Length=415, Percent_Identity=50.6024096385542, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=32.5062034739454, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=34.6835443037975, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI145693181, Length=384, Percent_Identity=33.8541666666667, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786991, Length=333, Percent_Identity=33.9339339339339, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=30.3724928366762, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32564660, Length=417, Percent_Identity=34.2925659472422, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=29.9270072992701, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=28.8372093023256, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=320, Percent_Identity=28.125, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=410, Percent_Identity=26.8292682926829, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=30.9178743961353, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=30.1234567901235, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=372, Percent_Identity=23.3870967741935, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6321456, Length=246, Percent_Identity=28.0487804878049, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI161085790, Length=459, Percent_Identity=29.8474945533769, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574759, Length=441, Percent_Identity=30.1587301587302, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=29.8029556650246, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=28.978622327791, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI281366494, Length=397, Percent_Identity=24.9370277078086, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24667139, Length=397, Percent_Identity=24.9370277078086, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24667143, Length=397, Percent_Identity=24.9370277078086, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45498; Mature: 45367

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNESLMVRRQAAVANGVGQIHPIYTQRAENATVWDVEGREFIDFAGGIAVLNTGHLHD
CCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCHHHHHCCCEEEEECCCHHH
KVKAAVAEQLELFSHTCFMVLGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVK
HHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHCCCCCCCHHHHHHEECCCHHHHHHHHH
VARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMSANVFRAEFPCALHGVTD
HHHHHHHCCCEEEEECCCCCCCEEHHHHHCCCCCCCCCCCHHCCCCCCEECCEEECCCCC
DDAIASIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCHKHGIMLIADE
HHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHCCEEEEEEC
VQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGG
CCCCCCCCCCEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
SPLACAAALAVIEVFEEEQLLQRANALGAKLKESLKAMAAKHEQIFDVRGLGAMIAVELM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QEGKPAPELCAQMLKEARDKGLILLSCGTYGNVLRILVPLTAPDELVDRGLEIIRACFDV
HCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEHEEEECCCCHHHHHHHHHHHHHHHHH
VLKPV
HHCCC
>Mature Secondary Structure 
TTNESLMVRRQAAVANGVGQIHPIYTQRAENATVWDVEGREFIDFAGGIAVLNTGHLHD
CCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCCCHHHHHCCCEEEEECCCHHH
KVKAAVAEQLELFSHTCFMVLGYENYIQVCEKLNHLVPGDFAKKTALFTSGSEAVENAVK
HHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHCCCCCCCHHHHHHEECCCHHHHHHHHH
VARAYTKRSGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMSANVFRAEFPCALHGVTD
HHHHHHHCCCEEEEECCCCCCCEEHHHHHCCCCCCCCCCCHHCCCCCCEECCEEECCCCC
DDAIASIERIFKNDAEPDDIAAIIIEPVQGEGGFYHTSVEFMQRLRQLCHKHGIMLIADE
HHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCEEECHHHHHHHHHHHHHHCCEEEEEEC
VQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGRAEVMDSIGAGGLGGTYGG
CCCCCCCCCCEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCC
SPLACAAALAVIEVFEEEQLLQRANALGAKLKESLKAMAAKHEQIFDVRGLGAMIAVELM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QEGKPAPELCAQMLKEARDKGLILLSCGTYGNVLRILVPLTAPDELVDRGLEIIRACFDV
HCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEHEEEECCCCHHHHHHHHHHHHHHHHH
VLKPV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]